LOCUS       NM_020412               3032 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens charged multivesicular body protein 1B (CHMP1B), mRNA.
ACCESSION   NM_020412
VERSION     NM_020412.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3032)
  AUTHORS   Wenzel,D.M., Mackay,D.R., Skalicky,J.J., Paine,E.L., Miller,M.S.,
            Ullman,K.S. and Sundquist,W.I.
  TITLE     Comprehensive analysis of the human ESCRT-III-MIT domain
            interactome reveals new cofactors for cytokinetic abscission
  JOURNAL   Elife 11, e77779 (2022)
   PUBMED   36107470
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3032)
  AUTHORS   Cada,A.K., Pavlin,M.R., Castillo,J.P., Tong,A.B., Larsen,K.P.,
            Ren,X., Yokom,A.L., Tsai,F.C., Shiah,J.V., Bassereau,P.M.,
            Bustamante,C.J. and Hurley,J.H.
  TITLE     Friction-driven membrane scission by the human ESCRT-III proteins
            CHMP1B and IST1
  JOURNAL   Proc Natl Acad Sci U S A 119 (29), e2204536119 (2022)
   PUBMED   35858336
  REMARK    GeneRIF: Friction-driven membrane scission by the human ESCRT-III
            proteins CHMP1B and IST1.
REFERENCE   3  (bases 1 to 3032)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 3032)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3032)
  AUTHORS   Nguyen,H.C., Talledge,N., McCullough,J., Sharma,A., Moss,F.R. 3rd,
            Iwasa,J.H., Vershinin,M.D., Sundquist,W.I. and Frost,A.
  TITLE     Membrane constriction and thinning by sequential ESCRT-III
            polymerization
  JOURNAL   Nat Struct Mol Biol 27 (4), 392-399 (2020)
   PUBMED   32251413
  REMARK    GeneRIF: To learn how certain ESCRT-IIIs shape positively curved
            membranes, we determined structures of human membrane-bound
            CHMP1B-only, membrane-bound CHMP1B + IST1, and IST1-only filaments
            by cryo-EM
REFERENCE   6  (bases 1 to 3032)
  AUTHORS   von Schwedler,U.K., Stuchell,M., Muller,B., Ward,D.M., Chung,H.Y.,
            Morita,E., Wang,H.E., Davis,T., He,G.P., Cimbora,D.M., Scott,A.,
            Krausslich,H.G., Kaplan,J., Morham,S.G. and Sundquist,W.I.
  TITLE     The protein network of HIV budding
  JOURNAL   Cell 114 (6), 701-713 (2003)
   PUBMED   14505570
REFERENCE   7  (bases 1 to 3032)
  AUTHORS   Strack,B., Calistri,A., Craig,S., Popova,E. and Gottlinger,H.G.
  TITLE     AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning
            in virus budding
  JOURNAL   Cell 114 (6), 689-699 (2003)
   PUBMED   14505569
REFERENCE   8  (bases 1 to 3032)
  AUTHORS   Howard,T.L., Stauffer,D.R., Degnin,C.R. and Hollenberg,S.M.
  TITLE     CHMP1 functions as a member of a newly defined family of vesicle
            trafficking proteins
  JOURNAL   J Cell Sci 114 (Pt 13), 2395-2404 (2001)
   PUBMED   11559748
REFERENCE   9  (bases 1 to 3032)
  AUTHORS   Stauffer,D.R., Howard,T.L., Nyun,T. and Hollenberg,S.M.
  TITLE     CHMP1 is a novel nuclear matrix protein affecting chromatin
            structure and cell-cycle progression
  JOURNAL   J Cell Sci 114 (Pt 13), 2383-2393 (2001)
   PUBMED   11559747
REFERENCE   10 (bases 1 to 3032)
  AUTHORS   Vuoristo,J.T., Berrettini,W.H. and Ala-Kokko,L.
  TITLE     C18orf2, a novel, highly conserved intronless gene within intron 5
            of the GNAL gene on chromosome 18p11
  JOURNAL   Cytogenet Cell Genet 93 (1-2), 19-22 (2001)
   PUBMED   11474171
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX494191.1, BC065933.1 and AP005137.2.
            
            On May 17, 2019 this sequence version replaced NM_020412.4.
            
            Summary: CHMP1B belongs to the chromatin-modifying protein/charged
            multivesicular body protein (CHMP) family. These proteins are
            components of ESCRT-III (endosomal sorting complex required for
            transport III), a complex involved in degradation of surface
            receptor proteins and formation of endocytic multivesicular bodies
            (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular
            distributions, and one such CHMP, CHMP1A (MIM 164010), is required
            for both MVB formation and regulation of cell cycle progression
            (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR1803616.96171.1, DRR138524.315395.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000526991.3/ ENSP00000432279.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                BX494191.1         25-38
            15-1186             BC065933.1         1-1172
            1187-3032           AP005137.2         66324-68169
FEATURES             Location/Qualifiers
     source          1..3032
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18p11.21"
     gene            1..3032
                     /gene="CHMP1B"
                     /gene_synonym="C10orf2; C18-ORF2; C18orf2; CHMP1.5;
                     hVps46-2; Vps46-2; Vps46B"
                     /note="charged multivesicular body protein 1B"
                     /db_xref="GeneID:57132"
                     /db_xref="HGNC:HGNC:24287"
                     /db_xref="MIM:606486"
     exon            1..3032
                     /gene="CHMP1B"
                     /gene_synonym="C10orf2; C18-ORF2; C18orf2; CHMP1.5;
                     hVps46-2; Vps46-2; Vps46B"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..699
                     /gene="CHMP1B"
                     /gene_synonym="C10orf2; C18-ORF2; C18orf2; CHMP1.5;
                     hVps46-2; Vps46-2; Vps46B"
                     /note="vacuolar protein sorting 46-2; chromatin-modifying
                     protein 1b; vacuolar protein sorting-associated protein
                     46-2; chromatin modifying protein 1B; VPS46 homolog B"
                     /codon_start=1
                     /product="charged multivesicular body protein 1b"
                     /protein_id="NP_065145.2"
                     /db_xref="CCDS:CCDS54180.1"
                     /db_xref="GeneID:57132"
                     /db_xref="HGNC:HGNC:24287"
                     /db_xref="MIM:606486"
                     /translation="MSNMEKHLFNLKFAAKELSRSAKKCDKEEKAEKAKIKKAIQKGN
                     MEVARIHAENAIRQKNQAVNFLRMSARVDAVAARVQTAVTMGKVTKSMAGVVKSMDAT
                     LKTMNLEKISALMDKFEHQFETLDVQTQQMEDTMSSTTTLTTPQNQVDMLLQEMADEA
                     GLDLNMELPQGQTGSVGTSVASAEQDELSQRLARLRDQV"
     regulatory      1264..1269
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CHMP1B"
                     /gene_synonym="C10orf2; C18-ORF2; C18orf2; CHMP1.5;
                     hVps46-2; Vps46-2; Vps46B"
                     /note="hexamer: AATAAA"
     polyA_site      1294
                     /gene="CHMP1B"
                     /gene_synonym="C10orf2; C18-ORF2; C18orf2; CHMP1.5;
                     hVps46-2; Vps46-2; Vps46B"
                     /note="major polyA site"
     regulatory      1417..1422
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CHMP1B"
                     /gene_synonym="C10orf2; C18-ORF2; C18orf2; CHMP1.5;
                     hVps46-2; Vps46-2; Vps46B"
                     /note="hexamer: ATTAAA"
     polyA_site      1436
                     /gene="CHMP1B"
                     /gene_synonym="C10orf2; C18-ORF2; C18orf2; CHMP1.5;
                     hVps46-2; Vps46-2; Vps46B"
     regulatory      2919..2924
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CHMP1B"
                     /gene_synonym="C10orf2; C18-ORF2; C18orf2; CHMP1.5;
                     hVps46-2; Vps46-2; Vps46B"
                     /note="hexamer: CATAAA"
     polyA_site      2941
                     /gene="CHMP1B"
                     /gene_synonym="C10orf2; C18-ORF2; C18orf2; CHMP1.5;
                     hVps46-2; Vps46-2; Vps46B"
                     /note="major polyA site"
     regulatory      3012..3017
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CHMP1B"
                     /gene_synonym="C10orf2; C18-ORF2; C18orf2; CHMP1.5;
                     hVps46-2; Vps46-2; Vps46B"
                     /note="hexamer: ATTAAA"
     polyA_site      3032
                     /gene="CHMP1B"
                     /gene_synonym="C10orf2; C18-ORF2; C18orf2; CHMP1.5;
                     hVps46-2; Vps46-2; Vps46B"
                     /note="major polyA site"
ORIGIN      
        1 caaaacaaag gagcggcggc cgggagcgga cttaccttac cttctctgcc ttcggcgcgc
       61 ttctcagccg ggccgccgac ccaaaggagc cgtccgacta tgtctaacat ggagaaacac
      121 ctgttcaacc tgaagttcgc ggccaaagaa ctgagtagga gtgccaaaaa atgcgataag
      181 gaggaaaagg ccgaaaaggc caaaattaaa aaggccattc agaagggcaa catggaagtt
      241 gcgaggatac acgccgaaaa tgccatccgc cagaagaacc aggcggtgaa tttcttgaga
      301 atgagtgcgc gagtcgatgc agtggctgcc agggtccaga cggcggtgac gatgggcaag
      361 gtgaccaagt cgatggctgg tgtggttaag tcgatggatg cgacattgaa gaccatgaat
      421 ctggagaaga tttctgcttt gatggacaaa ttcgagcacc agtttgagac tctggacgtc
      481 cagacgcagc aaatggaaga cacgatgagc agcacgacga cgctcaccac tccccagaac
      541 caagtggata tgctgctcca ggaaatggca gatgaggcgg gcctcgacct caacatggag
      601 ctgccgcagg gccagaccgg ctccgtgggc acgagcgtgg cttcggcgga gcaggatgaa
      661 ctgtctcaga gactggcccg ccttcgggat caagtgtgac ggcagaaccc gctctgaggt
      721 ttcctggcca tagccaccct ttgaaatgct ctctgtgtgt tagagagata ctatacccta
      781 gaaactctga acacgccaga atgctgaaat gcccttctac ctttgggttt acagccccct
      841 ccacataaat taagaaattc agtatttctg cactcttagc tggattctaa agttctgtat
      901 agctcgtaat gatggtattt ttatagcagc cttttaacag aactagttaa tttcgtgtat
      961 atgaatcttt ctcgaagatc tggtcaaaac tgtattcagt ttcctgccca gaatgatcag
     1021 attgaaggtg gttggttttt attattattt agtgtgattg atagtatcta gaatggcagg
     1081 tggtgcataa aagttaaaga gaggggaaag attacttagt ttggttatac agttataaac
     1141 accatgcagt gtattcggtg gactgtgcta tttctgttta tcctttgggt tttggttttt
     1201 gttttttttt tttttgcctt cacagtgaga ctgcaaatga ttgttctcat aacgtatatt
     1261 attaataaat gtggtcctat aatttatact gaaattacct taggatattt ttgcataata
     1321 ctctcttact gcttacattc tataaatttt tcacgtgata attgtctttg cgtaactggg
     1381 aaaaatgccg aataacttcc tttattatct ggaaaaatta aatttgttca tttatatttt
     1441 ctacttacta aattgagttt ttaaaaagac ttagtgtgac atttgacagt gtctttcaaa
     1501 cgaacttctc taacaagttt atagttattt tcctgtttca acactattag aagtcttata
     1561 aattatgcta attagcatgg cagtcatgtt acacactctt aacattgcca aagaactgtt
     1621 gatttcgttt gagaaaaccc taggactgtg tgtgtgtagg ttttgttttg attttaacaa
     1681 ccaaaaatag aaataaaatt agaactgcgt tttaagttct aatttgcatt tattaatttg
     1741 tccaaaagca agaactcttg gaaatccttg aaaatataag ctggaatgtt ttacttagcc
     1801 atgcaagtca tttatgtata catccagcca gctggaaatc tgagaagtaa agaggtagga
     1861 ctggaaggaa ggagaaagct tgagtcttta aggctagagc ccagctgtgc tgcctgccat
     1921 cttctcagga atggcagtgc gtattttctg gctgaaaagt aaagcatgta tccaccgctt
     1981 tctcatagcc tcgaaacatg gagaaaagca acttgctttt gccttggcaa gcatgctaac
     2041 ctaagttaat tcaagttttt tttaacttac cctttccttc actggaagat ttttccataa
     2101 gagaattcca ttgtttcaga aaataattat aggggccctt ccaagttctt tgaaagattc
     2161 ataaccaact attcactatt ataacatgtt tcccagtgta aatgagtaag gaaaaaaaaa
     2221 gtgtaacagg tgcgtgcaga tgaggagtga ccctcatatt taagttattt tatatttgac
     2281 tggacattgt tcagaagtgt gctttaaggg acacttgtta gttgtctgcc cagcatctct
     2341 caagaatatc cctcctgtcc tccacatggt tgtgcagggc catgtgtgaa gacagcatga
     2401 gtcttaaccc ctcttttatt ttatttttga gacagagtct cgctctgttg cccaggctgg
     2461 agtgctgtgg cgcgatctct gctcactgca acctccacct cccgggttca agtgattctc
     2521 ctgcctcagc ctgccgagta gctggaatta caggtgtgca ccaccatgcc cagctagttt
     2581 ttttgtattt ttagtagaga cagggtttca ctatgttggc caggctggtc ttgaactcct
     2641 gacctcaggt gatccgccca cctcagcctc ccaaagtgct gggattacag gcatgagcca
     2701 ctgcacctgg ccttaacccc tctttagatt ggaaaaaata attacaactt taaaaatagc
     2761 ttagtgttga accctttggt aaactaaaga cccttttata atgcacatat tcccaacaaa
     2821 attaatatat tttgtgagat taaacaatgc ttgtatatgc ttgaactttc ttaaaatatg
     2881 tccatgtcat actattatga atgtacattt ttatgagtca taaatattat tttcaaaagc
     2941 actacaggcc catgaattac ttcctcactt ttgcagttga ttactgaaat gtaaatcaca
     3001 agaatttgtc aattaaatca ttttaaactg ca
//
