LOCUS       NM_001275               1985 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens chromogranin A (CHGA), transcript variant 1, mRNA.
ACCESSION   NM_001275
VERSION     NM_001275.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1985)
  AUTHORS   Pamies,A., Llop,D., Ibarretxe,D., Rosales,R., Girona,J., Masana,L.,
            Vallve,J.C. and Paredes,S.
  TITLE     Enhanced Association of Novel Cardiovascular Biomarkers Fetuin-A
            and Catestatin with Serological and Inflammatory Markers in
            Rheumatoid Arthritis Patients
  JOURNAL   Int J Mol Sci 25 (18), 9910 (2024)
   PUBMED   39337398
  REMARK    GeneRIF: Enhanced Association of Novel Cardiovascular Biomarkers
            Fetuin-A and Catestatin with Serological and Inflammatory Markers
            in Rheumatoid Arthritis Patients.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1985)
  AUTHORS   Bralewska,M., Pietrucha,T. and Sakowicz,A.
  TITLE     The Role of Catestatin in Preeclampsia
  JOURNAL   Int J Mol Sci 25 (5), 2461 (2024)
   PUBMED   38473713
  REMARK    GeneRIF: The Role of Catestatin in Preeclampsia.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1985)
  AUTHORS   Zalewska,E., Kmiec,P., Sobolewski,J., Koprowski,A. and Sworczak,K.
  TITLE     Low catestatin as a risk factor for cardiovascular disease -
            assessment in patients with adrenal incidentalomas
  JOURNAL   Front Endocrinol (Lausanne) 14, 1198911 (2023)
   PUBMED   37522122
  REMARK    GeneRIF: Low catestatin as a risk factor for cardiovascular disease
            - assessment in patients with adrenal incidentalomas.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1985)
  AUTHORS   Lee,Y.H., Suk,C., Shin,S.I. and Hong,J.Y.
  TITLE     Salivary cortisol, dehydroepiandrosterone, and chromogranin A
            levels in patients with gingivitis and periodontitis and a novel
            biomarker for psychological stress
  JOURNAL   Front Endocrinol (Lausanne) 14, 1147739 (2023)
   PUBMED   37113482
  REMARK    GeneRIF: Salivary cortisol, dehydroepiandrosterone, and
            chromogranin A levels in patients with gingivitis and periodontitis
            and a novel biomarker for psychological stress.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1985)
  AUTHORS   Mahata,S.K., Mahata,M., Fung,M.M. and O'Connor,D.T.
  TITLE     Reprint of: Catestatin: a multifunctional peptide from chromogranin
            A
  JOURNAL   Regul Pept 165 (1), 52-62 (2010)
   PUBMED   20965217
  REMARK    GeneRIF: Catestatin is an antimicrobial peptide with activity
            against bacteria, fungi, and malaria.
REFERENCE   6  (bases 1 to 1985)
  AUTHORS   Lugardon,K., Chasserot-Golaz,S., Kieffer,A.E., Maget-Dana,R.,
            Nullans,G., Kieffer,B., Aunis,D. and Metz-Boutigue,M.H.
  TITLE     Structural and biological characterization of chromofungin, the
            antifungal chromogranin A (47-66)-derived peptide
  JOURNAL   Ann N Y Acad Sci 971, 359-361 (2002)
   PUBMED   12438152
  REMARK    GeneRIF: Chromofungin is an antimicrobial peptide with antifungal
            activity.
REFERENCE   7  (bases 1 to 1985)
  AUTHORS   Curry,W.J., Shaw,C., Johnston,C.F., Thim,L. and Buchanan,K.D.
  TITLE     Isolation and primary structure of a novel chromogranin A-derived
            peptide, WE-14, from a human midgut carcinoid tumour
  JOURNAL   FEBS Lett 301 (3), 319-321 (1992)
   PUBMED   1577173
REFERENCE   8  (bases 1 to 1985)
  AUTHORS   Tamamura,H., Ohta,M., Yoshizawa,K., Ono,Y., Funakoshi,A.,
            Miyasaka,K., Tateishi,K., Jimi,A., Yajima,H., Fujii,N. et al.
  TITLE     Isolation and characterization of a tumor-derived human protein
            related to chromogranin A and its in vitro conversion to human
            pancreastatin-48
  JOURNAL   Eur J Biochem 191 (1), 33-39 (1990)
   PUBMED   2165909
REFERENCE   9  (bases 1 to 1985)
  AUTHORS   Sekiya,K., Ghatei,M.A., Minamino,N., Bretherton-Watt,D., Matsuo,H.
            and Bloom,S.R.
  TITLE     Isolation of human pancreastatin fragment containing the active
            sequence from a glucagonoma
  JOURNAL   FEBS Lett 228 (1), 153-156 (1988)
   PUBMED   2830133
  REMARK    Erratum:[FEBS Lett 1988 Apr 25;231(2):451]
REFERENCE   10 (bases 1 to 1985)
  AUTHORS   Konecki,D.S., Benedum,U.M., Gerdes,H.H. and Huttner,W.B.
  TITLE     The primary structure of human chromogranin A and pancreastatin
  JOURNAL   J Biol Chem 262 (35), 17026-17030 (1987)
   PUBMED   2445752
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA201149.1, BC001059.2,
            BX248263.1 and BC009384.2.
            
            On Nov 23, 2018 this sequence version replaced NM_001275.3.
            
            Summary: The protein encoded by this gene is a member of the
            chromogranin/secretogranin family of neuroendocrine secretory
            proteins. It is found in secretory vesicles of neurons and
            endocrine cells. This gene product is a precursor to three
            biologically active peptides; vasostatin, pancreastatin, and
            parastatin. These peptides act as autocrine or paracrine negative
            modulators of the neuroendocrine system. Two other peptides,
            catestatin and chromofungin, have antimicrobial activity and
            antifungal activity, respectively. Two transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Sep 2014].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC001059.2, SRR3476690.1076539.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000216492.10/
                                                  ENSP00000216492.5
            Protein has antimicrobial activity :: PMID: 12438152, 20965217
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-150               DA201149.1         51-200
            151-1532            BC001059.2         1-1382
            1533-1953           BX248263.1         1054-1474
            1954-1985           BC009384.2         1585-1616
FEATURES             Location/Qualifiers
     source          1..1985
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.12"
     gene            1..1985
                     /gene="CHGA"
                     /gene_synonym="CGA; PHE5; PHES"
                     /note="chromogranin A"
                     /db_xref="GeneID:1113"
                     /db_xref="HGNC:HGNC:1929"
                     /db_xref="MIM:118910"
     exon            1..256
                     /gene="CHGA"
                     /gene_synonym="CGA; PHE5; PHES"
                     /inference="alignment:Splign:2.1.0"
     CDS             211..1584
                     /gene="CHGA"
                     /gene_synonym="CGA; PHE5; PHES"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; parathyroid secretory protein 1; betagranin
                     (N-terminal fragment of chromogranin A); SP-I; pituitary
                     secretory protein I; chromofungin; catestatin"
                     /codon_start=1
                     /product="chromogranin-A isoform 1 preproprotein"
                     /protein_id="NP_001266.1"
                     /db_xref="CCDS:CCDS9906.1"
                     /db_xref="GeneID:1113"
                     /db_xref="HGNC:HGNC:1929"
                     /db_xref="MIM:118910"
                     /translation="MRSAAVLALLLCAGQVTALPVNSPMNKGDTEVMKCIVEVISDTL
                     SKPSPMPVSQECFETLRGDERILSILRHQNLLKELQDLALQGAKERAHQQKKHSGFED
                     ELSEVLENQSSQAELKEAVEEPSSKDVMEKREDSKEAEKSGEATDGARPQALPEPMQE
                     SKAEGNNQAPGEEEEEEEEATNTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREKGLS
                     AEPGWQAKREEEEEEEEEAEAGEEAVPEEEGPTVVLNPHPSLGYKEIRKGESRSEALA
                     VDGAGKPGAEEAQDPEGKGEQEHSQQKEEEEEMAVVPQGLFRGGKSGELEQEEERLSK
                     EWEDSKRWSKMDQLAKELTAEKRLEGQEEEEDNRDSSMKLSFRARAYGFRGPGPQLRR
                     GWRPSSREDSLEAGLPLQVRGYPEEKKEEEGSANRRPEDQELESLSAIEAELEKVAHQ
                     LQALRRG"
     exon            257..303
                     /gene="CHGA"
                     /gene_synonym="CGA; PHE5; PHES"
                     /inference="alignment:Splign:2.1.0"
     exon            304..397
                     /gene="CHGA"
                     /gene_synonym="CGA; PHE5; PHES"
                     /inference="alignment:Splign:2.1.0"
     exon            398..466
                     /gene="CHGA"
                     /gene_synonym="CGA; PHE5; PHES"
                     /inference="alignment:Splign:2.1.0"
     exon            467..565
                     /gene="CHGA"
                     /gene_synonym="CGA; PHE5; PHES"
                     /inference="alignment:Splign:2.1.0"
     exon            566..1018
                     /gene="CHGA"
                     /gene_synonym="CGA; PHE5; PHES"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1500
                     /gene="CHGA"
                     /gene_synonym="CGA; PHE5; PHES"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..1985
                     /gene="CHGA"
                     /gene_synonym="CGA; PHE5; PHES"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccaccgctc ctgccactgc agtgctcgag ccccgtgcag gggagcttgc gggaggatcg
       61 accgacagac ggacgcacgc cgaggcactg cgcccccagc cccgcgccgg tgccaccgca
      121 gcccgacccc ggccgccagt ccagccgccc ctcgcccggt gcctaggtgc ccggccccac
      181 accgccagct gctcggcgcc cgggtccgcc atgcgctccg ccgctgtcct ggctcttctg
      241 ctctgcgccg ggcaagtcac tgcgctccct gtgaacagcc ctatgaataa aggggatacc
      301 gaggtgatga aatgcatcgt tgaggtcatc tccgacacac tttccaagcc cagccccatg
      361 cctgtcagcc aggaatgttt tgagacactc cgaggagatg aacggatcct ttccattctg
      421 agacatcaga atttactgaa ggagctccaa gacctcgctc tccaaggcgc caaggagagg
      481 gcacatcagc agaagaaaca cagcggtttt gaagatgaac tctcagaggt tcttgagaac
      541 cagagcagcc aggccgagct gaaagaggcg gtggaagagc catcatccaa ggatgttatg
      601 gagaaaagag aggattccaa ggaggcagag aaaagtggtg aagccacaga cggagccagg
      661 ccccaggccc tcccggagcc catgcaggag tccaaggctg aggggaacaa tcaggcccct
      721 ggggaggaag aggaggagga ggaggaggcc accaacaccc accctccagc cagcctcccc
      781 agccagaaat acccaggccc acaggccgag ggggacagtg agggcctctc tcagggtctg
      841 gtggacagag agaagggcct gagtgcagag ccagggtggc aggcaaagag agaagaggag
      901 gaggaggagg aggaggaggc tgaggctgga gaggaggctg tccccgagga agaaggcccc
      961 actgtagtgc tgaaccccca cccgagcctt ggctacaagg agatccggaa aggcgagagt
     1021 cggtcggagg ctctggctgt ggatggagct gggaagcctg gggctgagga ggctcaggac
     1081 cccgaaggga agggagaaca ggagcactcc cagcagaaag aggaggagga ggagatggca
     1141 gtggtcccgc aaggcctctt ccggggtggg aagagcggag agctggagca ggaggaggag
     1201 cggctctcca aggagtggga ggactccaaa cgctggagca agatggacca gctggccaag
     1261 gagctgacgg ctgagaagcg gctggagggg caggaggagg aggaggacaa ccgggacagt
     1321 tccatgaagc tctccttccg ggcccgggcc tacggcttca ggggccctgg gccgcagctg
     1381 cgacgaggct ggaggccatc ctcccgggag gacagccttg aggcgggcct gcccctccag
     1441 gtccgaggct accccgagga gaagaaagag gaggagggca gcgcaaaccg cagaccagag
     1501 gaccaggagc tggagagcct gtcggccatt gaagcagagc tggagaaagt ggcccaccag
     1561 ctgcaggcac tacggcgggg ctgagacacc ggctggcagg gctggcccca gggcaccctg
     1621 tggccctggc tctgctgtcc ccttggcagg tcctggccag atggcccgga tgctgcttcc
     1681 ggtagggagg cagcctccag cctgcccaag cccaggccac cctatcgccc cctacgcgcc
     1741 ttgtctccta ctcctgactc ctacctgccc tggaacatcc tttgcagggc agccccacaa
     1801 ctttaaacat tgacgattcc ttctctgaac acaggcagct ttctagaagt ttcccttcct
     1861 ccatcctatc cactgggcac aactgcaata acttctgacc ttttggtgaa agctgagaac
     1921 tcctgactgt aacatattct gtatgaactt tatctaaaga aaaataaatc tgttctgggc
     1981 tcttt
//
