LOCUS       NM_003956               1689 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens cholesterol 25-hydroxylase (CH25H), mRNA.
ACCESSION   NM_003956
VERSION     NM_003956.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1689)
  AUTHORS   Xiang,Z., Yu,S., Xu,Y., Xiong,H., Hu,D., Li,Q. and Wu,Z.
  TITLE     CH25H Promotes Autophagy and Regulates the Malignant Progression of
            Laryngeal Squamous Cell Carcinoma Through the PI3K-AKT Pathway
  JOURNAL   Cancer Med 13 (20), e70312 (2024)
   PUBMED   39428922
  REMARK    GeneRIF: CH25H Promotes Autophagy and Regulates the Malignant
            Progression of Laryngeal Squamous Cell Carcinoma Through the
            PI3K-AKT Pathway.
REFERENCE   2  (bases 1 to 1689)
  AUTHORS   Zhang,L., Fang,Z., Zhu,Q., Yang,S., Fu,J., Sun,Z., Lu,G., Wei,C.,
            Zhang,Z., Lee,K., Zhong,Y., Liu,R. and He,J.C.
  TITLE     Cholesterol 25-Hydroxylase Protects Against Diabetic Kidney Disease
            by Regulating ADP Ribosylation Factor 4
  JOURNAL   Adv Sci (Weinh) 11 (29), e2309642 (2024)
   PUBMED   38816950
  REMARK    GeneRIF: Cholesterol 25-Hydroxylase Protects Against Diabetic
            Kidney Disease by Regulating ADP Ribosylation Factor 4.
REFERENCE   3  (bases 1 to 1689)
  AUTHORS   Fan,D., Geng,Q., Wang,B., Wang,X., Xia,Y., Yang,L., Zhang,Q.,
            Deng,T., Xu,Y., Zhao,H., Liu,B., Lu,C., Gu,X. and Xiao,C.
  TITLE     Hypoxia-induced ALKBH5 aggravates synovial aggression and
            inflammation in rheumatoid arthritis by regulating the m6A
            modification of CH25H
  JOURNAL   Clin Immunol 261, 109929 (2024)
   PUBMED   38331303
  REMARK    GeneRIF: Hypoxia-induced ALKBH5 aggravates synovial aggression and
            inflammation in rheumatoid arthritis by regulating the m6A
            modification of CH25H.
REFERENCE   4  (bases 1 to 1689)
  AUTHORS   Roozbehani,M., Razizadeh,M.H., Keyvani,H., Nejati,F., Soleymani,S.
            and Mousavizadeh,L.
  TITLE     Expression Pattern of Cholesterol 25-Hydroxylase and Serum Level of
            25-Hydroxycholesterol and Relevant Inflammatory Cytokines in
            Patients with Varying Disease Severity of COVID-19
  JOURNAL   Viral Immunol 36 (9), 610-616 (2023)
   PUBMED   37831916
  REMARK    GeneRIF: Expression Pattern of Cholesterol 25-Hydroxylase and Serum
            Level of 25-Hydroxycholesterol and Relevant Inflammatory Cytokines
            in Patients with Varying Disease Severity of COVID-19.
REFERENCE   5  (bases 1 to 1689)
  AUTHORS   Zhong,G., He,C., Wang,S., Lin,C. and Li,M.
  TITLE     Research progress on the mechanism of cholesterol-25-hydroxylase in
            intestinal immunity
  JOURNAL   Front Immunol 14, 1241262 (2023)
   PUBMED   37720208
  REMARK    GeneRIF: Research progress on the mechanism of
            cholesterol-25-hydroxylase in intestinal immunity.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1689)
  AUTHORS   Shibata,N., Kawarai,T., Lee,J.H., Lee,H.S., Shibata,E., Sato,C.,
            Liang,Y., Duara,R., Mayeux,R.P., St George-Hyslop,P.H. and
            Rogaeva,E.
  TITLE     Association studies of cholesterol metabolism genes (CH25H, ABCA1
            and CH24H) in Alzheimer's disease
  JOURNAL   Neurosci Lett 391 (3), 142-146 (2006)
   PUBMED   16157450
  REMARK    GeneRIF: Based on the results of genome-wide screens, along with
            biological studies, we selected three genes as candidates for AD
            risk factors: ATP-binding cassette transporter A1 (ABCA1),
            cholesterol 25-hydroxylase (CH25H) and cholesterol 24-hydroxylase
            (CH24H).
            GeneRIF: Observational study of gene-disease association and
            gene-gene interaction. (HuGE Navigator)
REFERENCE   7  (bases 1 to 1689)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 1689)
  AUTHORS   Riemenschneider,M., Mahmoodzadeh,S., Eisele,T., Klopp,N.,
            Schwarz,S., Wagenpfeil,S., Diehl,J., Mueller,U., Foerstl,H.,
            Illig,T. and Kurz,A.
  TITLE     Association analysis of genes involved in cholesterol metabolism
            located within the linkage region on chromosome 10 and Alzheimer's
            disease
  JOURNAL   Neurobiol Aging 25 (10), 1305-1308 (2004)
   PUBMED   15465627
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 1689)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
REFERENCE   10 (bases 1 to 1689)
  AUTHORS   Lund,E.G., Kerr,T.A., Sakai,J., Li,W.P. and Russell,D.W.
  TITLE     cDNA cloning of mouse and human cholesterol 25-hydroxylases,
            polytopic membrane proteins that synthesize a potent oxysterol
            regulator of lipid metabolism
  JOURNAL   J Biol Chem 273 (51), 34316-34327 (1998)
   PUBMED   9852097
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL513533.15 and BC017843.1.
            
            On May 17, 2019 this sequence version replaced NM_003956.3.
            
            Summary: This is an intronless gene that is involved in cholesterol
            and lipid metabolism. The encoded protein is a membrane protein and
            contains clusters of histidine residues essential for catalytic
            activity. Unlike most other sterol hydroxylases, this enzyme is a
            member of a small family of enzymes that utilize diiron cofactors
            to catalyze the hydroxylation of hydrophobic substrates. [provided
            by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR1660809.218929.1, DRR138524.275451.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371852.4/ ENSP00000360918.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AL513533.15        132009-132011       c
            4-1381              BC017843.1         1-1378
            1382-1689           AL513533.15        130323-130630       c
FEATURES             Location/Qualifiers
     source          1..1689
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23.31"
     gene            1..1689
                     /gene="CH25H"
                     /gene_synonym="C25H"
                     /note="cholesterol 25-hydroxylase"
                     /db_xref="GeneID:9023"
                     /db_xref="HGNC:HGNC:1907"
                     /db_xref="MIM:604551"
     exon            1..1689
                     /gene="CH25H"
                     /gene_synonym="C25H"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..844
                     /gene="CH25H"
                     /gene_synonym="C25H"
                     /EC_number="1.14.99.38"
                     /note="h25OH; cholesterol 25-monooxygenase"
                     /codon_start=1
                     /product="cholesterol 25-hydroxylase"
                     /protein_id="NP_003947.1"
                     /db_xref="CCDS:CCDS7400.1"
                     /db_xref="GeneID:9023"
                     /db_xref="HGNC:HGNC:1907"
                     /db_xref="MIM:604551"
                     /translation="MSCHNCSDPQVLCSSGQLFLQPLWDHLRSWEALLQSPFFPVIFS
                     ITTYVGFCLPFVVLDILCSWVPALRRYKIHPDFSPSAQQLLPCLGQTLYQHVMFVFPV
                     TLLHWARSPALLPHEAPELLLLLHHILFCLLLFDMEFFVWHLLHHKVPWLYRTFHKVH
                     HQNSSSFALATQYMSVWELFSLGFFDMMNVTLLGCHPLTTLTFHVVNIWLSVEDHSGY
                     NFPWSTHRLVPFGWYGGVVHHDLHHSHFNCNFAPYFTHWDKILGTLRTASVPAR"
     polyA_site      1381
                     /gene="CH25H"
                     /gene_synonym="C25H"
                     /note="major polyA site"
ORIGIN      
        1 ctcagctgcc ttgcacagcc tcgcaatgag ctgccacaac tgctccgacc cccaggtcct
       61 ttgcagctcc gggcagctgt tcctgcagcc cctctgggac cacctgagga gctgggaggc
      121 cctcctacag tcgcccttct tcccggtcat cttctccatc accacatacg tgggcttttg
      181 cctgcccttc gtggtcctgg atatcctgtg ctcctgggtg cccgccctgc ggcgctacaa
      241 gatccaccct gacttctcgc catccgcgca gcagctgcta ccttgcctgg ggcagaccct
      301 ctaccagcat gtgatgtttg tgttccccgt gacgctgctg cattgggccc gcagcccggc
      361 cctcctgccc cacgaagctc ccgagctgct cctgctgctg caccacatcc tgttctgcct
      421 gctactcttc gacatggagt tcttcgtgtg gcacctgctg caccacaagg tgccctggct
      481 gtaccgcacc ttccacaagg tgcaccacca gaactcgtcc tcgttcgcgc tggcaacgca
      541 gtatatgagc gtctgggaac tgttttcttt gggcttcttc gacatgatga acgtcacact
      601 gctcgggtgc cacccgctca ccaccctgac cttccacgtg gtcaacatct ggctttccgt
      661 ggaggaccac tccggctaca acttcccttg gtccactcac agactggtgc ccttcgggtg
      721 gtacgggggt gtggtgcacc acgacctgca tcactctcac tttaactgca acttcgctcc
      781 gtactttaca cactgggaca aaatactggg aacgctgcgg actgcatctg tcccagcgcg
      841 gtgatgtggc tgcggtgggt gcccctaaga ctcgggactg ctgtgccttt cacacttgaa
      901 tgaagagaaa cacctgagct atatattttt ttaaagcaac taacttattg ctttatgttt
      961 atctatgaaa accatagata aaatctgatg catttttgta atctgacaaa gtaatttaca
     1021 tactgtttgt gtatcaatac aattttgtgt tcttggtatt cttagtctag ctcacctcaa
     1081 tagccttgaa tcctgcatat gaattagaca ttcatcactg gcatatttag aatatctcta
     1141 aaaggacttg tttgtagaat aaggaatttt ctatgtttca aagtgttcta aaacctggct
     1201 aaaagaatgt atttttgtgg atggtgttga cttctgactc taaaagcaat caaacatgtt
     1261 tctgctggac agtgaccaag aattatagta ccttcttata tttttttata gaactgtata
     1321 tttattttga aagaaatgtt attcgtgctt taaaaaggaa aaaaaaccat gaatcaaata
     1381 agtattgact tccgtttcac tggtattttg actgataaaa aagggaagag ggagcgggca
     1441 taccaagtgt ccttctaagc ctccatcagc ctcaccatgg aaagagagga atctgggtgt
     1501 agggtgttct gttgggggtt gttagagaaa aggaggcagg agaaggggct ctgtttgttg
     1561 tgctctagca atttcatgga ggaaaaacac gctaatattc ttaatgcttt tcagctgatt
     1621 tctgtataac aggcaaatga taggattact ctgtaaagtt tcatagaaag attaacgctg
     1681 agcagtcaa
//
