LOCUS       NM_203298                850 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens coiled-coil-helix-coiled-coil-helix domain containing
            1 (CHCHD1), mRNA.
ACCESSION   NM_203298
VERSION     NM_203298.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 850)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 850)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 850)
  AUTHORS   Floyd,B.J., Wilkerson,E.M., Veling,M.T., Minogue,C.E., Xia,C.,
            Beebe,E.T., Wrobel,R.L., Cho,H., Kremer,L.S., Alston,C.L.,
            Gromek,K.A., Dolan,B.K., Ulbrich,A., Stefely,J.A., Bohl,S.L.,
            Werner,K.M., Jochem,A., Westphall,M.S., Rensvold,J.W., Taylor,R.W.,
            Prokisch,H., Kim,J.P., Coon,J.J. and Pagliarini,D.J.
  TITLE     Mitochondrial Protein Interaction Mapping Identifies Regulators of
            Respiratory Chain Function
  JOURNAL   Mol Cell 63 (4), 621-632 (2016)
   PUBMED   27499296
REFERENCE   4  (bases 1 to 850)
  AUTHORS   Greber,B.J. and Ban,N.
  TITLE     Structure and Function of the Mitochondrial Ribosome
  JOURNAL   Annu Rev Biochem 85, 103-132 (2016)
   PUBMED   27023846
  REMARK    Review article
REFERENCE   5  (bases 1 to 850)
  AUTHORS   Amunts,A., Brown,A., Toots,J., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Ribosome. The structure of the human mitochondrial ribosome
  JOURNAL   Science 348 (6230), 95-98 (2015)
   PUBMED   25838379
REFERENCE   6  (bases 1 to 850)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   7  (bases 1 to 850)
  AUTHORS   Jager,S., Cimermancic,P., Gulbahce,N., Johnson,J.R., McGovern,K.E.,
            Clarke,S.C., Shales,M., Mercenne,G., Pache,L., Li,K., Hernandez,H.,
            Jang,G.M., Roth,S.L., Akiva,E., Marlett,J., Stephens,M., D'Orso,I.,
            Fernandes,J., Fahey,M., Mahon,C., O'Donoghue,A.J., Todorovic,A.,
            Morris,J.H., Maltby,D.A., Alber,T., Cagney,G., Bushman,F.D.,
            Young,J.A., Chanda,S.K., Sundquist,W.I., Kortemme,T.,
            Hernandez,R.D., Craik,C.S., Burlingame,A., Sali,A., Frankel,A.D.
            and Krogan,N.J.
  TITLE     Global landscape of HIV-human protein complexes
  JOURNAL   Nature 481 (7381), 365-370 (2011)
   PUBMED   22190034
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 850)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 850)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   10 (bases 1 to 850)
  AUTHORS   Westerman,B.A., Poutsma,A., Steegers,E.A. and Oudejans,C.B.
  TITLE     C2360, a nuclear protein expressed in human proliferative
            cytotrophoblasts, is a representative member of a novel protein
            family with a conserved coiled coil-helix-coiled coil-helix domain
  JOURNAL   Genomics 83 (6), 1094-1104 (2004)
   PUBMED   15177562
  REMARK    GeneRIF: C2360, a nuclear protein expressed in cytotrophoblasts, is
            a representative member of a multifamily of proteins, sharing a
            protein domain that is conserved in eukaryotes.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC022400.9, BM787401.1 and BC020852.1.
            
            On Nov 22, 2018 this sequence version replaced NM_203298.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279835.10596.1,
                                           SRR1803614.228437.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372833.6/ ENSP00000361923.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC022400.9         114759-114760
            3-15                BM787401.1         2-14
            16-562              BC020852.1         1-547
            563-850             AC022400.9         116076-116363
FEATURES             Location/Qualifiers
     source          1..850
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q22.2"
     gene            1..850
                     /gene="CHCHD1"
                     /gene_synonym="C10orf34; C2360; MRP-S37; mS37"
                     /note="coiled-coil-helix-coiled-coil-helix domain
                     containing 1"
                     /db_xref="GeneID:118487"
                     /db_xref="HGNC:HGNC:23518"
                     /db_xref="MIM:608842"
     exon            1..152
                     /gene="CHCHD1"
                     /gene_synonym="C10orf34; C2360; MRP-S37; mS37"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..385
                     /gene="CHCHD1"
                     /gene_synonym="C10orf34; C2360; MRP-S37; mS37"
                     /note="coiled-coil-helix-coiled-coil-helix
                     domain-containing protein 1; nuclear protein C2360; 28S
                     ribosomal protein S37, mitochondrial; mitochondrial small
                     ribosomal subunit protein mS37"
                     /codon_start=1
                     /product="small ribosomal subunit protein mS37"
                     /protein_id="NP_976043.1"
                     /db_xref="CCDS:CCDS7334.1"
                     /db_xref="GeneID:118487"
                     /db_xref="HGNC:HGNC:23518"
                     /db_xref="MIM:608842"
                     /translation="MATPSLRGRLARFGNPRKPVLKPNKPLILANRVGERRREKGEAT
                     CITEMSVMMACWKQNEFRDDACRKEIQGFLDCAARAQEARKMRSIQETLGESGSLLPN
                     KLNKLLQRFPNKPYLS"
     exon            153..271
                     /gene="CHCHD1"
                     /gene_synonym="C10orf34; C2360; MRP-S37; mS37"
                     /inference="alignment:Splign:2.1.0"
     exon            272..850
                     /gene="CHCHD1"
                     /gene_synonym="C10orf34; C2360; MRP-S37; mS37"
                     /inference="alignment:Splign:2.1.0"
     regulatory      551..556
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CHCHD1"
                     /gene_synonym="C10orf34; C2360; MRP-S37; mS37"
                     /note="hexamer: AATAAA"
     polyA_site      571
                     /gene="CHCHD1"
                     /gene_synonym="C10orf34; C2360; MRP-S37; mS37"
                     /note="major polyA site"
     regulatory      825..830
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CHCHD1"
                     /gene_synonym="C10orf34; C2360; MRP-S37; mS37"
                     /note="hexamer: AATAAA"
     polyA_site      850
                     /gene="CHCHD1"
                     /gene_synonym="C10orf34; C2360; MRP-S37; mS37"
ORIGIN      
        1 gcaaagcctg ccgggagctt ggtgcgctat ggcgacaccc agcctgcggg gtcgtctggc
       61 gcggtttggg aacccgcgga agcctgtgct gaagcccaat aaacctctca ttctagctaa
      121 ccgcgtcggg gagcggcgcc gggagaaggg cgaggcgact tgcatcacgg agatgtcggt
      181 gatgatggct tgctggaagc agaatgaatt ccgcgacgat gcgtgcagaa aagagatcca
      241 gggcttcctc gattgtgccg cgagggctca ggaagcccga aagatgagat caatacagga
      301 aaccctggga gagtctggga gtttacttcc aaataaattg aataagttgt tacagaggtt
      361 tcctaacaaa ccttacctca gctgaaaatg gacaagtatt ttcaatgact gaaatatagc
      421 ttctgacaac tatgcagagg cattttagag acattggcat tgccatgccc tctttggagg
      481 gtagaagagg caaaacactt ttttcaccct ttggaatcat agtatgggta gaagttatga
      541 tttatcttga aataaaatcc tctgaacaga acttggcctt ttgttgtgaa ttaggtactc
      601 tcttcattct tgagcctccc ctagaccctg gaaattcttt ccttcctgat ttgccctagg
      661 agcaggacaa ataccgttgt attgtctttc cctgcatttg aagtctttta caccatttag
      721 tgcccttgct tttggatgca ataaggaagt tgaagttgcc ttcgtctgta aatacttagt
      781 gattgcctat tttgtgcgta gtccctgcaa ggtgctctct gaataataaa gttaacaaac
      841 tggtgaccta
//
