LOCUS       NM_024111               1520 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens ChaC glutathione specific
            gamma-glutamylcyclotransferase 1 (CHAC1), transcript variant 1,
            mRNA.
ACCESSION   NM_024111
VERSION     NM_024111.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1520)
  AUTHORS   Wanbiao,Z., Jing,M., Shi,Z., Tengxiang,C., Xueke,Z. and Haiyang,L.
  TITLE     MIA3 promotes the degradation of GSH (glutathione) by binding to
            CHAC1, thereby promoting the progression of hepatocellular
            carcinoma
  JOURNAL   Mol Cell Biochem 479 (10), 2769-2784 (2024)
   PUBMED   37948019
  REMARK    GeneRIF: MIA3 promotes the degradation of GSH (glutathione) by
            binding to CHAC1, thereby promoting the progression of
            hepatocellular carcinoma.
REFERENCE   2  (bases 1 to 1520)
  AUTHORS   Zhao,J., Shen,J., Mao,L., Yang,T., Liu,J. and Hongbin,S.
  TITLE     Cancer associated fibroblast secreted miR-432-5p targets CHAC1 to
            inhibit ferroptosis and promote acquired chemoresistance in
            prostate cancer
  JOURNAL   Oncogene 43 (27), 2104-2114 (2024)
   PUBMED   38769193
  REMARK    GeneRIF: Cancer associated fibroblast secreted miR-432-5p targets
            CHAC1 to inhibit ferroptosis and promote acquired chemoresistance
            in prostate cancer.
REFERENCE   3  (bases 1 to 1520)
  AUTHORS   Yang,X., Zhang,M., Xia,W., Mai,Z., Ye,Y., Zhao,B. and Song,Y.
  TITLE     CHAC1 promotes cell ferroptosis and enhances radiation sensitivity
            in thyroid carcinoma
  JOURNAL   Neoplasma 70 (6), 777-786 (2023)
   PUBMED   38247333
  REMARK    GeneRIF: CHAC1 promotes cell ferroptosis and enhances radiation
            sensitivity in thyroid carcinoma.
REFERENCE   4  (bases 1 to 1520)
  AUTHORS   Zhou,Z. and Zhang,H.
  TITLE     CHAC1 exacerbates LPS-induced ferroptosis and apoptosis in HK-2
            cells by promoting oxidative stress
  JOURNAL   Allergol Immunopathol (Madr) 51 (2), 99-110 (2023)
   PUBMED   36916093
  REMARK    GeneRIF: CHAC1 exacerbates LPS-induced ferroptosis and apoptosis in
            HK-2 cells by promoting oxidative stress.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1520)
  AUTHORS   Liu,Y., Wu,D., Fu,Q., Hao,S., Gu,Y., Zhao,W., Chen,S., Sheng,F.,
            Xu,Y., Chen,Z. and Yao,K.
  TITLE     CHAC1 as a Novel Contributor of Ferroptosis in Retinal Pigment
            Epithelial Cells with Oxidative Damage
  JOURNAL   Int J Mol Sci 24 (2), 1582 (2023)
   PUBMED   36675091
  REMARK    GeneRIF: CHAC1 as a Novel Contributor of Ferroptosis in Retinal
            Pigment Epithelial Cells with Oxidative Damage.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1520)
  AUTHORS   Chi,Z., Zhang,J., Tokunaga,A., Harraz,M.M., Byrne,S.T., Dolinko,A.,
            Xu,J., Blackshaw,S., Gaiano,N., Dawson,T.M. and Dawson,V.L.
  TITLE     Botch promotes neurogenesis by antagonizing Notch
  JOURNAL   Dev Cell 22 (4), 707-720 (2012)
   PUBMED   22445366
REFERENCE   7  (bases 1 to 1520)
  AUTHORS   Goebel,G., Berger,R., Strasak,A.M., Egle,D., Muller-Holzner,E.,
            Schmidt,S., Rainer,J., Presul,E., Parson,W., Lang,S., Jones,A.,
            Widschwendter,M. and Fiegl,H.
  TITLE     Elevated mRNA expression of CHAC1 splicing variants is associated
            with poor outcome for breast and ovarian cancer patients
  JOURNAL   Br J Cancer 106 (1), 189-198 (2012)
   PUBMED   22108517
  REMARK    GeneRIF: High CHAC1 mRNA expression could be an independent
            indicator for elevated risk of cancer recurrence in breast and
            ovarian cancer
REFERENCE   8  (bases 1 to 1520)
  AUTHORS   Fox,C.S., Liu,Y., White,C.C., Feitosa,M., Smith,A.V.,
            Heard-Costa,N., Lohman,K., Johnson,A.D., Foster,M.C.,
            Greenawalt,D.M., Griffin,P., Ding,J., Newman,A.B., Tylavsky,F.,
            Miljkovic,I., Kritchevsky,S.B., Launer,L., Garcia,M.,
            Eiriksdottir,G., Carr,J.J., Gudnason,V., Harris,T.B., Cupples,L.A.
            and Borecki,I.B.
  CONSRTM   GIANT Consortium; MAGIC Consortium; GLGC Consortium
  TITLE     Genome-wide association for abdominal subcutaneous and visceral
            adipose reveals a novel locus for visceral fat in women
  JOURNAL   PLoS Genet 8 (5), e1002695 (2012)
   PUBMED   22589738
REFERENCE   9  (bases 1 to 1520)
  AUTHORS   Mungrue,I.N., Pagnon,J., Kohannim,O., Gargalovic,P.S. and
            Lusis,A.J.
  TITLE     CHAC1/MGC4504 is a novel proapoptotic component of the unfolded
            protein response, downstream of the ATF4-ATF3-CHOP cascade
  JOURNAL   J Immunol 182 (1), 466-476 (2009)
   PUBMED   19109178
REFERENCE   10 (bases 1 to 1520)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BQ900544.1 and BC001847.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_024111.5.
            
            Summary: This gene encodes a member of the
            gamma-glutamylcyclotransferase family of proteins. The encoded
            protein has been shown to promote neuronal differentiation by
            deglycination of the Notch receptor, which prevents receptor
            maturation and inhibits Notch signaling. This protein may also play
            a role in the unfolded protein response, and in regulation of
            glutathione levels and oxidative balance in the cell. Elevated
            expression of this gene may indicate increased risk of cancer
            recurrence among breast and ovarian cancer patients. [provided by
            RefSeq, Sep 2016].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC019625.1, SRR3476690.196463.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000617768.5/ ENSP00000484644.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                BQ900544.1         34-55
            23-1520             BC001847.2         1-1498
FEATURES             Location/Qualifiers
     source          1..1520
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q15.1"
     gene            1..1520
                     /gene="CHAC1"
                     /note="ChaC glutathione specific
                     gamma-glutamylcyclotransferase 1"
                     /db_xref="GeneID:79094"
                     /db_xref="HGNC:HGNC:28680"
                     /db_xref="MIM:614587"
     exon            1..344
                     /gene="CHAC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..782
                     /gene="CHAC1"
                     /EC_number="4.3.2.7"
                     /note="isoform a is encoded by transcript variant 1; ChaC,
                     cation transport regulator-like 1; botch; blocks Notch
                     protein; gamma-GCT acting on glutathione homolog 1; ChaC,
                     cation transport regulator homolog 1; gamma-GCG 1"
                     /codon_start=1
                     /product="glutathione-specific
                     gamma-glutamylcyclotransferase 1 isoform a"
                     /protein_id="NP_077016.3"
                     /db_xref="CCDS:CCDS10070.3"
                     /db_xref="GeneID:79094"
                     /db_xref="HGNC:HGNC:28680"
                     /db_xref="MIM:614587"
                     /translation="MKQESAAPNTPPTSQSPTPSAQFPRNDGDPQALWIFGYGSLVWR
                     PDFAYSDSRVGFVRGYSRRFWQGDTFHRGSDKMPGRVVTLLEDHEGCTWGVAYQVQGE
                     QVSKALKYLNVREAVLGGYDTKEVTFYPQDAPDQPLKALAYVATPQNPGYLGPAPEEA
                     IATQILACRGFSGHNLEYLLRLADFMQLCGPQAQDEHLAAIVDAVGTMLPCFCPTEQA
                     LALV"
     exon            345..380
                     /gene="CHAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            381..1520
                     /gene="CHAC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1503..1508
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CHAC1"
                     /note="hexamer: CATAAA"
     polyA_site      1520
                     /gene="CHAC1"
                     /note="major polyA site"
ORIGIN      
        1 agctggagct accgagcggt gccaggccag gtgtgtgcgt ccgtcggtct ttccgtgccc
       61 acgccggaga ccagccccgg aggccgcctg ggcctatccc tgtgccaggc accatgaagc
      121 aggagtctgc agccccgaac accccgccca cctcgcagtc ccctacgccg tccgctcagt
      181 tcccccgaaa cgacggcgac cctcaagcgc tgtggatttt cgggtacggc tccctggtgt
      241 ggaggcccga cttcgcctac agcgacagcc gtgtgggctt cgtgcgcggc tacagccgcc
      301 gtttctggca gggagacacc ttccatcggg gcagcgacaa gatgcctggc cgtgtggtga
      361 cgctccttga agatcatgag ggctgcactt ggggcgtggc ataccaagtg caaggggagc
      421 aggtaagcaa ggccctgaag tacctgaatg tgcgagaggc agtgcttggt ggctacgata
      481 ccaaggaggt caccttctat ccccaagatg ctcctgacca accactgaag gcattggcct
      541 atgtggccac cccacagaac cctggttacc tgggccctgc gcctgaagag gccattgcca
      601 cgcagatcct ggcctgccgg ggcttctccg gccacaacct tgaatacttg ctgcgtctgg
      661 cagacttcat gcagctctgt gggcctcagg cgcaggacga gcacctggca gccatcgtgg
      721 acgctgtggg caccatgttg ccctgcttct gccccaccga gcaggctctg gcgctggtgt
      781 gaggggctga gcccctgcgg ggagtgctca tgtggacatc agggccagac acccactcca
      841 gtgcacaaga cagacttgcg accgcttgag cccactgagc agatatggtg ggtggctgga
      901 ggcttctctt tctcagtccc tgcctgtctg ccagcctgca gctctcctgc ttgacactga
      961 cttactactt gaaactttat ttattgcacc atgttggtgt ggtgggcagg tggagggcct
     1021 gccctggaca caggggccct gctgagcagt ggccccatcc tggaacttga ccagattccc
     1081 cccagtgctg ctgctaaccc cacaccaccc aggcctccac ctccccaggg agtctccaag
     1141 agcctcgatc ctctgctcac tcagcccagc catccatagc cctgggaatt ccacctgcca
     1201 aggatcccag caggctggat gagggatagt agggcatgag gagaaggagc cctgtaagga
     1261 ctgaggcccc ggccagccct tctcctccac cagttcccca gagcagagct ggagctgatg
     1321 cctggacaca gctgctgagc ctggcctggg cctcttaccc acttggttgt tttcttgtcc
     1381 ctctgtctgt ctgtctatct acttgtctgt ctgggccact cctgcctgtg tgttggtcta
     1441 ttcctgggaa gctcatcact acaggccctg gcaaccttcc cagtctgtcc catactgtta
     1501 cccataaaac tatctcttta
//
