LOCUS       NM_152284               1852 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens charged multivesicular body protein 4C (CHMP4C), mRNA.
ACCESSION   NM_152284
VERSION     NM_152284.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1852)
  AUTHORS   Xiao,X., Li,Z., Li,Q., Qing,L., Wang,Y., Ye,F., Dong,Y., Di,X. and
            Mi,J.
  TITLE     Exploring the clinical and biological significance of the cell
            cycle-related gene CHMP4C in prostate cancer
  JOURNAL   BMC Med Genomics 17 (1), 210 (2024)
   PUBMED   39138470
  REMARK    GeneRIF: Exploring the clinical and biological significance of the
            cell cycle-related gene CHMP4C in prostate cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1852)
  AUTHORS   Wenzel,D.M., Mackay,D.R., Skalicky,J.J., Paine,E.L., Miller,M.S.,
            Ullman,K.S. and Sundquist,W.I.
  TITLE     Comprehensive analysis of the human ESCRT-III-MIT domain
            interactome reveals new cofactors for cytokinetic abscission
  JOURNAL   Elife 11, e77779 (2022)
   PUBMED   36107470
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1852)
  AUTHORS   Salas,N., Coceres,V.M., Melo,T.D.S., Pereira-Neves,A.,
            Maguire,V.G., Rodriguez,T.M., Sabatke,B., Ramirez,M.I., Sha,J.,
            Wohlschlegel,J.A. and de Miguel,N.
  TITLE     VPS32, a member of the ESCRT complex, modulates adherence to host
            cells in the parasite Trichomonas vaginalis by affecting biogenesis
            and cargo sorting of released extracellular vesicles
  JOURNAL   Cell Mol Life Sci 79 (1), 11 (2021)
   PUBMED   34951683
  REMARK    GeneRIF: VPS32, a member of the ESCRT complex, modulates adherence
            to host cells in the parasite Trichomonas vaginalis by affecting
            biogenesis and cargo sorting of released extracellular vesicles.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1852)
  AUTHORS   Russell,T., Samolej,J., Hollinshead,M., Smith,G.L., Kite,J. and
            Elliott,G.
  TITLE     Novel Role for ESCRT-III Component CHMP4C in the Integrity of the
            Endocytic Network Utilized for Herpes Simplex Virus Envelopment
  JOURNAL   mBio 12 (3), e02183-20 (2021)
   PUBMED   33975940
  REMARK    GeneRIF: Novel Role for ESCRT-III Component CHMP4C in the Integrity
            of the Endocytic Network Utilized for Herpes Simplex Virus
            Envelopment.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1852)
  AUTHORS   Lin,S.L., Wang,M., Cao,Q.Q. and Li,Q.
  TITLE     Chromatin modified protein 4C (CHMP4C) facilitates the malignant
            development of cervical cancer cells
  JOURNAL   FEBS Open Bio 10 (7), 1295-1303 (2020)
   PUBMED   32406588
  REMARK    GeneRIF: Chromatin modified protein 4C (CHMP4C) facilitates the
            malignant development of cervical cancer cells.
REFERENCE   6  (bases 1 to 1852)
  AUTHORS   Martin-Serrano,J., Yarovoy,A., Perez-Caballero,D. and Bieniasz,P.D.
  TITLE     Divergent retroviral late-budding domains recruit vacuolar protein
            sorting factors by using alternative adaptor proteins
  JOURNAL   Proc Natl Acad Sci U S A 100 (21), 12414-12419 (2003)
   PUBMED   14519844
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):152845.
            Yaravoy, A [corrected to Yarovoy, A]]
REFERENCE   7  (bases 1 to 1852)
  AUTHORS   Katoh,K., Shibata,H., Suzuki,H., Nara,A., Ishidoh,K., Kominami,E.,
            Yoshimori,T. and Maki,M.
  TITLE     The ALG-2-interacting protein Alix associates with CHMP4b, a human
            homologue of yeast Snf7 that is involved in multivesicular body
            sorting
  JOURNAL   J Biol Chem 278 (40), 39104-39113 (2003)
   PUBMED   12860994
REFERENCE   8  (bases 1 to 1852)
  AUTHORS   von Schwedler,U.K., Stuchell,M., Muller,B., Ward,D.M., Chung,H.Y.,
            Morita,E., Wang,H.E., Davis,T., He,G.P., Cimbora,D.M., Scott,A.,
            Krausslich,H.G., Kaplan,J., Morham,S.G. and Sundquist,W.I.
  TITLE     The protein network of HIV budding
  JOURNAL   Cell 114 (6), 701-713 (2003)
   PUBMED   14505570
REFERENCE   9  (bases 1 to 1852)
  AUTHORS   Strack,B., Calistri,A., Craig,S., Popova,E. and Gottlinger,H.G.
  TITLE     AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning
            in virus budding
  JOURNAL   Cell 114 (6), 689-699 (2003)
   PUBMED   14505569
REFERENCE   10 (bases 1 to 1852)
  AUTHORS   Lippincott-Schwartz,J., Roberts,T.H. and Hirschberg,K.
  TITLE     Secretory protein trafficking and organelle dynamics in living
            cells
  JOURNAL   Annu Rev Cell Dev Biol 16, 557-589 (2000)
   PUBMED   11031247
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132219.3 and BC014321.1.
            
            On Nov 22, 2018 this sequence version replaced NM_152284.3.
            
            Summary: CHMP4C belongs to the chromatin-modifying protein/charged
            multivesicular body protein (CHMP) family. These proteins are
            components of ESCRT-III (endosomal sorting complex required for
            transport III), a complex involved in degradation of surface
            receptor proteins and formation of endocytic multivesicular bodies
            (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular
            distributions, and one such CHMP, CHMP1A (MIM 164010), is required
            for both MVB formation and regulation of cell cycle progression
            (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK000049.1, SRR5189655.54306.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000297265.5/ ENSP00000297265.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AC132219.3         41786-41790
            6-1181              BC014321.1         5-1180
            1182-1852           AC132219.3         68183-68853
FEATURES             Location/Qualifiers
     source          1..1852
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q21.13"
     gene            1..1852
                     /gene="CHMP4C"
                     /gene_synonym="Shax3; SNF7-3; VPS32C"
                     /note="charged multivesicular body protein 4C"
                     /db_xref="GeneID:92421"
                     /db_xref="HGNC:HGNC:30599"
                     /db_xref="MIM:610899"
     exon            1..369
                     /gene="CHMP4C"
                     /gene_synonym="Shax3; SNF7-3; VPS32C"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..881
                     /gene="CHMP4C"
                     /gene_synonym="Shax3; SNF7-3; VPS32C"
                     /note="Snf7 homologue associated with Alix 3; hSnf7-3;
                     vps32-3; hVps32-3; chromatin-modifying protein 4c; SNF7
                     homolog associated with Alix 3; vacuolar protein
                     sorting-associated protein 32-3; chromatin modifying
                     protein 4C"
                     /codon_start=1
                     /product="charged multivesicular body protein 4c"
                     /protein_id="NP_689497.1"
                     /db_xref="CCDS:CCDS6233.1"
                     /db_xref="GeneID:92421"
                     /db_xref="HGNC:HGNC:30599"
                     /db_xref="MIM:610899"
                     /translation="MSKLGKFFKGGGSSKSRAAPSPQEALVRLRETEEMLGKKQEYLE
                     NRIQREIALAKKHGTQNKRAALQALKRKKRFEKQLTQIDGTLSTIEFQREALENSHTN
                     TEVLRNMGFAAKAMKSVHENMDLNKIDDLMQEITEQQDIAQEISEAFSQRVGFGDDFD
                     EDELMAELEELEQEELNKKMTNIRLPNVPSSSLPAQPNRKPGMSSTARRSRAASSQRA
                     EEEDDDIKQLAAWAT"
     exon            370..547
                     /gene="CHMP4C"
                     /gene_synonym="Shax3; SNF7-3; VPS32C"
                     /inference="alignment:Splign:2.1.0"
     exon            548..662
                     /gene="CHMP4C"
                     /gene_synonym="Shax3; SNF7-3; VPS32C"
                     /inference="alignment:Splign:2.1.0"
     exon            663..816
                     /gene="CHMP4C"
                     /gene_synonym="Shax3; SNF7-3; VPS32C"
                     /inference="alignment:Splign:2.1.0"
     exon            817..1852
                     /gene="CHMP4C"
                     /gene_synonym="Shax3; SNF7-3; VPS32C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1829..1834
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CHMP4C"
                     /gene_synonym="Shax3; SNF7-3; VPS32C"
                     /note="hexamer: ATTAAA"
     polyA_site      1852
                     /gene="CHMP4C"
                     /gene_synonym="Shax3; SNF7-3; VPS32C"
                     /note="major polyA site"
ORIGIN      
        1 agccaggaaa tgccctggag tgtgtgtcac ctgtccagga cgacttgttg attcccagga
       61 gggccgcctt tccggtctgg gtccccgaga ggactgcctt gctcacctgt cccctcggcg
      121 cggccccggg gagctcccga gaggcccccg ggatcgctgg ccctccgaac tccacagcaa
      181 tgagcaagtt gggcaagttc tttaaagggg gcggctcttc taagagccga gccgctccca
      241 gtccccagga ggccctggtc cgacttcggg agactgagga gatgctgggc aagaaacaag
      301 agtacctgga aaatcgaatc cagagagaaa tcgccctggc caagaagcac ggcacgcaga
      361 ataagcgagc tgcattacag gcactaaaga gaaagaagag gttcgagaaa cagctcactc
      421 agattgatgg cacactttct accattgagt tccagagaga agccctggag aactcacaca
      481 ccaacactga ggtgttgagg aacatgggct ttgcagcaaa agcgatgaaa tctgttcatg
      541 aaaacatgga tctgaacaaa atagatgatt tgatgcaaga gatcacagag caacaggata
      601 tcgcccaaga aatctcagaa gcattttctc aacgggttgg ctttggtgat gactttgatg
      661 aggatgagtt gatggcagaa cttgaagaat tggaacagga ggaattaaat aagaagatga
      721 caaatatccg ccttccaaat gtgccttcct cttctctccc agcacagcca aatagaaaac
      781 caggcatgtc gtccactgca cgtcgatccc gagcagcatc ttcccagagg gcagaagaag
      841 aggatgatga tatcaaacaa ttggcagctt gggctaccta aactaaaaca catttttgat
      901 acctaaatta atgagctata gataaaatat aaaaaatgtt tttaccaagt tcagaagtta
      961 acaaagactc tgctttataa ttatattgaa tgaataattg tgttttaagc ctcctaagta
     1021 aaagtaaaaa aggagtcatg tgcatacata gaatcagtga tggaggccag gcacggtatc
     1081 tcatgcctat aatcccagca ctttgggagg ctgaggcagt tgagaccagg agttcgagtc
     1141 cagcctgacc aacatgaaga aaccctgtct gtactaaaaa tacaaaaatt agccggacat
     1201 ggtggcaggc acctgtaatc ccagctactt gggaggctga gtcaggagaa tcgcttgagc
     1261 ccaggagatg gaggttgcag tgagccaaga tcatgccact gcactccaga ctgggcaaca
     1321 gagggagact ccgtctcaaa aactaaaaaa aaaaaataca tttagtatag cggggggtgg
     1381 gggggagaaa taatgttatt tcctatgcga atgacgtgta tccctgtacc catggtaaat
     1441 gtaaatatac tgtgtctctt ttgggagagc cttttagtag aggagtctta tatgagtctc
     1501 tacataagta gtttcacttg agttttgcag tttgaaatct taaaggagct ttaattgaca
     1561 tttattatac caattaagct tggaatgggg caatggatgc atttcccaaa acgtgtgaaa
     1621 gcactaacag cttatattgc tgaatgagaa tctcctgggt gtaatttagc cacttaggga
     1681 actgcgtgaa cactcccagg ccattatgat gctgttacag cttcagtgta taaatgcatg
     1741 agtattcttt ctgttctgtt ttgtgctctc ttgtacattt atttaccctt tacagaatat
     1801 ttcttgtaaa tacataaaaa tattggcaat taaaagtaca tcttgaataa aa
//
