LOCUS       NM_001381853            7711 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens CHM like Rab escort protein (CHML), transcript variant
            1, mRNA.
ACCESSION   NM_001381853
VERSION     NM_001381853.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7711)
  AUTHORS   Dodson,M., Dai,W., Anandhan,A., Schmidlin,C.J., Liu,P.,
            Wilson,N.C., Wei,Y., Kitamura,N., Galligan,J.J., Ooi,A., Chapman,E.
            and Zhang,D.D.
  TITLE     CHML is an NRF2 target gene that regulates mTOR function
  JOURNAL   Mol Oncol 16 (8), 1714-1727 (2022)
   PUBMED   35184380
  REMARK    GeneRIF: CHML is an NRF2 target gene that regulates mTOR function.
REFERENCE   2  (bases 1 to 7711)
  AUTHORS   Dong,C., Cao,H., Liu,Z., Xi,L., Shi,Y. and Yang,R.
  TITLE     CHML targeted by miR-199a-3p promotes non-small cell lung cancer
            cell growth via binding to Rab5A
  JOURNAL   Pathol Res Pract 227, 153626 (2021)
   PUBMED   34649053
  REMARK    GeneRIF: CHML targeted by miR-199a-3p promotes non-small cell lung
            cancer cell growth via binding to Rab5A.
            Erratum:[Pathol Res Pract. 2022 Jan;229:153698. doi:
            10.1016/j.prp.2021.153698.. PMID: 34826741]
REFERENCE   3  (bases 1 to 7711)
  AUTHORS   Chen,T.W., Yin,F.F., Yuan,Y.M., Guan,D.X., Zhang,E., Zhang,F.K.,
            Jiang,H., Ma,N., Wang,J.J., Ni,Q.Z., Qiu,L., Feng,J., Zhang,X.L.,
            Bao,Y., Wang,K., Cheng,S.Q., Wang,X.F., Wang,X., Li,J.J. and Xie,D.
  TITLE     CHML promotes liver cancer metastasis by facilitating Rab14 recycle
  JOURNAL   Nat Commun 10 (1), 2510 (2019)
   PUBMED   31175290
  REMARK    GeneRIF: CHML promotes migration, invasion and metastasis of
            hepatocellular carcinoma cells, in a Rab14-dependent manner.
            Mechanism study reveals that CHML facilitates constant recycling of
            Rab14 by escorting Rab14 to the membrane.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7711)
  AUTHORS   McCauley,J.L., Zuvich,R.L., Bradford,Y., Kenealy,S.J.,
            Schnetz-Boutaud,N., Gregory,S.G., Hauser,S.L., Oksenberg,J.R.,
            Mortlock,D.P., Pericak-Vance,M.A. and Haines,J.L.
  TITLE     Follow-up examination of linkage and association to chromosome 1q43
            in multiple sclerosis
  JOURNAL   Genes Immun 10 (7), 624-630 (2009)
   PUBMED   19626040
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 7711)
  AUTHORS   White,J.H., Chiano,M., Wigglesworth,M., Geske,R., Riley,J.,
            White,N., Hall,S., Zhu,G., Maurio,F., Savage,T., Anderson,W.,
            Cordy,J., Ducceschi,M., Vestbo,J. and Pillai,S.G.
  CONSRTM   GAIN investigators
  TITLE     Identification of a novel asthma susceptibility gene on chromosome
            1qter and its functional evaluation
  JOURNAL   Hum Mol Genet 17 (13), 1890-1903 (2008)
   PUBMED   18344558
  REMARK    GeneRIF: Polymorphisms in the OPN3 and CHML genes are associated
            with asthma and atopic asthma.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 7711)
  AUTHORS   Seabra,M.C., Ho,Y.K. and Anant,J.S.
  TITLE     Deficient geranylgeranylation of Ram/Rab27 in choroideremia
  JOURNAL   J Biol Chem 270 (41), 24420-24427 (1995)
   PUBMED   7592656
REFERENCE   7  (bases 1 to 7711)
  AUTHORS   van Bokhoven,H., van den Hurk,J.A., Bogerd,L., Philippe,C.,
            Gilgenkrantz,S., de Jong,P., Ropers,H.H. and Cremers,F.P.
  TITLE     Cloning and characterization of the human choroideremia gene
  JOURNAL   Hum Mol Genet 3 (7), 1041-1046 (1994)
   PUBMED   7981670
REFERENCE   8  (bases 1 to 7711)
  AUTHORS   Cremers,F.P., Armstrong,S.A., Seabra,M.C., Brown,M.S. and
            Goldstein,J.L.
  TITLE     REP-2, a Rab escort protein encoded by the choroideremia-like gene
  JOURNAL   J Biol Chem 269 (3), 2111-2117 (1994)
   PUBMED   8294464
REFERENCE   9  (bases 1 to 7711)
  AUTHORS   von Bokhoven,H., von Genderen,C., Molloy,C.M., van de Pol,D.J.,
            Cremers,C.W., von Aarem,A., Schwartz,M., Rosenberg,T., Geurts van
            Kessel,A.H., Ropers,H.H. et al.
  TITLE     Mapping of the choroideremia-like (CHML) gene at 1q42-qter and
            mutation analysis in patients with Usher syndrome type II
  JOURNAL   Genomics 19 (2), 385-387 (1994)
   PUBMED   8188272
REFERENCE   10 (bases 1 to 7711)
  AUTHORS   Cremers,F.P., Molloy,C.M., van de Pol,D.J., van den Hurk,J.A.,
            Bach,I., Geurts van Kessel,A.H. and Ropers,H.H.
  TITLE     An autosomal homologue of the choroideremia gene colocalizes with
            the Usher syndrome type II locus on the distal part of chromosome
            1q
  JOURNAL   Hum Mol Genet 1 (2), 71-75 (1992)
   PUBMED   1301160
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL133390.7.
            
            Summary: The product of the CHML gene supports geranylgeranylation
            of most Rab proteins and may substitute for REP-1 in tissues other
            than retina. CHML is localized close to the gene for Usher syndrome
            type II. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. All three variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138508.18337.1,
                                           SRR7346977.2677540.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000366553.3/ ENSP00000355511.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-488               AL133390.7         64056-64543         c
            489-7711            AL133390.7         53025-60247         c
FEATURES             Location/Qualifiers
     source          1..7711
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q43"
     gene            1..7711
                     /gene="CHML"
                     /gene_synonym="REP2"
                     /note="CHM like Rab escort protein"
                     /db_xref="GeneID:1122"
                     /db_xref="HGNC:HGNC:1941"
                     /db_xref="MIM:118825"
     exon            1..488
                     /gene="CHML"
                     /gene_synonym="REP2"
                     /inference="alignment:Splign:2.1.0"
     exon            489..7711
                     /gene="CHML"
                     /gene_synonym="REP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             796..2766
                     /gene="CHML"
                     /gene_synonym="REP2"
                     /note="choroideraemia-like protein; CHM like Rab escort
                     protein 2; choroideremia-like protein; choroideremia-like
                     (Rab escort protein 2)"
                     /codon_start=1
                     /product="rab proteins geranylgeranyltransferase component
                     A 2"
                     /protein_id="NP_001368782.1"
                     /db_xref="CCDS:CCDS31073.1"
                     /db_xref="GeneID:1122"
                     /db_xref="HGNC:HGNC:1941"
                     /db_xref="MIM:118825"
                     /translation="MADNLPTEFDVVIIGTGLPESILAAACSRSGQRVLHIDSRSYYG
                     GNWASFSFSGLLSWLKEYQQNNDIGEESTVVWQDLIHETEEAITLRKKDETIQHTEAF
                     CYASQDMEDNVEEIGALQKNPSLGVSNTFTEVLDSALPEESQLSYFNSDEMPAKHTQK
                     SDTEISLEVTDVEESVEKEKYCGDKTCMHTVSDKDGDKDESKSTVEDKADEPIRNRIT
                     YSQIVKEGRRFNIDLVSKLLYSQGLLIDLLIKSDVSRYVEFKNVTRILAFREGKVEQV
                     PCSRADVFNSKELTMVEKRMLMKFLTFCLEYEQHPDEYQAFRQCSFSEYLKTKKLTPN
                     LQHFVLHSIAMTSESSCTTIDGLNATKNFLQCLGRFGNTPFLFPLYGQGEIPQGFCRM
                     CAVFGGIYCLRHKVQCFVVDKESGRCKAIIDHFGQRINAKYFIVEDSYLSEETCSNVQ
                     YKQISRAVLITDQSILKTDLDQQTSILIVPPAEPGACAVRVTELCSSTMTCMKDTYLV
                     HLTCSSSKTAREDLESVVKKLFTPYTETEINEEELTKPRLLWALYFNMRDSSGISRSS
                     YNGLPSNVYVCSGPDCGLGNEHAVKQAETLFQEIFPTEEFCPPPPNPEDIIFDGDDKQ
                     PEAPGTNNVVMAKLESSEESKNLESPEKHLQN"
     regulatory      7671..7676
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CHML"
                     /gene_synonym="REP2"
                     /note="hexamer: AATAAA"
     regulatory      7678..7683
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CHML"
                     /gene_synonym="REP2"
                     /note="hexamer: AATAAA"
     polyA_site      7690
                     /gene="CHML"
                     /gene_synonym="REP2"
     polyA_site      7711
                     /gene="CHML"
                     /gene_synonym="REP2"
                     /note="major polyA site"
ORIGIN      
        1 agtgcacaat ggctagagca ggcggcggag ccccaacccc acccagtgcg gagcgcgccg
       61 cgagccccgc cgcaagctga gcgcctccgc ccgccaggcg cgccggcgcc gggccatgta
      121 ctcggggaac cgcagcggcg gccacggcta ctgggacggc ggcggggccg cgggcgctga
      181 ggggccggcg ccggcgggga cactgagccc cgcgcccctc ttcagccccg gcacctacga
      241 gcgcctggcg ctgctgctgg gctccattgg gctgctgggc gtcggcaaca acctgctggt
      301 gctcgtcctc tactacaagt tccagcggct ccgcactccc actcacctcc tcctggtcaa
      361 catcagcctc agcgacctgc tggtgtccct cttcggggtc acctttacct tcgtgtcctg
      421 cctgaggaac ggctgggtgt gggacaccgt gggctgcgtg tgggacgggt ttagcggcag
      481 cctcttcgag aagagttcca gtcacaaatg catatatgat gcattttgac atttactgct
      541 aagatgaaat gcagaaatga aaccacacat ccattttagt attctcagat gtgattagat
      601 gtacttgctc atgtttttat gctactgact tataagaaaa aaaatatttt aaaagggtaa
      661 ccgttaaaca gctaggacct gcaacttcag tgcttctggg ataactggaa catcagaagg
      721 acagatttta ttacagcata atcacacctc atttctttca tcagcagttg tcaccagacg
      781 ctgttacttc ctaaaatggc ggacaatctt cccacagagt ttgatgtggt tataataggg
      841 acaggtttgc ccgaatccat ccttgcagct gcatgttcaa gaagtggtca gagggttctg
      901 catattgatt caagaagcta ctatggagga aactgggcta gtttcagctt ttcaggattg
      961 ctatcctggt tgaaggagta tcagcaaaac aatgacattg gggaagaaag tactgttgta
     1021 tggcaggacc tgatccatga aacagaagaa gccatcactc ttcgcaagaa ggatgaaact
     1081 attcaacaca cagaagcttt ttgctacgcc agtcaggata tggaggacaa cgttgaagag
     1141 attggtgctc tgcagaaaaa tccttctttg ggggtgtcta ataccttcac tgaagttctg
     1201 gattctgcat tacctgaaga aagccagtta tcgtatttta atagcgacga aatgcctgca
     1261 aaacacactc agaaaagtga tacagagatt tcactagaag taactgatgt agaggaatca
     1321 gtggagaagg aaaagtattg tggagataaa acttgtatgc acacagtttc agataaagat
     1381 ggagataaag atgaaagcaa atctacagta gaagataagg ccgatgaacc aattagaaat
     1441 aggattactt actctcaaat agttaaagaa ggcaggaggt ttaatattga tttggtgtca
     1501 aaactgctgt attctcaagg attgctaatt gatcttttaa tcaaatcaga tgttagtcgt
     1561 tatgtagaat ttaaaaatgt cactaggatt cttgcatttc gggaaggaaa ggtagaacaa
     1621 gttccttgtt ccagagcaga tgtctttaat agcaaggaac tcaccatggt tgaaaagagg
     1681 atgctaatga aatttctcac attttgttta gagtatgaac aacatcctga tgaataccaa
     1741 gctttcaggc agtgttcatt ttcagaatac ttaaaaacta aaaaactaac tcccaacctt
     1801 caacattttg tactgcactc aattgcaatg acatcagaat catcttgcac tacaatagat
     1861 ggtcttaacg caactaaaaa cttccttcag tgtctcggac ggtttggcaa cacccccttt
     1921 ttatttccct tgtatggcca aggagaaatt ccccagggtt tctgtaggat gtgtgcagtt
     1981 tttggtggaa tctattgtct tcgtcataaa gtacaatgct ttgtagtcga caaagaatct
     2041 ggacgatgta aagcaattat agatcacttt ggtcaaagaa taaatgctaa atattttatt
     2101 gtggaagaca gttacctttc tgaggaaaca tgctcaaatg tgcagtataa gcagatctct
     2161 agggcagtac tcattacaga tcagtctata ctaaagacag atttagatca gcagacttcc
     2221 attctgatag ttcctccagc agagccagga gcttgtgctg tacgggtcac agaattatgt
     2281 tcttcaacca tgacatgcat gaaggacacc tatctggtac atttgacatg ttcatcttct
     2341 aaaacagcaa gagaagactt agaatcagtg gtgaagaaat tattcactcc gtatactgaa
     2401 acagaaataa acgaggaaga acttacaaag ccaagactct tgtgggctct ttattttaat
     2461 atgagagatt cctcgggaat cagcagaagc tcgtataatg gcttgccttc caatgtttat
     2521 gtctgctctg ggcctgactg tggcctggga aatgagcatg ctgtcaagca agctgaaaca
     2581 cttttccagg agatctttcc aactgaagaa ttctgccctc cacctccaaa tccagaagac
     2641 attatctttg atggtgatga taagcagcca gaggctcctg gaaccaataa tgtagtaatg
     2701 gccaaactag aatcctctga ggaaagcaaa aacctagaaa gcccagagaa gcaccttcaa
     2761 aattagaaaa gagcaatctc gaaatgctgt tttggacctc cttcatggca tcagaatttt
     2821 ctcatttaaa ggacagtttc ccatatgagt aattagaagt ggttatatat gatgaatgct
     2881 atgcagatgt tgtctttaac tctcagacat tcagcattga atatctttgt taacctatca
     2941 atgagtgatt tattgattat tgaacatttt gtttagaatg ggctatatga cccagaatct
     3001 taaaacagag ttagctttat tttagtattg ggtatatatg taagggttcc atattagcaa
     3061 ctcagcttaa aggtaatgta tttgctaatg atcttcagat tttatctttg tctacagaac
     3121 aattagtaat acccaagtaa tattttaatt acttttgcag ctgttacagt tgctgcggcc
     3181 tgttcgaata gtgaaacata cacaaatggt aaattatgtg gatcttttgc atataatata
     3241 aatgtataga catggtggta ggaatagcaa ctaatacaaa tgccaatatg ataataaaat
     3301 acatttgtct ataatcgttt aaagattagc tttgcatgat cctttatgca ctgtgaaggt
     3361 ctgaagttta taatactcac ttgacccttg taactgatga ggcaatgatg ccaccacagt
     3421 attctaattt acaaaaagaa ttggagttca attagtggtt gtaaagctca ttttggggag
     3481 gttgattgca aaggaaattt gaaagataag atttattctt atttaatact tcagaaaatt
     3541 tctgcagagc cctgccctgg cacttaaaat agcttccaat aagtaactta gaccaaaagg
     3601 aaaaatgaag tgccccagga gaagatactt cagaagggct gttctgaaat tcctaaggag
     3661 gaattcttag gaattcctaa ggagaaacag agtgaggcct ttttaacctg agattacaga
     3721 tacttataaa accctctata aatagattac ccaaggtttt tcagtgagaa tgaaacatac
     3781 caccttgttg gctctaccac tttaattaat atcactataa cataactgat aggaatgaat
     3841 caaaggagga tttaccatgc cctttcggtt gtgtcccact taacaaattg tgaagtaaca
     3901 attttctgta atctctcttg cctcttagct gttatccaga gtatagaaac tttttttctc
     3961 ccagagccac ccaacgtcat aaaactggta gtactctaat ggtgaaaacc tgtggagctg
     4021 tcagaagaca tgaacttgct tttcctctag tccagtttcc attcttcagt cagagtatga
     4081 tgatccctgt gacagttttt gctctgaaat agtatttatc atgtgtttgg tacctagtat
     4141 tatgctttct catgacagtt tctcaacaat cctgtgaggc aaattcgcat gtaccctctg
     4201 tattagtgtg ttctcatgct gttgataaag acacacctga gatggtaatt tgtaaagaaa
     4261 aaggtttaat ggactcacag ttccatgtgg ctggggaggc ctcacaatca tggtggaagg
     4321 tgaaaggcac gtcttacatg gcggtggaca agagagaatg agaactaagt gaaaagggaa
     4381 acccttttaa aaccatcaga tatcgtgaga cttatttact accatgagaa cagtatgggg
     4441 gaaacaactc catgattcag ttatctccca ccaggttcct cccacaacac gtgggaatta
     4501 taggagctac aattcaagat gagatttgag tgggaacaca gccaaaccat atcaccttca
     4561 aagaagaaat aagagaatta ttagtaattt gctcagaatc tggtatgtgg aagagccaac
     4621 atggggaccc agccttttgt gattctaaaa cctttgatct ttctactaac attcactgtt
     4681 agagagtgta ggcgctgcag gagaaagaga aagtgcccac gaaaattagt ctagcattgc
     4741 cgggggtaaa aagcacacac tggtcctgca gcttattgaa tcagagaaat gtgaagataa
     4801 gatgaactaa acaaacatat tttagagcat ggatctcgaa gcagaatttg gctaaatttt
     4861 aacaaaatgt tcttcagtaa cacatctcat gatctgaaga ttgtgttaca aaaaatatta
     4921 tcaggccaaa atttgttcgg aatacactaa tttttgctcc tctatatgtg aggaaaatga
     4981 gactagacag atttaagtaa ttgacaactt acttaaagta gcaaagtcat ggattgtatt
     5041 gacttttaaa aatatagtaa aagtcatatt taaactttat cctaaagttt aaatctaaca
     5101 gaacaactga aatacttgaa atagacctat aaaatagtaa ttaaaatgag aaatacataa
     5161 gatgataaat aaaatgaagg tgaaggtatt ccagatctac cgaaaagatt ttcagtatca
     5221 cagattattc ataagaaatt gagaaaagga acaatcagaa gttgcaaaag atggtatagc
     5281 cgaatataat ggaaatagga aaaattagtc gaaaataaag gttgatttag aaatgaagaa
     5341 aatgaatata tttcttaata caaaataagt gggaaatgag aagttatacc aataaaaagc
     5401 atttaaaaat ttaggggata ttgtaaccca gtataatttt ctgacaggtt ggactttgac
     5461 cctaatggac ttactggtga actttttcaa atgtttaaat aatgtctatc catgtatcat
     5521 gaaggacagt atgcttcaaa ttgtcttttg aggcagacat gttctcagta ctaaaagaca
     5581 tttttagaag gattttattc tcaacagatg caaaatgcaa aataaaatat tggcaaacaa
     5641 tacagcaaca aataatttac tatcactcag gattataagg ctggtgttaa gcagaacagc
     5701 cattaaatca gcatcaaaag aacaaatagt aaaatccaaa gtattaatta cagataactt
     5761 ttcaaaaatt catcattcac ccttgattta attatttctc tggcaatgat ttaatagact
     5821 tctcggagtc tgttaagtac ttaaaccaag aactaccatt attcctactg ggaaaacata
     5881 aacatttctc aagtggaaag taaacagtgt tggcactatt tttatatatg gttaaagaga
     5941 cctgtcattg caataaaagc cagcattcac aaaatgagga agataaggaa agtagcataa
     6001 atattttcta ttaacatggc tttacaactg ctaaaactta tagtataaaa atgtactaac
     6061 aaagactaat tcaagaagtt gcaggataca caatttttaa aaatctcatt tctacatctt
     6121 agcagtgaca aactgcaatt taaaaagtgt gtttggttat taatatatat gagactttta
     6181 aagaaagtta tataactaca tagagataaa ttaagaaaga tgcctaaata gaagcaagtt
     6241 taaagagcta tatttttaaa catgaacaaa ctcccatggg agccatgcca gtgtagtgga
     6301 aaagtagtac atggggagat ggggagtttt tttgaaaacc agaattacag ttctcatttc
     6361 actacttacc agttgtatac tcttgggaaa gtcactccta gtatctattt caccatctac
     6421 agaagagaaa tacttcacag aattattgtg gggattaagt tagataatgt gttttaaaat
     6481 ataaagctac atccaaagaa atgccaatat gtgacattag tatgaaattt actacagttc
     6541 catttaacat tccaactggt tgctgtgtgg aatatggcat aattgtaata aattatttag
     6601 gaaagcaagc aaagatgtaa gtttttttaa tttaggggga aaaaatggga gccttgctct
     6661 ccaaatcctt aaaacatgct attaagcaac ctttctgaat attctgtggt gccaagtaga
     6721 aagtttaact gaaattaata agccaatgga aagaaagaaa tattaataac tgctggtgga
     6781 aagactagct agatgtcagt gtggaaagat tagatccact ttacatgtga tattccaaat
     6841 gaattaaaat gttaagtata aaaagaaaaa tactacaagt ctcacaccaa tagtggtata
     6901 aaggaacttc atggcaattg gcaaggtaga tcaactaaga gaaaaagttt taaatgtgta
     6961 gtaaatagga aaaagacaaa acaagatgga atttaaaaga agctatttgc attacacatg
     7021 gatgcactca gtttttgtaa aactatatgc atatccataa gggtttgtac tcttaggcaa
     7081 atttataaag cgatcgtgta taaatgatat aaaaaatcaa tttgaatggt attcaaattt
     7141 cctaatatta aaaatgcaac tttgacttag ttcatgctat tgtattagca aaactgtttt
     7201 aattgcatgt gtccttatag cagcagcatt gtgtattagt agccttttaa gagaactgtg
     7261 tagaagacta taaaaagggc tttataactg atcttttgac atactcactt tgagtggcat
     7321 atgcccagga aaatatttaa aagaaagaaa agctatttgt acaaagtttt ctagcagttc
     7381 cactcagata actttaaggg ggaaaaaagc ccaacgattg gaaatggtta agtaaatttt
     7441 ggtgtattgc tagtgctatc acagaatgtt atatagccat tcaataatat tgatatatgt
     7501 caaattgtat gcaaaaaagt gagattcaaa aatgttaata agaacataaa ttgtgtttac
     7561 tgatacatgt gaaaatttag gtctacattg aaaagaatca gaagataaca tgtaattcag
     7621 tttaacatta ggggttcttt atttttcttc tgttaaatat tgatgtatgc aataaaaaat
     7681 aaaagattaa ttggtaaagt ggtttactga a
//
