LOCUS       NM_001819               2462 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens chromogranin B (CHGB), mRNA.
ACCESSION   NM_001819
VERSION     NM_001819.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2462)
  AUTHORS   Jiang,Q.X. and Yadav,G.
  TITLE     The mechanisms of chromogranin B-regulated Cl- homeostasis
  JOURNAL   Biochem Soc Trans 50 (6), 1659-1672 (2022)
   PUBMED   36511243
  REMARK    GeneRIF: The mechanisms of chromogranin B-regulated Cl-
            homeostasis.
REFERENCE   2  (bases 1 to 2462)
  AUTHORS   Lyubimova,N.V., Timofeev,Y.S., Markovich,A.A., Lebedeva,A.V.,
            Karamisheva,E.I., Delektorskaya,V.V. and Kushlinskii,N.E.
  TITLE     Chromogranin B in blood serum of patients with neuroendocrine
            tumors
  JOURNAL   Klin Lab Diagn 67 (8), 440-443 (2022)
   PUBMED   36095079
  REMARK    GeneRIF: Chromogranin B in blood serum of patients with
            neuroendocrine tumors.', trans 'capital HA, Cyrillicsmall er,
            Cyrillicsmall o, Cyrillicsmall em, Cyrillicsmall o, Cyrillicsmall
            ghe, Cyrillicsmall er, Cyrillicsmall a, Cyrillicsmall en,
            Cyrillicsmall i, Cyrillicsmall en, Cyrillic capital VE, Cyrillic
            small ve, Cyrillic small es, Cyrillicsmall yeru, Cyrillicsmall ve,
            Cyrillicsmall o, Cyrillicsmall er, Cyrillicsmall o, Cyril...
REFERENCE   3  (bases 1 to 2462)
  AUTHORS   Xu,D.J., Wei,L.Y., Li,H.F. and Zhang,W.Q.
  TITLE     Serum levels of chromogranins and secretogranins correlate with the
            progress and severity of Parkinson's disease
  JOURNAL   Kaohsiung J Med Sci 35 (3), 146-150 (2019)
   PUBMED   30887724
  REMARK    GeneRIF: serum levels of CgA, CgB, and SgII were determined in
            Parkinson's disease patients and assessed their association with
            disease severity.
REFERENCE   4  (bases 1 to 2462)
  AUTHORS   Stenman,A., Svahn,F., Hojjat-Farsangi,M., Zedenius,J.,
            Soderkvist,P., Gimm,O., Larsson,C. and Juhlin,C.C.
  TITLE     Molecular Profiling of Pheochromocytoma and Abdominal Paraganglioma
            Stratified by the PASS Algorithm Reveals Chromogranin B as
            Associated With Histologic Prediction of Malignant Behavior
  JOURNAL   Am J Surg Pathol 43 (3), 409-421 (2019)
   PUBMED   30451732
  REMARK    GeneRIF: These data collectively point out CHGB as a possible
            preoperative and postoperative marker for pheochromocytomas and
            abdominal paragangliomas with potential for aggressive behavior
REFERENCE   5  (bases 1 to 2462)
  AUTHORS   Tomkins,J.E., Dihanich,S., Beilina,A., Ferrari,R., Ilacqua,N.,
            Cookson,M.R., Lewis,P.A. and Manzoni,C.
  TITLE     Comparative Protein Interaction Network Analysis Identifies Shared
            and Distinct Functions for the Human ROCO Proteins
  JOURNAL   Proteomics 18 (10), e1700444 (2018)
   PUBMED   29513927
REFERENCE   6  (bases 1 to 2462)
  AUTHORS   Erickson,J.D., Lloyd,R., Trojanowski,J.Q., Iacangelo,A. and
            Eiden,E.
  TITLE     Sites of synthesis of chromogranins A and B in the human brain
  JOURNAL   Neuropeptides 21 (4), 239-244 (1992)
   PUBMED   1518561
REFERENCE   7  (bases 1 to 2462)
  AUTHORS   Levine,M.A., Modi,W.S. and O'Brien,S.J.
  TITLE     Mapping of the gene encoding the alpha subunit of the stimulatory G
            protein of adenylyl cyclase (GNAS1) to 20q13.2----q13.3 in human by
            in situ hybridization
  JOURNAL   Genomics 11 (2), 478-479 (1991)
   PUBMED   1769666
REFERENCE   8  (bases 1 to 2462)
  AUTHORS   Gill,B.M., Barbosa,J.A., Dinh,T.Q., Garrod,S. and O'Connor,D.T.
  TITLE     Chromogranin B: isolation from pheochromocytoma, N-terminal
            sequence, tissue distribution and secretory vesicle processing
  JOURNAL   Regul Pept 33 (2), 223-235 (1991)
   PUBMED   1882087
REFERENCE   9  (bases 1 to 2462)
  AUTHORS   Benjannet,S., Leduc,R., Adrouche,N., Falgueyret,J.P.,
            Marcinkiewicz,M., Seidah,N.G., Mbikay,M., Lazure,C. and Chretien,M.
  TITLE     Chromogranin B (secretogranin I), a putative precursor of two novel
            pituitary peptides through processing at paired basic residues
  JOURNAL   FEBS Lett 224 (1), 142-148 (1987)
   PUBMED   3678488
REFERENCE   10 (bases 1 to 2462)
  AUTHORS   Benedum,U.M., Lamouroux,A., Konecki,D.S., Rosa,P., Hille,A.,
            Baeuerle,P.A., Frank,R., Lottspeich,F., Mallet,J. and Huttner,W.B.
  TITLE     The primary structure of human secretogranin I (chromogranin B):
            comparison with chromogranin A reveals homologous terminal domains
            and a large intervening variable region
  JOURNAL   EMBO J 6 (5), 1203-1211 (1987)
   PUBMED   3608978
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC312240.1, BC000375.2,
            BP422638.1 and BM681923.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001819.2.
            
            Summary: This gene encodes a tyrosine-sulfated secretory protein
            abundant in peptidergic endocrine cells and neurons. This protein
            may serve as a precursor for regulatory peptides. [provided by
            RefSeq, Jan 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.63507.1,
                                           SRR1803611.247990.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000378961.9/ ENSP00000368244.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                DC312240.1         183-202
            21-850              BC000375.2         1-830
            851-1138            BP422638.1         231-518
            1139-2241           BC000375.2         1119-2221
            2242-2462           BM681923.1         23-243              c
FEATURES             Location/Qualifiers
     source          1..2462
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p12.3"
     gene            1..2462
                     /gene="CHGB"
                     /gene_synonym="SCG1"
                     /note="chromogranin B"
                     /db_xref="GeneID:1114"
                     /db_xref="HGNC:HGNC:1930"
                     /db_xref="MIM:118920"
     exon            1..173
                     /gene="CHGB"
                     /gene_synonym="SCG1"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..2158
                     /gene="CHGB"
                     /gene_synonym="SCG1"
                     /note="secretogranin-1; secretogranin B; cgB; sgI;
                     secretogranin I"
                     /codon_start=1
                     /product="secretogranin-1 precursor"
                     /protein_id="NP_001810.2"
                     /db_xref="CCDS:CCDS13092.1"
                     /db_xref="GeneID:1114"
                     /db_xref="HGNC:HGNC:1930"
                     /db_xref="MIM:118920"
                     /translation="MQPTLLLSLLGAVGLAAVNSMPVDNRNHNEGMVTRCIIEVLSNA
                     LSKSSAPPITPECRQVLKTSRKDVKDKETTENENTKFEVRLLRDPADASEAHESSSRG
                     EAGAPGEEDIQGPTKADTEKWAEGGGHSRERADEPQWSLYPSDSQVSEEVKTRHSEKS
                     QREDEEEEEGENYQKGERGEDSSEEKHLEEPGETQNAFLNERKQASAIKKEELVARSE
                     THAAGHSQEKTHSREKSSQESGEETGSQENHPQESKGQPRSQEESEEGEEDATSEVDK
                     RRTRPRHHHGRSRPDRSSQGGSLPSEEKGHPQEESEESNVSMASLGEKRDHHSTHYRA
                     SEEEPEYGEEIKGYPGVQAPEDLEWERYRGRGSEEYRAPRPQSEESWDEEDKRNYPSL
                     ELDKMAHGYGEESEEERGLEPGKGRHHRGRGGEPRAYFMSDTREEKRFLGEGHHRVQE
                     NQMDKARRHPQGAWKELDRNYLNYGEEGAPGKWQQQGDLQDTKENREEARFQDKQYSS
                     HHTAEKRKRLGELFNPYYDPLQWKSSHFERRDNMNDNFLEGEEENELTLNEKNFFPEY
                     NYDWWEKKPFSEDVNWGYEKRNLARVPKLDLKRQYDRVAQLDQLLHYRKKSAEFPDFY
                     DSEEPVSTHQEAENEKDRADQTVLTEDEKKELENLAAMDLELQKIAEKFSQRG"
     exon            174..220
                     /gene="CHGB"
                     /gene_synonym="SCG1"
                     /inference="alignment:Splign:2.1.0"
     exon            221..314
                     /gene="CHGB"
                     /gene_synonym="SCG1"
                     /inference="alignment:Splign:2.1.0"
     exon            315..2080
                     /gene="CHGB"
                     /gene_synonym="SCG1"
                     /inference="alignment:Splign:2.1.0"
     exon            2081..2462
                     /gene="CHGB"
                     /gene_synonym="SCG1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acaccgcggg gaccaggagg cacgctggtt ttccggggcc gctccatcgc gccttcctcc
       61 tgcgcctcgc ttctccggtc cagccgccat cttcctttcc gcacaggggc cgccgagcgg
      121 ggccatgcag ccaacgctgc ttctcagcct cctgggagcc gtggggctgg cggctgtcaa
      181 ttccatgcca gtggataaca ggaaccacaa tgaaggaatg gtgactcgct gcatcattga
      241 ggtcctctca aatgccttgt cgaagtccag cgctccaccc atcacccctg agtgccgcca
      301 agtcctgaag acgagtagaa aagacgtcaa agacaaagag acaactgaaa atgaaaacac
      361 aaagtttgaa gtaagattgt taagagaccc agctgatgcc tcggaagccc acgagtcctc
      421 cagcagggga gaggcaggag ccccagggga ggaggacatc caaggcccaa caaaggcaga
      481 cacagagaaa tgggcagagg gaggcgggca cagccgagag cgagcggatg agccccagtg
      541 gagcctctat ccctccgaca gccaagtctc tgaagaagtg aagacacgcc attctgagaa
      601 gagccagaga gaggatgagg aggaggagga gggagagaac tatcaaaaag gggagcgagg
      661 ggaagatagc agtgaagaga aacaccttga agagccagga gagacacaaa acgcttttct
      721 caatgaaaga aagcaggctt cagctataaa aaaagaggag ttagtggcca gatcggaaac
      781 acatgctgcc gggcattctc aggagaagac acatagccga gagaagagta gccaggagag
      841 tggagaggag acagggagcc aggagaatca cccccaggag tctaaaggcc aaccccgaag
      901 ccaggaagaa tctgaggaag gtgaggaaga tgccacctct gaggtggaca aacgacgcac
      961 gaggcccaga caccaccacg ggaggagcag gcccgacagg tcctctcaag gagggagtct
     1021 tccctctgag gaaaagggac acccccagga ggaatctgag gagtcaaacg tcagcatggc
     1081 cagtttaggg gaaaagaggg accaccattc aacccactac agggcttcag aggaagaacc
     1141 tgaatatgga gaagaaataa agggttatcc aggcgtccag gcccctgagg acctggagtg
     1201 ggagcgctat aggggcagag gaagtgaaga atacagggct ccaagacctc agagtgagga
     1261 gagttgggat gaggaggaca agagaaacta ccccagctta gagcttgata agatggcaca
     1321 tggatatggt gaagaaagtg aggaagagag gggccttgag ccgggaaagg gacgccatca
     1381 cagaggcagg ggaggggagc cacgtgccta tttcatgtct gacaccagag aagagaaaag
     1441 gttcttgggt gaaggacacc accgtgtcca agaaaaccag atggacaagg caaggaggca
     1501 tccacaaggt gcgtggaaag agctggacag aaattatctc aactacggtg aggaaggagc
     1561 cccagggaag tggcagcagc agggagacct gcaggacact aaagaaaaca gggaggaagc
     1621 taggtttcaa gataaacaat atagctccca tcacacagct gaaaagagga agagattagg
     1681 ggaactgttc aacccatact acgaccctct ccagtggaag agcagccatt ttgaaagaag
     1741 agacaacatg aatgacaatt ttctcgaggg tgaggaggaa aatgagctga ccttgaacga
     1801 gaagaatttc ttcccagaat acaactatga ctggtgggag aaaaagccct tctctgagga
     1861 tgtgaactgg gggtatgaga agagaaacct cgccagggtc cccaagctgg acctgaaaag
     1921 gcaatatgac agggtggccc aactggacca gctccttcac tacaggaaga agtcagctga
     1981 gtttccagac ttctatgatt ctgaggagcc ggtgagcacc caccaggagg cagaaaatga
     2041 aaaggacagg gctgaccaga cagtcctgac agaggacgag aaaaaagaac tcgaaaactt
     2101 ggctgcaatg gatttggaac tacagaagat agctgagaaa ttcagccaaa ggggctgact
     2161 gtcattggag cggtgggcac tgttaagaag cagccatcac atgatctgtt tttcaccact
     2221 tcactgaaag acaccattta tctacccaag ggcagaaagt agaacttact attcattaaa
     2281 tgtttgacac aattggaatt gtctttaatt tctgtcagaa tgctattgaa aatgtgaatt
     2341 gcatgacttg tagcatattc ttttctgcaa aatagacata ttaacatgct tatgacaatg
     2401 actgtgctac tgtctttgga aaaatgtttg tctcagttgg aaataataaa agattcacct
     2461 ga
//
