LOCUS       NM_033043                877 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens chorionic gonadotropin subunit beta 5 (CGB5), mRNA.
ACCESSION   NM_033043
VERSION     NM_033043.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 877)
  AUTHORS   Li,L., Liu,Y., Zhou,W., Yang,C., Feng,T. and Li,H.
  TITLE     Human chorionic gonadotrophin indirectly activates peripheral
            gammadeltaT cells to produce interleukin-10 during early pregnancy
  JOURNAL   Immun Inflamm Dis 12 (1), e1119 (2024)
   PUBMED   38270320
  REMARK    GeneRIF: Human chorionic gonadotrophin indirectly activates
            peripheral gammadeltaT cells to produce interleukin-10 during early
            pregnancy.
REFERENCE   2  (bases 1 to 877)
  AUTHORS   Xu,T., Xu,S., Ma,G., Chang,J., Zhang,C., Zhou,P., Wang,C., Xu,P.,
            Yang,J., Hu,Y. and Wu,Y.
  TITLE     Human Chorionic Gonadotropin Regulates the Smad Signaling Pathway
            by Antagonizing TGF-beta in Giant Cell Tumor of Bone
  JOURNAL   Recent Pat Anticancer Drug Discov 19 (2), 188-198 (2024)
   PUBMED   38214358
  REMARK    GeneRIF: Human Chorionic Gonadotropin Regulates the Smad Signaling
            Pathway by Antagonizing TGF-beta in Giant Cell Tumor of Bone.
REFERENCE   3  (bases 1 to 877)
  AUTHORS   Kankova,S., Hlavacova,J., Roberts,K., Benesova,J., Havlicek,J.,
            Calda,P., Dlouha,D. and Roberts,S.C.
  TITLE     Associations between nausea and vomiting in pregnancy, disgust
            sensitivity, and first-trimester maternal serum free beta-hCG and
            PAPP-A
  JOURNAL   Horm Behav 152, 105360 (2023)
   PUBMED   37062114
  REMARK    GeneRIF: Associations between nausea and vomiting in pregnancy,
            disgust sensitivity, and first-trimester maternal serum free
            beta-hCG and PAPP-A.
REFERENCE   4  (bases 1 to 877)
  AUTHORS   Ji,B., Qiao,L. and Zhai,W.
  TITLE     CGB5, INHBA and TRAJ19 Hold Prognostic Potential as Immune Genes
            for Patients with Gastric Cancer
  JOURNAL   Dig Dis Sci 68 (3), 791-802 (2023)
   PUBMED   35624327
  REMARK    GeneRIF: CGB5, INHBA and TRAJ19 Hold Prognostic Potential as Immune
            Genes for Patients with Gastric Cancer.
REFERENCE   5  (bases 1 to 877)
  AUTHORS   Abide Yayla,C., Ozkaya,E., Yenidede,I., Eser,A., Ergen,E.B.,
            Tayyar,A.T., Senturk,M.B. and Karateke,A.
  TITLE     Predictive value of some hematological parameters for non-invasive
            and invasive mole pregnancies
  JOURNAL   J Matern Fetal Neonatal Med 31 (3), 271-277 (2018)
   PUBMED   28093002
  REMARK    GeneRIF: in mole pregnancy, levels at baseline, first, second, and
            third weeks post-evacuation predict persistent disease
REFERENCE   6  (bases 1 to 877)
  AUTHORS   Bo,M. and Boime,I.
  TITLE     Identification of the transcriptionally active genes of the
            chorionic gonadotropin beta gene cluster in vivo
  JOURNAL   J Biol Chem 267 (5), 3179-3184 (1992)
   PUBMED   1371113
REFERENCE   7  (bases 1 to 877)
  AUTHORS   Otani,T., Otani,F., Krych,M., Chaplin,D.D. and Boime,I.
  TITLE     Identification of a promoter region in the CG beta gene cluster
  JOURNAL   J Biol Chem 263 (15), 7322-7329 (1988)
   PUBMED   2452822
  REMARK    Erratum:[J Biol Chem 1988 Dec 15;263(35):19256-7]
REFERENCE   8  (bases 1 to 877)
  AUTHORS   Jameson,J.L., Lindell,C.M. and Habener,J.F.
  TITLE     Evolution of different transcriptional start sites in the human
            luteinizing hormone and chorionic gonadotropin beta-subunit genes
  JOURNAL   DNA 5 (3), 227-234 (1986)
   PUBMED   2424697
REFERENCE   9  (bases 1 to 877)
  AUTHORS   Policastro,P.F., Daniels-McQueen,S., Carle,G. and Boime,I.
  TITLE     A map of the hCG beta-LH beta gene cluster
  JOURNAL   J Biol Chem 261 (13), 5907-5916 (1986)
   PUBMED   2422163
REFERENCE   10 (bases 1 to 877)
  AUTHORS   Moyle,W.R., Bahl,O.P. and Marz,L.
  TITLE     Role of carbohydrate of human chorionic gonadotropin in the
            mechanism of hormone action
  JOURNAL   J Biol Chem 250 (23), 9163-9169 (1975)
   PUBMED   172504
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC008687.5.
            
            On Nov 26, 2018 this sequence version replaced NM_033043.1.
            
            Summary: This gene is a member of the glycoprotein hormone beta
            chain family and encodes the beta 5 subunit of chorionic
            gonadotropin (CG). Glycoprotein hormones are heterodimers
            consisting of a common alpha subunit and an unique beta subunit
            which confers biological specificity. CG is produced by the
            trophoblastic cells of the placenta and stimulates the ovaries to
            synthesize the steroids that are essential for the maintenance of
            pregnancy. The beta subunit of CG is encoded by 6 genes which are
            arranged in tandem and inverted pairs on chromosome 19q13.3 and
            contiguous with the luteinizing hormone beta subunit gene.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006290.2, BX454511.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142853, SAMEA2145893
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000301408.7/ ENSP00000301408.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-377               AC008687.5         55156-55532
            378-545             AC008687.5         55885-56052
            546-877             AC008687.5         56288-56619
FEATURES             Location/Qualifiers
     source          1..877
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..877
                     /gene="CGB5"
                     /gene_synonym="CGB; HCG; hCGB"
                     /note="chorionic gonadotropin subunit beta 5"
                     /db_xref="GeneID:93659"
                     /db_xref="HGNC:HGNC:16452"
                     /db_xref="MIM:608825"
     exon            1..377
                     /gene="CGB5"
                     /gene_synonym="CGB; HCG; hCGB"
                     /inference="alignment:Splign:2.1.0"
     CDS             363..860
                     /gene="CGB5"
                     /gene_synonym="CGB; HCG; hCGB"
                     /note="chorionic gonadotropin beta 5 subunit; chorionic
                     gonadotropin, beta polypeptide 5; chorionic gonadotropin
                     beta subunit 5"
                     /codon_start=1
                     /product="chorionic gonadotropin, beta polypeptide 5
                     precursor"
                     /protein_id="NP_149032.1"
                     /db_xref="CCDS:CCDS12752.1"
                     /db_xref="GeneID:93659"
                     /db_xref="HGNC:HGNC:16452"
                     /db_xref="MIM:608825"
                     /translation="MEMFQGLLLLLLLSMGGTWASKEPLRPRCRPINATLAVEKEGCP
                     VCITVNTTICAGYCPTMTRVLQGVLPALPQVVCNYRDVRFESIRLPGCPRGVNPVVSY
                     AVALSCQCALCRRSTTDCGGPKDHPLTCDDPRFQDSSSSKAPPPSLPSPSRLPGPSDT
                     PILPQ"
     exon            378..545
                     /gene="CGB5"
                     /gene_synonym="CGB; HCG; hCGB"
                     /inference="alignment:Splign:2.1.0"
     exon            546..877
                     /gene="CGB5"
                     /gene_synonym="CGB; HCG; hCGB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      856..861
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CGB5"
                     /gene_synonym="CGB; HCG; hCGB"
                     /note="hexamer: AATAAA"
     polyA_site      877
                     /gene="CGB5"
                     /gene_synonym="CGB; HCG; hCGB"
                     /note="major polyA site"
ORIGIN      
        1 agcactttgc tcgggtcacg gcctcctcct ggctcccagg accccaccat aggcagaggc
       61 aggccttcct acaccctact ccctgtgcct ccaggctcga ctagtcccta gcactcgacg
      121 actgagtctc tgagatcact tcaccgtggt ctccgcctca cccttggcgc tggaccagtg
      181 agaggagagg gctggggcgc tccgctgagc cactcctgcg cccccctggc cttgtctacc
      241 tcttgccccc cgaagggtta gtgtcgagct caccccagca tcctacaacc tcctggtggc
      301 cttgccgccc ccacaacccc gaggtataaa gccaggtaca cgaggcaggg gacgcaccaa
      361 ggatggagat gttccagggg ctgctgctgt tgctgctgct gagcatgggc gggacatggg
      421 catccaagga gccgcttcgg ccacggtgcc gccccatcaa tgccaccctg gctgtggaga
      481 aggagggctg ccccgtgtgc atcaccgtca acaccaccat ctgtgccggc tactgcccca
      541 ccatgacccg cgtgctgcag ggggtcctgc cggccctgcc tcaggtggtg tgcaactacc
      601 gcgatgtgcg cttcgagtcc atccggctcc ctggctgccc gcgcggcgtg aaccccgtgg
      661 tctcctacgc cgtggctctc agctgtcaat gtgcactctg ccgccgcagc accactgact
      721 gcgggggtcc caaggaccac cccttgacct gtgatgaccc ccgcttccag gactcctctt
      781 cctcaaaggc ccctcccccc agccttccaa gtccatcccg actcccgggg ccctcggaca
      841 ccccgatcct cccacaataa aggcttctca atccgca
//
