LOCUS       NM_033183                887 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens chorionic gonadotropin subunit beta 8 (CGB8), mRNA.
ACCESSION   NM_033183
VERSION     NM_033183.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 887)
  AUTHORS   Bellet,D., Lazar,V., Bieche,I., Paradis,V., Giovangrandi,Y.,
            Paterlini,P., Lidereau,R., Bedossa,P., Bidart,J.M. and Vidaud,M.
  TITLE     Malignant transformation of nontrophoblastic cells is associated
            with the expression of chorionic gonadotropin beta genes normally
            transcribed in trophoblastic cells
  JOURNAL   Cancer Res 57 (3), 516-523 (1997)
   PUBMED   9012484
REFERENCE   2  (bases 1 to 887)
  AUTHORS   Bo,M. and Boime,I.
  TITLE     Identification of the transcriptionally active genes of the
            chorionic gonadotropin beta gene cluster in vivo
  JOURNAL   J Biol Chem 267 (5), 3179-3184 (1992)
   PUBMED   1371113
REFERENCE   3  (bases 1 to 887)
  AUTHORS   Jameson,J.L. and Lindell,C.M.
  TITLE     Isolation and characterization of the human chorionic gonadotropin
            beta subunit (CG beta) gene cluster: regulation of
            transcriptionally active CG beta gene by cyclic AMP
  JOURNAL   Mol Cell Biol 8 (12), 5100-5107 (1988)
   PUBMED   2468994
REFERENCE   4  (bases 1 to 887)
  AUTHORS   Otani,T., Otani,F., Krych,M., Chaplin,D.D. and Boime,I.
  TITLE     Identification of a promoter region in the CG beta gene cluster
  JOURNAL   J Biol Chem 263 (15), 7322-7329 (1988)
   PUBMED   2452822
  REMARK    Erratum:[J Biol Chem 1988 Dec 15;263(35):19256-7]
REFERENCE   5  (bases 1 to 887)
  AUTHORS   Jameson,J.L., Lindell,C.M. and Habener,J.F.
  TITLE     Evolution of different transcriptional start sites in the human
            luteinizing hormone and chorionic gonadotropin beta-subunit genes
  JOURNAL   DNA 5 (3), 227-234 (1986)
   PUBMED   2424697
REFERENCE   6  (bases 1 to 887)
  AUTHORS   Policastro,P.F., Daniels-McQueen,S., Carle,G. and Boime,I.
  TITLE     A map of the hCG beta-LH beta gene cluster
  JOURNAL   J Biol Chem 261 (13), 5907-5916 (1986)
   PUBMED   2422163
REFERENCE   7  (bases 1 to 887)
  AUTHORS   Talmadge,K., Boorstein,W.R., Vamvakopoulos,N.C., Gething,M.J. and
            Fiddes,J.C.
  TITLE     Only three of the seven human chorionic gonadotropin beta subunit
            genes can be expressed in the placenta
  JOURNAL   Nucleic Acids Res 12 (22), 8415-8436 (1984)
   PUBMED   6209613
REFERENCE   8  (bases 1 to 887)
  AUTHORS   Talmadge,K., Vamvakopoulos,N.C. and Fiddes,J.C.
  TITLE     Evolution of the genes for the beta subunits of human chorionic
            gonadotropin and luteinizing hormone
  JOURNAL   Nature 307 (5946), 37-40 (1984)
   PUBMED   6690982
REFERENCE   9  (bases 1 to 887)
  AUTHORS   Julier,C., Weil,D., Couillin,P., Cote,J.C., Nguyen,V.C.,
            Foubert,C., Boue,A., Thirion,J.P., Kaplan,J.C. and Junien,C.
  TITLE     The beta chorionic gonadotropin-beta luteinizing gene cluster maps
            to human chromosome 19
  JOURNAL   Hum Genet 67 (2), 174-177 (1984)
   PUBMED   6204923
REFERENCE   10 (bases 1 to 887)
  AUTHORS   Talmadge,K., Boorstein,W.R. and Fiddes,J.C.
  TITLE     The human genome contains seven genes for the beta-subunit of
            chorionic gonadotropin but only one gene for the beta-subunit of
            luteinizing hormone
  JOURNAL   DNA 2 (4), 281-289 (1983)
   PUBMED   6319099
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX118262.1, BC030994.1,
            BX380841.2 and BQ011275.1.
            
            On Feb 27, 2020 this sequence version replaced NM_033183.2.
            
            Summary: This gene is a member of the glycoprotein hormone beta
            chain family and encodes the beta 8 subunit of chorionic
            gonadotropin (CG). Glycoprotein hormones are heterodimers
            consisting of a common alpha subunit and an unique beta subunit
            which confers biological specificity. CG is produced by the
            trophoblastic cells of the placenta and stimulates the ovaries to
            synthesize the steroids that are essential for the maintenance of
            pregnancy. The beta subunit of CG is encoded by 6 genes which are
            arranged in tandem and inverted pairs on chromosome 19q13.3 and
            contiguous with the luteinizing hormone beta subunit gene.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX336447.2, BX396345.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2162568 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000448456.4/ ENSP00000403649.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 BX118262.1         1-5
            6-107               BC030994.1         1-102
            108-265             BX380841.2         90-247
            266-884             BC030994.1         261-879
            885-887             BQ011275.1         18-20               c
FEATURES             Location/Qualifiers
     source          1..887
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..887
                     /gene="CGB8"
                     /note="chorionic gonadotropin subunit beta 8"
                     /db_xref="GeneID:94115"
                     /db_xref="HGNC:HGNC:16453"
                     /db_xref="MIM:608827"
     exon            1..387
                     /gene="CGB8"
                     /inference="alignment:Splign:2.1.0"
     CDS             373..870
                     /gene="CGB8"
                     /note="chorionic gonadotropin beta 8 subunit; chorionic
                     gonadotropin, beta polypeptide 8; chorionic gonadotropin
                     beta subunit 8"
                     /codon_start=1
                     /product="chorionic gonadotropin, beta polypeptide 8
                     precursor"
                     /protein_id="NP_149439.1"
                     /db_xref="CCDS:CCDS12753.1"
                     /db_xref="GeneID:94115"
                     /db_xref="HGNC:HGNC:16453"
                     /db_xref="MIM:608827"
                     /translation="MEMFQGLLLLLLLSMGGTWASKEPLRPRCRPINATLAVEKEGCP
                     VCITVNTTICAGYCPTMTRVLQGVLPALPQVVCNYRDVRFESIRLPGCPRGVNPVVSY
                     AVALSCQCALCRRSTTDCGGPKDHPLTCDDPRFQDSSSSKAPPPSLPSPSRLPGPSDT
                     PILPQ"
     exon            388..555
                     /gene="CGB8"
                     /inference="alignment:Splign:2.1.0"
     exon            556..887
                     /gene="CGB8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      866..871
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CGB8"
                     /note="hexamer: AATAAA"
     polyA_site      887
                     /gene="CGB8"
                     /note="major polyA site"
ORIGIN      
        1 gcttcagtcc agcacctttc tcgggtcacg gcctcctcct ggctcccagg accccaccat
       61 aggcagaggc aggccttcct acaccctact ccctgtgcct ccaggctcga ctagtcccta
      121 gcactcgacg actgagtctc tgaggtcact tcaccgtggt ctccgcctca cccttggcgc
      181 tggaccagtg agaggagagg gctggggcgc tccgctgagc cactcctgcg cccccctggc
      241 cttgtctacc tcttgccccc cgaagggtta gtgtcgagct cactccagca tcctacaacc
      301 tcctggtggc cttgccgccc ccacaacccc gaggtttaaa gccaggtaca cgaggcaggg
      361 gacacaccaa ggatggagat gttccagggg ctgctgctgt tgctgctgct gagcatgggc
      421 gggacatggg catccaagga gccgcttcgg ccacggtgcc gccccatcaa tgccaccctg
      481 gctgtggaga aggagggctg ccccgtgtgc atcaccgtca acaccaccat ctgtgccggc
      541 tactgcccca ccatgacccg cgtgctgcag ggggtcctgc cggccctgcc tcaggtggtg
      601 tgcaactacc gcgatgtgcg cttcgagtcc atccggctcc ctggctgccc gcgcggcgtg
      661 aaccccgtgg tctcctacgc cgtggctctc agctgtcaat gtgcactctg ccgccgcagc
      721 accactgact gcgggggtcc caaggaccac cccttgacct gtgatgaccc ccgcttccag
      781 gactcctctt cctcaaaggc ccctcccccc agccttccaa gtccatcccg actcccgggg
      841 ccctcggaca ccccgatcct cccacaataa aggcttctca atccgca
//
