LOCUS       NM_006568               1962 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens cell growth regulator with ring finger domain 1
            (CGRRF1), mRNA.
ACCESSION   NM_006568
VERSION     NM_006568.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1962)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1962)
  AUTHORS   Lee,Y.J., Ho,S.R., Graves,J.D., Xiao,Y., Huang,S. and Lin,W.C.
  TITLE     CGRRF1, a growth suppressor, regulates EGFR ubiquitination in
            breast cancer
  JOURNAL   Breast Cancer Res 21 (1), 134 (2019)
   PUBMED   31801577
  REMARK    GeneRIF: We demonstrate that CGRRF1 suppresses growth of breast
            cancer and its E3 ligase activity is involved in CGRRF1-mediated
            growth suppression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1962)
  AUTHORS   Kaneko,M., Iwase,I., Yamasaki,Y., Takai,T., Wu,Y., Kanemoto,S.,
            Matsuhisa,K., Asada,R., Okuma,Y., Watanabe,T., Imaizumi,K. and
            Nomura,Y.
  TITLE     Genome-wide identification and gene expression profiling of
            ubiquitin ligases for endoplasmic reticulum protein degradation
  JOURNAL   Sci Rep 6, 30955 (2016)
   PUBMED   27485036
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1962)
  AUTHORS   Zhang,Q., Schmandt,R., Celestino,J., McCampbell,A., Yates,M.S.,
            Urbauer,D.L., Broaddus,R.R., Loose,D.S., Shipley,G.L. and Lu,K.H.
  TITLE     CGRRF1 as a novel biomarker of tissue response to metformin in the
            context of obesity
  JOURNAL   Gynecol Oncol 133 (1), 83-89 (2014)
   PUBMED   24680596
  REMARK    GeneRIF: CGRRF1 represents a novel, reproducible tissue marker of
            metformin response in the obese endometrium and our preliminary
            data suggests that up-regulation of CGRRF1 expression may prove
            clinically useful in the prevention or treatment of endometrial
            cancer
REFERENCE   5  (bases 1 to 1962)
  AUTHORS   Wang,X., Shaffer,J.R., Zeng,Z., Begum,F., Vieira,A.R., Noel,J.,
            Anjomshoaa,I., Cuenco,K.T., Lee,M.K., Beck,J., Boerwinkle,E.,
            Cornelis,M.C., Hu,F.B., Crosslin,D.R., Laurie,C.C., Nelson,S.C.,
            Doheny,K.F., Pugh,E.W., Polk,D.E., Weyant,R.J., Crout,R.,
            McNeil,D.W., Weeks,D.E., Feingold,E. and Marazita,M.L.
  TITLE     Genome-wide association scan of dental caries in the permanent
            dentition
  JOURNAL   BMC Oral Health 12, 57 (2012)
   PUBMED   23259602
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1962)
  AUTHORS   Shimada,M., Miyagawa,T., Kawashima,M., Tanaka,S., Honda,Y.,
            Honda,M. and Tokunaga,K.
  TITLE     An approach based on a genome-wide association study reveals
            candidate loci for narcolepsy
  JOURNAL   Hum Genet 128 (4), 433-441 (2010)
   PUBMED   20677014
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 1962)
  AUTHORS   Gomes,I., Sharma,T.T., Edassery,S., Fulton,N., Mar,B.G. and
            Westbrook,C.A.
  TITLE     Novel transcription factors in human CD34 antigen-positive
            hematopoietic cells
  JOURNAL   Blood 100 (1), 107-119 (2002)
   PUBMED   12070015
  REMARK    GeneRIF: Novel transcription factors identified in human CD34
            antigen-positive hematopoietic stem cells.
REFERENCE   8  (bases 1 to 1962)
  AUTHORS   Madden,S.L., Galella,E.A., Riley,D., Bertelsen,A.H. and
            Beaudry,G.A.
  TITLE     Induction of cell growth regulatory genes by p53
  JOURNAL   Cancer Res 56 (23), 5384-5390 (1996)
   PUBMED   8968090
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG701924.1, U66469.1, AW664053.1 and AL359792.3.
            
            On Nov 23, 2018 this sequence version replaced NM_006568.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.136110.1,
                                           SRR1660809.262721.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000216420.12/ ENSP00000216420.7
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-298               BG701924.1         99-396
            299-1257            U66469.1           272-1230
            1258-1286           AW664053.1         6-34                c
            1287-1962           AL359792.3         61142-61817         c
FEATURES             Location/Qualifiers
     source          1..1962
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q22.2"
     gene            1..1962
                     /gene="CGRRF1"
                     /gene_synonym="CGR19; RNF197"
                     /note="cell growth regulator with ring finger domain 1"
                     /db_xref="GeneID:10668"
                     /db_xref="HGNC:HGNC:15528"
                     /db_xref="MIM:606138"
     exon            1..158
                     /gene="CGRRF1"
                     /gene_synonym="CGR19; RNF197"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..1053
                     /gene="CGRRF1"
                     /gene_synonym="CGR19; RNF197"
                     /note="RING finger protein 197; cell growth regulatory
                     gene 19 protein"
                     /codon_start=1
                     /product="cell growth regulator with RING finger domain
                     protein 1"
                     /protein_id="NP_006559.1"
                     /db_xref="CCDS:CCDS9719.1"
                     /db_xref="GeneID:10668"
                     /db_xref="HGNC:HGNC:15528"
                     /db_xref="MIM:606138"
                     /translation="MAAVFLVTLYEYSPLFYIAVVFTCFIVTTGLVLGWFGWDVPVIL
                     RNSEETQFSTRVFKKQMRQVKNPFGLEITNPSSASITTGITLTTDCLEDSLLTCYWGC
                     SVQKLYEALQKHVYCFRISTPQALEDALYSEYLYQEQYFIKKDSKEEIYCQLPRDTKI
                     EDFGTVPRSRYPLVALLTLADEDDREIYDIISMVSVIHIPDRTYKLSCRILYQYLLLA
                     QGQFHDLKQLFMSANNNFTPSNNSSSEEKNTDRSLLEKVGLSESEVEPSEENSKDCVV
                     CQNGTVNWVLLPCRHTCLCDGCVKYFQQCPMCRQFVQESFALCSQKEQDKDKPKTL"
     exon            159..298
                     /gene="CGRRF1"
                     /gene_synonym="CGR19; RNF197"
                     /inference="alignment:Splign:2.1.0"
     exon            299..476
                     /gene="CGRRF1"
                     /gene_synonym="CGR19; RNF197"
                     /inference="alignment:Splign:2.1.0"
     exon            477..624
                     /gene="CGRRF1"
                     /gene_synonym="CGR19; RNF197"
                     /inference="alignment:Splign:2.1.0"
     exon            625..732
                     /gene="CGRRF1"
                     /gene_synonym="CGR19; RNF197"
                     /inference="alignment:Splign:2.1.0"
     exon            733..1962
                     /gene="CGRRF1"
                     /gene_synonym="CGR19; RNF197"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1257..1262
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CGRRF1"
                     /gene_synonym="CGR19; RNF197"
                     /note="hexamer: CATAAA"
     polyA_site      1286
                     /gene="CGRRF1"
                     /gene_synonym="CGR19; RNF197"
                     /note="major polyA site"
     regulatory      1933..1938
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CGRRF1"
                     /gene_synonym="CGR19; RNF197"
                     /note="hexamer: AATAAA"
     polyA_site      1962
                     /gene="CGRRF1"
                     /gene_synonym="CGR19; RNF197"
ORIGIN      
        1 gggctgggct gggctccgcg gctggagccg ggctctaccc agagcaagac cctgatggct
       61 gcggtgtttc tggtaacgct ttatgaatac tcgccgcttt tctacatcgc ggtggtcttt
      121 acctgcttca tcgtgaccac cggcctggta ttgggatggt ttggttggga tgttccagta
      181 attctgagaa attcagaaga gacccagttc agcacaagag ttttcaaaaa gcaaatgaga
      241 caagtcaaga atccttttgg cttagagatc actaatccat cttcagcttc aattacaact
      301 ggcataacct tgacaacaga ttgccttgaa gatagcctcc ttacatgcta ctgggggtgc
      361 agtgttcaaa aattatatga agctctgcag aagcatgttt attgcttcag aataagcact
      421 ccccaagcat tagaagatgc tctgtatagt gaatatctct atcaggaaca gtattttatt
      481 aaaaaggata gcaaagaaga aatatattgc cagttaccaa gagatactaa aattgaagac
      541 tttggtacag tacccagatc tcgctatcca ttggtagcgc tattgacctt agctgatgag
      601 gatgaccggg aaatttatga tattatttcc atggtgtcag tgattcatat tcctgatagg
      661 acttataaac tatcctgcag aatattgtat caatatttac tcttggctca aggtcaattt
      721 catgatctta agcaactttt catgtctgca aataataatt tcactccctc caacaattcc
      781 tcttcagaag aaaaaaacac agacagaagt ttgttggaaa aggtgggact ctctgaaagt
      841 gaagttgagc catcggaaga gaacagcaag gactgtgttg tttgccagaa tgggactgtg
      901 aactgggtac tcttaccatg cagacacaca tgcctgtgtg atggctgtgt gaagtatttt
      961 cagcagtgcc caatgtgcag gcagtttgtt caggaatctt ttgcactttg cagtcaaaaa
     1021 gagcaagata aagacaaacc gaagactctt tgaagacatc gtaacactga aaagtacact
     1081 ttctactaaa gatgcagaaa ttgatgatct tggaattcat cataacatgg aatctacagt
     1141 actgaccatc aatgaaaatt atattttaac ttcatatttg tatggtactt ggatgataaa
     1201 aattaattat tcctttctgc ttagtgaatg aatactggaa tccatctgtg ttgatacata
     1261 aaaattcatt caactcttga aaagaatcta agagtttggc cttttattag ctagatttcc
     1321 tctcatgtta attagaaaaa tcattctgaa aggcaatcca ttgaaaattt gaggaggtta
     1381 aattcttaag atcactaaat gttttacctt tgatgtaatc ggagtgcaat taagaaaaaa
     1441 cttaattcta cttaaagtaa ttgtgtgttc cctagtttat acaaaggagt tggaatgagc
     1501 ttctttagat cttttcctga aataacagct tttataaata tccatctgtt tggtttctaa
     1561 tgtcccttat tatagttacg taaatacagg tcatagtttt aaatataggt tcttaaatca
     1621 taaatacaag atataattct tgactgttct ccgtgtatta taaaatgata ctcatctata
     1681 ggaggcagat atataaaatt cggataataa gattttttgg ataattaaat ttattaaatt
     1741 gatagtcaag tgtgattaga ttagcagaat gtgatctcca gggaagatct gtgagacctt
     1801 taatgcctta ccttagattt ctgcctgcac agcaaatcca tccagaactg aggtgggagg
     1861 tggaggttat agagctagaa aaatcactaa aagaaacaaa taactatttt tttctagtgt
     1921 atttttattc caaataaacc ctgtattctt ctgaatagta aa
//
