LOCUS       NM_138481               2530 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens chondroadherin like (CHADL), mRNA.
ACCESSION   NM_138481
VERSION     NM_138481.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2530)
  AUTHORS   Styrkarsdottir,U., Helgason,H., Sigurdsson,A., Norddahl,G.L.,
            Agustsdottir,A.B., Reynard,L.N., Villalvilla,A., Halldorsson,G.H.,
            Jonasdottir,A., Magnusdottir,A., Oddson,A., Sulem,G., Zink,F.,
            Sveinbjornsson,G., Helgason,A., Johannsdottir,H.S., Helgadottir,A.,
            Stefansson,H., Gretarsdottir,S., Rafnar,T., Almdahl,I.S.,
            Braekhus,A., Fladby,T., Selbaek,G., Hosseinpanah,F., Azizi,F.,
            Koh,J.M., Tang,N.L.S., Daneshpour,M.S., Mayordomo,J.I., Welt,C.,
            Braund,P.S., Samani,N.J., Kiemeney,L.A., Lohmander,L.S.,
            Christiansen,C., Andreassen,O.A., Magnusson,O., Masson,G., Kong,A.,
            Jonsdottir,I., Gudbjartsson,D., Sulem,P., Jonsson,H., Loughlin,J.,
            Ingvarsson,T., Thorsteinsdottir,U. and Stefansson,K.
  CONSRTM   arcOGEN consortium
  TITLE     Whole-genome sequencing identifies rare genotypes in COMP and CHADL
            associated with high risk of hip osteoarthritis
  JOURNAL   Nat Genet 49 (5), 801-805 (2017)
   PUBMED   28319091
  REMARK    GeneRIF: Data show that a rare missense variant in the COMP gene
            (cartilage oligomeric matrix protein) and a frameshift variant in
            the CHADL gene (chondroadherin-like protein) strongly associate
            with osteoarthritis total hip replacement.
            Erratum:[Nat Genet. 2017 Jul 27;49(8):1286. doi:
            10.1038/ng0817-1286b.. PMID: 28747754]
REFERENCE   2  (bases 1 to 2530)
  AUTHORS   Tillgren,V., Ho,J.C., Onnerfjord,P. and Kalamajski,S.
  TITLE     The novel small leucine-rich protein chondroadherin-like (CHADL) is
            expressed in cartilage and modulates chondrocyte differentiation
  JOURNAL   J Biol Chem 290 (2), 918-925 (2015)
   PUBMED   25451920
  REMARK    GeneRIF: CHADL appears to have a negative regulatory role, possibly
            ensuring the formation of a stable extracellular matrix.
REFERENCE   3  (bases 1 to 2530)
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium
  TITLE     Biological insights from 108 schizophrenia-associated genetic loci
  JOURNAL   Nature 511 (7510), 421-427 (2014)
   PUBMED   25056061
REFERENCE   4  (bases 1 to 2530)
  AUTHORS   Barallobre-Barreiro,J., Didangelos,A., Schoendube,F.A., Drozdov,I.,
            Yin,X., Fernandez-Caggiano,M., Willeit,P., Puntmann,V.O.,
            Aldama-Lopez,G., Shah,A.M., Domenech,N. and Mayr,M.
  TITLE     Proteomics analysis of cardiac extracellular matrix remodeling in a
            porcine model of ischemia/reperfusion injury
  JOURNAL   Circulation 125 (6), 789-802 (2012)
   PUBMED   22261194
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL035681.13.
            
            On Nov 22, 2018 this sequence version replaced NM_138481.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC068590.1, SRR14038196.3060878.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2157437, SAMEA2162841
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000216241.14/ ENSP00000216241.9
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                AL035681.13        34300-34357         c
            59-236              AL035681.13        32869-33046         c
            237-1946            AL035681.13        30602-32311         c
            1947-2113           AL035681.13        29910-30076         c
            2114-2312           AL035681.13        28571-28769         c
            2313-2530           AL035681.13        22939-23156         c
FEATURES             Location/Qualifiers
     source          1..2530
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.2"
     gene            1..2530
                     /gene="CHADL"
                     /gene_synonym="SLRR4B"
                     /note="chondroadherin like"
                     /db_xref="GeneID:150356"
                     /db_xref="HGNC:HGNC:25165"
                     /db_xref="MIM:616236"
     exon            1..58
                     /gene="CHADL"
                     /gene_synonym="SLRR4B"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..2339
                     /gene="CHADL"
                     /gene_synonym="SLRR4B"
                     /note="chondroadherin-like protein"
                     /codon_start=1
                     /product="chondroadherin-like protein precursor"
                     /protein_id="NP_612490.1"
                     /db_xref="CCDS:CCDS46715.1"
                     /db_xref="GeneID:150356"
                     /db_xref="HGNC:HGNC:25165"
                     /db_xref="MIM:616236"
                     /translation="MEGPRSSTHVPLVLPLLVLLLLAPARQAAAQRCPQACICDNSRR
                     HVACRYQNLTEVPDAIPELTQRLDLQGNLLKVIPAAAFQGVPHLTHLDLRHCEVELVA
                     EGAFRGLGRLLLLNLASNHLRELPQEALDGLGSLRRLELEGNALEELRPGTFGALGAL
                     ATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNALSVLAPEALAGLPALRRLSLHHNEL
                     QALPGPVLSQARGLARLELGHNPLTYAGEEDGLALPGLRELLLDGGALQALGPRAFAH
                     CPRLHTLDLRGNQLDTLPPLQGPGQLRRLRLQGNPLWCGCQARPLLEWLARARVRSDG
                     ACQGPRRLRGEALDALRPWDLRCPGDAAQEEEELEERAVAGPRAPPRGPPRGPGEERA
                     VAPCPRACVCVPESRHSSCEGCGLQAVPRGFPSDTQLLDLRRNHFPSVPRAAFPGLGH
                     LVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAALEGAPRLGYLYLERNR
                     FLQVPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGALG
                     PARELEKLHLDRNQLREVPTGALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQHLF
                     LNSSGLEQICPGAFSGLGPGLQSLHLQKNQLRALPALPSLSQLELIDLSSNPFHCDCQ
                     LLPLHRWLTGLNLRVGATCATPPNARGQRVKAAAAVFEDCPGWAARKAKRTPASRPSA
                     RRTPIKGRQCGADKVGKEKGRL"
     exon            59..236
                     /gene="CHADL"
                     /gene_synonym="SLRR4B"
                     /inference="alignment:Splign:2.1.0"
     exon            237..1946
                     /gene="CHADL"
                     /gene_synonym="SLRR4B"
                     /inference="alignment:Splign:2.1.0"
     exon            1947..2113
                     /gene="CHADL"
                     /gene_synonym="SLRR4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2114..2312
                     /gene="CHADL"
                     /gene_synonym="SLRR4B"
                     /inference="alignment:Splign:2.1.0"
     exon            2313..2530
                     /gene="CHADL"
                     /gene_synonym="SLRR4B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2509..2514
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CHADL"
                     /gene_synonym="SLRR4B"
                     /note="hexamer: AATAAA"
     polyA_site      2530
                     /gene="CHADL"
                     /gene_synonym="SLRR4B"
                     /note="major polyA site"
ORIGIN      
        1 agcctgtccc tgcgctgcgc ctccaggctg gaccagcagt tccaggcggc atggaggggc
       61 cccggagctc cacccatgtc cccttggtgc tgccgcttct tgtacttctg ctgctggccc
      121 cggctaggca ggccgccgcc cagcgctgcc cacaggcctg catctgtgac aactccaggc
      181 gacacgttgc ctgccggtac cagaacctca ctgaggtgcc agacgccatc cctgagctga
      241 cccagcggct ggacctgcag ggcaatttgc tgaaggtgat ccccgcagcc gccttccagg
      301 gcgtgcctca cctcacacac ctggacctgc gccactgcga ggtggagctg gtggccgagg
      361 gcgccttccg tggcctgggc cgcctgctcc tgctcaacct ggcctccaac cacctgcgtg
      421 agctgcccca ggaggcgctg gacgggctgg gctcgttgcg gcggctggag ctggagggga
      481 acgcactgga ggagctgcgg ccggggacgt tcggggcact gggtgcgctg gccacgctaa
      541 acctggccca caacgccctg gtttacctgc ccgccatggc cttccagggg ctactgcgcg
      601 tccgctggct gcggctgtcg cacaacgcgc tcagcgtgct ggcccccgag gccctggctg
      661 gcctgcccgc cctgagacgg ctcagcctac accacaacga gctccaggct ctgcccgggc
      721 ctgtcttgtc ccaggcccgc ggcctggccc gtctggagct gggccacaac ccgctcacct
      781 acgcgggcga ggaggacggg ctggcgctgc ccggcctgcg ggagctgctg ctggacggcg
      841 gggccctgca ggccctgggt cccagggcct tcgcacactg tccgcgcctg cacaccctcg
      901 acctccgcgg gaaccagcta gacaccctgc ccccgctgca gggcccgggc cagctgcgcc
      961 ggctgcggct gcaggggaat ccgctgtggt gcggctgcca ggcgcggccc ctactcgagt
     1021 ggctggcgcg ggcgcgcgtg cgctcggacg gcgcgtgcca ggggccgcgg cgcctgcggg
     1081 gcgaggctct ggacgccctg cggccctggg acctgcgctg ccctggggac gcggcgcagg
     1141 aagaggaaga gctggaagag cgggctgtgg ccgggccccg cgcccctccg cgcggccctc
     1201 cgcgcggccc cggggaggag cgggcagtcg cgccttgccc tcgcgcctgc gtgtgcgtcc
     1261 ccgagtcccg gcacagcagc tgcgagggct gcggcctgca ggcggtgccc cgcggcttcc
     1321 ccagcgacac ccagctcctg gacctgaggc ggaaccactt cccctcggtg ccccgagcgg
     1381 ccttccccgg cctgggccac ctggtgtcgc tgcacctgca gcactgcggc atcgcggagc
     1441 tggaagcggg cgccctggcc gggctgggcc gcctgatcta cctgtacctc tccgacaacc
     1501 agctcgcagg cctcagcgct gctgcccttg aaggggctcc ccgcctcggc tacctgtacc
     1561 tagaacgcaa ccgtttcctg caggtgccag gggctgccct gcgcgccctg cccagcctct
     1621 tctccctgca cctgcaggac aacgctgtgg accgcctggc acctggggac ctggggagaa
     1681 cacgggcctt gcgctgggtc tacctgagtg gaaaccgcat caccgaagtg tcccttgggg
     1741 cgctgggccc agctcgggag ctggagaagc tgcacctgga caggaatcag ctgcgagagg
     1801 tgcccactgg ggccttggag gggctgcctg ccctcctgga gctgcagctc tcgggcaacc
     1861 cactcagggc cttgcgtgac ggagccttcc agcctgtggg caggtcgctg cagcacctct
     1921 tcctgaacag cagtggcctg gagcagattt gtcctggggc cttttcaggc ctggggcccg
     1981 ggctccagag cctgcacctg cagaagaacc agcttcgggc cctgcctgcc ctgcccagtc
     2041 tcagccagct ggagctcatc gacctcagca gcaatccctt ccactgtgac tgccagctgc
     2101 ttccgctgca caggtggctt actgggctga acctgcgggt gggggccacc tgcgccaccc
     2161 ctcccaatgc ccgtggccag agggtgaagg ctgcagctgc tgtctttgaa gactgcccgg
     2221 gctgggctgc cagaaaggcc aagcggacac cagcctccag gcccagtgcc aggagaaccc
     2281 ccatcaaagg aagacagtgt ggagcagata aggtggggaa ggagaagggt cgtctctgag
     2341 cacggagcag gctggtcctg ccttgaccca gcccggtggc tcttactctc gccaggaaca
     2401 ggctccgacg agatcttcct ggcaccctga gggtcgtcct ccagcagggg cttcttggac
     2461 ccctgtctga ggggtcgcgt cttagtgggc gggattcttt tccctttgaa taaaaatgga
     2521 ttcaaaccca
//
