LOCUS       NM_001270               8145 bp    mRNA    linear   PRI 30-APR-2025
DEFINITION  Homo sapiens chromodomain helicase DNA binding protein 1 (CHD1),
            transcript variant 2, mRNA.
ACCESSION   NM_001270 XM_005271867
VERSION     NM_001270.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8145)
  AUTHORS   Li,J., Xu,J., Zheng,S. and Cheng,S.
  TITLE     LncRNA LINC02535 Induces Colorectal Adenocarcinoma Progression via
            Modulating miR-30d-5p/CHD1
  JOURNAL   Mol Biotechnol 65 (8), 1346-1358 (2023)
   PUBMED   36577835
  REMARK    GeneRIF: LncRNA LINC02535 Induces Colorectal Adenocarcinoma
            Progression via Modulating miR-30d-5p/CHD1.
REFERENCE   2  (bases 1 to 8145)
  AUTHORS   Wang,X., Zhao,H., Wang,P., Zhang,J., Li,N., Liu,Y., Zhang,F. and
            Yu,Y.
  TITLE     MiR-30a-5p/CHD1 axis enhances cisplatin sensitivity of ovarian
            cancer cells via inactivating the Wnt/beta-catenin pathway
  JOURNAL   Anticancer Drugs 33 (10), 989-998 (2022)
   PUBMED   36206129
  REMARK    GeneRIF: MiR-30a-5p/CHD1 axis enhances cisplatin sensitivity of
            ovarian cancer cells via inactivating the Wnt/beta-catenin pathway.
REFERENCE   3  (bases 1 to 8145)
  AUTHORS   Li,H., Wang,Y., Lin,K., Venkadakrishnan,V.B., Bakht,M., Shi,W.,
            Meng,C., Zhang,J., Tremble,K., Liang,X., Song,J.H., Feng,X.,
            Van,V., Deng,P., Burks,J.K., Aparicio,A., Keyomarsi,K., Chen,J.,
            Lu,Y., Beltran,H. and Zhao,D.
  TITLE     CHD1 Promotes Sensitivity to Aurora Kinase Inhibitors by
            Suppressing Interaction of AURKA with Its Coactivator TPX2
  JOURNAL   Cancer Res 82 (17), 3088-3101 (2022)
   PUBMED   35771632
  REMARK    GeneRIF: CHD1 Promotes Sensitivity to Aurora Kinase Inhibitors by
            Suppressing Interaction of AURKA with Its Coactivator TPX2.
REFERENCE   4  (bases 1 to 8145)
  AUTHORS   Hernandez-Llodra,S., Segales,L., Juanpere,N., Marta Lorenzo,T.,
            Salido,M., Nonell,L., David Lopez,T., Rodriguez-Vida,A.,
            Bellmunt,J., Fumado,L., Cecchini,L. and Lloreta-Trull,J.
  TITLE     SPOP and CHD1 alterations in prostate cancer: Relationship with
            PTEN loss, tumor grade, perineural infiltration, and PSA recurrence
  JOURNAL   Prostate 81 (16), 1267-1277 (2021)
   PUBMED   34533858
  REMARK    GeneRIF: SPOP and CHD1 alterations in prostate cancer: Relationship
            with PTEN loss, tumor grade, perineural infiltration, and PSA
            recurrence.
REFERENCE   5  (bases 1 to 8145)
  AUTHORS   Roehrig,A.E., Klupsch,K., Oses-Prieto,J.A., Chaib,S., Henderson,S.,
            Emmett,W., Young,L.C., Surinova,S., Blees,A., Pfeiffer,A.,
            Tijani,M., Brunk,F., Hartig,N., Munoz-Alegre,M., Hergovich,A.,
            Jennings,B.H., Burlingame,A.L. and Rodriguez-Viciana,P.
  TITLE     Cell-cell adhesion regulates Merlin/NF2 interaction with the PAF
            complex
  JOURNAL   PLoS One 16 (8), e0254697 (2021)
   PUBMED   34424918
  REMARK    GeneRIF: Cell-cell adhesion regulates Merlin/NF2 interaction with
            the PAF complex.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8145)
  AUTHORS   Salomon,A.R., Ficarro,S.B., Brill,L.M., Brinker,A., Phung,Q.T.,
            Ericson,C., Sauer,K., Brock,A., Horn,D.M., Schultz,P.G. and
            Peters,E.C.
  TITLE     Profiling of tyrosine phosphorylation pathways in human cells using
            mass spectrometry
  JOURNAL   Proc Natl Acad Sci U S A 100 (2), 443-448 (2003)
   PUBMED   12522270
REFERENCE   7  (bases 1 to 8145)
  AUTHORS   Kelley,D.E., Stokes,D.G. and Perry,R.P.
  TITLE     CHD1 interacts with SSRP1 and depends on both its chromodomain and
            its ATPase/helicase-like domain for proper association with
            chromatin
  JOURNAL   Chromosoma 108 (1), 10-25 (1999)
   PUBMED   10199952
REFERENCE   8  (bases 1 to 8145)
  AUTHORS   Woodage,T., Basrai,M.A., Baxevanis,A.D., Hieter,P. and Collins,F.S.
  TITLE     Characterization of the CHD family of proteins
  JOURNAL   Proc Natl Acad Sci U S A 94 (21), 11472-11477 (1997)
   PUBMED   9326634
REFERENCE   9  (bases 1 to 8145)
  AUTHORS   Stokes,D.G. and Perry,R.P.
  TITLE     DNA-binding and chromatin localization properties of CHD1
  JOURNAL   Mol Cell Biol 15 (5), 2745-2753 (1995)
   PUBMED   7739555
REFERENCE   10 (bases 1 to 8145)
  AUTHORS   Delmas,V., Stokes,D.G. and Perry,R.P.
  TITLE     A mammalian DNA-binding protein that contains a chromodomain and an
            SNF2/SWI2-like helicase domain
  JOURNAL   Proc Natl Acad Sci U S A 90 (6), 2414-2418 (1993)
   PUBMED   8460153
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC022121.6 and KC877055.1.
            
            On Dec 30, 2019 this sequence version replaced NM_001270.3.
            
            Summary: The CHD family of proteins is characterized by the
            presence of chromo (chromatin organization modifier) domains and
            SNF2-related helicase/ATPase domains.  CHD genes alter gene
            expression possibly by modification of chromatin structure thus
            altering access of the transcriptional apparatus to its chromosomal
            DNA template. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.2086480.1,
                                           SRR14038191.232183.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000614616.5/ ENSP00000483667.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-469               AC022121.6         147186-147654       c
            470-670             AC022121.6         144981-145181       c
            671-872             AC022121.6         123544-123745       c
            873-989             AC022121.6         122439-122555       c
            990-1054            AC022121.6         121547-121611       c
            1055-1204           AC022121.6         119833-119982       c
            1205-1476           AC022121.6         119458-119729       c
            1477-1702           AC022121.6         118127-118352       c
            1703-1803           AC022121.6         117311-117411       c
            1804-1982           AC022121.6         116903-117081       c
            1983-2110           AC022121.6         115840-115967       c
            2111-2327           AC022121.6         114873-115089       c
            2328-2417           AC022121.6         113244-113333       c
            2418-2608           AC022121.6         112063-112253       c
            2609-2797           AC022121.6         111172-111360       c
            2798-2960           AC022121.6         107723-107885       c
            2961-3113           AC022121.6         106735-106887       c
            3114-3185           AC022121.6         104225-104296       c
            3186-3335           AC022121.6         101735-101884       c
            3336-3484           AC022121.6         100622-100770       c
            3485-3581           AC022121.6         99926-100022        c
            3582-3677           AC022121.6         99723-99818         c
            3678-3854           AC022121.6         98199-98375         c
            3855-4015           AC022121.6         95045-95205         c
            4016-4057           AC022121.6         93719-93760         c
            4058-4188           AC022121.6         92240-92370         c
            4189-4327           AC022121.6         91064-91202         c
            4328-4478           AC022121.6         90698-90848         c
            4479-4595           AC022121.6         89334-89450         c
            4596-4724           AC022121.6         88401-88529         c
            4725-4865           AC022121.6         87142-87282         c
            4866-5044           AC022121.6         82055-82233         c
            5045-5141           AC022121.6         78619-78715         c
            5142-5193           AC022121.6         77611-77662         c
            5194-5404           AC022121.6         76827-77037         c
            5405-7340           AC022121.6         73437-75372         c
            7341-7880           KC877055.1         1-540               c
            7881-8145           AC022121.6         72632-72896         c
FEATURES             Location/Qualifiers
     source          1..8145
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q15-q21.1"
     gene            1..8145
                     /gene="CHD1"
                     /gene_synonym="CHD-1; PILBOS"
                     /note="chromodomain helicase DNA binding protein 1"
                     /db_xref="GeneID:1105"
                     /db_xref="HGNC:HGNC:1915"
                     /db_xref="MIM:602118"
     exon            1..469
                     /gene="CHD1"
                     /gene_synonym="CHD-1; PILBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            470..670
                     /gene="CHD1"
                     /gene_synonym="CHD-1; PILBOS"
                     /inference="alignment:Splign:2.1.0"
     CDS             618..5750
                     /gene="CHD1"
                     /gene_synonym="CHD-1; PILBOS"
                     /EC_number="3.6.4.12"
                     /note="isoform 2 is encoded by transcript variant 2;
                     ATP-dependent helicase CHD1"
                     /codon_start=1
                     /product="chromodomain-helicase-DNA-binding protein 1
                     isoform 2"
                     /protein_id="NP_001261.2"
                     /db_xref="CCDS:CCDS34204.1"
                     /db_xref="GeneID:1105"
                     /db_xref="HGNC:HGNC:1915"
                     /db_xref="MIM:602118"
                     /translation="MNGHSDEESVRNSSGESSQSDDDSGSASGSGSGSSSGSSSDGSS
                     SQSGSSDSDSGSESGSQSESESDTSRENKVQAKPPKVDGAEFWKSSPSILAVQRSAIL
                     KKQQQQQQQQQHQASSNSGSEEDSSSSEDSDDSSSEVKRKKHKDEDWQMSGSGSPSQS
                     GSDSESEEEREKSSCDETESDYEPKNKVKSRKPQNRSKSKNGKKILGQKKRQIDSSEE
                     DDDEEDYDNDKRSSRRQATVNVSYKEDEEMKTDSDDLLEVCGEDVPQPEEEEFETIER
                     FMDCRIGRKGATGATTTIYAVEADGDPNAGFEKNKEPGEIQYLIKWKGWSHIHNTWET
                     EETLKQQNVRGMKKLDNYKKKDQETKRWLKNASPEDVEYYNCQQELTDDLHKQYQIVE
                     RIIAHSNQKSAAGYPDYYCKWQGLPYSECSWEDGALISKKFQACIDEYFSRNQSKTTP
                     FKDCKVLKQRPRFVALKKQPSYIGGHEGLELRDYQLNGLNWLAHSWCKGNSCILADEM
                     GLGKTIQTISFLNYLFHEHQLYGPFLLVVPLSTLTSWQREIQTWASQMNAVVYLGDIN
                     SRNMIRTHEWTHHQTKRLKFNILLTTYEILLKDKAFLGGLNWAFIGVDEAHRLKNDDS
                     LLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFSSWEDFEEEHGKGREYG
                     YASLHKELEPFLLRRVKKDVEKSLPAKVEQILRMEMSALQKQYYKWILTRNYKALSKG
                     SKGSTSGFLNIMMELKKCCNHCYLIKPPDNNEFYNKQEALQHLIRSSGKLILLDKLLI
                     RLRERGNRVLIFSQMVRMLDILAEYLKYRQFPFQRLDGSIKGELRKQALDHFNAEGSE
                     DFCFLLSTRAGGLGINLASADTVVIFDSDWNPQNDLQAQARAHRIGQKKQVNIYRLVT
                     KGSVEEDILERAKKKMVLDHLVIQRMDTTGKTVLHTGSAPSSSTPFNKEELSAILKFG
                     AEELFKEPEGEEQEPQEMDIDEILKRAETHENEPGPLTVGDELLSQFKVANFSNMDED
                     DIELEPERNSKNWEEIIPEDQRRRLEEEERQKELEEIYMLPRMRNCAKQISFNGSEGR
                     RSRSRRYSGSDSDSISEGKRPKKRGRPRTIPRENIKGFSDAEIRRFIKSYKKFGGPLE
                     RLDAIARDAELVDKSETDLRRLGELVHNGCIKALKDSSSGTERTGGRLGKVKGPTFRI
                     SGVQVNAKLVISHEEELIPLHKSIPSDPEERKQYTIPCHTKAAHFDIDWGKEDDSNLL
                     IGIYEYGYGSWEMIKMDPDLSLTHKILPDDPDKKPQAKQLQTRADYLIKLLSRDLAKK
                     EALSGAGSSKRRKARAKKNKAMKSIKVKEEIKSDSSPLPSEKSDEDDDKLSESKSDGR
                     ERSKKSSVSDAPVHITASGEPVPISEESEELDQKTFSICKERMRPVKAALKQLDRPEK
                     GLSEREQLEHTRQCLIKIGDHITECLKEYTNPEQIKQWRKNLWIFVSKFTEFDARKLH
                     KLYKHAIKKRQESQQNSDQNSNLNPHVIRNPDVERLKENTNHDDSSRDSYSSDRHLTQ
                     YHDHHKDRHQGDSYKKSDSRKRPYSSFSNGKDHRDWDHYKQDSRYYSDREKHRKLDDH
                     RSRDHRSNLEGSLKDRSHSDHRSHSDHRLHSDHRSSSEYTHHKSSRDYRYHSDWQMDH
                     RASSSGPRSPLDQRSPYGSRSPFEHSVEHKSTPEHTWSSRKT"
     exon            671..872
                     /gene="CHD1"
                     /gene_synonym="CHD-1; PILBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            873..989
                     /gene="CHD1"
                     /gene_synonym="CHD-1; PILBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1054
                     /gene="CHD1"
                     /gene_synonym="CHD-1; PILBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1204
                     /gene="CHD1"
                     /gene_synonym="CHD-1; PILBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1476
                     /gene="CHD1"
                     /gene_synonym="CHD-1; PILBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            1477..1702
                     /gene="CHD1"
                     /gene_synonym="CHD-1; PILBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            1703..1803
                     /gene="CHD1"
                     /gene_synonym="CHD-1; PILBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..1982
                     /gene="CHD1"
                     /gene_synonym="CHD-1; PILBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            1983..2110
                     /gene="CHD1"
                     /gene_synonym="CHD-1; PILBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            2111..2327
                     /gene="CHD1"
                     /gene_synonym="CHD-1; PILBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            2328..2417
                     /gene="CHD1"
                     /gene_synonym="CHD-1; PILBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            2418..2608
                     /gene="CHD1"
                     /gene_synonym="CHD-1; PILBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            2609..2797
                     /gene="CHD1"
                     /gene_synonym="CHD-1; PILBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            2798..2960
                     /gene="CHD1"
                     /gene_synonym="CHD-1; PILBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            2961..3113
                     /gene="CHD1"
                     /gene_synonym="CHD-1; PILBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            3114..3185
                     /gene="CHD1"
                     /gene_synonym="CHD-1; PILBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            3186..3335
                     /gene="CHD1"
                     /gene_synonym="CHD-1; PILBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            3336..3484
                     /gene="CHD1"
                     /gene_synonym="CHD-1; PILBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            3485..3581
                     /gene="CHD1"
                     /gene_synonym="CHD-1; PILBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            3582..3677
                     /gene="CHD1"
                     /gene_synonym="CHD-1; PILBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            3678..3854
                     /gene="CHD1"
                     /gene_synonym="CHD-1; PILBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            3855..4015
                     /gene="CHD1"
                     /gene_synonym="CHD-1; PILBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            4016..4057
                     /gene="CHD1"
                     /gene_synonym="CHD-1; PILBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            4058..4188
                     /gene="CHD1"
                     /gene_synonym="CHD-1; PILBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            4189..4327
                     /gene="CHD1"
                     /gene_synonym="CHD-1; PILBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            4328..4478
                     /gene="CHD1"
                     /gene_synonym="CHD-1; PILBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            4479..4595
                     /gene="CHD1"
                     /gene_synonym="CHD-1; PILBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            4596..4724
                     /gene="CHD1"
                     /gene_synonym="CHD-1; PILBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            4725..4865
                     /gene="CHD1"
                     /gene_synonym="CHD-1; PILBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            4866..5044
                     /gene="CHD1"
                     /gene_synonym="CHD-1; PILBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            5045..5141
                     /gene="CHD1"
                     /gene_synonym="CHD-1; PILBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            5142..5193
                     /gene="CHD1"
                     /gene_synonym="CHD-1; PILBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            5194..5404
                     /gene="CHD1"
                     /gene_synonym="CHD-1; PILBOS"
                     /inference="alignment:Splign:2.1.0"
     exon            5405..8145
                     /gene="CHD1"
                     /gene_synonym="CHD-1; PILBOS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6366..6371
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CHD1"
                     /gene_synonym="CHD-1; PILBOS"
                     /note="hexamer: ATTAAA"
     polyA_site      6384
                     /gene="CHD1"
                     /gene_synonym="CHD-1; PILBOS"
     regulatory      6907..6912
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CHD1"
                     /gene_synonym="CHD-1; PILBOS"
                     /note="hexamer: ATTAAA"
     polyA_site      6926
                     /gene="CHD1"
                     /gene_synonym="CHD-1; PILBOS"
                     /note="major polyA site"
     regulatory      8129..8134
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CHD1"
                     /gene_synonym="CHD-1; PILBOS"
                     /note="hexamer: AATAAT"
     polyA_site      8145
                     /gene="CHD1"
                     /gene_synonym="CHD-1; PILBOS"
ORIGIN      
        1 gcctcgcgct ctgtcgggaa ggggagtgag cagaggcgct tacgtcgcgc gggaggcgga
       61 ggcgacggcg acctcggtgg cggcggcggc tacgacggag acggttgcgc tcgcttgctt
      121 tctcggcgtc atggcggctg ccgggggcag ataagcggag ggagcgggag cgcgcgcgcg
      181 acggcggcgg cggcggcggc gacgactggt tacttatagc tcttgctgcc ctcgcccttg
      241 gtgcttcaat aatgaattgt tagctccact ccgcagggga tcgcgcgttg gtgctgcgga
      301 ccggggcttc cccttcccct ccgcgtctgt ccccttcccc ctcccccgca cggactcttg
      361 cttaccccga gacgccggag ccctaggact gggcggcgga gatcccgggc ctgggcgcgg
      421 gggaggccgt ccacccgagt cggctccctc cgccccgcca agcccgccgg tgaatcaaag
      481 gagagtccca gaaaacctgt gactgttgaa gaaaattcat ctgtgaattt ttatattcaa
      541 ggagtcagta tttatattca tcttttaaac tgggaagatt tatattttac tttaaaactt
      601 cttgataata atttacaatg aatggacaca gtgatgaaga aagtgttaga aacagtagtg
      661 gagaatcaag ccagtcggat gatgattctg ggtcagcttc aggctctgga tctggttcga
      721 gttctggaag cagtagtgat ggaagcagta gccagtcagg tagcagtgac tctgactccg
      781 gatctgaatc aggcagtcag tcagagtctg agtcagacac ttcccgagaa aacaaagttc
      841 aagcaaaacc accgaaagtt gatggagctg agttttggaa atctagtcct agtattctgg
      901 ccgttcagag atctgcaatc ctcaagaagc agcaacagca gcagcagcaa caacaacatc
      961 aagcctcatc taatagcgga tcagaagagg attcctctag cagtgaagat tccgatgact
     1021 catcaagtga ggtcaaaagg aaaaagcata aagatgaaga ttggcaaatg tctgggtcag
     1081 gatctccatc tcagtctggt tcagattcag aatctgaaga agagagagag aaaagcagtt
     1141 gtgatgaaac agaatctgat tatgagccaa aaaacaaagt caaaagcaga aaacctcaaa
     1201 atagatctaa gtcaaaaaat ggaaagaaga ttcttggaca aaaaaagaga cagattgatt
     1261 catctgagga ggatgatgat gaagaagatt atgataatga taaaagaagt tctcgtcgcc
     1321 aagcaactgt taatgttagc tataaggagg atgaagaaat gaaaacagat tctgatgacc
     1381 tactggaagt ctgtggagag gatgttcctc aacctgagga agaggaattt gaaaccatag
     1441 aaagatttat ggattgtcgg attgggagaa aaggagctac tggtgctact acaaccatct
     1501 atgcagttga agcagatggt gacccaaatg caggctttga aaaaaacaaa gaaccaggag
     1561 agattcagta tttaattaaa tggaaaggat ggtcccatat ccacaacact tgggagacag
     1621 aagaaaccct caagcagcag aatgttagag gaatgaaaaa attggataat tataagaaaa
     1681 aagatcagga aacaaaaaga tggttgaaaa atgcctctcc agaagatgtg gaatattata
     1741 attgccagca agaacttaca gatgatctac ataaacagta tcaaatagtg gaacgtataa
     1801 ttgctcattc caatcaaaag tcagcagctg gttatcctga ttattactgc aaatggcagg
     1861 gccttccata ctcagagtgc agctgggaag atggagctct catttccaaa aagtttcaag
     1921 catgcattga tgagtatttt agcaggaacc aatcaaaaac cactcctttt aaagattgca
     1981 aagtattaaa acaaaggcca aggtttgtag ccctgaagaa gcagccatcc tatattggag
     2041 gacatgaggg cttagaatta agagattatc aactgaatgg tttaaattgg cttgctcatt
     2101 cttggtgcaa aggaaatagt tgcatactcg ctgatgaaat gggccttgga aaaacaatac
     2161 agacgatctc atttctgaat tatttgtttc atgaacatca attatatgga ccttttttat
     2221 tggtagtacc gctctccact cttacttcct ggcaaaggga aattcagact tgggcttctc
     2281 aaatgaatgc tgtggtttat ttaggtgaca ttaacagcag aaacatgata agaactcatg
     2341 aatggacgca tcatcagacc aaacggttaa aatttaatat attgttaaca acttatgaaa
     2401 ttttattaaa agataaggca ttccttggag gtctaaattg ggcatttata ggtgttgatg
     2461 aagcacaccg attaaagaat gatgactccc ttctgtataa aactttaata gattttaaat
     2521 ccaatcatcg tctccttatc actggaactc ctctacagaa ttccctcaaa gagctctggt
     2581 ctttgctaca tttcattatg ccagaaaagt tttcttcctg ggaagatttt gaagaagaac
     2641 atggcaaagg gagagaatat ggttatgcaa gccttcacaa ggagcttgag ccatttctgt
     2701 tacgccgagt taagaaagat gtggaaaaat ctcttcctgc caaggttgag cagattttaa
     2761 gaatggaaat gagtgcttta cagaaacaat attacaaatg gattttaact aggaattaca
     2821 aagccctcag caaaggttcc aagggcagta cctcaggctt tttgaacatt atgatggagc
     2881 taaagaaatg ttgtaaccat tgctacctca ttaaaccacc agataataat gaattctata
     2941 ataaacagga ggccttacaa cacttaattc gtagtagcgg aaaattgatt cttcttgaca
     3001 agctattaat tcgcctaaga gaacgaggca atcgagttct tattttttca caaatggtgc
     3061 ggatgttaga tatacttgca gaatatttga aatatcgtca attccccttt caaagattag
     3121 atggatcaat aaaaggagaa ctgaggaaac aagctctaga tcattttaat gctgagggat
     3181 cagaggattt ttgctttttg ctgtccacaa gagctggagg tctagggatt aatttagcct
     3241 ctgctgacac tgttgttata tttgattccg attggaatcc acagaatgat cttcaggcac
     3301 aggctagagc ccatcgaatt gggcaaaaga aacaggtgaa tatttatcgt ctagttacaa
     3361 agggatcagt tgaagaagat attcttgaaa gggcgaaaaa gaagatggtt ttagatcatc
     3421 ttgtaattca aagaatggac acaactggga agacagtact acatacaggt tctgccccat
     3481 caagttctac tcctttcaat aaagaagagt tatcagccat tttaaagttt ggtgctgaag
     3541 aactttttaa ggaacctgaa ggagaagaac aagagcccca ggaaatggat atagatgaaa
     3601 tcttgaagag agctgaaact catgaaaatg aaccaggtcc tttaactgta ggagatgaat
     3661 tgctttccca gttcaaggtt gccaacttct caaatatgga tgaggatgac attgagttgg
     3721 aacctgaaag aaattcaaag aattgggagg aaattattcc agaagatcaa agaagacgat
     3781 tagaagaaga agaaagacaa aaggaacttg aagaaattta tatgctccca agaatgagaa
     3841 attgtgcaaa acagattagt ttcaatggaa gtgaagggag gcgcagtaga agtaggagat
     3901 actctggatc tgatagtgat tccatctcag aagggaaaag gccaaagaaa cgtggaagac
     3961 cacggactat tcctcgggag aatattaaag gatttagtga tgcagaaatt aggcggttta
     4021 tcaagagcta taagaaattt ggtggtcctc tggaaagatt agatgcaatt gctcgagatg
     4081 ctgagttagt tgataagtca gaaacagacc ttagacgact gggagaattg gtacataatg
     4141 gttgcattaa agcattaaag gatagttctt caggaacaga acgaacaggt ggtagactcg
     4201 gaaaagtgaa gggtccaaca ttccgaatat caggagtaca ggtgaatgcc aaactagtca
     4261 tctcccatga agaagaatta atacctttgc acaaatccat tccttctgat ccagaagaaa
     4321 gaaagcagta tactatccca tgccacacaa aggcagctca ttttgatata gactggggca
     4381 aagaagatga ttccaatttg ttaattggca tctatgaata tggatatgga agctgggaaa
     4441 tgattaaaat ggatcctgac ctcagtctaa cacacaagat tcttccagat gatcccgata
     4501 aaaaaccaca agcaaaacag ttgcagaccc gtgcagacta cctcatcaaa ttacttagta
     4561 gagatcttgc aaaaaaagaa gctctttctg gtgcgggaag ttcaaagagg agaaaagcaa
     4621 gagctaagaa gaataaagca atgaagtcta taaaagtgaa agaggaaata aagagtgatt
     4681 cttctcctct gccttcagag aagtctgatg aagatgatga taaattgagt gaatccaagt
     4741 ctgatggtag ggaaagatcc aagaaatctt cagtgtcaga tgctccagtt catatcacgg
     4801 caagtggtga accagttccc atttctgaag aatctgaaga gctggatcag aagacattca
     4861 gcatttgtaa agaaagaatg aggcctgtta aagcagcttt gaaacaactt gataggcctg
     4921 agaaaggcct ttcagaaaga gaacaactag agcatactag acaatgttta ataaaaattg
     4981 gagaccatat cacagaatgt ctaaaagagt atacaaatcc tgaacaaatt aagcaatgga
     5041 gaaaaaacct gtggattttt gtatctaagt ttactgaatt tgatgcaaga aaattacata
     5101 aattatataa gcatgctatt aaaaaacggc aggagtctca gcaaaacagt gatcaaaaca
     5161 gcaacttgaa tcctcacgtg attagaaatc cagatgtgga aagattaaaa gagaatacaa
     5221 atcacgatga tagcagcagg gacagttatt cctctgatag acacttaact cagtaccatg
     5281 atcatcataa agaccgacat cagggagatt cttacaaaaa aagtgattcc aggaaaagac
     5341 cctattcttc ttttagtaat ggtaaagacc atcgtgattg ggatcactac aagcaagaca
     5401 gcagatatta cagtgacaga gagaaacaca gaaaactgga tgatcacagg agtagagatc
     5461 acaggtcaaa tttggaagga agtttaaaag atagatctca ttctgatcat cgttctcact
     5521 cagatcatcg gttacattca gaccaccggt caagttctga atatacgcac cataaatctt
     5581 ccagggatta taggtatcac tcagactggc aaatggacca cagagcttcc agcagtggcc
     5641 ctaggtcacc actagatcag agatctcctt atggctccag atctccattt gaacattcag
     5701 ttgaacacaa aagtacaccg gagcatacct ggagtagtcg gaaaacataa caaaaactga
     5761 tacttcgtct ttctggactt ttcttttagc catatatcat aaaccaacac agtaattgcc
     5821 ttacatgact tgaaagatat aaacagatct tctatcagta gcagtattgt tacttctttc
     5881 caggatgcaa ggtctattat cccaacagaa gagaaaatat ttttatattt aaggattatg
     5941 ctgcactgta ctacaaaatt gtagtacttt tttttgtttt cttttttaaa gaaatggaaa
     6001 atgtttacta ttacagggac ctcaacactg ccctcccata caggctggat aaaactgttt
     6061 ttaagtcagt gattttagac tgacctccat ttaaattatg tttatatatg aactttactc
     6121 tgacctgtga tcatgtttca ggaaggaatg aaagagagtt ctttcttaat aaagaaaaac
     6181 actcaaggac tttgttcatt tccaaagcta cttgtttaca ttgtacactg cgaccacctt
     6241 gccgcttttc atcacaagct tgaatattta aattctgtac ttatatctgt aaaatagcca
     6301 ggaatttcct gtttgtgatc tattatgcct ttttacaaaa aaaatggctg taaattattg
     6361 taaatattaa aggaactttc cttacttcct tccctttctc aggctttttt tgactgttcc
     6421 tttccctacc aactcaggcc ttcttattaa aaaaaaaaaa atcagtgtaa taacactttt
     6481 taatgatttg tcttgatgga atcattgttt agaatgtaaa aatggggaaa ggggccactt
     6541 aattccatta gtcctctttt tatactgaat attttattag atacatgtta ttcccttttt
     6601 tttccttttt tagtcaatat tgtgtttgta gttttaaaaa atggcgagat atgtaaaatc
     6661 taaactgcat gctctggaaa cacttttttc agatgcatct ggtttaaaag ggtaggtgta
     6721 taaacacttt tcagaatcca aaacggccaa aagttattgt aaatccgttt gttttcccgt
     6781 tttatgtggg caataatgtc aaatgtgcta tgcagccagg ttaacatttt agataaactt
     6841 gattgacttt taatataaac tgttacaatg cacactgatt gtatataaaa acgttatata
     6901 tgacaaatta aatttaagaa aaaggatatg tgggctcctg taattttctg ctgcattctt
     6961 actccctcaa gcacttacca ccaccaccac cgccccctac ccccgttttt aagtaacatt
     7021 ttgctgccag aaaaagtatt ttggtaagca gttgaatatt tgtaatgtgt agcattacaa
     7081 ctaaatctgt tttggagact atgaatattc ctatgaagta aaacttaggt catagacatt
     7141 tttgttggcc ccttttggct tcctacagat attattatgg gatgctttat atttattcac
     7201 agatttttat tttgttttat attcagcggg aagtttttaa gtcatgtggc acacattctt
     7261 gcatgtatgc tttgatgtaa caaatttgaa tctttgacga atataagtat gtggacataa
     7321 tttctatagt attgctatgt gtgtcactgt taattagctg tgggagcaac ctacagatat
     7381 ttgtccatag gtgtattttt taatattttc ctttgtccaa ttaggtttat gtgtataaaa
     7441 gcttgtgggt ttttttgctt tttgttttgt tttttgcagt aatttctctt tctgatacag
     7501 ttaccctgaa gaataataat gctttgtttc ttttctggta tatgagagaa catgtgaggg
     7561 agtagctcag ttttttaaac atctaattta taattaaata taaaagtaat gaaggtagtc
     7621 ctggcacaca tttttgaaac ttttatcact tttctctaca tttagtatga ctattttatt
     7681 ccacaagata gcatttgact aattcataat gcttaagtca taagatggtg gctggcattt
     7741 tttaatttat tactaaaagc taagatattt gcattatatt gtgcaaattt cacagaacaa
     7801 tgttgcattt tctgagataa ggctctaatt ttttaaatag tgctacattt agttgaaagt
     7861 ttcagtcagc tagttagctg agttgaatga aaaatataga actgtatgta catttatcaa
     7921 atgataaaat atgttcattt ttgtaagaaa tcagaaaaat taagacgcaa tggtgaagaa
     7981 cattagtaca taaatatagc agaacattct ccataaaata ttctgttttc attctgcttt
     8041 gttattttta tccagttatg tttaattttt caagggtgag agattatgta tagtactgta
     8101 ccaattaacc ttccactttt atacaataaa taattcttac taaaa
//
