LOCUS       NM_001276               1747 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens chitinase 3 like 1 (CHI3L1), mRNA.
ACCESSION   NM_001276
VERSION     NM_001276.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1747)
  AUTHORS   Ma,B., Kamle,S., Sadanaga,T., Lee,C.M., Lee,J.H., Yee,D.C., Zhu,Z.,
            Silverman,E.K., DeMeo,D.L., Choi,A.M.K., Lee,C.G. and Elias,J.A.
  TITLE     Chitinase 3-like-1 Inhibits Innate Antitumor and Tissue Remodeling
            Immune Responses by Regulating CD47-SIRPalpha- and
            CD24-Siglec10-Mediated Phagocytosis
  JOURNAL   J Immunol 213 (9), 1279-1291 (2024)
   PUBMED   39291933
  REMARK    GeneRIF: Chitinase 3-like-1 Inhibits Innate Antitumor and Tissue
            Remodeling Immune Responses by Regulating CD47-SIRPalpha- and
            CD24-Siglec10-Mediated Phagocytosis.
REFERENCE   2  (bases 1 to 1747)
  AUTHORS   Yamanaka,K., Koma,Y.I., Urakami,S., Takahashi,R., Nagamata,S.,
            Omori,M., Torigoe,R., Yokoo,H., Nakanishi,T., Ishihara,N.,
            Tsukamoto,S., Kodama,T., Nishio,M., Shigeoka,M., Yokozaki,H. and
            Terai,Y.
  TITLE     YKL40/Integrin beta4 Axis Induced by the Interaction between Cancer
            Cells and Tumor-Associated Macrophages Is Involved in the
            Progression of High-Grade Serous Ovarian Carcinoma
  JOURNAL   Int J Mol Sci 25 (19), 10598 (2024)
   PUBMED   39408927
  REMARK    GeneRIF: YKL40/Integrin beta4 Axis Induced by the Interaction
            between Cancer Cells and Tumor-Associated Macrophages Is Involved
            in the Progression of High-Grade Serous Ovarian Carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1747)
  AUTHORS   Liang,B., Zhang,Y., Ke,D., Yan,R., Jiang,M.N., Li,L., Zhang,L.X.,
            Zhao,X.G., Yuan,G.P., Xu,B. and Liu,X.M.
  TITLE     Serum YKL-40 and Serum Krebs von den Lungen-6 as Potential
            Predictive Biomarkers for Rheumatoid Arthritis-Associated
            Interstitial Lung Disease
  JOURNAL   Immunol Invest 53 (6), 989-1000 (2024)
   PUBMED   38900045
  REMARK    GeneRIF: Serum YKL-40 and Serum Krebs von den Lungen-6 as Potential
            Predictive Biomarkers for Rheumatoid Arthritis-Associated
            Interstitial Lung Disease.
REFERENCE   4  (bases 1 to 1747)
  AUTHORS   Song,Y., Jiang,W., Afridi,S.K., Wang,T., Zhu,F., Xu,H., Nazir,F.H.,
            Liu,C., Wang,Y., Long,Y., Huang,Y.A., Qiu,W. and Tang,C.
  TITLE     Astrocyte-derived CHI3L1 signaling impairs neurogenesis and
            cognition in the demyelinated hippocampus
  JOURNAL   Cell Rep 43 (5), 114226 (2024)
   PUBMED   38733586
  REMARK    GeneRIF: Astrocyte-derived CHI3L1 signaling impairs neurogenesis
            and cognition in the demyelinated hippocampus.
REFERENCE   5  (bases 1 to 1747)
  AUTHORS   Mizoguchi,E., Sadanaga,T., Nanni,L., Wang,S. and Mizoguchi,A.
  TITLE     Recently Updated Role of Chitinase 3-like 1 on Various Cell Types
            as a Major Influencer of Chronic Inflammation
  JOURNAL   Cells 13 (8), 678 (2024)
   PUBMED   38667293
  REMARK    GeneRIF: Recently Updated Role of Chitinase 3-like 1 on Various
            Cell Types as a Major Influencer of Chronic Inflammation.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1747)
  AUTHORS   Renkema,G.H., Boot,R.G., Au,F.L., Donker-Koopman,W.E.,
            Strijland,A., Muijsers,A.O., Hrebicek,M. and Aerts,J.M.
  TITLE     Chitotriosidase, a chitinase, and the 39-kDa human cartilage
            glycoprotein, a chitin-binding lectin, are homologues of family 18
            glycosyl hydrolases secreted by human macrophages
  JOURNAL   Eur J Biochem 251 (1-2), 504-509 (1998)
   PUBMED   9492324
REFERENCE   7  (bases 1 to 1747)
  AUTHORS   Kirkpatrick,R.B., Emery,J.G., Connor,J.R., Dodds,R., Lysko,P.G. and
            Rosenberg,M.
  TITLE     Induction and expression of human cartilage glycoprotein 39 in
            rheumatoid inflammatory and peripheral blood monocyte-derived
            macrophages
  JOURNAL   Exp Cell Res 237 (1), 46-54 (1997)
   PUBMED   9417865
REFERENCE   8  (bases 1 to 1747)
  AUTHORS   Rehli,M., Krause,S.W. and Andreesen,R.
  TITLE     Molecular characterization of the gene for human cartilage gp-39
            (CHI3L1), a member of the chitinase protein family and marker for
            late stages of macrophage differentiation
  JOURNAL   Genomics 43 (2), 221-225 (1997)
   PUBMED   9244440
REFERENCE   9  (bases 1 to 1747)
  AUTHORS   Hakala,B.E., White,C. and Recklies,A.D.
  TITLE     Human cartilage gp-39, a major secretory product of articular
            chondrocytes and synovial cells, is a mammalian member of a
            chitinase protein family
  JOURNAL   J Biol Chem 268 (34), 25803-25810 (1993)
   PUBMED   8245017
REFERENCE   10 (bases 1 to 1747)
  AUTHORS   Nyirkos,P. and Golds,E.E.
  TITLE     Human synovial cells secrete a 39 kDa protein similar to a bovine
            mammary protein expressed during the non-lactating period
  JOURNAL   Biochem J 269 (1), 265-268 (1990)
   PUBMED   2375755
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC105940.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 31, 2019 this sequence version replaced NM_001276.3.
            
            Summary: Chitinases catalyze the hydrolysis of chitin, which is an
            abundant glycopolymer found in insect exoskeletons and fungal cell
            walls. The glycoside hydrolase 18 family of chitinases includes
            eight human family members. This gene encodes a glycoprotein member
            of the glycosyl hydrolase 18 family. The protein lacks chitinase
            activity and is secreted by activated macrophages, chondrocytes,
            neutrophils and synovial cells. The protein is thought to play a
            role in the process of inflammation and tissue remodeling.
            [provided by RefSeq, Sep 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK130142.1, AK225266.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000255409.8/ ENSP00000255409.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-106               AC105940.2         127960-128065       c
            107-136             AC105940.2         127677-127706       c
            137-338             AC105940.2         126545-126746       c
            339-395             AC105940.2         125937-125993       c
            396-546             AC105940.2         125002-125152       c
            547-668             AC105940.2         124092-124213       c
            669-792             AC105940.2         122523-122646       c
            793-975             AC105940.2         121831-122013       c
            976-1092            AC105940.2         121122-121238       c
            1093-1747           AC105940.2         120292-120946       c
FEATURES             Location/Qualifiers
     source          1..1747
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..1747
                     /gene="CHI3L1"
                     /gene_synonym="ASRT7; CGP-39; GP-39; GP39; HC-gp39;
                     hCGP-39; HCGP-3P; YK-40; YKL-40; YKL40; YYL-40"
                     /note="chitinase 3 like 1"
                     /db_xref="GeneID:1116"
                     /db_xref="HGNC:HGNC:1932"
                     /db_xref="MIM:601525"
     exon            1..106
                     /gene="CHI3L1"
                     /gene_synonym="ASRT7; CGP-39; GP-39; GP39; HC-gp39;
                     hCGP-39; HCGP-3P; YK-40; YKL-40; YKL40; YYL-40"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..1233
                     /gene="CHI3L1"
                     /gene_synonym="ASRT7; CGP-39; GP-39; GP39; HC-gp39;
                     hCGP-39; HCGP-3P; YK-40; YKL-40; YKL40; YYL-40"
                     /note="chitinase-3-like protein 1; 39 kDa synovial
                     protein; cartilage glycoprotein 39; chitinase 3-like 1
                     (cartilage glycoprotein-39)"
                     /codon_start=1
                     /product="chitinase-3-like protein 1 precursor"
                     /protein_id="NP_001267.2"
                     /db_xref="CCDS:CCDS1435.1"
                     /db_xref="GeneID:1116"
                     /db_xref="HGNC:HGNC:1932"
                     /db_xref="MIM:601525"
                     /translation="MGVKASQTGFVVLVLLQCCSAYKLVCYYTSWSQYREGDGSCFPD
                     ALDRFLCTHIIYSFANISNDHIDTWEWNDVTLYGMLNTLKNRNPNLKTLLSVGGWNFG
                     SQRFSKIASNTQSRRTFIKSVPPFLRTHGFDGLDLAWLYPGRRDKQHFTTLIKEMKAE
                     FIKEAQPGKKQLLLSAALSAGKVTIDSSYDIAKISQHLDFISIMTYDFHGAWRGTTGH
                     HSPLFRGQEDASPDRFSNTDYAVGYMLRLGAPASKLVMGIPTFGRSFTLASSETGVGA
                     PISGPGIPGRFTKEAGTLAYYEICDFLRGATVHRILGQQVPYATKGNQWVGYDDQESV
                     KSKVQYLKDRQLAGAMVWALDLDDFQGSFCGQDLRFPLTNAIKDALAAT"
     exon            107..136
                     /gene="CHI3L1"
                     /gene_synonym="ASRT7; CGP-39; GP-39; GP39; HC-gp39;
                     hCGP-39; HCGP-3P; YK-40; YKL-40; YKL40; YYL-40"
                     /inference="alignment:Splign:2.1.0"
     exon            137..338
                     /gene="CHI3L1"
                     /gene_synonym="ASRT7; CGP-39; GP-39; GP39; HC-gp39;
                     hCGP-39; HCGP-3P; YK-40; YKL-40; YKL40; YYL-40"
                     /inference="alignment:Splign:2.1.0"
     exon            339..395
                     /gene="CHI3L1"
                     /gene_synonym="ASRT7; CGP-39; GP-39; GP39; HC-gp39;
                     hCGP-39; HCGP-3P; YK-40; YKL-40; YKL40; YYL-40"
                     /inference="alignment:Splign:2.1.0"
     exon            396..546
                     /gene="CHI3L1"
                     /gene_synonym="ASRT7; CGP-39; GP-39; GP39; HC-gp39;
                     hCGP-39; HCGP-3P; YK-40; YKL-40; YKL40; YYL-40"
                     /inference="alignment:Splign:2.1.0"
     exon            547..668
                     /gene="CHI3L1"
                     /gene_synonym="ASRT7; CGP-39; GP-39; GP39; HC-gp39;
                     hCGP-39; HCGP-3P; YK-40; YKL-40; YKL40; YYL-40"
                     /inference="alignment:Splign:2.1.0"
     exon            669..792
                     /gene="CHI3L1"
                     /gene_synonym="ASRT7; CGP-39; GP-39; GP39; HC-gp39;
                     hCGP-39; HCGP-3P; YK-40; YKL-40; YKL40; YYL-40"
                     /inference="alignment:Splign:2.1.0"
     exon            793..975
                     /gene="CHI3L1"
                     /gene_synonym="ASRT7; CGP-39; GP-39; GP39; HC-gp39;
                     hCGP-39; HCGP-3P; YK-40; YKL-40; YKL40; YYL-40"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1092
                     /gene="CHI3L1"
                     /gene_synonym="ASRT7; CGP-39; GP-39; GP39; HC-gp39;
                     hCGP-39; HCGP-3P; YK-40; YKL-40; YKL40; YYL-40"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1747
                     /gene="CHI3L1"
                     /gene_synonym="ASRT7; CGP-39; GP-39; GP39; HC-gp39;
                     hCGP-39; HCGP-3P; YK-40; YKL-40; YKL40; YYL-40"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1723..1728
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CHI3L1"
                     /gene_synonym="ASRT7; CGP-39; GP-39; GP39; HC-gp39;
                     hCGP-39; HCGP-3P; YK-40; YKL-40; YKL40; YYL-40"
                     /note="hexamer: AATAAA"
     polyA_site      1747
                     /gene="CHI3L1"
                     /gene_synonym="ASRT7; CGP-39; GP-39; GP39; HC-gp39;
                     hCGP-39; HCGP-3P; YK-40; YKL-40; YKL40; YYL-40"
                     /note="major polyA site"
ORIGIN      
        1 gaggccctgt ctaggtagct ggcaccagga gccgtgggca agggaagagg ccacaccctg
       61 ccctgctctg ctgcagccag aatgggtgtg aaggcgtctc aaacaggctt tgtggtcctg
      121 gtgctgctcc agtgctgctc tgcatacaaa ctggtctgct actacaccag ctggtcccag
      181 taccgggaag gcgatgggag ctgcttccca gatgcccttg accgcttcct ctgtacccac
      241 atcatctaca gctttgccaa tataagcaac gatcacatcg acacctggga gtggaatgat
      301 gtgacgctct acggcatgct caacacactc aagaacagga accccaacct gaagactctc
      361 ttgtctgtcg gaggatggaa ctttgggtct caaagatttt ccaagatagc ctccaacacc
      421 cagagtcgcc ggactttcat caagtcagta ccgccatttc tgcgcaccca tggctttgat
      481 gggctggacc ttgcctggct ctaccctgga cggagagaca aacagcattt taccacccta
      541 atcaaggaaa tgaaggccga atttataaag gaagcccagc cagggaaaaa gcagctcctg
      601 ctcagcgcag cactgtctgc ggggaaggtc accattgaca gcagctatga cattgccaag
      661 atatcccaac acctggattt cattagcatc atgacctacg attttcatgg agcctggcgt
      721 gggaccacag gccatcacag tcccctgttc cgaggtcagg aggatgcaag tcctgacaga
      781 ttcagcaaca ctgactatgc tgtggggtac atgttgaggc tgggggctcc tgccagtaag
      841 ctggtgatgg gcatccccac cttcgggagg agcttcactc tggcttcttc tgagactggt
      901 gttggagccc caatctcagg accgggaatt ccaggccggt tcaccaagga ggcagggacc
      961 cttgcctact atgagatctg tgacttcctc cgcggagcca cagtccatag aatcctcggc
     1021 cagcaggtcc cctatgccac caagggcaac cagtgggtag gatacgacga ccaggaaagc
     1081 gtcaaaagca aggtgcagta cctgaaggac aggcagctgg cgggcgccat ggtatgggcc
     1141 ctggacctgg atgacttcca gggctccttc tgtggccagg atctgcgctt ccctctcacc
     1201 aatgccatca aggatgcact cgctgcaacg tagccctctg ttctgcacac agcacggggg
     1261 ccaaggatgc cccgtccccc tctggctcca gctggccggg agcctgatca cctgccctgc
     1321 tgagtcccag gctgagcctc agtctccctc ccttggggcc tatgcagagg tccacaacac
     1381 acagatttga gctcagccct ggtgggcaga gaggtaggga tggggctgtg gggatagtga
     1441 ggcatcgcaa tgtaagactc gggattagta cacacttgtt gattaatgga aatgtttaca
     1501 gatccccaag cctggcaagg gaatttcttc aactccctgc cccccagccc tccttatcaa
     1561 aggacaccat tttggcaagc tctatcacca aggagccaaa catcctacaa gacacagtga
     1621 ccatactaat tataccccct gcaaagccca gcttgaaacc ttcacttagg aacgtaatcg
     1681 tgtcccctat cctacttccc cttcctaatt ccacagctgc tcaataaagt acaagagctt
     1741 aacagtg
//
