LOCUS       NM_023947               3260 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens chitinase domain containing 1 (CHID1), transcript
            variant 3, mRNA.
ACCESSION   NM_023947
VERSION     NM_023947.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3260)
  AUTHORS   Castrogiovanni,P., Barbagallo,I., Imbesi,R., Musumeci,G.,
            Sanfilippo,C., Broggi,G., Caltabiano,R., Tibullo,D., Giallongo,C.,
            Forte,S., Li Volti,G. and Di Rosa,M.
  TITLE     Chitinase domain containing 1 increase is associated with low
            survival rate and M0 macrophages infiltrates in colorectal cancer
            patients
  JOURNAL   Pathol Res Pract 237, 154038 (2022)
   PUBMED   35932496
  REMARK    GeneRIF: Chitinase domain containing 1 increase is associated with
            low survival rate and M0 macrophages infiltrates in colorectal
            cancer patients.
REFERENCE   2  (bases 1 to 3260)
  AUTHORS   Castrogiovanni,P., Sanfilippo,C., Imbesi,R., Maugeri,G., Lo
            Furno,D., Tibullo,D., Castorina,A., Musumeci,G. and Di Rosa,M.
  TITLE     Brain CHID1 Expression Correlates with NRGN and CALB1 in Healthy
            Subjects and AD Patients
  JOURNAL   Cells 10 (4), 882 (2021)
   PUBMED   33924468
  REMARK    GeneRIF: Brain CHID1 Expression Correlates with NRGN and CALB1 in
            Healthy Subjects and AD Patients.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3260)
  AUTHORS   Kovaleva,O.V., Rashidova,M.A., Samoilova,D.V., Podlesnaya,P.A.,
            Tabiev,R.M., Mochalnikova,V.V. and Gratchev,A.
  TITLE     CHID1 Is a Novel Prognostic Marker of Non-Small Cell Lung Cancer
  JOURNAL   Int J Mol Sci 22 (1), 450 (2021)
   PUBMED   33466316
  REMARK    GeneRIF: CHID1 Is a Novel Prognostic Marker of Non-Small Cell Lung
            Cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3260)
  AUTHORS   Li,S.N., Ling,T., Yang,Y.X., Huang,J.P. and Xu,L.G.
  TITLE     CHID1 positively regulates RLR antiviral signaling by targeting the
            RIG-I/VISA signalosome
  JOURNAL   J Med Virol 91 (9), 1668-1678 (2019)
   PUBMED   31106867
  REMARK    GeneRIF: These results indicate that CHID1 positively regulates RLR
            antiviral signal, revealing the novel mechanism of the RIG-I
            antiviral signaling pathway.
REFERENCE   5  (bases 1 to 3260)
  AUTHORS   Kzhyshkowska,J., Yin,S., Liu,T., Riabov,V. and Mitrofanova,I.
  TITLE     Role of chitinase-like proteins in cancer
  JOURNAL   Biol Chem 397 (3), 231-247 (2016)
   PUBMED   26733160
  REMARK    GeneRIF: This review comprehensively analyzes recent data about
            expression pattern, and involvement of human YKL-40, YKL-39 and
            SI-CLP in cancer. [review]
            Review article
REFERENCE   6  (bases 1 to 3260)
  AUTHORS   Meng,G., Zhao,Y., Bai,X., Liu,Y., Green,T.J., Luo,M. and Zheng,X.
  TITLE     Structure of human stabilin-1 interacting chitinase-like protein
            (SI-CLP) reveals a saccharide-binding cleft with lower
            sugar-binding selectivity
  JOURNAL   J Biol Chem 285 (51), 39898-39904 (2010)
   PUBMED   20724479
  REMARK    GeneRIF: Structure of human stabilin-1 interacting chitinase-like
            protein (SI-CLP) reveals a saccharide-binding cleft with lower
            sugar-binding selectivity.
REFERENCE   7  (bases 1 to 3260)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   8  (bases 1 to 3260)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   9  (bases 1 to 3260)
  AUTHORS   Meng,G., Bai,X., Green,T.J., Luo,M. and Zheng,X.
  TITLE     Crystallization and preliminary X-ray crystallographic studies on
            SI-CLP, a novel human Glyco_18 domain-containing protein
  JOURNAL   Protein Pept Lett 16 (3), 336-338 (2009)
   PUBMED   19275751
  REMARK    GeneRIF: The crystals of SI-CLP belong to the space group P3(2)21
            with unit cell parameters a=b=99.79 A, c=250.53 A, alpha=beta=90
            degrees, gamma=120 degrees.
REFERENCE   10 (bases 1 to 3260)
  AUTHORS   Kzhyshkowska,J., Mamidi,S., Gratchev,A., Kremmer,E.,
            Schmuttermaier,C., Krusell,L., Haus,G., Utikal,J., Schledzewski,K.,
            Scholtze,J. and Goerdt,S.
  TITLE     Novel stabilin-1 interacting chitinase-like protein (SI-CLP) is
            up-regulated in alternatively activated macrophages and secreted
            via lysosomal pathway
  JOURNAL   Blood 107 (8), 3221-3228 (2006)
   PUBMED   16357325
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC095409.1, AP006623.1 and CK904484.1.
            
            On May 17, 2019 this sequence version replaced NM_023947.3.
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, and 3 encode isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC095409.1, AK027711.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000323578.13/ ENSP00000325055.8
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1091              BC095409.1         1-1091
            1092-1092           AP006623.1         51663-51663         c
            1093-1838           BC095409.1         1093-1838
            1839-2953           AP006623.1         49383-50497         c
            2954-3260           CK904484.1         1-307
FEATURES             Location/Qualifiers
     source          1..3260
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.5"
     gene            1..3260
                     /gene="CHID1"
                     /gene_synonym="GL008; SI-CLP; SICLP"
                     /note="chitinase domain containing 1"
                     /db_xref="GeneID:66005"
                     /db_xref="HGNC:HGNC:28474"
                     /db_xref="MIM:615692"
     exon            1..36
                     /gene="CHID1"
                     /gene_synonym="GL008; SI-CLP; SICLP"
                     /inference="alignment:Splign:2.1.0"
     exon            37..190
                     /gene="CHID1"
                     /gene_synonym="GL008; SI-CLP; SICLP"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..1261
                     /gene="CHID1"
                     /gene_synonym="GL008; SI-CLP; SICLP"
                     /EC_number="3.6.5.4"
                     /note="isoform a precursor is encoded by transcript
                     variant 3; chitinase domain-containing protein 1;
                     stabilin-1 interacting chitinase-like protein"
                     /codon_start=1
                     /product="chitinase domain-containing protein 1 isoform a
                     precursor"
                     /protein_id="NP_076436.3"
                     /db_xref="CCDS:CCDS7722.1"
                     /db_xref="GeneID:66005"
                     /db_xref="HGNC:HGNC:28474"
                     /db_xref="MIM:615692"
                     /translation="MRTLFNLLWLALACSPVHTTLSKSDAKKAASKTLLEKSQFSDKP
                     VQDRGLVVTDLKAESVVLEHRSYCSAKARDRHFAGDVLGYVTPWNSHGYDVTKVFGSK
                     FTQISPVWLQLKRRGREMFEVTGLHDVDQGWMRAVRKHAKGLHIVPRLLFEDWTYDDF
                     RNVLDSEDEIEELSKTVVQVAKNQHFDGFVVEVWNQLLSQKRVGLIHMLTHLAEALHQ
                     ARLLALLVIPPAITPGTDQLGMFTHKEFEQLAPVLDGFSLMTYDYSTAHQPGPNAPLS
                     WVRACVQVLDPKSKWRSKILLGLNFYGMDYATSKDAREPVVGARYIQTLKDHRPRMVW
                     DSQASEHFFEYKKSRSGRHVVFYPTLKSLQVRLELARELGVGVSIWELGQGLDYFYDL
                     L"
     exon            191..340
                     /gene="CHID1"
                     /gene_synonym="GL008; SI-CLP; SICLP"
                     /inference="alignment:Splign:2.1.0"
     exon            341..473
                     /gene="CHID1"
                     /gene_synonym="GL008; SI-CLP; SICLP"
                     /inference="alignment:Splign:2.1.0"
     exon            474..518
                     /gene="CHID1"
                     /gene_synonym="GL008; SI-CLP; SICLP"
                     /inference="alignment:Splign:2.1.0"
     exon            519..625
                     /gene="CHID1"
                     /gene_synonym="GL008; SI-CLP; SICLP"
                     /inference="alignment:Splign:2.1.0"
     exon            626..687
                     /gene="CHID1"
                     /gene_synonym="GL008; SI-CLP; SICLP"
                     /inference="alignment:Splign:2.1.0"
     exon            688..780
                     /gene="CHID1"
                     /gene_synonym="GL008; SI-CLP; SICLP"
                     /inference="alignment:Splign:2.1.0"
     exon            781..882
                     /gene="CHID1"
                     /gene_synonym="GL008; SI-CLP; SICLP"
                     /inference="alignment:Splign:2.1.0"
     exon            883..1038
                     /gene="CHID1"
                     /gene_synonym="GL008; SI-CLP; SICLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1119
                     /gene="CHID1"
                     /gene_synonym="GL008; SI-CLP; SICLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1162
                     /gene="CHID1"
                     /gene_synonym="GL008; SI-CLP; SICLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..3260
                     /gene="CHID1"
                     /gene_synonym="GL008; SI-CLP; SICLP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1329..1334
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CHID1"
                     /gene_synonym="GL008; SI-CLP; SICLP"
                     /note="hexamer: AATACA"
     polyA_site      1357
                     /gene="CHID1"
                     /gene_synonym="GL008; SI-CLP; SICLP"
                     /note="major polyA site"
     regulatory      2706..2711
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CHID1"
                     /gene_synonym="GL008; SI-CLP; SICLP"
                     /note="hexamer: AATAGA"
     polyA_site      2724
                     /gene="CHID1"
                     /gene_synonym="GL008; SI-CLP; SICLP"
     polyA_site      2875
                     /gene="CHID1"
                     /gene_synonym="GL008; SI-CLP; SICLP"
     polyA_site      2911
                     /gene="CHID1"
                     /gene_synonym="GL008; SI-CLP; SICLP"
     polyA_site      2924
                     /gene="CHID1"
                     /gene_synonym="GL008; SI-CLP; SICLP"
ORIGIN      
        1 gtgcgtttgt ggccgtccgg cctccctgac atgcagccct ctggaccccg aggttggacc
       61 ctactgtgac acacctacca tgcggacact cttcaacctc ctctggcttg ccctggcctg
      121 cagccctgtt cacactaccc tgtcaaagtc agatgccaaa aaagccgcct caaagacgct
      181 gctggagaag agtcagtttt cagataagcc ggtgcaagac cggggtttgg tggtgacgga
      241 cctcaaagct gagagtgtgg ttcttgagca tcgcagctac tgctcggcaa aggcccggga
      301 cagacacttt gctggggatg tactgggcta tgtcactcca tggaacagcc atggctacga
      361 tgtcaccaag gtctttggga gcaagttcac acagatctca cccgtctggc tgcagctgaa
      421 gagacgtggc cgtgagatgt ttgaggtcac gggcctccac gacgtggacc aagggtggat
      481 gcgagctgtc aggaagcatg ccaagggcct gcacatagtg cctcggctcc tgtttgagga
      541 ctggacttac gatgatttcc ggaacgtctt agacagtgag gatgagatag aggagctgag
      601 caagaccgtg gtccaggtgg caaagaacca gcatttcgat ggcttcgtgg tggaggtctg
      661 gaaccagctg ctaagccaga agcgcgtggg cctcatccac atgctcaccc acttggccga
      721 ggctctgcac caggcccggc tgctggccct cctggtcatc ccgcctgcca tcacccccgg
      781 gaccgaccag ctgggcatgt tcacgcacaa ggagtttgag cagctggccc ccgtgctgga
      841 tggtttcagc ctcatgacct acgactactc tacagcgcat cagcctggcc ctaatgcacc
      901 cctgtcctgg gttcgagcct gcgtccaggt cctggacccg aagtccaagt ggcgaagcaa
      961 aatcctcctg gggctcaact tctatggtat ggactacgcg acctccaagg atgcccgtga
     1021 gcctgttgtc ggggccaggt acatccagac actgaaggac cacaggcccc ggatggtgtg
     1081 ggacagccag gcctcagagc acttcttcga gtacaagaag agccgcagtg ggaggcacgt
     1141 cgtcttctac ccaaccctga agtccctgca ggtgcggctg gagctggccc gggagctggg
     1201 cgttggggtc tctatctggg agctgggcca gggcctggac tacttctacg acctgctcta
     1261 ggtgggcatt gcggcctccg cggtggacgt gttcttttct aagccatgga gtgagtgagc
     1321 aggtgtgaaa tacaggcctc cactccgttt gctgtgacgg gtctgctgca gtcctcagtc
     1381 gggggtcctg ggcaccatgt gactccccat cctcccatga ggggtccctg ccctggatga
     1441 gtcctagctg ggggacaccc tgagagctcg agcccctccc acccgggcat ccgctggctg
     1501 cctcctgtca gctgggcagg cggggcccac agtacctgcc ccaccaggac agcctggctc
     1561 aggcctttct gggctgcttc tcacatcctg ggctggatgt gggtttggaa gctctggaac
     1621 catcccggac tcgcccactc ctggattcga gggccctcgc agggacagct ctgcccagca
     1681 tcaccccagg gcctggcagt gatagagctg agagctccac ccccacatac ctgccaccca
     1741 cctggccagc cacagcacgt gtgtcacctg cagagagcca cccagacgtc cccaccgagt
     1801 ccagcacggc aagggtgcag gggctgccct agaaatgggc tcagaggagc ctggcccacc
     1861 ctcttgaaac tggtcctgga ccttggctca gctctgccgc ctcaggtagc acgaccccca
     1921 ggccagcctg gacacatcag ggagcatggt gaggggcaac ggcaggaccc gtgggccata
     1981 tcgggacagg catttccagc gaggggtggg gcagaggaca tgtggctggc aggctacacc
     2041 caccctgcca tgcagcggtg tccaggctct ggggaggccc tggggaattt ggaggcatca
     2101 tgagccaagg cctggtggcc ctcgttcccc tgcccctcgt caccatcctg tccttggctg
     2161 gccgtgagga ctcccctcct caccactggg tcccacaggg ctgaggtggg cagtagaggg
     2221 cataggtggg tacatgtccc gggcaaggtc tctcgggggg acagaagtga gtccagggag
     2281 tgggtgggcc tgggcgtccc tcactcagaa tgccgtgggg tgaggacggt gaggacaggg
     2341 tgggcactgg gttctggttt agagtcagta atgttagggc gcagtgggca gggggtcagg
     2401 acatctccag ccggtggtga ggaagcatgg tggggtctcc tccacaggac gggagctggg
     2461 gagggggtcc tgggtcggac ccaaggcacc cacacttgag aaagcctccg cctggacgtc
     2521 agggaggcct gcgagctgcc acagtgcagg tgcagccgtt cccaccgccc tgctgctgct
     2581 tgacacgggc ataggagata caagtggtgt gtgcggcggt tcatgcctgt aatcccagta
     2641 ctttggaaag ccgtggcggg aggaacgctg ggcaacatgg tgaaaccccg tctctacccc
     2701 ctaaaaatag aaaaattagc aagacatggt ggcatgtgcc tgtactcctg gctactcagg
     2761 aggctgagat gggaggatcg cttgatgagg ttgaggctgc agtgagctgt gaccgactgc
     2821 actccaaaaa ccttgtctaa aaaaacacaa gctgccactg gctttggggc actgaccttg
     2881 tctccccaga ggtgctgacg ctaacattca agttgttctc gggggtcctg tggcttctgt
     2941 tggagtgagg gtgggggaca cgcaggtctg ggagggtggt gtgggcctgg agctaggcat
     3001 tgccagatca gcattgggtg gaggcagggg tggggatgcc acacaggatg ggatgtctag
     3061 agcgggctgt gtctcccggg gggatgggca gagggtgggg caggaattag ctggaaatga
     3121 gattgtgggg tgcagtttgg ggatcagatg ccccaacctg aactgaccgt catccctgtg
     3181 gccagggtcc ccacacaacc ctcacccctg gctgtgagaa tcctgaggca ccttgatgca
     3241 ttttttttca tgccctgtga
//
