LOCUS       NM_006569               1931 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens cell growth regulator with EF-hand domain 1 (CGREF1),
            transcript variant 1, mRNA.
ACCESSION   NM_006569
VERSION     NM_006569.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1931)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1931)
  AUTHORS   Deng,W., Wang,L., Xiong,Y., Li,J., Wang,Y., Shi,T. and Ma,D.
  TITLE     The novel secretory protein CGREF1 inhibits the activation of AP-1
            transcriptional activity and cell proliferation
  JOURNAL   Int J Biochem Cell Biol 65, 32-39 (2015)
   PUBMED   26022276
  REMARK    GeneRIF: Results clearly indicated that CGREF1 is a novel secretory
            protein, and plays an important role in regulation of AP-1
            transcriptional activity and cell proliferation.
REFERENCE   3  (bases 1 to 1931)
  AUTHORS   Li,L., Fridley,B.L., Kalari,K., Niu,N., Jenkins,G., Batzler,A.,
            Abo,R.P., Schaid,D. and Wang,L.
  TITLE     Discovery of genetic biomarkers contributing to variation in drug
            response of cytidine analogues using human lymphoblastoid cell
            lines
  JOURNAL   BMC Genomics 15, 93 (2014)
   PUBMED   24483146
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1931)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   5  (bases 1 to 1931)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 1931)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   7  (bases 1 to 1931)
  AUTHORS   Madden,S.L., Galella,E.A., Riley,D., Bertelsen,A.H. and
            Beaudry,G.A.
  TITLE     Induction of cell growth regulatory genes by p53
  JOURNAL   Cancer Res 56 (23), 5384-5390 (1996)
   PUBMED   8968090
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC013403.9.
            
            On Nov 23, 2018 this sequence version replaced NM_006569.5.
            
            This variant (1) represents the longest transcript and encodes the
            longest isoform (a). Variants 1 and 2 encode the same isoform (a)
            and both contain a 51-nucleotide tandem repeat in their 3' CDS.
            This tandem repeat is present in the reference genome sequence but
            is absent or shorter in other human genomes.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.331962.1, BI819843.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000402394.6/ ENSP00000385452.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-283               AC013403.9         59546-59828         c
            284-374             AC013403.9         44987-45077         c
            375-440             AC013403.9         43226-43291         c
            441-511             AC013403.9         43060-43130         c
            512-636             AC013403.9         42797-42921         c
            637-1931            AC013403.9         41294-42588         c
FEATURES             Location/Qualifiers
     source          1..1931
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p23.3"
     gene            1..1931
                     /gene="CGREF1"
                     /gene_synonym="CGR11"
                     /note="cell growth regulator with EF-hand domain 1"
                     /db_xref="GeneID:10669"
                     /db_xref="HGNC:HGNC:16962"
                     /db_xref="MIM:606137"
     exon            1..283
                     /gene="CGREF1"
                     /gene_synonym="CGR11"
                     /inference="alignment:Splign:2.1.0"
     exon            284..374
                     /gene="CGREF1"
                     /gene_synonym="CGR11"
                     /inference="alignment:Splign:2.1.0"
     CDS             295..1251
                     /gene="CGREF1"
                     /gene_synonym="CGR11"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; cell growth regulator with EF hand domain
                     protein 1; hydrophobestin; cell growth regulatory gene 11
                     protein"
                     /codon_start=1
                     /product="cell growth regulator with EF hand domain
                     protein 1 isoform a precursor"
                     /protein_id="NP_006560.3"
                     /db_xref="CCDS:CCDS33162.2"
                     /db_xref="GeneID:10669"
                     /db_xref="HGNC:HGNC:16962"
                     /db_xref="MIM:606137"
                     /translation="MLPLTMTVLILLLLPTGQAAPKDGVTRPDSEVQHQLLPNPFQPG
                     QEQLGLLQSYLKGLGRTEVQLEHLSREQVLLYLFALHDYDQSGQLDGLELLSMLTAAL
                     APGAANSPTTNPVILIVDKVLETQDLNGDGLMTPAELINFPGVALRHVEPGEPLAPSP
                     QEPQAVGRQSLLAKSPLRQETQEAPGPREEAKGQVEARRESLDPVQEPGGQAEADGDV
                     PGPRGEAEGQAEAKGDAPGPRGEAGGQAEAEGDAPGPRGEAGGQAEAEGDAPGPRGEA
                     GGQAEARENGEEAKELPGETLESKNTQNDFEVHIVQVENDEI"
     exon            375..440
                     /gene="CGREF1"
                     /gene_synonym="CGR11"
                     /inference="alignment:Splign:2.1.0"
     exon            441..511
                     /gene="CGREF1"
                     /gene_synonym="CGR11"
                     /inference="alignment:Splign:2.1.0"
     exon            512..636
                     /gene="CGREF1"
                     /gene_synonym="CGR11"
                     /inference="alignment:Splign:2.1.0"
     exon            637..1931
                     /gene="CGREF1"
                     /gene_synonym="CGR11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1426..1431
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CGREF1"
                     /gene_synonym="CGR11"
                     /note="hexamer: AATAAA"
     polyA_site      1447
                     /gene="CGREF1"
                     /gene_synonym="CGR11"
                     /note="major polyA site"
     regulatory      1909..1914
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CGREF1"
                     /gene_synonym="CGR11"
                     /note="hexamer: ATTAAA"
     polyA_site      1924
                     /gene="CGREF1"
                     /gene_synonym="CGR11"
     polyA_site      1931
                     /gene="CGREF1"
                     /gene_synonym="CGR11"
ORIGIN      
        1 acacacgcgc acactcacac gggcgcgcgc agcccctccg gccgcgggcg cagcgggggc
       61 gctggtggag ctgcgaaggg ccaggtccgg cgggcggggc ggcggctggc actggctccg
      121 gactctgccc ggccagggcg gcggctccag ccgggagggc gacgtggagc ggccacgtgg
      181 agcggcccgg gggaggctgg cggcgggagg cgaggcgcgg gcggcgcagc agccaggagc
      241 gcccacggag ctggaccccc agagccgcgc ggcgccgcag cagttccagg aaggatgtta
      301 cctttgacga tgacagtgtt aatcctgctg ctgctcccca cgggtcaggc tgccccaaag
      361 gatggagtca caaggccaga ctctgaagtg cagcatcagc tcctgcccaa ccccttccag
      421 ccaggccagg agcagctcgg acttctgcag agctacctaa agggactagg aaggacagaa
      481 gtgcaactgg agcatctgag ccgggagcag gttctcctct acctctttgc cctccatgac
      541 tatgaccaga gtggacagct ggatggcctg gagctgctgt ccatgttgac agctgctctg
      601 gcccctggag ctgccaactc tcctaccacc aacccggtga tcttgatagt ggacaaagtg
      661 ctcgagaccc aggacctgaa tggggatggg ctcatgaccc ctgctgagct catcaacttc
      721 ccgggagtag ccctcaggca cgtggagccc ggagagcccc ttgctccatc tcctcaggag
      781 ccacaagctg ttggaaggca gtccctatta gctaaaagcc cattaagaca agaaacacag
      841 gaagcccctg gtcccagaga agaagcaaag ggccaggtag aggccagaag ggagtctttg
      901 gatcctgtcc aggagcctgg gggccaggca gaggctgatg gagatgttcc agggcccaga
      961 ggggaagctg agggccaggc agaggctaaa ggagatgccc ctgggcccag aggggaagct
     1021 gggggccagg cagaggctga aggagatgcc cccgggccca gaggggaagc tgggggccag
     1081 gcagaggctg aaggagatgc ccccgggccc agaggggaag ctgggggcca ggcagaggcc
     1141 agggagaatg gagaggaggc caaggaactt ccaggggaaa cactggagtc taagaacacc
     1201 caaaatgact ttgaggtgca cattgttcaa gtggagaatg atgagatcta gatcttgaag
     1261 atacaggtac cccacgaagt ctcagtgcca gaacataagc cctgaagtgg gcaggggaaa
     1321 tgtacgctgg gacaaggacc atctctgtgc cccctgcctg gtcccagtag gtatcaggtc
     1381 tttctgtgca gctcagggag accctaagtt aaggggcaga ttaccaataa agaactgaat
     1441 gaattcatcc ccccggccac ctctctaccc gtccagcctg cccagaccct ctcagaggaa
     1501 cggggttggg gaccgaaagg acagggatgc cgcctgccca gtgtttctgg gcctcacggt
     1561 gctccggcag cagagcgcat ggtgctagcc atggccggct gcagaggacc cagtgaggaa
     1621 agctcagtct atccctgggc cccaaaccct caccggttcc ccctcacctg gtgttcagac
     1681 accccatgct ctcctgcagc tcagggcagg tgaccccatc cccagtaata ttaatcatca
     1741 ctagaacttt ttgagagcct tgtacacatc aggcatcatg ctgggcattt tatatatgat
     1801 tttatcctca caataattct gtagccaagc agaattggtt ccatttgaca gatgaagaaa
     1861 ttgaggcaga ttgcgttaag tgctgtaccc taaggtgata tgcagctaat taaatggcag
     1921 attttaatcc a
//
