LOCUS       NM_024591               1664 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens charged multivesicular body protein 6 (CHMP6), mRNA.
ACCESSION   NM_024591 XM_941273
VERSION     NM_024591.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1664)
  AUTHORS   Li,H., Chen,Z., Huang,Y., Chen,C. and Cai,L.
  TITLE     ELK4 targets CHMP6 to inhibit ferroptosis and enhance malignant
            properties of skin cutaneous melanoma cells
  JOURNAL   Arch Dermatol Res 316 (9), 634 (2024)
   PUBMED   39305302
  REMARK    GeneRIF: ELK4 targets CHMP6 to inhibit ferroptosis and enhance
            malignant properties of skin cutaneous melanoma cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1664)
  AUTHORS   Wenzel,D.M., Mackay,D.R., Skalicky,J.J., Paine,E.L., Miller,M.S.,
            Ullman,K.S. and Sundquist,W.I.
  TITLE     Comprehensive analysis of the human ESCRT-III-MIT domain
            interactome reveals new cofactors for cytokinetic abscission
  JOURNAL   Elife 11, e77779 (2022)
   PUBMED   36107470
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1664)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1664)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 1664)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1664)
  AUTHORS   Martin-Serrano,J., Yarovoy,A., Perez-Caballero,D. and Bieniasz,P.D.
  TITLE     Divergent retroviral late-budding domains recruit vacuolar protein
            sorting factors by using alternative adaptor proteins
  JOURNAL   Proc Natl Acad Sci U S A 100 (21), 12414-12419 (2003)
   PUBMED   14519844
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):152845.
            Yaravoy, A [corrected to Yarovoy, A]]
REFERENCE   7  (bases 1 to 1664)
  AUTHORS   von Schwedler,U.K., Stuchell,M., Muller,B., Ward,D.M., Chung,H.Y.,
            Morita,E., Wang,H.E., Davis,T., He,G.P., Cimbora,D.M., Scott,A.,
            Krausslich,H.G., Kaplan,J., Morham,S.G. and Sundquist,W.I.
  TITLE     The protein network of HIV budding
  JOURNAL   Cell 114 (6), 701-713 (2003)
   PUBMED   14505570
REFERENCE   8  (bases 1 to 1664)
  AUTHORS   Strack,B., Calistri,A., Craig,S., Popova,E. and Gottlinger,H.G.
  TITLE     AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning
            in virus budding
  JOURNAL   Cell 114 (6), 689-699 (2003)
   PUBMED   14505569
REFERENCE   9  (bases 1 to 1664)
  AUTHORS   Howard,T.L., Stauffer,D.R., Degnin,C.R. and Hollenberg,S.M.
  TITLE     CHMP1 functions as a member of a newly defined family of vesicle
            trafficking proteins
  JOURNAL   J Cell Sci 114 (Pt 13), 2395-2404 (2001)
   PUBMED   11559748
REFERENCE   10 (bases 1 to 1664)
  AUTHORS   Lippincott-Schwartz,J., Roberts,T.H. and Hirschberg,K.
  TITLE     Secretory protein trafficking and organelle dynamics in living
            cells
  JOURNAL   Annu Rev Cell Dev Biol 16, 557-589 (2000)
   PUBMED   11031247
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP196406.1, AK292105.1 and AK223187.1.
            
            On Nov 22, 2018 this sequence version replaced NM_024591.4.
            
            Summary: This gene encodes a member of the chromatin-modifying
            protein/charged multivesicular body protein family. Proteins in
            this family are part of the ESCRT-III (endosomal sorting complex
            required for transport III) which degrades surface receptors, and
            in biosynthesis of endosomes. [provided by RefSeq, Mar 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.306289.1,
                                           SRR3476690.158974.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000325167.9/ ENSP00000317468.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                BP196406.1         1-34
            35-1031             AK292105.1         1-997
            1032-1664           AK223187.1         994-1626
FEATURES             Location/Qualifiers
     source          1..1664
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..1664
                     /gene="CHMP6"
                     /gene_synonym="VPS20"
                     /note="charged multivesicular body protein 6"
                     /db_xref="GeneID:79643"
                     /db_xref="HGNC:HGNC:25675"
                     /db_xref="MIM:610901"
     exon            1..141
                     /gene="CHMP6"
                     /gene_synonym="VPS20"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..684
                     /gene="CHMP6"
                     /gene_synonym="VPS20"
                     /note="hVps20; chromatin-modifying protein 6; vacuolar
                     protein sorting-associated protein 20"
                     /codon_start=1
                     /product="charged multivesicular body protein 6"
                     /protein_id="NP_078867.2"
                     /db_xref="CCDS:CCDS11774.1"
                     /db_xref="GeneID:79643"
                     /db_xref="HGNC:HGNC:25675"
                     /db_xref="MIM:610901"
                     /translation="MGNLFGRKKQSRVTEQDKAILQLKQQRDKLRQYQKRIAQQLERE
                     RALARQLLRDGRKERAKLLLKKKRYQEQLLDRTENQISSLEAMVQSIEFTQIEMKVME
                     GLQFGNECLNKMHQVMSIEEVERILDETQEAVEYQRQIDELLAGSFTQEDEDAILEEL
                     SAITQEQIELPEVPSEPLPEKIPENVPVKARPRQAELVAAS"
     exon            142..251
                     /gene="CHMP6"
                     /gene_synonym="VPS20"
                     /inference="alignment:Splign:2.1.0"
     exon            252..339
                     /gene="CHMP6"
                     /gene_synonym="VPS20"
                     /inference="alignment:Splign:2.1.0"
     exon            340..426
                     /gene="CHMP6"
                     /gene_synonym="VPS20"
                     /inference="alignment:Splign:2.1.0"
     exon            427..492
                     /gene="CHMP6"
                     /gene_synonym="VPS20"
                     /inference="alignment:Splign:2.1.0"
     exon            493..573
                     /gene="CHMP6"
                     /gene_synonym="VPS20"
                     /inference="alignment:Splign:2.1.0"
     exon            574..628
                     /gene="CHMP6"
                     /gene_synonym="VPS20"
                     /inference="alignment:Splign:2.1.0"
     exon            629..1664
                     /gene="CHMP6"
                     /gene_synonym="VPS20"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1641..1646
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CHMP6"
                     /gene_synonym="VPS20"
                     /note="hexamer: ATTAAA"
     polyA_site      1664
                     /gene="CHMP6"
                     /gene_synonym="VPS20"
                     /note="major polyA site"
ORIGIN      
        1 aggacccgag ctacggtggc cgcggggcgg cggtggcgat tggacttggt gggtcccggg
       61 ccaggggcgg gcgccgccat gggtaacctg ttcggccgca agaagcagag ccgcgtcacg
      121 gagcaggaca aggccatcct gcaactgaag cagcagcggg acaagctgag gcagtaccag
      181 aagaggatcg cccagcagct ggagcgcgag cgcgccctgg cccggcagct gctgcgggac
      241 ggcaggaagg aacgggccaa gctgctgctc aagaagaagc gataccagga gcagctcctg
      301 gacaggacgg agaaccagat cagcagcctg gaggccatgg ttcagagtat tgagttcacc
      361 cagatcgaaa tgaaagtgat ggaggggctg cagtttggaa atgagtgtct gaacaagatg
      421 caccaggtga tgtccattga agaggtggag aggatcctgg acgagacgca ggaggccgtg
      481 gagtaccagc ggcaaataga cgagctcctg gcaggaagct tcactcagga ggatgaagac
      541 gccatcctgg aggagctgag cgcaatcact caggaacaaa tagagctgcc agaggttccc
      601 tccgagcccc ttcctgagaa gatcccagaa aacgtccctg tcaaggccag gcccaggcag
      661 gcggagctgg tggcagcttc gtaacgtggc ctcgtcttgt gggactcacg gggatgcccc
      721 agggactgtg gcccacagag agtttgggtc acggccagcc cctgaccggg ttccctggag
      781 cccagtgcgc acggtgctga gcagagctgc agccacgcag gcgcattgca ggaggactcc
      841 agagcgtctc ctggagacct tgagcctgaa cgcactcagg cgccactggc ctgctctcag
      901 tccggattaa ctctcgaccg agcccagctt ctgccggttg tgggctcccc cggtggccga
      961 ggcccaggcc caacgcctct ggtgctgttc ccctgcagtc ccagccccgc gtggctcgcg
     1021 ctcgtctgtg aggaagacac ctccagacct tggggtcccc gcgcttcctc ttgctcctcg
     1081 ctgctcccat tagctggtgc aggcttccgt taaggggtcc ctcccttggc ctggcttccc
     1141 ggcgcacctc agcttccctg ctggtggggg gatccccagg agaccagcat gtgctgaacc
     1201 tctctgtgcc tctgcctccg caccctagac acccacctcc agtttgaagg tggcgggcca
     1261 ggggctttct tgctgaattg acgactccga gagccctgac tcccgccttg ccactcacgg
     1321 ctctgtccac tagggctcag ccctgctgag aaaggacctc cgatgcttgg gagacgctgc
     1381 tccggcaggt gcagccccgg aagtttgtcc atgggggtcc ccgcggctgg ggctcatgga
     1441 actgcgagac ccgggaccct cctgccctgc gggtccccga gccaccagca gccaggactg
     1501 gaggctgtgg ggcatggcgt gacttctcgt gcacagggct ggtttggtta tgagacgatc
     1561 tcgctgggac cgcccctgcc cgtggaaagc cacaaggaca aagggagcgg ccacctcgac
     1621 ccccagacag gccggcccgt attaaagttg gccctgcacg ccca
//
