LOCUS       NM_032221              10719 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens chromodomain helicase DNA binding protein 6 (CHD6),
            mRNA.
ACCESSION   NM_032221
VERSION     NM_032221.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10719)
  AUTHORS   Zhao,D., Zhang,M., Huang,S., Liu,Q., Zhu,S., Li,Y., Jiang,W.,
            Kiss,D.L., Cao,Q., Zhang,L. and Chen,K.
  TITLE     CHD6 promotes broad nucleosome eviction for transcriptional
            activation in prostate cancer cells
  JOURNAL   Nucleic Acids Res 50 (21), 12186-12201 (2022)
   PUBMED   36408932
  REMARK    GeneRIF: CHD6 promotes broad nucleosome eviction for
            transcriptional activation in prostate cancer cells.
            Erratum:[Nucleic Acids Res. 2023 Mar 21;51(5):2498. doi:
            10.1093/nar/gkad114.. PMID: 36794715]
REFERENCE   2  (bases 1 to 10719)
  AUTHORS   Kargapolova,Y., Rehimi,R., Kayserili,H., Bruhl,J., Sofiadis,K.,
            Zirkel,A., Palikyras,S., Mizi,A., Li,Y., Yigit,G., Hoischen,A.,
            Frank,S., Russ,N., Trautwein,J., van Bon,B., Gilissen,C.,
            Laugsch,M., Gusmao,E.G., Josipovic,N., Altmuller,J., Nurnberg,P.,
            Langst,G., Kaiser,F.J., Watrin,E., Brunner,H., Rada-Iglesias,A.,
            Kurian,L., Wollnik,B., Bouazoune,K. and Papantonis,A.
  TITLE     Overarching control of autophagy and DNA damage response by CHD6
            revealed by modeling a rare human pathology
  JOURNAL   Nat Commun 12 (1), 3014 (2021)
   PUBMED   34021162
  REMARK    GeneRIF: Overarching control of autophagy and DNA damage response
            by CHD6 revealed by modeling a rare human pathology.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 10719)
  AUTHORS   Moore,S., Berger,N.D., Luijsterburg,M.S., Piett,C.G.,
            Stanley,F.K.T., Schrader,C.U., Fang,S., Chan,J.A., Schriemer,D.C.,
            Nagel,Z.D., van Attikum,H. and Goodarzi,A.A.
  TITLE     The CHD6 chromatin remodeler is an oxidative DNA damage response
            factor
  JOURNAL   Nat Commun 10 (1), 241 (2019)
   PUBMED   30651562
  REMARK    GeneRIF: Study shows that Chromodomain Helicase DNA-binding protein
            6 (CHD6), distinct to other CHD enzymes, is stabilized during
            oxidative stress via reduced degradation and suggests that CHD6 is
            a key regulator of the oxidative DNA damage response.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 10719)
  AUTHORS   Manning,B.J. and Yusufzai,T.
  TITLE     The ATP-dependent chromatin remodeling enzymes CHD6, CHD7, and CHD8
            exhibit distinct nucleosome binding and remodeling activities
  JOURNAL   J Biol Chem 292 (28), 11927-11936 (2017)
   PUBMED   28533432
  REMARK    GeneRIF: Data suggest that CHD6 and CHD7 both bind with high
            affinity to short linker DNA, whereas CHD8 requires longer DNA for
            binding; thus, CHD8 slides nucleosomes into positions with more
            flanking linker DNA than CHD7; CHD6 disrupts nucleosomes in a
            distinct non-sliding manner.
REFERENCE   5  (bases 1 to 10719)
  AUTHORS   Sancho,A., Li,S., Paul,T., Zhang,F., Aguilo,F., Vashisht,A.,
            Balasubramaniyan,N., Leleiko,N.S., Suchy,F.J., Wohlschlegel,J.A.,
            Zhang,W. and Walsh,M.J.
  TITLE     CHD6 regulates the topological arrangement of the CFTR locus
  JOURNAL   Hum Mol Genet 24 (10), 2724-2732 (2015)
   PUBMED   25631877
  REMARK    GeneRIF: The role of CHD6 in regulating the chromatin topology of
            CFTR as an exemplary genetic model for this mechanism was
            described.
            GeneRIF: CHD6 regulates the topology of the CFTR locus
REFERENCE   6  (bases 1 to 10719)
  AUTHORS   Alfonso,R., Lutz,T., Rodriguez,A., Chavez,J.P., Rodriguez,P.,
            Gutierrez,S. and Nieto,A.
  TITLE     CHD6 chromatin remodeler is a negative modulator of influenza virus
            replication that relocates to inactive chromatin upon infection
  JOURNAL   Cell Microbiol 13 (12), 1894-1906 (2011)
   PUBMED   21899694
  REMARK    GeneRIF: CHD6 has a negative role in the influenza virus cycle
            because the virus replicates more efficiently in CHD6-silenced
            cells.
REFERENCE   7  (bases 1 to 10719)
  AUTHORS   Fertey,J., Ammermann,I., Winkler,M., Stoger,R., Iftner,T. and
            Stubenrauch,F.
  TITLE     Interaction of the papillomavirus E8--E2C protein with the cellular
            CHD6 protein contributes to transcriptional repression
  JOURNAL   J Virol 84 (18), 9505-9515 (2010)
   PUBMED   20631145
  REMARK    GeneRIF: Both RNA knockdown experiments and mutational analyses of
            the E2C domain suggest that binding of CHD6 to E8--E2C contributes
            to the transcriptional repression of the huma papillomavirus E6/E7
            oncogene promoter.
REFERENCE   8  (bases 1 to 10719)
  AUTHORS   Lutz,T., Stoger,R. and Nieto,A.
  TITLE     CHD6 is a DNA-dependent ATPase and localizes at nuclear sites of
            mRNA synthesis
  JOURNAL   FEBS Lett 580 (25), 5851-5857 (2006)
   PUBMED   17027977
  REMARK    GeneRIF: CHD6 colocalizes with both hypo- and hyper-phosphorlylated
            forms of RNA polymerase II. CHD6 was found to be present at sites
            of mRNA synthesis and to be part of a high molecular weight
            complex.
REFERENCE   9  (bases 1 to 10719)
  AUTHORS   Nioi,P., Nguyen,T., Sherratt,P.J. and Pickett,C.B.
  TITLE     The carboxy-terminal Neh3 domain of Nrf2 is required for
            transcriptional activation
  JOURNAL   Mol Cell Biol 25 (24), 10895-10906 (2005)
   PUBMED   16314513
REFERENCE   10 (bases 1 to 10719)
  AUTHORS   Schuster,E.F. and Stoger,R.
  TITLE     CHD5 defines a new subfamily of chromodomain-SWI2/SNF2-like
            helicases
  JOURNAL   Mamm Genome 13 (2), 117-119 (2002)
   PUBMED   11889561
  REMARK    GeneRIF: Describes AY034072, the sequence of a gene whose original
            symbol, CHD5, has been changed to CHD6.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL031669.28, AL121674.12 and
            AL031667.21.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_032221.4.
            
            Summary: This gene encodes a member of the SNF2/RAD54 helicase
            protein family. The encoded protein contains two chromodomains, a
            helicase domain, and an ATPase domain. Several multi-subunit
            protein complexes remodel chromatin to allow patterns of cell
            type-specific gene expression, and the encoded protein is thought
            to be a core member of one or more of these chromatin remodeling
            complexes. The encoded protein may function as a transcriptional
            repressor and is involved in the cellular repression of influenza
            virus replication. [provided by RefSeq, Jul 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY034072.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373233.8/ ENSP00000362330.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                AL031669.28        79304-79341         c
            39-94               AL031669.28        12269-12324         c
            95-615              AL121674.12        32993-33513         c
            616-763             AL121674.12        14748-14895         c
            764-913             AL121674.12        12789-12938         c
            914-976             AL031667.21        141659-141721       c
            977-1035            AL031667.21        140532-140590       c
            1036-1153           AL031667.21        139748-139865       c
            1154-1240           AL031667.21        136222-136308       c
            1241-1375           AL031667.21        135902-136036       c
            1376-1497           AL031667.21        134062-134183       c
            1498-1741           AL031667.21        132142-132385       c
            1742-1918           AL031667.21        130792-130968       c
            1919-2062           AL031667.21        130029-130172       c
            2063-2318           AL031667.21        126716-126971       c
            2319-2529           AL031667.21        125673-125883       c
            2530-2725           AL031667.21        115686-115881       c
            2726-2890           AL031667.21        99628-99792         c
            2891-3070           AL031667.21        98164-98343         c
            3071-3181           AL031667.21        96990-97100         c
            3182-3384           AL031667.21        95104-95306         c
            3385-3584           AL031667.21        94190-94389         c
            3585-3744           AL031667.21        93310-93469         c
            3745-3834           AL031667.21        90246-90335         c
            3835-3938           AL031667.21        88029-88132         c
            3939-4068           AL031667.21        82364-82493         c
            4069-4129           AL031667.21        79638-79698         c
            4130-4190           AL031667.21        68457-68517         c
            4191-4407           AL031667.21        67542-67758         c
            4408-4616           AL031667.21        65856-66064         c
            4617-6188           AL031667.21        62872-64443         c
            6189-6340           AL031667.21        59562-59713         c
            6341-6547           AL031667.21        58952-59158         c
            6548-7000           AL031667.21        57550-58002         c
            7001-7192           AL031667.21        55688-55879         c
            7193-7312           AL031667.21        54508-54627         c
            7313-10719          AL031667.21        44447-47853         c
FEATURES             Location/Qualifiers
     source          1..10719
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q12"
     gene            1..10719
                     /gene="CHD6"
                     /gene_synonym="CHD-6; CHD5; RIGB"
                     /note="chromodomain helicase DNA binding protein 6"
                     /db_xref="GeneID:84181"
                     /db_xref="HGNC:HGNC:19057"
                     /db_xref="MIM:616114"
     exon            1..38
                     /gene="CHD6"
                     /gene_synonym="CHD-6; CHD5; RIGB"
                     /inference="alignment:Splign:2.1.0"
     exon            39..94
                     /gene="CHD6"
                     /gene_synonym="CHD-6; CHD5; RIGB"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..8209
                     /gene="CHD6"
                     /gene_synonym="CHD-6; CHD5; RIGB"
                     /EC_number="3.6.4.12"
                     /note="helicase C-terminal domain- and SNF2 N-terminal
                     domain-containing protein; ATP-dependent helicase CHD6;
                     radiation-induced gene B protein"
                     /codon_start=1
                     /product="chromodomain-helicase-DNA-binding protein 6"
                     /protein_id="NP_115597.3"
                     /db_xref="CCDS:CCDS13317.1"
                     /db_xref="GeneID:84181"
                     /db_xref="HGNC:HGNC:19057"
                     /db_xref="MIM:616114"
                     /translation="MKMKIQKKEKQLSNLKVLNHSPMSDASVNFDYKSPSPFDCSTDQ
                     EEKIEDVASHCLPQKDLYTAEEEAATLFPRKMTSHNGMEDSGGGGTGVKKKRKKKEPG
                     DQEGAAKGSKDREPKPKRKREPKEPKEPRKAKEPKKAKEHKEPKQKDGAKKARKPREA
                     SGTKEAKEKRSCTDSAARTKSRKASKEQGPTPVEKKKKGKRKSETTVESLELDQGLTN
                     PSLRSPEESTESTDSQKRRSGRQVKRRKYNEDLDFKVVDDDGETIAVLGAGRTSALSA
                     STLAWQAEEPPEDDANIIEKILASKTVQEVHPGEPPFDLELFYVKYRNFSYLHCKWAT
                     MEELEKDPRIAQKIKRFRNKQAQMKHIFTEPDEDLFNPDYVEVDRILEVAHTKDAETG
                     EEVTHYLVKWCSLPYEESTWELEEDVDPAKVKEFESLQVLPEIKHVERPASDSWQKLE
                     KSREYKNSNQLREYQLEGMNWLLFNWYNRKNCILADEMGLGKTIQSITFLSEIFLRGI
                     HGPFLIIAPLSTITNWEREFRTWTEMNAIVYHGSQISRQMIQQYEMVYRDAQGNPLSG
                     VFKFHVVITTFEMILADCPELKKIHWSCVIIDEAHRLKNRNCKLLEGLKLMALEHKVL
                     LTGTPLQNSVEELFSLLNFLEPSQFPSETAFLEEFGDLKTEEQVKKLQSILKPMMLRR
                     LKDDVEKNLAPKQETIIEVELTNIQKKYYRAILEKNFSFLTKGANQHNMPNLINTMME
                     LRKCCNHPYLINGAEEKILEDFRKTHSPDAPDFQLQAMIQAAGKLVLIDKLLPKLIAG
                     GHKVLIFSQMVRCLDILEDYLIQRRYTYERIDGRVRGNLRQAAIDRFCKPDSDRFVFL
                     LCTRAGGLGINLTAADTCIIFDSDWNPQNDLQAQARCHRIGQSKAVKVYRLITRNSYE
                     REMFDKASLKLGLDKAVLQDINRKGGTNGVQQLSKMEVEDLLRKGAYGALMDEEDEGS
                     KFCEEDIDQILQRRTHTITIQSEGKGSTFAKASFVASGNRTDISLDDPNFWQKWAKIA
                     ELDTEAKNEKESLVIDRPRVRKQTKHYNSFEEDELMEFSELDSDSDERPTRSRRLNDK
                     ARRYLRAECFRVEKNLLIFGWGRWKDILTHGRFKWHLNEKDMEMICRALLVYCVKHYK
                     GDEKIKSFIWELITPTKDGQAQTLQNHSGLSAPVPRGRKGKKTKNQLLIPELKDADWL
                     ATCNPEVVLHDDGYKKHLKQHCNKVLLRVRMLYYLKAEILGEAAEKAFEGSPARELDV
                     PLPDIDYMEIPVDWWDAEADKSLLIGVFKHGYERYNAMRADPALCFLEKVGMPDEKSL
                     SAEQGVTDGTSDIPERGNTDKEDNAEDKVDGLQKQTESSSDGGDGVFSEKKDDSRAAQ
                     DGSDPDKSPWPVSSALTARLRRLVTVYQRCNRKELCRPEILGPGNQGYWVQEEMFRRT
                     SEMDLINKEAQKRWTRREQADFYRTVSSFGVVYDQEKKTFDWTQFRIISRLDKKSDES
                     LEQYFYSFVAMCRNVCRLPTWKDGGPPDTTIYVEPITEERAARTLYRIELLRKVREQV
                     LKCPQLHERLQLCRPSLYLPVWWECGKHDRDLLIGTAKHGLNRTDCYIMNDPQLSFLD
                     AYRNYAQHKRSGTQAPGNLCCLYQTNSKLYESLTYSQMSRTSESLENEPENLVRVESR
                     DDHLSLPDVTCENFISKVQDVISINHDESLLPESLESMMYGKKVLSQEPSSFQESPST
                     NTESRKDVITISISKDGNCQSGGPEAEIASGPTFMGSLEAGGVAQANIKNGKHLLMSI
                     SKEGELCCSEAGQRPENIGQLEAKCLASPSLNPGNESGFVDMCSLSVCDSKRNLSSDQ
                     QLIDLLENKSLESKLILSQNHSDEEEEEEENEEENLAMAVGMGERPEVLHLTEPTTNI
                     SREKNQGFQDETKKGSLEVANQTPGLQRAFPAPAACQCHCKHMERWMHGLENDEFEIE
                     KPKAYIPDLFKSKTNTIAMEGEPTAIPSQPFKVKHELLKEPWKESAEGQNVFPTYPLE
                     GSELKSEDMDFENKDDYDRDGNCHSQDYPGKYSEEESKSSTSGITGDIGDELQEARAP
                     TIAQLLQEKTLYSFSEWPKDRVIINRLDNICHVVLKGKWPSSQQYEPSGTLPTPVLTS
                     SAGSRTSLSEPEAAEHSFSNGAALAAQIHKESFLAPVFTKDEQKHRRPYEFEVERDAK
                     ARGLEQFSATHGHTPIILNGWHGESAMDLSCSSEGSPGATSPFPVSASTPKIGAISSL
                     QGALGMDLSGILQAGLIHPVTGQIVNGSLRRDDAATRRRRGRRKHVEGGMDLIFLKEQ
                     TLQAGILEVHEDPGQATLSTTHPEGPGPATSAPEPATAASSQAEKSIPSKSLLDWLRQ
                     QADYSLEVPGFGANFSDKPKQRRPRCKEPGKLDVSSLSGEERVPAIPKEPGLRGFLPE
                     NKFNHTLAEPILRDTGPRRRGRRPRSELLKAPSIVADSPSGMGPLFMNGLIAGMDLVG
                     LQNMRNMPGIPLTGLVGFPAGFATMPTGEEVKSTLSMLPMMLPGMAAVPQMFGVGGLL
                     SPPMATTCTSTAPASLSSTTKSGTAVTEKTAEDKPSSHDVKTDTLAEDKPGPGPFSDQ
                     SEPAITTSSPVAFNPFLIPGVSPGLIYPSMFLSPGMGMALPAMQQARHSEIVGLESQK
                     RKKKKTKGDNPNSHPEPAPSCEREPSGDENCAEPSAPLPAEREHGAQAGEGALKDSNN
                     DTN"
     exon            95..615
                     /gene="CHD6"
                     /gene_synonym="CHD-6; CHD5; RIGB"
                     /inference="alignment:Splign:2.1.0"
     exon            616..763
                     /gene="CHD6"
                     /gene_synonym="CHD-6; CHD5; RIGB"
                     /inference="alignment:Splign:2.1.0"
     exon            764..913
                     /gene="CHD6"
                     /gene_synonym="CHD-6; CHD5; RIGB"
                     /inference="alignment:Splign:2.1.0"
     exon            914..976
                     /gene="CHD6"
                     /gene_synonym="CHD-6; CHD5; RIGB"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1035
                     /gene="CHD6"
                     /gene_synonym="CHD-6; CHD5; RIGB"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1153
                     /gene="CHD6"
                     /gene_synonym="CHD-6; CHD5; RIGB"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1240
                     /gene="CHD6"
                     /gene_synonym="CHD-6; CHD5; RIGB"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1375
                     /gene="CHD6"
                     /gene_synonym="CHD-6; CHD5; RIGB"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1497
                     /gene="CHD6"
                     /gene_synonym="CHD-6; CHD5; RIGB"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1741
                     /gene="CHD6"
                     /gene_synonym="CHD-6; CHD5; RIGB"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..1918
                     /gene="CHD6"
                     /gene_synonym="CHD-6; CHD5; RIGB"
                     /inference="alignment:Splign:2.1.0"
     exon            1919..2062
                     /gene="CHD6"
                     /gene_synonym="CHD-6; CHD5; RIGB"
                     /inference="alignment:Splign:2.1.0"
     exon            2063..2318
                     /gene="CHD6"
                     /gene_synonym="CHD-6; CHD5; RIGB"
                     /inference="alignment:Splign:2.1.0"
     exon            2319..2529
                     /gene="CHD6"
                     /gene_synonym="CHD-6; CHD5; RIGB"
                     /inference="alignment:Splign:2.1.0"
     exon            2530..2725
                     /gene="CHD6"
                     /gene_synonym="CHD-6; CHD5; RIGB"
                     /inference="alignment:Splign:2.1.0"
     exon            2726..2890
                     /gene="CHD6"
                     /gene_synonym="CHD-6; CHD5; RIGB"
                     /inference="alignment:Splign:2.1.0"
     exon            2891..3070
                     /gene="CHD6"
                     /gene_synonym="CHD-6; CHD5; RIGB"
                     /inference="alignment:Splign:2.1.0"
     exon            3071..3181
                     /gene="CHD6"
                     /gene_synonym="CHD-6; CHD5; RIGB"
                     /inference="alignment:Splign:2.1.0"
     exon            3182..3384
                     /gene="CHD6"
                     /gene_synonym="CHD-6; CHD5; RIGB"
                     /inference="alignment:Splign:2.1.0"
     exon            3385..3584
                     /gene="CHD6"
                     /gene_synonym="CHD-6; CHD5; RIGB"
                     /inference="alignment:Splign:2.1.0"
     exon            3585..3744
                     /gene="CHD6"
                     /gene_synonym="CHD-6; CHD5; RIGB"
                     /inference="alignment:Splign:2.1.0"
     exon            3745..3834
                     /gene="CHD6"
                     /gene_synonym="CHD-6; CHD5; RIGB"
                     /inference="alignment:Splign:2.1.0"
     exon            3835..3938
                     /gene="CHD6"
                     /gene_synonym="CHD-6; CHD5; RIGB"
                     /inference="alignment:Splign:2.1.0"
     exon            3939..4068
                     /gene="CHD6"
                     /gene_synonym="CHD-6; CHD5; RIGB"
                     /inference="alignment:Splign:2.1.0"
     exon            4069..4129
                     /gene="CHD6"
                     /gene_synonym="CHD-6; CHD5; RIGB"
                     /inference="alignment:Splign:2.1.0"
     exon            4130..4190
                     /gene="CHD6"
                     /gene_synonym="CHD-6; CHD5; RIGB"
                     /inference="alignment:Splign:2.1.0"
     exon            4191..4407
                     /gene="CHD6"
                     /gene_synonym="CHD-6; CHD5; RIGB"
                     /inference="alignment:Splign:2.1.0"
     exon            4408..4616
                     /gene="CHD6"
                     /gene_synonym="CHD-6; CHD5; RIGB"
                     /inference="alignment:Splign:2.1.0"
     exon            4617..6188
                     /gene="CHD6"
                     /gene_synonym="CHD-6; CHD5; RIGB"
                     /inference="alignment:Splign:2.1.0"
     exon            6189..6340
                     /gene="CHD6"
                     /gene_synonym="CHD-6; CHD5; RIGB"
                     /inference="alignment:Splign:2.1.0"
     exon            6341..6547
                     /gene="CHD6"
                     /gene_synonym="CHD-6; CHD5; RIGB"
                     /inference="alignment:Splign:2.1.0"
     exon            6548..7000
                     /gene="CHD6"
                     /gene_synonym="CHD-6; CHD5; RIGB"
                     /inference="alignment:Splign:2.1.0"
     exon            7001..7192
                     /gene="CHD6"
                     /gene_synonym="CHD-6; CHD5; RIGB"
                     /inference="alignment:Splign:2.1.0"
     exon            7193..7312
                     /gene="CHD6"
                     /gene_synonym="CHD-6; CHD5; RIGB"
                     /inference="alignment:Splign:2.1.0"
     exon            7313..10719
                     /gene="CHD6"
                     /gene_synonym="CHD-6; CHD5; RIGB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10185..10190
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CHD6"
                     /gene_synonym="CHD-6; CHD5; RIGB"
                     /note="hexamer: AATACA"
     regulatory      10196..10201
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CHD6"
                     /gene_synonym="CHD-6; CHD5; RIGB"
                     /note="hexamer: TATAAA"
     polyA_site      10203
                     /gene="CHD6"
                     /gene_synonym="CHD-6; CHD5; RIGB"
                     /note="major polyA site"
     polyA_site      10219
                     /gene="CHD6"
                     /gene_synonym="CHD-6; CHD5; RIGB"
                     /note="major polyA site"
     regulatory      10238..10243
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CHD6"
                     /gene_synonym="CHD-6; CHD5; RIGB"
                     /note="hexamer: ATTATA"
     polyA_site      10256
                     /gene="CHD6"
                     /gene_synonym="CHD-6; CHD5; RIGB"
                     /note="major polyA site"
     polyA_site      10586
                     /gene="CHD6"
                     /gene_synonym="CHD-6; CHD5; RIGB"
                     /note="major polyA site"
     regulatory      10700..10705
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CHD6"
                     /gene_synonym="CHD-6; CHD5; RIGB"
                     /note="hexamer: AAGAAA"
     polyA_site      10719
                     /gene="CHD6"
                     /gene_synonym="CHD-6; CHD5; RIGB"
ORIGIN      
        1 agctgtttgt attttggctg ctgcaggagc cattttagaa ataaatatct tccttcaata
       61 gatgaaaatg aaaatacaga aaaaagagaa gcagttgtca aatttaaaag ttttgaatca
      121 ctccccaatg tctgatgcct ctgtcaattt tgactacaaa tctccatccc catttgactg
      181 cagcactgat caagaagaga aaattgaaga tgttgctagt cactgtctgc ctcagaagga
      241 cctgtatact gctgaagagg aagctgctac cctttttcct aggaaaatga catcccataa
      301 tgggatggag gacagtggag gaggaggtac tggagtgaag aagaaacgga agaaaaagga
      361 gccaggagac caagagggtg cagcaaaggg aagcaaggac agagagccca agccaaagag
      421 gaaacgagaa ccgaaagagc caaaggaacc cagaaaggcc aaggagccga agaaggccaa
      481 ggagcacaag gagccgaagc aaaaagatgg ggcaaagaag gcacggaagc cccgggaggc
      541 ctcgggcacc aaggaggcca aagagaagag gagctgcact gactctgcag ccaggacgaa
      601 gtccaggaag gccagcaagg agcaaggacc aaccccagtg gagaaaaaga agaaaggaaa
      661 aaggaaaagt gaaactacag tggagagttt agagctggat cagggcctga cgaacccatc
      721 tctgcggagt cctgaggagt ccactgagtc tacagacagc cagaaacgac gctcgggaag
      781 gcaagtaaag cgcagaaaat acaatgagga cctggacttc aaagtggtgg atgatgatgg
      841 ggaaacaatt gctgttcttg gagctggtcg aacatctgca ctctcagcct ctacactggc
      901 ctggcaggcg gaggagcctc cagaagatga tgcaaacatc attgagaaga tcctggcatc
      961 taagactgtc caggaggttc acccaggaga acctccgttc gacttggagc tgttctacgt
     1021 taagtataga aatttttcct acttacattg taaatgggcc acaatggaag agctcgaaaa
     1081 ggatcctcgc atcgcacaga agatcaagcg atttaggaat aaacaagccc agatgaagca
     1141 catttttacg gagcctgatg aagacttgtt caatccagac tatgtagaag ttgatcgcat
     1201 cttggaggtg gcccacacca aggatgcaga aacaggggag gaggtaacac attacctggt
     1261 gaagtggtgc tcactaccat atgaagaaag cacgtgggag ctagaggaag atgtagatcc
     1321 tgcaaaagtt aaagaatttg aatctcttca agttctccct gaaattaagc atgtggagcg
     1381 gcctgcttca gactcctggc agaaacttga gaagtctcgc gagtataaga acagtaacca
     1441 gctccgggag taccagctgg aagggatgaa ctggcttctt tttaactggt ataacagaaa
     1501 aaactgtatt ttggctgatg agatgggcct agggaaaacc atccagtcca tcacattcct
     1561 ttcagaaata tttctgagag gaatccacgg cccttttctc attatcgccc ctctctccac
     1621 catcactaac tgggagcggg agttccggac atggacagag atgaatgcca ttgtgtacca
     1681 cggcagccag atcagcaggc agatgatcca gcagtatgaa atggtgtaca gagacgccca
     1741 gggaaacccc ctttcaggag tcttcaagtt ccacgtcgtc atcacaacat ttgaaatgat
     1801 cctagcagac tgcccagagt tgaagaagat tcactggagc tgtgtgataa ttgatgaagc
     1861 ccacagactg aagaatagga actgcaaact tctggagggt ctaaagctta tggccctgga
     1921 acataaagtg cttctcactg gaacaccctt gcagaactct gtggaggagc tcttcagttt
     1981 gttaaatttt ctggagccat cacagtttcc ttcagagacc gctttcttgg aggaatttgg
     2041 agatctgaaa acagaggagc aggtaaagaa actgcagtct atcctaaaac caatgatgct
     2101 tcggcggctg aaagatgatg tggaaaagaa ccttgctccc aaacaagaga cgatcattga
     2161 ggtggaactg accaatatcc agaaaaagta ctaccgtgcc atcctcgaga agaacttttc
     2221 cttcctgacc aagggggcaa atcagcacaa catgcccaat ctcatcaaca ccatgatgga
     2281 gctgaggaag tgctgtaacc atccctacct gatcaatgga gcagaggaga aaattctaga
     2341 agatttccga aaaacccaca gccctgatgc ccctgacttt cagctgcagg ccatgattca
     2401 ggcagcagga aagcttgtgt tgattgataa actactccct aagctgattg caggtggcca
     2461 caaagtactc atcttctccc agatggtgcg ctgcctcgac atcctagaag attacctcat
     2521 ccagagaaga tacacctatg agcgaattga tgggcgagta cggggaaacc tgcgccaggc
     2581 agccatcgac cggttctgta agccagattc agaccgcttt gtctttcttc tgtgcaccag
     2641 agcgggaggc ctggggatca atctcacagc tgctgatacc tgcatcatat ttgattctga
     2701 ctggaaccca caaaatgact tgcaggctca ggcccgatgt caccgcatag gccagagcaa
     2761 agctgtgaag gtgtatcgcc tcatcactcg aaattcctac gagcgcgaga tgtttgacaa
     2821 ggccagccta aagctggggc tggacaaggc tgttcttcag gacatcaacc gaaagggcgg
     2881 caccaatggg gtacagcagc tctcaaaaat ggaggtggag gacctactcc ggaaaggtgc
     2941 ttatggagcc ttaatggatg aagaagatga aggctccaag ttctgtgaag aagacataga
     3001 ccagattctg cagaggcgaa cgcacaccat caccatccag tctgagggga aagggtccac
     3061 ttttgccaag gctagctttg tggcttcagg aaacagaaca gatatttcct tagatgatcc
     3121 taacttttgg cagaaatggg ctaaaatagc tgaactagac actgaagcaa agaatgaaaa
     3181 ggaaagctta gtgatcgacc gacctcgcgt gagaaagcag accaaacact acaactcgtt
     3241 tgaggaagac gagctcatgg agttttcaga gttagacagc gactcagacg aaaggcccac
     3301 gagatccagg cgcctcaatg acaaagccag gcgctacctc cgagcggagt gcttccgggt
     3361 agagaagaac ctgctcatct ttggctgggg ccggtggaag gacatcctga ctcatggccg
     3421 attcaagtgg catctgaacg agaaggacat ggagatgatt tgccgtgccc tcctggtgta
     3481 ctgtgtcaag cattataagg gggacgagaa gatcaagagt ttcatttggg aactgatcac
     3541 acctaccaaa gatgggcaag cccagaccct ccagaaccac tcaggcttat ctgccccagt
     3601 ccccagaggg aggaagggga agaagacgaa gaaccagttg ctaatcccag agctaaagga
     3661 tgcagattgg ctagccacct gcaaccccga ggtggtcttg catgatgatg gctataagaa
     3721 acacctcaaa cagcactgca acaaagtact tttgcgagtc cggatgctgt actacctaaa
     3781 agctgaaata ctgggagaag cagctgagaa agcatttgaa ggatctcctg ccagggagct
     3841 ggatgtacct ctgcctgaca tcgactacat ggagatccca gtggactggt gggatgctga
     3901 agccgataag tcacttctca ttggcgtgtt caagcatggt tatgaaaggt acaatgccat
     3961 gcgagcagac ccagcacttt gcttcctgga gaaagttggg atgcccgatg agaagtccct
     4021 ttctgcagaa cagggtgtta cagatgggac ctcagacatt cctgaaagag gcaacacaga
     4081 taaagaagac aatgctgagg acaaagtaga tggcctccag aaacaaacgg agagttccag
     4141 tgatggaggt gatggcgttt ttagcgaaaa gaaggatgac agccgggcag cccaggatgg
     4201 ctccgaccca gacaaatcgc cctggccagt ttcctccgcc ctcacagctc gtctcagacg
     4261 tctggtcact gtttaccagc gctgcaaccg caaggaactg tgccggcctg aaattctggg
     4321 accaggtaac caaggatatt gggttcagga agagatgttc aggagaacct cagaaatgga
     4381 cctcatcaac aaggaagccc aaaagaggtg gactaggaga gaacaagcag acttctatag
     4441 aacagtgtct tcctttggtg ttgtttacga tcaagaaaag aaaacctttg actggacaca
     4501 gttccgcatc atttcccgtt tggacaagaa gtcggatgag agcctggaac agtattttta
     4561 tagttttgtg gccatgtgcc ggaatgtctg tcgtctaccc acatggaaag atggcggtcc
     4621 cccagatacc accatctacg ttgaacccat cactgaggaa cgtgctgcaa gaactctgta
     4681 ccgcattgaa ctgttacgga aagtccgaga gcaagtgctc aagtgccctc agctgcatga
     4741 acgcctccag ctgtgcaggc ccagcctcta cctcccagtc tggtgggagt gtgggaagca
     4801 tgatcgagac ctgctcatcg gcactgccaa acatgggctg aaccgcactg actgttacat
     4861 catgaacgac ccccagctgt ccttcctgga tgcctataga aactatgccc agcataaaag
     4921 atctggcacc caggcaccag gaaatctctg ttgcctttac cagaccaact ccaagttata
     4981 tgaatctctt acatattctc aaatgagtag gacttcagag tcccttgaaa atgaacctga
     5041 aaatctagtg agagtagaaa gcagagatga tcatctcagc ctgcctgatg tgacatgtga
     5101 aaactttatt tctaaagttc aggatgtcat ttccatcaac catgatgaaa gtctgctgcc
     5161 tgagtcctta gagagcatga tgtatggtaa gaaggtgctc agccaagaac caagctcttt
     5221 tcaggagagc ccaagtacca atactgaatc tagaaaagat gttattacca tctcaataag
     5281 caaagatggg aactgccagt ctggtggccc tgaggcagaa atagcttctg gccctacttt
     5341 tatgggtagc ttagaagcag gaggagtagc tcaagcaaac atcaaaaatg gaaaacattt
     5401 gttgatgtct atttcaaagg aaggggagct ctgctgcagt gaggcaggac agagacctga
     5461 aaacattggc cagctggaag ccaagtgttt agcttcccct tccttgaatc caggaaatga
     5521 aagtgggttt gtagatatgt gcagtcttag tgtctgtgac tccaaaagaa acctgtcatc
     5581 agatcagcaa ttaattgatt tattggaaaa caaaagctta gaaagtaaat tgattttgag
     5641 tcagaaccac agtgatgagg aggaagaaga ggaggaaaac gaggaggaaa acttagccat
     5701 ggcagtaggc atgggggaaa ggccagaggt attgcatctc acggagccca ctactaacat
     5761 ctcaagggaa aagaaccaag gcttccaaga tgaaaccaag aaaggaagct tagaggtggc
     5821 aaaccagact cctgggctac agagggcttt ccccgctcca gcagcctgtc agtgccactg
     5881 caaacacatg gagaggtgga tgcatggcct cgagaatgat gaatttgaaa tcgagaaacc
     5941 caaggcttat atcccagatc tgttcaaaag taaaaccaat actatcgcca tggagggtga
     6001 acccactgct attccatcac agccgtttaa agtgaagcat gagcttttaa aagaaccttg
     6061 gaaagaaagt gcagaggggc aaaacgtttt ccccacatat cctcttgaag gaagtgagct
     6121 caaatcagaa gacatggatt ttgagaataa agatgattat gatagagacg gaaactgcca
     6181 tagtcaagat tatccaggga agtactctga agaggagagc aagagctcaa catcgggcat
     6241 cacaggagac attggggatg agctacagga ggctcgagct cccactattg ctcagctgct
     6301 acaggagaaa actctctatt ccttctctga gtggccaaag gaccgcgtga taattaaccg
     6361 cctagataat atctgccacg tggtgttaaa ggggaagtgg ccctctagcc agcagtatga
     6421 gccctcaggc acactgccca ccccggtatt aaccagcagt gctggttctc gaaccagcct
     6481 ctcagagccg gaagcagcag aacacagctt cagcaacggc gcagcattgg cggcccagat
     6541 ccacaaggag agcttcttag ctccagtatt cacaaaggat gaacaaaagc acaggcgtcc
     6601 ctatgagttt gaggtggaga gggatgcaaa ggctcggggc ctggagcagt tctctgccac
     6661 ccacgggcac acccctatca tcctcaatgg ctggcatggg gagtcagcta tggacctctc
     6721 ctgctcatca gaggggtccc caggagccac atcccctttc ccagtgagcg ccagcacccc
     6781 taagattggg gctatcagtt cacttcaggg agcccttggc atggacttgt ctgggattct
     6841 gcaagctggc ctgatccatc ctgtgactgg acagattgtc aatggaagcc tcagaagaga
     6901 tgatgcagcc acgaggaggc ggagagggag gcggaaacat gttgaaggag ggatggacct
     6961 catctttttg aaggagcaga cacttcaggc gggaatcttg gaagtccatg aagacccagg
     7021 gcaggccacc ttgagcacca cacaccctga ggggccaggg cctgccacct cggctcctga
     7081 gccagctacg gcagccagca gccaagccga gaaatccatt cccagcaaga gtctgcttga
     7141 ctggctaagg cagcaggctg actactcctt agaagttcct ggctttgggg caaatttttc
     7201 agacaaacca aagcagagga ggccacgctg taaagaacct ggaaaattag atgtcagctc
     7261 cctgagcggg gaagagagag ttcctgccat ccccaaggag ccaggactga gggggtttct
     7321 tccagaaaac aagttcaatc acactctggc tgagcctatt cttcgagata cgggcccccg
     7381 caggaggggg aggcggcctc ggagcgaact cctgaaggct ccttccattg tggcagactc
     7441 tccctctgga atggggccac tgttcatgaa tggactgatt gctgggatgg acctggtagg
     7501 acttcagaac atgagaaata tgccaggcat ccccctcacc gggctggtgg ggtttccagc
     7561 tggctttgcc acgatgccaa caggtgaaga ggtcaaaagt accctgagca tgctgcccat
     7621 gatgctgcca ggcatggctg ctgtgcccca gatgtttggt gttgggggac tcctcagtcc
     7681 acccatggca accacctgca cttccactgc tccggcgtct ctatcaagca caacgaaaag
     7741 tggtacggca gtgactgaaa agactgcgga agacaagccg agtagccatg atgtgaaaac
     7801 agacacttta gctgaggaca agcctggtcc aggtccattt tctgatcagt ctgaacctgc
     7861 aataactact agtagtcctg tggcttttaa cccatttctc atcccaggag tatctcctgg
     7921 actcatttac ccatccatgt tcctctcccc tggtatgggc atggctctgc cagccatgca
     7981 gcaggccaga cactcggaaa tagtaggtct ggagagccag aagaggaaga agaagaagac
     8041 aaagggggac aaccccaact cccacccaga gcctgctccc agctgtgaaa gggagcccag
     8101 cggtgatgag aactgtgccg aacccagtgc ccctttgccc gcagagagag aacatggggc
     8161 acaggctggg gagggggcac tcaaagactc caacaacgac accaattaga acttttttca
     8221 tttaagaaat tattgtgact tgtaagtttc ttatcccata aaggtttgtt acttccctca
     8281 cttcacctcc ataagaacct gtgtttccat aagtaagatt acgtacctga tttcctgtct
     8341 gagaactatg gtaacagatg ttaatagttg cagggtctca ccacttcatt agataagtgt
     8401 tgtctaccta gtctaggagg cacagaattc tcattctgtt atccagttca ttccagcaat
     8461 catagttaat acagtacttg gtgacacgcc ctaccccctt ctcttccaag tttcccactc
     8521 acttgaggag gaaaaatggc aaaagaaagc tgtctagggt tttaccattg aagggtggaa
     8581 gaacagagac aaagaggagc tctttttctg tgagctgggt tgcacaggaa gaatgtcaca
     8641 gggaaccaaa aagcacagaa aaaggaagtg ctggtgcata tttttgagtt aaaatatttc
     8701 cctattttat catgattact aagtgagtag tatagacaga agtatataac taatggttga
     8761 aaatacatat attcatttct ttataaaaaa caaaaacctt accggtagta atataatttc
     8821 ccccttggtg gtttttcaga cacctgcagc aagaagaaat actgactgac taggcattat
     8881 tttctataca tccctctcac cagtgaaaag attcctcttg ctgcgagaaa gctttaccca
     8941 ccatgagtta ttgctgtcga cgggggtggg gcaaggaccc gcgctccgta gagctacacg
     9001 ctgcttcaca agcacacggc tagcgctctg ctctcacctg gttcgcttac agatttctct
     9061 agccattaat ttgcctctct gtgtttaaag agcaccagga ccgaatggat tttcacttca
     9121 ggctttcctt caccaagaat aaggttcttt ctggagcctg caagaagaca gttgcccaac
     9181 actttgacac ttgctagtag gtcctttgat caagagtgtc tgaggctgtc aaatgtgtgc
     9241 caccctttat aatacagcta tgaaaagtta cttctccatt aatttctcca ttctgtttat
     9301 atcttacagt tggacccaaa ttccaaatta tcagttaatc gaaactacat tgcaagtcaa
     9361 cattattttc tcttcttcct cagcttctcc atgtttagga actgagaaag aaactgccta
     9421 agcagcactt ccccatgtcc tttcaccttc atgttaacgt cccttctgat ggtctcactc
     9481 ttcacaggta gttcacactc tgagacttga agtaagctca tggttcagta ctctgggggc
     9541 gcagggctgc gcaggaccct tggaaatgtt gcaagtgtta ctagtaccag tttcactttt
     9601 tgttgtcaca atttactgta ttttttactt tttctgttac agttttgcta atttatcaga
     9661 aggtccaaaa gtctgacata actatttcat tttgcattat ttatttatga tgcttttttc
     9721 attgtctttt atacatttgg gattataaat tatgtaaatg ttaaaatgag catctcaaag
     9781 aagtctgtta aatcatgact gaaaaaaatc aatcagatgt atcttcaaaa agtggagtcc
     9841 cagttttatg aatcagagat ataaaccaga aattctataa ctgatcatag aagaagaatc
     9901 cagtaattga acaaatccta tttaatgaca tccttgtagc atagatggtc tataatgctg
     9961 accacagatt tcttagaaat gctgctctct ctatttaact aacattttgt tcagttttgc
    10021 ctccagtgga agcagaaagg gttttttcag ctgttaaatc ctaaaaatca atataattta
    10081 tttatgtaag aaaaataact caatcaatat atttttgaac cttttaagta ctaattttct
    10141 ttttatcaag tagaaaaaaa aatgtatttg ccctaaatcc ttaaaataca aatgctataa
    10201 aaattcctgt atcttgaaag ccttactgca aatgagtatt atagacatcc agcagagtct
    10261 ggttttcttt gttgtcgttg tgttgttgtt gttttgtatg gaaaagctgc tttccccggg
    10321 ttccacttat aacctccggt aggtcacagg gttcaatgtg gatctgactt aaaaacccac
    10381 cagcatgctc aatcccttgt tatccttatg gaatctgtat gttaactctc tgggtgttca
    10441 ggcttctatt tgactgctgt tgtgaccctg tttgcaaaat gaatatgaca ctctgtggat
    10501 tatttgctct gtaaggcaca agtgcttctt atgattattt tgacgtttcc aagagcaaaa
    10561 gccaaattta aactctcttc agcaaacttg agccttttca tctaattcca tgtcactcac
    10621 ggccataact ttccttgacc attcttcacc ccatgtctta cataataaat tgtggtcttg
    10681 atcctggatt taaaaacaaa agaaaaagtt taaaagtca
//
