LOCUS       NM_006614               7856 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens cell adhesion molecule L1 like (CHL1), transcript
            variant 1, mRNA.
ACCESSION   NM_006614
VERSION     NM_006614.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7856)
  AUTHORS   Yoo,M., Kayastha,N., Kwon,O., Man,W., Cai,L. and Schachner,M.
  TITLE     Analysis of the functional sequences in the promoter region of the
            human adhesion molecule close homolog of L1
  JOURNAL   Int J Neurosci 132 (5), 483-489 (2022)
   PUBMED   33054469
  REMARK    GeneRIF: Analysis of the functional sequences in the promoter
            region of the human adhesion molecule close homolog of L1.
REFERENCE   2  (bases 1 to 7856)
  AUTHORS   Qin,M., Gao,X., Luo,W., Ou,K., Lu,H., Liu,H. and Zhuang,Q.
  TITLE     Expression of CHL1 in Clear Cell Renal Cell Carcinoma and its
            Association With Prognosis
  JOURNAL   Appl Immunohistochem Mol Morphol 30 (3), 209-214 (2022)
   PUBMED   35262525
  REMARK    GeneRIF: Expression of CHL1 in Clear Cell Renal Cell Carcinoma and
            its Association With Prognosis.
REFERENCE   3  (bases 1 to 7856)
  AUTHORS   Tian,W., Yang,X., Yang,H., Lv,M., Sun,X. and Zhou,B.
  TITLE     Exosomal miR-338-3p suppresses non-small-cell lung cancer cells
            metastasis by inhibiting CHL1 through the MAPK signaling pathway
  JOURNAL   Cell Death Dis 12 (11), 1030 (2021)
   PUBMED   34718336
  REMARK    GeneRIF: Exosomal miR-338-3p suppresses non-small-cell lung cancer
            cells metastasis by inhibiting CHL1 through the MAPK signaling
            pathway.
            Erratum:[Cell Death Dis. 2022 May 19;13(5):473. doi:
            10.1038/s41419-022-04933-3.. PMID: 35589682]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7856)
  AUTHORS   Chen,Y., Sun,T., Niu,Y., Wang,D., Liu,K., Wang,T., Wang,S., Xu,H.
            and Liu,J.
  TITLE     Cell adhesion molecule L1 like plays a role in the pathogenesis of
            idiopathic hypogonadotropic hypogonadism
  JOURNAL   J Endocrinol Invest 44 (8), 1739-1751 (2021)
   PUBMED   33453020
  REMARK    GeneRIF: Cell adhesion molecule L1 like plays a role in the
            pathogenesis of idiopathic hypogonadotropic hypogonadism.
            Erratum:[J Endocrinol Invest. 2023 Apr;46(4):853. doi:
            10.1007/s40618-022-01942-z.. PMID: 36315353]
REFERENCE   5  (bases 1 to 7856)
  AUTHORS   Ognibene,M. and Pezzolo,A.
  TITLE     Ezrin interacts with the tumor suppressor CHL1 and promotes
            neuronal differentiation of human neuroblastoma
  JOURNAL   PLoS One 15 (12), e0244069 (2020)
   PUBMED   33326488
  REMARK    GeneRIF: Ezrin interacts with the tumor suppressor CHL1 and
            promotes neuronal differentiation of human neuroblastoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7856)
  AUTHORS   Gast,D., Riedle,S., Riedle,S., Schabath,H., Schlich,S.,
            Schneider,A., Issa,Y., Stoeck,A., Fogel,M., Joumaa,S., Wenger,T.,
            Herr,I., Gutwein,P. and Altevogt,P.
  TITLE     L1 augments cell migration and tumor growth but not beta3 integrin
            expression in ovarian carcinomas
  JOURNAL   Int J Cancer 115 (4), 658-665 (2005)
   PUBMED   15704102
  REMARK    GeneRIF: L1 could drive progression by enhancing cell migration and
            tumor growth in ovarian carcinoma.
REFERENCE   7  (bases 1 to 7856)
  AUTHORS   Chen,Q.Y., Chen,Q., Feng,G.Y., Lindpaintner,K., Chen,Y., Sun,X.,
            Chen,Z., Gao,Z., Tang,J. and He,L.
  TITLE     Case-control association study of the close homologue of L1 (CHL1)
            gene and schizophrenia in the Chinese population
  JOURNAL   Schizophr Res 73 (2-3), 269-274 (2005)
   PUBMED   15653271
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 7856)
  AUTHORS   Sakurai,K., Migita,O., Toru,M. and Arinami,T.
  TITLE     An association between a missense polymorphism in the close
            homologue of L1 (CHL1, CALL) gene and schizophrenia
  JOURNAL   Mol Psychiatry 7 (4), 412-415 (2002)
   PUBMED   11986985
  REMARK    GeneRIF: An association between a missense polymorphism in the
            close homologue of L1 (CHL1, CALL) gene and schizophrenia.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 7856)
  AUTHORS   Angeloni,D., Lindor,N.M., Pack,S., Latif,F., Wei,M.H. and
            Lerman,M.I.
  TITLE     CALL gene is haploinsufficient in a 3p- syndrome patient
  JOURNAL   Am J Med Genet 86 (5), 482-485 (1999)
   PUBMED   10508992
REFERENCE   10 (bases 1 to 7856)
  AUTHORS   Wei,M.H., Karavanova,I., Ivanov,S.V., Popescu,N.C., Keck,C.L.,
            Pack,S., Eisen,J.A. and Lerman,M.I.
  TITLE     In silico-initiated cloning and molecular characterization of a
            novel human member of the L1 gene family of neural cell adhesion
            molecules
  JOURNAL   Hum Genet 103 (3), 355-364 (1998)
   PUBMED   9799093
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA778898.1, AC066595.5,
            AF002246.1, AC011609.9 and R40400.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006614.3.
            
            Summary: The protein encoded by this gene is a member of the L1
            gene family of neural cell adhesion molecules. It is a neural
            recognition molecule that may be involved in signal transduction
            pathways. The deletion of one copy of this gene may be responsible
            for mental defects in patients with 3p- syndrome. This protein may
            also play a role in the growth of certain cancers. Alternate
            splicing results in both coding and non-coding variants. [provided
            by RefSeq, Nov 2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.123628.1,
                                           SRR1660807.14196.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000256509.7/ ENSP00000256509.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-120               DA778898.1         168-287
            121-121             AC066595.5         4713-4713           c
            122-204             DA778898.1         289-371
            205-1381            AF002246.1         1-1177
            1382-1382           AC011609.9         32458-32458
            1383-3622           AF002246.1         1179-3418
            3623-3688           AC011609.9         81321-81386
            3689-4818           AF002246.1         3485-4614
            4819-7648           AC011609.9         89421-92250
            7649-7856           R40400.1           9-216               c
FEATURES             Location/Qualifiers
     source          1..7856
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p26.3"
     gene            1..7856
                     /gene="CHL1"
                     /gene_synonym="CALL; L1CAM2"
                     /note="cell adhesion molecule L1 like"
                     /db_xref="GeneID:10752"
                     /db_xref="HGNC:HGNC:1939"
                     /db_xref="MIM:607416"
     exon            1..301
                     /gene="CHL1"
                     /gene_synonym="CALL; L1CAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            302..381
                     /gene="CHL1"
                     /gene_synonym="CALL; L1CAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            382..566
                     /gene="CHL1"
                     /gene_synonym="CALL; L1CAM2"
                     /inference="alignment:Splign:2.1.0"
     CDS             476..4150
                     /gene="CHL1"
                     /gene_synonym="CALL; L1CAM2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; cell adhesion molecule with homology to L1CAM
                     (close homologue of L1); cell adhesion molecule with
                     homology to L1CAM (close homolog of L1); L1 cell adhesion
                     molecule 2; neural cell adhesion molecule L1-like protein"
                     /codon_start=1
                     /product="neural cell adhesion molecule L1-like protein
                     isoform 1 precursor"
                     /protein_id="NP_006605.2"
                     /db_xref="CCDS:CCDS2556.1"
                     /db_xref="GeneID:10752"
                     /db_xref="HGNC:HGNC:1939"
                     /db_xref="MIM:607416"
                     /translation="MEPLLLGRGLIVYLMFLLLKFSKAIEIPSSVQQVPTIIKQSKVQ
                     VAFPFDEYFQIECEAKGNPEPTFSWTKDGNPFYFTDHRIIPSNNSGTFRIPNEGHISH
                     FQGKYRCFASNKLGIAMSEEIEFIVPSVPKFPKEKIDPLEVEEGDPIVLPCNPPKGLP
                     PLHIYWMNIELEHIEQDERVYMSQKGDLYFANVEEKDSRNDYCCFAAFPRLRTIVQKM
                     PMKLTVNSLKHANDSSSSTEIGSKANSIKQRKPKLLLPPTESGSESSITILKGEILLL
                     ECFAEGLPTPQVDWNKIGGDLPKGRETKENYGKTLKIENVSYQDKGNYRCTASNFLGT
                     ATHDFHVIVEEPPRWTKKPQSAVYSTGSNGILLCEAEGEPQPTIKWRVNGSPVDNHPF
                     AGDVVFPREISFTNLQPNHTAVYQCEASNVHGTILANANIDVVDVRPLIQTKDGENYA
                     TVVGYSAFLHCEFFASPEAVVSWQKVEEVKPLEGRRYHIYENGTLQINRTTEEDAGSY
                     SCWVENAIGKTAVTANLDIRNATKLRVSPKNPRIPKLHMLELHCESKCDSHLKHSLKL
                     SWSKDGEAFEINGTEDGRIIIDGANLTISNVTLEDQGIYCCSAHTALDSAADITQVTV
                     LDVPDPPENLHLSERQNRSVRLTWEAGADHNSNISEYIVEFEGNKEEPGRWEELTRVQ
                     GKKTTVILPLAPFVRYQFRVIAVNEVGRSQPSQPSDHHETPPAAPDRNPQNIRVQASQ
                     PKEMIIKWEPLKSMEQNGPGLEYRVTWKPQGAPVEWEEETVTNHTLRVMTPAVYAPYD
                     VKVQAINQLGSGPDPQSVTLYSGEDYPDTAPVIHGVDVINSTLVKVTWSTVPKDRVHG
                     RLKGYQINWWKTKSLLDGRTHPKEVNILRFSGQRNSGMVPSLDAFSEFHLTVLAYNSK
                     GAGPESEPYIFQTPEGVPEQPTFLKVIKVDKDTATLSWGLPKKLNGNLTGYLLQYQII
                     NDTYEIGELNDINITTPSKPSWHLSNLNATTKYKFYLRACTSQGCGKPITEESSTLGE
                     GSKGIGKISGVNLTQKTHPIEVFEPGAEHIVRLMTKNWGDNDSIFQDVIETRGREYAG
                     LYDDISTQGWFIGLMCAIALLTLLLLTVCFVKRNRGGKYSVKEKEDLHPDPEIQSVKD
                     ETFGEYSDSDEKPLKGSLRSLNRDMQPTESADSLVEYGEGDHGLFSEDGSFIGAYAGS
                     KEKGSVESNGSSTATFPLRA"
     exon            567..672
                     /gene="CHL1"
                     /gene_synonym="CALL; L1CAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            673..860
                     /gene="CHL1"
                     /gene_synonym="CALL; L1CAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            861..983
                     /gene="CHL1"
                     /gene_synonym="CALL; L1CAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1154
                     /gene="CHL1"
                     /gene_synonym="CALL; L1CAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1202
                     /gene="CHL1"
                     /gene_synonym="CALL; L1CAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1323
                     /gene="CHL1"
                     /gene_synonym="CALL; L1CAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1508
                     /gene="CHL1"
                     /gene_synonym="CALL; L1CAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1640
                     /gene="CHL1"
                     /gene_synonym="CALL; L1CAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..1781
                     /gene="CHL1"
                     /gene_synonym="CALL; L1CAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1782..1893
                     /gene="CHL1"
                     /gene_synonym="CALL; L1CAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1894..2060
                     /gene="CHL1"
                     /gene_synonym="CALL; L1CAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2061..2226
                     /gene="CHL1"
                     /gene_synonym="CALL; L1CAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2227..2351
                     /gene="CHL1"
                     /gene_synonym="CALL; L1CAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2352..2453
                     /gene="CHL1"
                     /gene_synonym="CALL; L1CAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2454..2651
                     /gene="CHL1"
                     /gene_synonym="CALL; L1CAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2652..2722
                     /gene="CHL1"
                     /gene_synonym="CALL; L1CAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2723..2945
                     /gene="CHL1"
                     /gene_synonym="CALL; L1CAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2946..3061
                     /gene="CHL1"
                     /gene_synonym="CALL; L1CAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            3062..3266
                     /gene="CHL1"
                     /gene_synonym="CALL; L1CAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            3267..3389
                     /gene="CHL1"
                     /gene_synonym="CALL; L1CAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            3390..3569
                     /gene="CHL1"
                     /gene_synonym="CALL; L1CAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            3570..3728
                     /gene="CHL1"
                     /gene_synonym="CALL; L1CAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            3729..3860
                     /gene="CHL1"
                     /gene_synonym="CALL; L1CAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            3861..3933
                     /gene="CHL1"
                     /gene_synonym="CALL; L1CAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            3934..7856
                     /gene="CHL1"
                     /gene_synonym="CALL; L1CAM2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7826..7831
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CHL1"
                     /gene_synonym="CALL; L1CAM2"
                     /note="hexamer: AATAAA"
     polyA_site      7856
                     /gene="CHL1"
                     /gene_synonym="CALL; L1CAM2"
                     /note="major polyA site"
ORIGIN      
        1 gcagaaccca ggaagggagc agaggcgaga gccagcctcc ggcaggaggg cgtagacccc
       61 ggtgccagcc agaacggctc cagccttccc gcggccagag agccagcggc gggaggggac
      121 gggcgggacc tccgcggaca gccccgggtg cggaccagcg ggcagcggcc ggcgagaccc
      181 tccctggatc cgcccagagc ttaccggacc ctgcgcgccc ccgtcccggc tcccggccgg
      241 ctcgggggag aaggcgcccg aggggaggcg ccggacagat cgcgtttcgg aggcggcgca
      301 ggtgctgtaa actgcaaacc ataatcctgt cttaatactg caaacaaatc atagtggaac
      361 taaggggaac ttaatttact gtttccaggt taactaaggt ctcagctgta aaccaaaagt
      421 gagaggagac attaagattt tcattcttac cgggttgtct tcttcctgaa gagcaatgga
      481 gccgctttta cttggaagag gactaatcgt atatctaatg ttcctcctgt taaaattctc
      541 aaaagcaatt gaaataccat cttcagttca acaggttcca acaatcataa aacagtcaaa
      601 agtccaagtt gcctttccct tcgatgagta ttttcaaatt gaatgtgaag ctaaaggaaa
      661 tccagaacca acattttcgt ggactaagga tggcaaccct ttttatttca ctgaccatcg
      721 gataattcca tcgaacaatt caggaacatt caggatccca aacgaggggc acatatctca
      781 ctttcaaggg aaataccgct gctttgcttc aaataaactg ggaatcgcta tgtcagaaga
      841 aatagaattt atagttccaa gtgttccaaa attcccaaaa gaaaaaattg accctcttga
      901 agtggaggag ggagatccaa ttgtcctccc atgcaatcct cccaaaggcc tcccaccttt
      961 acacatttat tggatgaata ttgaattaga acacatcgaa caagatgaaa gagtatacat
     1021 gagccaaaag ggagatctat acttcgcaaa cgtggaagaa aaggacagtc gcaatgacta
     1081 ctgttgcttt gctgcatttc caagattaag gactattgta cagaaaatgc caatgaaact
     1141 aacagttaac agtttaaagc atgctaatga ctcaagttca tccacagaaa ttggttccaa
     1201 ggcaaattcc atcaagcaaa gaaaacccaa actgctgttg cctcccactg agagtggcag
     1261 tgagtcttca attaccatcc tcaaagggga aatcttgctg cttgagtgtt ttgctgaagg
     1321 cttgccaact ccacaggttg attggaacaa aattggtggt gacttaccaa aggggagaga
     1381 aacaaaagaa aattatggca agactttgaa gatagagaat gtctcctacc aggacaaagg
     1441 aaattatcgc tgcacagcca gcaatttctt gggaacagcc actcacgatt ttcacgttat
     1501 agtagaagag cctcctcgct ggacaaagaa gcctcagagt gctgtgtata gcaccggaag
     1561 caatggcatc ttgttatgtg aggctgaagg agaacctcaa cccacaatca agtggagagt
     1621 caatggctcc ccagttgaca atcatccatt tgctggtgat gttgtcttcc ccagggaaat
     1681 cagttttacc aaccttcaac caaatcatac tgctgtgtac cagtgtgaag cctcaaatgt
     1741 ccatggaact atccttgcca atgccaatat tgatgttgtg gatgtccgtc cattgataca
     1801 aaccaaagat ggagaaaatt acgctacagt ggttgggtac agtgctttct tacattgcga
     1861 gttctttgct tcacctgagg cagtcgtgtc ctggcagaag gtggaagaag tgaaacccct
     1921 ggagggcagg cggtatcata tctatgaaaa tggcacattg cagatcaaca gaaccaccga
     1981 agaagatgct gggtcttact catgttgggt agaaaatgct ataggaaaaa ctgcagtcac
     2041 agccaatttg gatattagaa atgctacaaa acttagagtt tctcctaaga atcctcgtat
     2101 ccccaaattg catatgcttg aattacattg tgaaagcaaa tgtgactcac atttgaaaca
     2161 cagtttgaag ttgtcctgga gtaaagatgg agaagccttt gaaattaatg gcacagaaga
     2221 tggcaggata attattgatg gagctaattt gaccatatct aatgtaactt tagaggacca
     2281 aggtatttac tgctgttcag ctcatactgc tctagacagt gctgccgata taactcaagt
     2341 aactgttctt gatgttccgg atccaccaga aaaccttcac ttgtctgaaa gacagaacag
     2401 gagtgttcgg ctgacctggg aagctggagc tgaccacaac agcaatatta gcgagtatat
     2461 tgttgaattt gaaggaaaca aagaagagcc tggaaggtgg gaggaactga ccagagtcca
     2521 aggaaagaaa accacagtta tcttaccttt ggctccattt gtgagatacc agttcagggt
     2581 catagccgtg aacgaagtag ggagaagtca gcctagccag ccgtcagacc atcatgaaac
     2641 accaccagca gctccagata ggaatccaca aaacataagg gttcaagcct ctcaacccaa
     2701 ggaaatgatt ataaagtggg agcctttgaa atccatggag cagaatggac caggcctaga
     2761 gtacagagtg acctggaagc cacagggagc cccagtggag tgggaagaag aaacagtcac
     2821 aaaccacaca ttgcgggtga tgacgcctgc tgtctatgcc ccttatgatg tcaaggtcca
     2881 ggctatcaat caactaggat ctgggcctga ccctcagtca gtgactctct attctggaga
     2941 agactatcct gatacagctc cagtgatcca tggggtggac gttataaaca gtacattagt
     3001 taaagttacc tggtcaacag ttccaaagga cagagtacat ggacgtctga aaggctatca
     3061 gataaattgg tggaaaacaa aaagtctgtt ggatggaaga acacatccca aagaagtgaa
     3121 cattctaaga ttttcaggac aaagaaactc tggaatggtt ccttccttag atgcctttag
     3181 tgaatttcat ttaacagtct tagcctataa ctctaaagga gctggtcctg aaagtgagcc
     3241 ttatatattt caaacaccag aaggagtacc tgaacagcca acttttctaa aggtcatcaa
     3301 agttgataaa gacactgcca ctttatcttg gggactacct aagaaattaa atggaaactt
     3361 aactggctat cttttgcaat atcagataat aaatgacacc tacgagattg gagaattaaa
     3421 tgatattaac attacaactc catcaaagcc cagctggcac ctctcaaacc tgaatgcaac
     3481 taccaagtac aaattctact tgagggcttg cacttcacag ggctgtggaa aaccgatcac
     3541 ggaggaaagc tccaccttag gagaagggag taaaggtatc gggaagatat caggagtaaa
     3601 tcttactcaa aagactcacc caatagaggt atttgagccg ggagctgaac atatagttcg
     3661 cctaatgact aagaattggg gcgataatga tagcattttt caagatgtaa ttgagacaag
     3721 agggagagaa tatgctggtt tatatgatga catctccact caaggctggt ttattggact
     3781 gatgtgtgcg attgctcttc tcacactact attattaact gtttgctttg tgaagaggaa
     3841 tagaggtgga aagtactcag ttaaagaaaa ggaagatttg catccagacc cagaaattca
     3901 gtcagtaaaa gatgaaacct ttggtgaata cagtgacagt gatgaaaagc ctctcaaagg
     3961 aagccttcgg tcccttaata gggatatgca gcctactgaa agtgctgaca gcttagtcga
     4021 atacggagag ggagaccatg gtctcttcag tgaagatgga tcatttattg gtgcctacgc
     4081 tggatctaag gagaagggat ctgttgaaag caatggaagt tctacagcaa cttttcccct
     4141 tcgggcataa acacaacata tgtaagcaac gctactggtt caccccaacc ttccatattt
     4201 atctgttcaa aggagcaaga actttcatat aggaatagaa acatgctggc cgaagatttc
     4261 atccagaagt caacatcctg caattatgtt gaaaagagta gtactttctt caaaatataa
     4321 aatgccaagc acttcaggcc tatgttttgc ttatattgtt ttcaggtgct caaaatgcaa
     4381 aacacaaaac aaatcctgca tttagataca cctcaactaa atccaaagtc cccattcagt
     4441 atattccata tttgcctgat tttactattc ggtgtgtttg catagatgtt gctacttggt
     4501 gggtttttct ccgtatgcac attggtatac agtctctgag aactggcttg gtgactttgc
     4561 ttcactacag gttaaaagac cataagcaaa ctggttattt aaaatgtaaa aaggaatatg
     4621 aaagtcttat taaaacactt cattgaaaat atacagtcta aatttattat ttaaatttta
     4681 ctagcaaaag tcttaggtga acaatcaact agtatttgtt gagctcctat ttgcccagag
     4741 atggtcatat ttaaacagaa gtatacgttt ttcagtttca acatgaattt ttttatttct
     4801 gtcagttatg acatccacaa gcatcacttt ttgtgtctgt tttttttttt tttcttggac
     4861 taaattcaac tgcatggaag cggtggtcag aaggttgttt tatacgagaa caggcagaaa
     4921 gtgcccattg ttcaggattc taatagctac atctacttaa tatcttcatt tctaaattga
     4981 ctgcttttac ctttttctca tgtttatata atggtatgct tgcatatatt tcatgaatac
     5041 attgtacata ttatgttaat atttacacaa tttaaaatat agatgtgttt tattttgaag
     5101 tgagaaaatg aacattaaca ggcatgtttg tacagctaga atatattagt aagatactgt
     5161 ttttcgtcat tccagagcta caactaataa cacgaggttc caaagctgaa gactttgtat
     5221 aaagtatttg ggttttgttc ttgtattgct ttctttcaac agtttcaaaa taaaatatca
     5281 tataaatatt gagggaaatg ttttcatatt tttcaaaata ggtttttatt gttgaatgta
     5341 catctacccc agcccctcaa aagaaaaact gtttacatag aaattcctac acatacgttt
     5401 gcgtatatgt tattttaaac atctttgtgg tgagaatttt ttccccgata ttctccttct
     5461 gtcaaagtca gaacaaattc agggaattta ttttctggca gttgtgctcc agtcctttta
     5521 aaattgtaca tgaacatgtt ttagaaacaa tatggaggat gatgcataca tgtcggtcaa
     5581 gttcagcgct cgacatttta tggaaagatt tttttaacct taccacgaaa tacttaacta
     5641 ctgtttaagt gaattgactt atttcacttt agtttttgaa ctgtgattat tggtatactg
     5701 ttatatcctc aacttggatt tatggtaacc ccttatagtt catggagacc aaaatttggg
     5761 gtatttataa tagtcagcgc aggaatgcac atggaatatc tacttgtcct tttgaacctc
     5821 acgagtcatc cagaatgtat agacaggaaa agcatgtctt atttaaaact gtaatttatg
     5881 ggctcaggat ctgaccgcag tcccgggagt aagcatttca aagggggaag gcagtgtggt
     5941 ccctaccctg tgtgaatgtg aggatgtaga catccatcag tgcaactcga gctccatcct
     6001 cctccgattt ctaaggttcc agttttctgg agggacagtc atcatgtttt gatttatctg
     6061 ggagaaaact gtggtgcaca gcttgtgagg agggcaaggt tgtgacgttc gagcttagtt
     6121 ctggtgttat tctgtctcct cttctttgtc atcagccaaa acgtggtttt taaagagagt
     6181 catgcaggtt agaaataatg tcaaaaatat ttaggaattt aataaccttt aagtcagaaa
     6241 ctaaaacaaa tactgaaata ttagctcttc ctacacttcg tgttcccctt tagctgcctg
     6301 aaaatcaaga ttgctcctgc tcagatcttc tgagtggcta aaacttatgg atatgaaaaa
     6361 tgagattgaa tgatgactat gctttgctat cattgttacc tttcctcaat actatttggc
     6421 aactactggg actcttcagc acaaaaggaa tagatctatg attgaccctg attttaattg
     6481 tgaaattata tgattcatat attttatgaa tcagaataac cttcaaataa aataaatcta
     6541 agtcggttaa aatggatttc atgattttcc ctcagaaaat gagtaacaga gtccacggcg
     6601 tgcaatggta attataaatt ggtgatgctt gtttgcaaat tgcccactcg tgataagtca
     6661 acagccaata tttaaaactt tgttcgttac tggctttacc ctaactttct ctagtctact
     6721 gtcaatatca ttttaatgta attgattgta tatagtctca agaatggttg gtgggcatga
     6781 gttcctagag aactgtccaa gggttgggaa aatccaaatt ctcttcctgg ttccagcact
     6841 gattttgtac ataaacatta ggcaggttgc ttaacctttt tatttcaaac tctctcaact
     6901 ctaaagtgct aataataatc tcagttacct tatctttgtc acagggtgtt cttttttatg
     6961 aagaaaaatt tgaaaatgat aaaagctaag atgccttcta acttcataag caaaccttta
     7021 actaattatg tatctgaaag tcacccccac ataccaactc aacttttttc ctgtgaacac
     7081 ataaatatat ttttatagaa aaacaaatct acataaaata aatctactgt ttagtgagca
     7141 gtatgatttg tacatgccat tgaaaattat taatcagaag aaaattaagc agggtctttg
     7201 ctatacaaaa gtgttttcca ctaattttgc atgcgtattt ataagaaaaa tgtgaatttg
     7261 gtggttttat tctatcggta taaaggcatt gatattttag atgcacccgt gtttgtaaaa
     7321 atgtagagca caatggaatt atgctggaag tctcaaataa tatttttttc ctattttata
     7381 ctcatggaag agataagcta aagaggggac aataatgaga aatgttggtg tgcttttcta
     7441 agcatttaaa acataattgc caattgaaac cctaaatatg tttacatacc attaagatat
     7501 gattcatgta acaatgttaa attaattata atgggattgg gtttgttatc tgtggtagta
     7561 tatatcctag tgttcctata gtgaaataag tagggttcag ccaaagcttt ctttgttttg
     7621 taccttaaat tgttcgatta cgtcatcaaa agagatgaaa ggtatgtaga acaggttcac
     7681 gtgattacct ttttcttttg gcttggatta atattcatag tagaacttta taaaacgtgt
     7741 ttgtattgta ggtggtgttt gtattatgct tatgactatg tatggtttga aaatattttc
     7801 attatacatg aaattcaact ttccaaataa aagttctact tcatgtaatc caaaaa
//
