LOCUS       NM_001385261            2151 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens chorionic gonadotropin subunit beta 7 (CGB7),
            transcript variant 1, mRNA.
ACCESSION   NM_001385261
VERSION     NM_001385261.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2151)
  AUTHORS   Biskup,K., Blanchard,V., Castillo-Binder,P., Alexander,H.,
            Engeland,K. and Schug,S.
  TITLE     N- and O-glycosylation patterns and functional testing of CGB7
            versus CGB3/5/8 variants of the human chorionic gonadotropin (hCG)
            beta subunit
  JOURNAL   Glycoconj J 37 (5), 599-610 (2020)
   PUBMED   32767150
  REMARK    GeneRIF: N- and O-glycosylation patterns and functional testing of
            CGB7 versus CGB3/5/8 variants of the human chorionic gonadotropin
            (hCG) beta subunit.
REFERENCE   2  (bases 1 to 2151)
  AUTHORS   Sohr,S. and Engeland,K.
  TITLE     The tumor suppressor p53 induces expression of the
            pregnancy-supporting human chorionic gonadotropin (hCG) CGB7 gene
  JOURNAL   Cell Cycle 10 (21), 3758-3767 (2011)
   PUBMED   22032922
  REMARK    GeneRIF: Expression of the CGB7 gene is upregulated upon p53
            induction in human HFF, HCT116 and DLD1 cells as well as in cell
            preparations enriched in human primary first-trimester
            trophoblasts.
REFERENCE   3  (bases 1 to 2151)
  AUTHORS   Maston,G.A. and Ruvolo,M.
  TITLE     Chorionic gonadotropin has a recent origin within primates and an
            evolutionary history of selection
  JOURNAL   Mol Biol Evol 19 (3), 320-335 (2002)
   PUBMED   11861891
REFERENCE   4  (bases 1 to 2151)
  AUTHORS   Hizaki,H., Segi,E., Sugimoto,Y., Hirose,M., Saji,T., Ushikubi,F.,
            Matsuoka,T., Noda,Y., Tanaka,T., Yoshida,N., Narumiya,S. and
            Ichikawa,A.
  TITLE     Abortive expansion of the cumulus and impaired fertility in mice
            lacking the prostaglandin E receptor subtype EP(2)
  JOURNAL   Proc Natl Acad Sci U S A 96 (18), 10501-10506 (1999)
   PUBMED   10468638
REFERENCE   5  (bases 1 to 2151)
  AUTHORS   Bellet,D., Lazar,V., Bieche,I., Paradis,V., Giovangrandi,Y.,
            Paterlini,P., Lidereau,R., Bedossa,P., Bidart,J.M. and Vidaud,M.
  TITLE     Malignant transformation of nontrophoblastic cells is associated
            with the expression of chorionic gonadotropin beta genes normally
            transcribed in trophoblastic cells
  JOURNAL   Cancer Res 57 (3), 516-523 (1997)
   PUBMED   9012484
REFERENCE   6  (bases 1 to 2151)
  AUTHORS   Bo,M. and Boime,I.
  TITLE     Identification of the transcriptionally active genes of the
            chorionic gonadotropin beta gene cluster in vivo
  JOURNAL   J Biol Chem 267 (5), 3179-3184 (1992)
   PUBMED   1371113
REFERENCE   7  (bases 1 to 2151)
  AUTHORS   Weisshaar,G., Hiyama,J. and Renwick,A.G.
  TITLE     Site-specific N-glycosylation of human chorionic
            gonadotrophin--structural analysis of glycopeptides by one- and
            two-dimensional 1H NMR spectroscopy
  JOURNAL   Glycobiology 1 (4), 393-404 (1991)
   PUBMED   1820200
REFERENCE   8  (bases 1 to 2151)
  AUTHORS   Beebe,J.S., Mountjoy,K., Krzesicki,R.F., Perini,F. and Ruddon,R.W.
  TITLE     Role of disulfide bond formation in the folding of human chorionic
            gonadotropin beta subunit into an alpha beta dimer
            assembly-competent form
  JOURNAL   J Biol Chem 265 (1), 312-317 (1990)
   PUBMED   1688430
REFERENCE   9  (bases 1 to 2151)
  AUTHORS   Policastro,P.F., Daniels-McQueen,S., Carle,G. and Boime,I.
  TITLE     A map of the hCG beta-LH beta gene cluster
  JOURNAL   J Biol Chem 261 (13), 5907-5916 (1986)
   PUBMED   2422163
REFERENCE   10 (bases 1 to 2151)
  AUTHORS   Morgan,F.J., Birken,S. and Canfield,R.E.
  TITLE     The amino acid sequence of human chorionic gonadotropin. The alpha
            subunit and beta subunit
  JOURNAL   J Biol Chem 250 (13), 5247-5258 (1975)
   PUBMED   1150658
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC008687.5.
            
            Summary: This gene is a member of the glycoprotein hormone beta
            chain family and encodes the beta 7 subunit of chorionic
            gonadotropin (CG). Glycoprotein hormones are heterodimers
            consisting of a common alpha subunit and an unique beta subunit
            which confers biological specificity. CG is produced by the
            trophoblastic cells of the placenta and stimulates the ovaries to
            synthesize the steroids that are essential for the maintenance of
            pregnancy. The beta subunit of CG is encoded by 6 genes which are
            arranged in tandem and inverted pairs on chromosome 19q13.3 and
            contiguous with the luteinizing hormone beta subunit gene.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 both encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.3135705.1,
                                           SRR14038192.2619792.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968968,
                                           SAMEA2142853 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000684222.1/ ENSP00000507822.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-288               AC008687.5         68770-69057         c
            289-416             AC008687.5         68429-68556         c
            417-1651            AC008687.5         66669-67903         c
            1652-1819           AC008687.5         66149-66316         c
            1820-2151           AC008687.5         65582-65913         c
FEATURES             Location/Qualifiers
     source          1..2151
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..2151
                     /gene="CGB7"
                     /gene_synonym="CG-beta-a; CGB6"
                     /note="chorionic gonadotropin subunit beta 7"
                     /db_xref="GeneID:94027"
                     /db_xref="HGNC:HGNC:16451"
                     /db_xref="MIM:608826"
     exon            1..288
                     /gene="CGB7"
                     /gene_synonym="CG-beta-a; CGB6"
                     /inference="alignment:Splign:2.1.0"
     exon            289..416
                     /gene="CGB7"
                     /gene_synonym="CG-beta-a; CGB6"
                     /inference="alignment:Splign:2.1.0"
     exon            417..1651
                     /gene="CGB7"
                     /gene_synonym="CG-beta-a; CGB6"
                     /inference="alignment:Splign:2.1.0"
     CDS             1637..2134
                     /gene="CGB7"
                     /gene_synonym="CG-beta-a; CGB6"
                     /note="chorionic gonadotropin beta 7 subunit; chorionic
                     gonadotropin, beta polypeptide 7; choriogonadotropin
                     subunit beta 7; chorionic gonadotropin beta subunit 7"
                     /codon_start=1
                     /product="choriogonadotropin subunit beta 7 precursor"
                     /protein_id="NP_001372190.1"
                     /db_xref="CCDS:CCDS33071.1"
                     /db_xref="GeneID:94027"
                     /db_xref="HGNC:HGNC:16451"
                     /db_xref="MIM:608826"
                     /translation="MEMFQGLLLLLLLSMGGTWASREMLRPRCRPINATLAVEKEGCP
                     VCITVNTTICAGYCPTMTRVLQGVLPALPQVVCNYRDVRFESIRLPGCPRGVNPVVSY
                     AVALSCQCALCRRSTTDCGGPKDHPLTCDDPRFQASSSSKAPPPSLPSPSRLPGPSDT
                     PILPQ"
     exon            1652..1819
                     /gene="CGB7"
                     /gene_synonym="CG-beta-a; CGB6"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..2151
                     /gene="CGB7"
                     /gene_synonym="CG-beta-a; CGB6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2130..2135
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CGB7"
                     /gene_synonym="CG-beta-a; CGB6"
                     /note="hexamer: AATAAA"
     polyA_site      2151
                     /gene="CGB7"
                     /gene_synonym="CG-beta-a; CGB6"
                     /note="major polyA site"
ORIGIN      
        1 atccacgcca ggccagaagg accaggggct ggaaactcgc cttcagggct cctaagctgc
       61 tgcggagcta gacggcgggc tgtgggtggg gaggagacta gaatattctg agacgtggta
      121 gggtgggagt taggagaggt aacctggagt tgttgcccaa gatgcagctc agctccagtg
      181 gccacaccaa gaaggcttga gaccgggggc agaaccaggg ggattttgtg gtggctgggg
      241 gcctgcattt gagttccttg accagcagga gggcttggat ttagggaggc tctaatcgcc
      301 tgcacgaaga accccgcgct gtctggccca cccttcacag tatccgaccg gggcgtcctg
      361 aaccgccgcc agctctatct gaccacctcg gcgcgggact ttcggttcta tcccaagacg
      421 gagccgtccg gatacccccg caaggactac ctgacctact ggagcttaga agagacgccc
      481 caactctgga gtcacgaccc gcagcggcag ccctgtctct gctcttccag gccgcctcga
      541 gcgccgcacg gcgggccatg tctccggctc aggaaaccta cagctcctcg ccgcacccgc
      601 tccgccggct cgaccgcttc cgcccgctgg aggcgacttg gggtggcccc cactggaagc
      661 ccctgccggg catacacagc gtcccgaaag cctacagcac cgagaactcc cgctcaggcc
      721 gctgtaagcc ggggctagtg ggagcctgcc gggccagccc caccccagac acgccccctg
      781 gcgtgggggc ggagcagagc tctgggcagc cgctcactac gcggtgtcgg acctaggtgg
      841 gctcgcactc attaagtcta tccgcagtgt ggggacagga ctagcccaga cacgcccact
      901 cagctgcggc tggatcgcgg ggaagggact aagtccagac aatgtcctcc gaggctgcgg
      961 ccccgcgggc aggacacacc tcctgcgggc ctattcaata atcagttaaa tcacctgaag
     1021 cacacgcatt tccggggacc gctccgggca tcctggcttg agggtagggt gggcggaggt
     1081 tcctaaggga gaggtggggc tcgggctgaa tccctcgttg gggggcatct gggtcaagtg
     1141 gcttccctgg cagcacagtc acggggagac cctctctcac tgggcagaag ctaagtccga
     1201 agccgcgccc ctcctgttag gttggactgt ggtgcaggaa tggctcaagt agaggagggt
     1261 tgaggcttca gtccagcacc tttctcgggt cacggcctcc tcctggttcc caagacccca
     1321 ccataggcag aggcaggcct tcctacaccc tactctctgt gcctccagcc tcgactagtc
     1381 cctagcactc gacgactgag tctcagaggt cacttcaccg tggtctccgc ctcatccttg
     1441 gcgctagacc actgagggga gaggactggg gtgctccgct gagccactcc tgtgcctccc
     1501 tggccttgtc tacttctcgc cccccgaagg gttagtgtcc agctcactcc agcatcctac
     1561 aacctcctgg tggccttgac gcccccacaa acccgaggta taaagccagg tacaccaggc
     1621 aggggacgca ccaaggatgg agatgttcca ggggctgctg ctgttgctgc tgctgagcat
     1681 gggcgggaca tgggcatcca gggagatgct tcggccacgg tgccgcccca tcaatgccac
     1741 cctggctgtg gagaaggagg gctgccccgt gtgcatcacc gtcaacacca ccatctgtgc
     1801 cggctactgc cccaccatga cccgcgtgct gcagggggtc ctgccggccc tgcctcaggt
     1861 ggtgtgcaac taccgcgatg tgcgcttcga gtccatccgg ctccctggct gcccgcgcgg
     1921 cgtgaacccc gtggtctcct acgccgtggc tctcagctgt caatgtgcac tctgccgccg
     1981 cagcaccact gactgcgggg gtcccaagga ccaccccttg acctgtgatg acccccgctt
     2041 ccaggcctcc tcttcctcaa aggcccctcc ccccagcctt ccaagtccat cccgactccc
     2101 ggggccctca gacaccccga tcctcccaca ataaaggctt ctcaatccgc a
//
