LOCUS       NM_006387               4075 bp    mRNA    linear   PRI 04-MAR-2025
DEFINITION  Homo sapiens calcium homeostasis endoplasmic reticulum protein
            (CHERP), transcript variant 2, mRNA.
ACCESSION   NM_006387
VERSION     NM_006387.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4075)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4075)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 4075)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 4075)
  AUTHORS   Wang,Q., Wang,Y., Liu,Y., Zhang,C., Luo,Y., Guo,R., Zhan,Z.,
            Wei,N., Xie,Z., Shen,L., Wu,G., Wu,W. and Feng,Y.
  TITLE     U2-related proteins CHERP and SR140 contribute to colorectal
            tumorigenesis via alternative splicing regulation
  JOURNAL   Int J Cancer 145 (10), 2728-2739 (2019)
   PUBMED   30977118
  REMARK    GeneRIF: Study observed that CHERP and its binding partner SR140
            are significantly upregulated in human clinical colorectal cancer
            tissues (CRC) and clarified how CHERP/SR140 exert an oncogenic role
            in CRC development partially through regulating expression of UPF3A
            variants.
REFERENCE   5  (bases 1 to 4075)
  AUTHORS   Fasci,D., van Ingen,H., Scheltema,R.A. and Heck,A.J.R.
  TITLE     Histone Interaction Landscapes Visualized by Crosslinking Mass
            Spectrometry in Intact Cell Nuclei
  JOURNAL   Mol Cell Proteomics 17 (10), 2018-2033 (2018)
   PUBMED   30021884
REFERENCE   6  (bases 1 to 4075)
  AUTHORS   Ryan,T., Sharma,P., Ignatchenko,A., MacLennan,D.H., Kislinger,T.
            and Gramolini,A.O.
  TITLE     Identification of novel ryanodine receptor 1 (RyR1) protein
            interaction with calcium homeostasis endoplasmic reticulum protein
            (CHERP)
  JOURNAL   J Biol Chem 286 (19), 17060-17068 (2011)
   PUBMED   21454501
  REMARK    GeneRIF: CHERP is an RyR1 interacting protein that may be involved
            in the regulation of excitation-contraction coupling
REFERENCE   7  (bases 1 to 4075)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   8  (bases 1 to 4075)
  AUTHORS   O'Rourke,F.A., LaPlante,J.M. and Feinstein,M.B.
  TITLE     Antisense-mediated loss of calcium homoeostasis endoplasmic
            reticulum protein (CHERP; ERPROT213-21) impairs Ca2+ mobilization,
            nuclear factor of activated T-cells (NFAT) activation and cell
            proliferation in Jurkat T-lymphocytes
  JOURNAL   Biochem J 373 (Pt 1), 133-143 (2003)
   PUBMED   12656674
REFERENCE   9  (bases 1 to 4075)
  AUTHORS   Laplante,J.M., O'Rourke,F., Lu,X., Fein,A., Olsen,A. and
            Feinstein,M.B.
  TITLE     Cloning of human Ca2+ homoeostasis endoplasmic reticulum protein
            (CHERP): regulated expression of antisense cDNA depletes CHERP,
            inhibits intracellular Ca2+ mobilization and decreases cell
            proliferation
  JOURNAL   Biochem J 348 Pt 1 (Pt 1), 189-199 (2000)
   PUBMED   10794731
REFERENCE   10 (bases 1 to 4075)
  AUTHORS   Imbert,G., Saudou,F., Yvert,G., Devys,D., Trottier,Y.,
            Garnier,J.M., Weber,C., Mandel,J.L., Cancel,G., Abbas,N., Durr,A.,
            Didierjean,O., Stevanin,G., Agid,Y. and Brice,A.
  TITLE     Cloning of the gene for spinocerebellar ataxia 2 reveals a locus
            with high sensitivity to expanded CAG/glutamine repeats
  JOURNAL   Nat Genet 14 (3), 285-291 (1996)
   PUBMED   8896557
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC021294.2, U94836.2 and AA782418.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006387.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021294.2, AF536542.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000546361.7/ ENSP00000439856.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1951              BC021294.2         1-1951
            1952-4073           U94836.2           1869-3990
            4074-4075           AA782418.1         16-17               c
FEATURES             Location/Qualifiers
     source          1..4075
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..4075
                     /gene="CHERP"
                     /gene_synonym="DAN16; SCAF6; SRA1"
                     /note="calcium homeostasis endoplasmic reticulum protein"
                     /db_xref="GeneID:10523"
                     /db_xref="HGNC:HGNC:16930"
                     /db_xref="MIM:618539"
     exon            1..84
                     /gene="CHERP"
                     /gene_synonym="DAN16; SCAF6; SRA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..2810
                     /gene="CHERP"
                     /gene_synonym="DAN16; SCAF6; SRA1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     ERPROT213-21; protein with polyglutamine repeat;
                     SR-related CTD associated factor 6; ERPROT 213-21"
                     /codon_start=1
                     /product="calcium homeostasis endoplasmic reticulum
                     protein isoform 2"
                     /protein_id="NP_006378.3"
                     /db_xref="CCDS:CCDS42518.1"
                     /db_xref="GeneID:10523"
                     /db_xref="HGNC:HGNC:16930"
                     /db_xref="MIM:618539"
                     /translation="MEMPLPPDDQELRNVIDKLAQFVARNGPEFEKMTMEKQKDNPKF
                     SFLFGGEFYSYYKCKLALEQQQLICKQQTPELEPAATMPPLPQPPLAPAAPIPPAQGA
                     PSMDELIQQSQWNLQQQEQHLLALRQEQVTAAVAHAVEQQMQKLLEETQLDMNEFDNL
                     LQPIIDTCTKDAISAGKNWMFSNAKSPPHCELMAGHLRNRITADGAHFELRLHLIYLI
                     NDVLHHCQRKQARELLAALQKVVVPIYCTSFLAVEEDKQQKIARLLQLWEKNGYFDDS
                     IIQQLQSPALGLGQYQATLINEYSSVVQPVQLAFQQQIQTLKTQHEEFVTSLAQQQQQ
                     QQQQQQQLQMPQMEAEVKATPPPPAPPPAPAPAPAIPPTTQPDDSKPPIQMPGSSEYE
                     APGGVQDPAAAGPRGPGPHDQIPPNKPPWFDQPHPVAPWGQQQPPEQPPYPHHQGGPP
                     HCPPWNNSHEGMWGEQRGDPGWNGQRDAPWNNQPDAAWNSQFEGPWNSQHEQPPWGGG
                     QREPPFRMQRPPHFRGPFPPHQQHPQFNQPPHPHNFNRFPPRFMQDDFPPRHPFERPP
                     YPHRFDYPQGDFPAEMGPPHHHPGHRMPHPGINEHPPWAGPQHPDFGPPPHGFNGQPP
                     HMRRQGPPHINHDDPSLVPNVPYFDLPAGLMAPLVKLEDHEYKPLDPKDIRLPPPMPP
                     SERLLAAVEAFYSPPSHDRPRNSEGWEQNGLYEFFRAKMRARRRKGQEKRNSGPSRSR
                     SRSKSRGRSSSRSNSRSSKSSGSYSRSRSRSCSRSYSRSRSRSRSRSRSSRSRSRSQS
                     RSRSKSYSPGRRRRSRSRSPTPPSSAGLGSNSAPPIPDSRLGEENKGHQMLVKMGWSG
                     SGGLGAKEQGIQDPIKGGDVRDKWDQYKGVGVALDDPYENYRRNKSYSFIARMKARDE
                     CK"
     exon            85..258
                     /gene="CHERP"
                     /gene_synonym="DAN16; SCAF6; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            259..443
                     /gene="CHERP"
                     /gene_synonym="DAN16; SCAF6; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            444..581
                     /gene="CHERP"
                     /gene_synonym="DAN16; SCAF6; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            582..733
                     /gene="CHERP"
                     /gene_synonym="DAN16; SCAF6; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            734..845
                     /gene="CHERP"
                     /gene_synonym="DAN16; SCAF6; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            846..935
                     /gene="CHERP"
                     /gene_synonym="DAN16; SCAF6; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1188
                     /gene="CHERP"
                     /gene_synonym="DAN16; SCAF6; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1364
                     /gene="CHERP"
                     /gene_synonym="DAN16; SCAF6; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1800
                     /gene="CHERP"
                     /gene_synonym="DAN16; SCAF6; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1801..2039
                     /gene="CHERP"
                     /gene_synonym="DAN16; SCAF6; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2040..2173
                     /gene="CHERP"
                     /gene_synonym="DAN16; SCAF6; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2174..2260
                     /gene="CHERP"
                     /gene_synonym="DAN16; SCAF6; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2261..2404
                     /gene="CHERP"
                     /gene_synonym="DAN16; SCAF6; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2405..2521
                     /gene="CHERP"
                     /gene_synonym="DAN16; SCAF6; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2522..2616
                     /gene="CHERP"
                     /gene_synonym="DAN16; SCAF6; SRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2617..4075
                     /gene="CHERP"
                     /gene_synonym="DAN16; SCAF6; SRA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4055..4060
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CHERP"
                     /gene_synonym="DAN16; SCAF6; SRA1"
                     /note="hexamer: AATAAA"
     polyA_site      4075
                     /gene="CHERP"
                     /gene_synonym="DAN16; SCAF6; SRA1"
                     /note="major polyA site"
ORIGIN      
        1 gcagacggcg ctggtggtcg atcgtgtggc gccggaggac gttccccgcg gccggagcca
       61 tggagatgcc gctgcccccc gatgaccagg agcttcgaaa tgtcatcgac aagctcgccc
      121 agttcgtggc tcgcaatggg cccgagtttg agaagatgac tatggagaag cagaaggaca
      181 accccaaatt ctcgtttctt ttcggaggcg aattctacag ttactacaag tgcaagctgg
      241 cgctggagca gcagcagctc atctgcaagc agcagacccc ggagctggag ccagccgcca
      301 ccatgccacc cctgccacag cccccgctgg cccccgccgc gcccatcccg ccggcccagg
      361 gcgcgccatc catggacgag ctcatccagc agagccagtg gaacctccag cagcaggagc
      421 agcacttgct ggcgctcaga caggagcaag tgacagcggc cgtggcccac gcggtggagc
      481 agcagatgca gaagcttctg gaggagaccc agctagacat gaacgagttt gacaacctcc
      541 tgcagcccat catcgacacg tgcaccaagg acgccatctc ggccgggaag aactggatgt
      601 tcagcaatgc caagtccccg ccgcactgtg agctgatggc cggccacctc cggaaccgca
      661 tcacggctga tggggcacac ttcgagctgc ggctgcacct catctacctg atcaatgacg
      721 tgctgcacca ctgccagcgc aagcaggccc gggagctgct ggccgccctg cagaaggtcg
      781 tggtgcccat ctactgcacc agcttcttgg ccgtggagga agacaagcag cagaagatcg
      841 cccggctcct gcagctctgg gagaaaaacg gctacttcga tgactccatc attcagcagc
      901 tacagagccc agccctgggg cttggtcagt accaggccac cctcatcaac gagtactcct
      961 cagtggtcca gccggtgcag ctggccttcc agcagcagat ccagaccctc aagacgcagc
     1021 acgaggagtt tgtcaccagc ctggcccagc agcagcagca gcagcaacag cagcagcagc
     1081 agctccagat gccgcagatg gaggctgaag tcaaggccac gcctccaccg cctgctccac
     1141 ccccggcccc agcacctgcc cctgccatcc cgcccaccac ccagcctgat gacagcaagc
     1201 ctcccatcca gatgcctggc tcttcagagt acgaagctcc aggaggggtc caggatcctg
     1261 cagctgccgg cccccggggc cccgggccac acgaccagat cccaccaaac aagccccctt
     1321 ggtttgacca gcctcacccc gtggctcctt ggggccagca gcagccgcca gagcagccac
     1381 cctacccgca ccaccagggc ggcccacccc actgcccccc ctggaacaac agccatgagg
     1441 gcatgtgggg cgagcagcgc ggtgaccccg gctggaacgg ccagcgcgac gcgccctgga
     1501 acaaccagcc cgacgccgcc tggaacagcc agttcgaggg cccctggaac agccagcacg
     1561 agcagccgcc ctggggcggg ggccagcgcg agccaccctt ccgcatgcag cggcccccac
     1621 acttccgggg gcccttcccg ccccaccagc agcacccgca gttcaaccag cctccgcacc
     1681 cccacaactt caaccgcttc ccgccccgct tcatgcagga cgacttcccg ccacggcacc
     1741 ccttcgagcg gccgccctat ccccaccgct tcgactaccc ccagggggac ttccctgccg
     1801 aaatggggcc ccctcaccac caccctggcc accgcatgcc tcatcctggc atcaacgagc
     1861 acccgccttg ggctggaccc cagcaccctg acttcggccc tcccccccat ggcttcaacg
     1921 ggcagccccc acacatgcgg cgacagggcc caccccacat caaccacgat gaccccagcc
     1981 tggtccccaa tgtgccctac ttcgatctcc ctgctgggct gatggccccc ctcgtgaagc
     2041 tggaagatca cgagtacaag cctttggacc ctaaagacat ccgcctccca ccccccatgc
     2101 cgcccagcga gaggctgctg gctgcagtgg aggccttcta cagccccccg tcccacgaca
     2161 ggcccaggaa cagtgaaggc tgggagcaga acggcctcta tgagttcttc cgagcaaaaa
     2221 tgcgggcccg gcggaggaaa ggccaggaga agaggaacag cggaccctcg aggtctcgga
     2281 gcagatccaa gagtcgaggg cgttcttcct cccgctccaa ctcaagatcc tccaagtctt
     2341 caggctcgta ctcaaggtca aggtcgcgct cctgctcccg ttcctactcc cgctccagat
     2401 ctagaagtcg gagcaggtcg cgctcctcca gaagccgctc ccggtcccag tcgcggtccc
     2461 ggtccaagtc gtactcccca ggaagaagac gccggtcacg gtccaggagc cccaccccgc
     2521 cttcctctgc tggtctgggt tctaattcgg cgcctcccat ccctgactca aggctcggag
     2581 aagagaacaa aggccatcag atgctggtga agatgggctg gagcggctca ggcggcctcg
     2641 gtgcgaagga gcaagggatc caggacccca tcaagggcgg ggacgtccgg gataagtggg
     2701 accagtataa aggcgtgggc gtggctctgg atgaccccta tgagaactac cgcaggaaca
     2761 agagctactc cttcatcgcc cgcatgaagg ccagggacga gtgtaagtag gcgcccatgc
     2821 cgggagccgc gccggtggcc agcggtgccg gctgtgggac cttcctggct gactggcaga
     2881 ggaagattgc agtgacagct cagttcttac accgtctcca cttgtggaga gccacaggaa
     2941 gagaaggaag accagcgcat gcccagtggg aacgccgtgc tccatggcgt ggagggcacg
     3001 ggtgccaccc acaaaccaca ccaggaggcg ctgcagccac cagggcccca ggctcgtttt
     3061 cctttatagc gaagcaaaaa acacaagacc ctccgcccga gtaaattctt cagccacgaa
     3121 gggatggatg tgcatctgcc ctaagtcaga ttgaagcctc ctcctaggct ccaggaggag
     3181 catgtgcagg aagggttggc ctgagccaga gccggcaccc cagctccttc ctccagctcc
     3241 ccgcacccac cggccctgac ctggcttccc ctcggctgtg tagggacaaa gccgaagccc
     3301 agtgccatga ctgcccgcgg attgaaaaac agaaacacaa aactttgact tgacttgcga
     3361 agtgaagcag ggttttcatt tttactctcc ttggtttagg tctagaaaga agaatactga
     3421 cctgagagga ggcccagtga gattctgaaa cctaattctt cgaaggcgta ctggccctta
     3481 gttcagttat tttagttgta taagttgata ttttttttct ggaatgtagc catttgctgt
     3541 tatctgggaa acaagattct aacaggaaac cagcctaaga cacttcaggt tgagcgctgc
     3601 ctcggagtct gtgcccgtcg cgtcccctgc ttgagttttg cacttggaag aaccctgcac
     3661 cggctggcgt gtgcgacggc ccagtcccat ccagagcatg gagcccgacc ccagccagcg
     3721 ccttccactc catcatttca tttcacaccc ccgaagggag gggaggccag gaggggagct
     3781 gctcctgcca gaagctggtg ggtgaccgtt gggaatcggc cacacctggt gtccatgggc
     3841 agcctggtgc aattccattc atttgtacag aaacattttt gaaaaattct tttcaataag
     3901 atgcaaaatc ttccaacttt tcaacccaac gtgatgaata tttgattttg ttctagattt
     3961 cctgtagctg tgaattgtta aaatgtatga ttcaggataa aacgtaaaca cgtgctgtta
     4021 gtaatttctt gtggatttca ttgttttgcc ttcaaataaa gccttttttt aaaga
//
