LOCUS       NM_016410               1901 bp    mRNA    linear   PRI 13-OCT-2024
DEFINITION  Homo sapiens charged multivesicular body protein 5 (CHMP5),
            transcript variant 1, mRNA.
ACCESSION   NM_016410 NM_015961
VERSION     NM_016410.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1901)
  AUTHORS   Gao,W., Liu,R., Huang,K., Fu,W., Wang,A., Du,G., Tang,H., Yin,L.
            and Yin,Z.S.
  TITLE     CHMP5 attenuates osteoarthritis via inhibiting chondrocyte
            apoptosis and extracellular matrix degradation: involvement of
            NF-kappaB pathway
  JOURNAL   Mol Med 30 (1), 55 (2024)
   PUBMED   38664616
  REMARK    GeneRIF: CHMP5 attenuates osteoarthritis via inhibiting chondrocyte
            apoptosis and extracellular matrix degradation: involvement of
            NF-kappaB pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1901)
  AUTHORS   Pfitzner,A.K., Zivkovic,H., Bernat-Silvestre,C., West,M.,
            Peltier,T., Humbert,F., Odorizzi,G. and Roux,A.
  TITLE     Vps60 initiates alternative ESCRT-III filaments
  JOURNAL   J Cell Biol 222 (11) (2023)
   PUBMED   37768378
  REMARK    GeneRIF: Vps60 initiates alternative ESCRT-III filaments.
REFERENCE   3  (bases 1 to 1901)
  AUTHORS   Wang,Y., Liu,P., Chen,X. and Yang,W.
  TITLE     Circ_CHMP5 aggravates oxidized low-density lipoprotein-induced
            damage to human umbilical vein endothelial cells through
            miR-516b-5p/TGFbetaR2 axis
  JOURNAL   Clin Hemorheol Microcirc 85 (4), 325-339 (2023)
   PUBMED   37212088
  REMARK    GeneRIF: Circ_CHMP5 aggravates oxidized low-density
            lipoprotein-induced damage to human umbilical vein endothelial
            cells through miR-516b-5p/TGFbetaR2 axis.
REFERENCE   4  (bases 1 to 1901)
  AUTHORS   Wenzel,D.M., Mackay,D.R., Skalicky,J.J., Paine,E.L., Miller,M.S.,
            Ullman,K.S. and Sundquist,W.I.
  TITLE     Comprehensive analysis of the human ESCRT-III-MIT domain
            interactome reveals new cofactors for cytokinetic abscission
  JOURNAL   Elife 11, e77779 (2022)
   PUBMED   36107470
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1901)
  AUTHORS   Pashkova,N., Yu,L., Schnicker,N.J., Tseng,C.C., Gakhar,L.,
            Katzmann,D.J. and Piper,R.C.
  TITLE     Interactions of ubiquitin and CHMP5 with the V domain of HD-PTP
            reveals role for regulation of Vps4 ATPase
  JOURNAL   Mol Biol Cell 32 (22), ar42 (2021)
   PUBMED   34586919
  REMARK    GeneRIF: Interactions of ubiquitin and CHMP5 with the V domain of
            HD-PTP reveals role for regulation of Vps4 ATPase.
REFERENCE   6  (bases 1 to 1901)
  AUTHORS   Martin-Serrano,J., Yarovoy,A., Perez-Caballero,D. and Bieniasz,P.D.
  TITLE     Divergent retroviral late-budding domains recruit vacuolar protein
            sorting factors by using alternative adaptor proteins
  JOURNAL   Proc Natl Acad Sci U S A 100 (21), 12414-12419 (2003)
   PUBMED   14519844
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):152845.
            Yaravoy, A [corrected to Yarovoy, A]]
REFERENCE   7  (bases 1 to 1901)
  AUTHORS   von Schwedler,U.K., Stuchell,M., Muller,B., Ward,D.M., Chung,H.Y.,
            Morita,E., Wang,H.E., Davis,T., He,G.P., Cimbora,D.M., Scott,A.,
            Krausslich,H.G., Kaplan,J., Morham,S.G. and Sundquist,W.I.
  TITLE     The protein network of HIV budding
  JOURNAL   Cell 114 (6), 701-713 (2003)
   PUBMED   14505570
REFERENCE   8  (bases 1 to 1901)
  AUTHORS   Strack,B., Calistri,A., Craig,S., Popova,E. and Gottlinger,H.G.
  TITLE     AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning
            in virus budding
  JOURNAL   Cell 114 (6), 689-699 (2003)
   PUBMED   14505569
REFERENCE   9  (bases 1 to 1901)
  AUTHORS   Howard,T.L., Stauffer,D.R., Degnin,C.R. and Hollenberg,S.M.
  TITLE     CHMP1 functions as a member of a newly defined family of vesicle
            trafficking proteins
  JOURNAL   J Cell Sci 114 (Pt 13), 2395-2404 (2001)
   PUBMED   11559748
REFERENCE   10 (bases 1 to 1901)
  AUTHORS   Lippincott-Schwartz,J., Roberts,T.H. and Hirschberg,K.
  TITLE     Secretory protein trafficking and organelle dynamics in living
            cells
  JOURNAL   Annu Rev Cell Dev Biol 16, 557-589 (2000)
   PUBMED   11031247
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC016698.1, BC007457.1, AL356472.17 and AI128062.1.
            
            On Nov 23, 2018 this sequence version replaced NM_016410.5.
            
            Summary: CHMP5 belongs to the chromatin-modifying protein/charged
            multivesicular body protein (CHMP) family. These proteins are
            components of ESCRT-III (endosomal sorting complex required for
            transport III), a complex involved in degradation of surface
            receptor proteins and formation of endocytic multivesicular bodies
            (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular
            distributions, and one such CHMP, CHMP1A (MIM 164010), is required
            for both MVB formation and regulation of cell cycle progression
            (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar
            2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer protein (isoform 1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189655.91351.1,
                                           SRR1803615.136315.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000223500.9/ ENSP00000223500.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                BC016698.1         50-134
            86-1354             BC007457.1         118-1386
            1355-1510           AL356472.17        23770-23925
            1511-1900           AI128062.1         1-390               c
            1901-1901           AL356472.17        24316-24316
FEATURES             Location/Qualifiers
     source          1..1901
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p13.3"
     gene            1..1901
                     /gene="CHMP5"
                     /gene_synonym="C9orf83; CGI-34; HSPC177; PNAS-2; SNF7DC2;
                     Spike; Vps60"
                     /note="charged multivesicular body protein 5"
                     /db_xref="GeneID:51510"
                     /db_xref="HGNC:HGNC:26942"
                     /db_xref="MIM:610900"
     exon            1..99
                     /gene="CHMP5"
                     /gene_synonym="C9orf83; CGI-34; HSPC177; PNAS-2; SNF7DC2;
                     Spike; Vps60"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..690
                     /gene="CHMP5"
                     /gene_synonym="C9orf83; CGI-34; HSPC177; PNAS-2; SNF7DC2;
                     Spike; Vps60"
                     /note="isoform 1 is encoded by transcript variant 1; SNF7
                     domain containing 2; apoptosis-related protein PNAS-2;
                     hVps60; chromatin-modifying protein 5; SNF7
                     domain-containing protein 2; vacuolar protein
                     sorting-associated protein 60; small protein with inherent
                     killing effect"
                     /codon_start=1
                     /product="charged multivesicular body protein 5 isoform 1"
                     /protein_id="NP_057494.3"
                     /db_xref="CCDS:CCDS6537.1"
                     /db_xref="GeneID:51510"
                     /db_xref="HGNC:HGNC:26942"
                     /db_xref="MIM:610900"
                     /translation="MNRLFGKAKPKAPPPSLTDCIGTVDSRAESIDKKISRLDAELVK
                     YKDQIKKMREGPAKNMVKQKALRVLKQKRMYEQQRDNLAQQSFNMEQANYTIQSLKDT
                     KTTVDAMKLGVKEMKKAYKQVKIDQIEDLQDQLEDMMEDANEIQEALSRSYGTPELDE
                     DDLEAELDALGDELLADEDSSYLDEAASAPAIPEGVPTDTKNKDGVLVDEFGLPQIPA
                     S"
     exon            100..204
                     /gene="CHMP5"
                     /gene_synonym="C9orf83; CGI-34; HSPC177; PNAS-2; SNF7DC2;
                     Spike; Vps60"
                     /inference="alignment:Splign:2.1.0"
     exon            205..251
                     /gene="CHMP5"
                     /gene_synonym="C9orf83; CGI-34; HSPC177; PNAS-2; SNF7DC2;
                     Spike; Vps60"
                     /inference="alignment:Splign:2.1.0"
     exon            252..345
                     /gene="CHMP5"
                     /gene_synonym="C9orf83; CGI-34; HSPC177; PNAS-2; SNF7DC2;
                     Spike; Vps60"
                     /inference="alignment:Splign:2.1.0"
     exon            346..417
                     /gene="CHMP5"
                     /gene_synonym="C9orf83; CGI-34; HSPC177; PNAS-2; SNF7DC2;
                     Spike; Vps60"
                     /inference="alignment:Splign:2.1.0"
     exon            418..526
                     /gene="CHMP5"
                     /gene_synonym="C9orf83; CGI-34; HSPC177; PNAS-2; SNF7DC2;
                     Spike; Vps60"
                     /inference="alignment:Splign:2.1.0"
     exon            527..639
                     /gene="CHMP5"
                     /gene_synonym="C9orf83; CGI-34; HSPC177; PNAS-2; SNF7DC2;
                     Spike; Vps60"
                     /inference="alignment:Splign:2.1.0"
     exon            640..1901
                     /gene="CHMP5"
                     /gene_synonym="C9orf83; CGI-34; HSPC177; PNAS-2; SNF7DC2;
                     Spike; Vps60"
                     /inference="alignment:Splign:2.1.0"
     regulatory      972..977
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CHMP5"
                     /gene_synonym="C9orf83; CGI-34; HSPC177; PNAS-2; SNF7DC2;
                     Spike; Vps60"
                     /note="hexamer: AATAAA"
     polyA_site      1000
                     /gene="CHMP5"
                     /gene_synonym="C9orf83; CGI-34; HSPC177; PNAS-2; SNF7DC2;
                     Spike; Vps60"
                     /note="major polyA site"
     regulatory      1324..1329
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CHMP5"
                     /gene_synonym="C9orf83; CGI-34; HSPC177; PNAS-2; SNF7DC2;
                     Spike; Vps60"
                     /note="hexamer: AATAAA"
     polyA_site      1344
                     /gene="CHMP5"
                     /gene_synonym="C9orf83; CGI-34; HSPC177; PNAS-2; SNF7DC2;
                     Spike; Vps60"
     regulatory      1675..1680
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CHMP5"
                     /gene_synonym="C9orf83; CGI-34; HSPC177; PNAS-2; SNF7DC2;
                     Spike; Vps60"
                     /note="hexamer: AATAAA"
     polyA_site      1695
                     /gene="CHMP5"
                     /gene_synonym="C9orf83; CGI-34; HSPC177; PNAS-2; SNF7DC2;
                     Spike; Vps60"
     regulatory      1881..1886
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CHMP5"
                     /gene_synonym="C9orf83; CGI-34; HSPC177; PNAS-2; SNF7DC2;
                     Spike; Vps60"
                     /note="hexamer: AATAAA"
     polyA_site      1901
                     /gene="CHMP5"
                     /gene_synonym="C9orf83; CGI-34; HSPC177; PNAS-2; SNF7DC2;
                     Spike; Vps60"
ORIGIN      
        1 agtgtttggg tttcttcgcg gctgctcaag atgaaccgac tcttcgggaa agcgaaaccc
       61 aaggctccgc cgcccagcct gactgactgc attggcacgg tggacagtag agcagaatcc
      121 attgacaaga agatttctcg attggatgct gagctagtga agtataagga tcagatcaag
      181 aagatgagag agggtcctgc aaagaatatg gtcaagcaga aagccttgcg agttttaaag
      241 caaaagagga tgtatgagca gcagcgggac aatcttgccc aacagtcatt caacatggaa
      301 caagccaatt ataccatcca gtctttgaag gacaccaaga ccacggttga tgctatgaaa
      361 ctgggagtaa aggaaatgaa gaaggcatac aagcaagtga agatcgacca gattgaggat
      421 ttacaagacc agctagagga tatgatggaa gatgcaaatg aaatccaaga agcactgagt
      481 cgcagttatg gcaccccaga actggatgaa gatgatttag aagcagagtt ggatgcacta
      541 ggtgatgagc ttctggctga tgaagacagt tcttatttgg atgaggcagc atctgcacct
      601 gcaattccag aaggtgttcc cactgataca aaaaacaagg atggagttct ggtggatgaa
      661 tttggattgc cacagatccc tgcttcatag atttgcatca ttcaagcata tcttgtaaaa
      721 caaacacata ttatgggact aggaaatatt tatctttcca aatttgccat aacagattta
      781 ggtttctttc ctttctttga aggaaagttt aattacattg ctcttttatt ttttccatta
      841 agagactcat tgcttgggaa atgctttctt cgtactaaaa tttgattcct ttttttctta
      901 tgaaaaacga actcagttta aaagtatttt tagctcgtat gacttgtttt cattcattaa
      961 taataatttg aaataaaact aaggaaatgg aatcttaaaa gtctatgaca gtgtaactct
     1021 acagtctcaa aatgacctga taaattgata agacaaagat gagattattg gggctgttca
     1081 tattatgatt cagaatcatt ttctattgtg gtattatagg ttggttaaag tgatggcctt
     1141 tttgatgggt tttgttgtgt cttgtgaaca agtcgttact gtgtccatta ttggaatgga
     1201 attatcacta ctgtatcatg agtgggtatt ttgattctat ggttccctca gtattacatc
     1261 ttgacttgta atcaattatg aatatttctt gatatttaat gtataggaca tttatttata
     1321 ctcaataaat atttttcaaa aggatataat tttaataata tcacttcagc ttaaaacctc
     1381 tactgcggaa accaaattta atagaatttt aatgtcattt cagcctataa ctccactaca
     1441 gaaaccaaat taaccagtag cattgtgagg aaagagcaag gaacaatctg ggcttgggcc
     1501 ctgggtctac catttactaa ctactgagta gtctattcaa cctctctaac cttctgtttc
     1561 cttattagta aaatcatgct taactcacag agcttttgtg aggaataatt gaggtaatgg
     1621 tcataagtac cttgttaact gcaaggggct attcttatat gagggattgt taacaataaa
     1681 aaagaaactg cttcattctt ttcttggaag gtgcctggag tactacagca agttcaaact
     1741 cctgcccaat ttcagggtct ttaatgatcc tgtcctccct tcctcattca acttgttgcc
     1801 aacagcatgg cccctccagc ctagctgggt gcctcacagt gctatgtgca cctgactctc
     1861 atgtgtctgc agatcaaacc aataaacatt taggaacacc a
//
