LOCUS       NM_000737                877 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens chorionic gonadotropin subunit beta 3 (CGB3), mRNA.
ACCESSION   NM_000737
VERSION     NM_000737.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 877)
  AUTHORS   Hematian,M.N., Hessami,K., Torabi,S., Saleh,M., Nouri,B. and
            Saleh,M.
  TITLE     A prospective cohort study on association of first-trimester serum
            biomarkers and risk of isolated foetal congenital heart defects
  JOURNAL   Biomarkers 26 (8), 747-751 (2021)
   PUBMED   34645361
  REMARK    GeneRIF: A prospective cohort study on association of
            first-trimester serum biomarkers and risk of isolated foetal
            congenital heart defects.
REFERENCE   2  (bases 1 to 877)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 877)
  AUTHORS   Zhang,T., Zeng,X., Xu,H., Gao,L., Xiong,L., An,R. and Xue,Y.
  TITLE     Clinical characteristics and outcomes of extrauterine epithelioid
            trophoblastic tumors
  JOURNAL   Arch Gynecol Obstet 300 (3), 725-735 (2019)
   PUBMED   31312959
  REMARK    GeneRIF: In this study, we observed that abnormal levels of serum
            hCG titers and the local presentation of lesions with varying
            intervals after antecedent term pregnancy were the most common
            presenting features of extrauterine ETT [Epithelioid trophoblastic
            tumor].
REFERENCE   4  (bases 1 to 877)
  AUTHORS   Choi,S.G., Olivet,J., Cassonnet,P., Vidalain,P.O., Luck,K.,
            Lambourne,L., Spirohn,K., Lemmens,I., Dos Santos,M., Demeret,C.,
            Jones,L., Rangarajan,S., Bian,W., Coutant,E.P., Janin,Y.L., van der
            Werf,S., Trepte,P., Wanker,E.E., De Las Rivas,J., Tavernier,J.,
            Twizere,J.C., Hao,T., Hill,D.E., Vidal,M., Calderwood,M.A. and
            Jacob,Y.
  TITLE     Maximizing binary interactome mapping with a minimal number of
            assays
  JOURNAL   Nat Commun 10 (1), 3907 (2019)
   PUBMED   31467278
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 877)
  AUTHORS   Meda,S., Reginald,B.A. and Reddy,B.S.
  TITLE     Immunohistochemical study of the expression of human chorionic
            gonadotropin-beta in salivary gland tumors
  JOURNAL   J Cancer Res Ther 14 (5), 952-956 (2018)
   PUBMED   30197330
  REMARK    GeneRIF: The presence of hCGbeta positive tumor cells appears to
            potentially reflect the aggressive behavior of mucoepidermoid
            carcinoma and adenoid cystic carcinoma
REFERENCE   6  (bases 1 to 877)
  AUTHORS   Rothman,P.A., Chao,V.A., Taylor,M.R., Kuhn,R.W., Jaffe,R.B. and
            Taylor,R.N.
  TITLE     Extraplacental human fetal tissues express mRNA transcripts
            encoding the human chorionic gonadotropin-beta subunit protein
  JOURNAL   Mol Reprod Dev 33 (1), 1-6 (1992)
   PUBMED   1510839
REFERENCE   7  (bases 1 to 877)
  AUTHORS   Maruo,T., Ladines-Llave,C.A., Matsuo,H., Manalo,A.S. and
            Mochizuki,M.
  TITLE     A novel change in cytologic localization of human chorionic
            gonadotropin and human placental lactogen in first-trimester
            placenta in the course of gestation
  JOURNAL   Am J Obstet Gynecol 167 (1), 217-222 (1992)
   PUBMED   1442929
REFERENCE   8  (bases 1 to 877)
  AUTHORS   Bo,M. and Boime,I.
  TITLE     Identification of the transcriptionally active genes of the
            chorionic gonadotropin beta gene cluster in vivo
  JOURNAL   J Biol Chem 267 (5), 3179-3184 (1992)
   PUBMED   1371113
REFERENCE   9  (bases 1 to 877)
  AUTHORS   Weisshaar,G., Hiyama,J. and Renwick,A.G.
  TITLE     Site-specific N-glycosylation of human chorionic
            gonadotrophin--structural analysis of glycopeptides by one- and
            two-dimensional 1H NMR spectroscopy
  JOURNAL   Glycobiology 1 (4), 393-404 (1991)
   PUBMED   1820200
REFERENCE   10 (bases 1 to 877)
  AUTHORS   Beebe,J.S., Mountjoy,K., Krzesicki,R.F., Perini,F. and Ruddon,R.W.
  TITLE     Role of disulfide bond formation in the folding of human chorionic
            gonadotropin beta subunit into an alpha beta dimer
            assembly-competent form
  JOURNAL   J Biol Chem 265 (1), 312-317 (1990)
   PUBMED   1688430
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK291552.1 and BC106059.1.
            
            On Nov 20, 2020 this sequence version replaced NM_000737.4.
            
            Summary: This gene is a member of the glycoprotein hormone beta
            chain family and encodes the beta 3 subunit of chorionic
            gonadotropin (CG). Glycoprotein hormones are heterodimers
            consisting of a common alpha subunit and an unique beta subunit
            which confers biological specificity. CG is produced by the
            trophoblastic cells of the placenta and stimulates the ovaries to
            synthesize the steroids that are essential for the maintenance of
            pregnancy. The beta subunit of CG is encoded by 6 genes which are
            arranged in tandem and inverted pairs on chromosome 19q13.3 and
            contiguous with the luteinizing hormone beta subunit gene.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK291552.1, BC106059.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2162568 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357383.4/ ENSP00000349954.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-860               AK291552.1         1-860
            861-877             BC106059.1         849-865
FEATURES             Location/Qualifiers
     source          1..877
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..877
                     /gene="CGB3"
                     /gene_synonym="CGB; CGB5; CGB7; CGB8; hCGB; LHB"
                     /note="chorionic gonadotropin subunit beta 3"
                     /db_xref="GeneID:1082"
                     /db_xref="HGNC:HGNC:1886"
                     /db_xref="MIM:118860"
     exon            1..377
                     /gene="CGB3"
                     /gene_synonym="CGB; CGB5; CGB7; CGB8; hCGB; LHB"
                     /inference="alignment:Splign:2.1.0"
     CDS             363..860
                     /gene="CGB3"
                     /gene_synonym="CGB; CGB5; CGB7; CGB8; hCGB; LHB"
                     /note="chorionic gonadotropin beta chain; chorionic
                     gonadotropin beta 3 subunit; CG-beta; chorionic
                     gonadotrophin chain beta; chorionic gonadotropin, beta
                     polypeptide; chorionic gonadotropin chain beta;
                     choriogonadotropin subunit beta 3; chorionic gonadotropin
                     beta subunit 3; luteinizing hormone beta subunit"
                     /codon_start=1
                     /product="choriogonadotropin subunit beta 3 precursor"
                     /protein_id="NP_000728.1"
                     /db_xref="CCDS:CCDS12749.1"
                     /db_xref="GeneID:1082"
                     /db_xref="HGNC:HGNC:1886"
                     /db_xref="MIM:118860"
                     /translation="MEMFQGLLLLLLLSMGGTWASKEPLRPRCRPINATLAVEKEGCP
                     VCITVNTTICAGYCPTMTRVLQGVLPALPQVVCNYRDVRFESIRLPGCPRGVNPVVSY
                     AVALSCQCALCRRSTTDCGGPKDHPLTCDDPRFQDSSSSKAPPPSLPSPSRLPGPSDT
                     PILPQ"
     exon            378..545
                     /gene="CGB3"
                     /gene_synonym="CGB; CGB5; CGB7; CGB8; hCGB; LHB"
                     /inference="alignment:Splign:2.1.0"
     exon            546..877
                     /gene="CGB3"
                     /gene_synonym="CGB; CGB5; CGB7; CGB8; hCGB; LHB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      856..861
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CGB3"
                     /gene_synonym="CGB; CGB5; CGB7; CGB8; hCGB; LHB"
                     /note="hexamer: AATAAA"
     polyA_site      877
                     /gene="CGB3"
                     /gene_synonym="CGB; CGB5; CGB7; CGB8; hCGB; LHB"
                     /note="major polyA site"
ORIGIN      
        1 agcacctttc tcgggtcacg gcctcctcct ggctcccagg accccaccat aggcagaggc
       61 aggccttcct acaccctact ccctgtgcct ccagcctcga ctagtcccta gcactcgacg
      121 actgagtctc tgaggtcact tcaccgtggt ctccgcctca cccttggcgc tggaccagtg
      181 agaggagagg gctggggcgc tccgctgagc cactcctgcg cccccctggc cttgtctacc
      241 tcttgccccc cgaggggtta gtgtcgagct caccccagca tcctatcacc tcctggtggc
      301 cttgccgccc ccacaacccc gaggtataaa gccaggtaca cgaggcaggg gacgcaccaa
      361 ggatggagat gttccagggg ctgctgctgt tgctgctgct gagcatgggc gggacatggg
      421 catccaagga gccgcttcgg ccacggtgcc gccccatcaa tgccaccctg gctgtggaga
      481 aggagggctg ccccgtgtgc atcaccgtca acaccaccat ctgtgccggc tactgcccca
      541 ccatgacccg cgtgctgcag ggggtcctgc cggccctgcc tcaggtggtg tgcaactacc
      601 gcgatgtgcg cttcgagtcc atccggctcc ctggctgccc gcgcggcgtg aaccccgtgg
      661 tctcctacgc cgtggctctc agctgtcaat gtgcactctg ccgccgcagc accactgact
      721 gcgggggtcc caaggaccac cccttgacct gtgatgaccc ccgcttccag gactcctctt
      781 cctcaaaggc ccctcccccc agccttccaa gcccatcccg actcccgggg ccctcggaca
      841 ccccgatcct cccacaataa aggcttctca atccgca
//
