LOCUS       NM_033378                715 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens chorionic gonadotropin subunit beta 2 (CGB2),
            transcript variant 1, mRNA.
ACCESSION   NM_033378
VERSION     NM_033378.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 715)
  AUTHORS   Burczynska,B.B., Kobrouly,L., Butler,S.A., Naase,M. and Iles,R.K.
  TITLE     Novel insights into the expression of CGB1 & 2 genes by epithelial
            cancer cell lines secreting ectopic free hCGbeta
  JOURNAL   Anticancer Res 34 (5), 2239-2248 (2014)
   PUBMED   24778026
REFERENCE   2  (bases 1 to 715)
  AUTHORS   Kubiczak,M., Walkowiak,G.P., Nowak-Markwitz,E. and Jankowska,A.
  TITLE     Human chorionic gonadotropin beta subunit genes CGB1 and CGB2 are
            transcriptionally active in ovarian cancer
  JOURNAL   Int J Mol Sci 14 (6), 12650-12660 (2013)
   PUBMED   23774837
  REMARK    GeneRIF: The presence of CGB1 and CGB2 transcripts in 41% of
            analyzed ovarian cancer cases, is reported.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 715)
  AUTHORS   Goto-Kazeto,R., Kazeto,Y. and Trant,J.M.
  TITLE     Molecular cloning, characterization and expression of
            thyroid-stimulating hormone receptor in channel catfish
  JOURNAL   Gen Comp Endocrinol 161 (3), 313-319 (2009)
   PUBMED   19523396
REFERENCE   4  (bases 1 to 715)
  AUTHORS   Rull,K., Hallast,P., Uuskula,L., Jackson,J., Punab,M., Salumets,A.,
            Campbell,R.K. and Laan,M.
  TITLE     Fine-scale quantification of HCG beta gene transcription in human
            trophoblastic and non-malignant non-trophoblastic tissues
  JOURNAL   Mol Hum Reprod 14 (1), 23-31 (2008)
   PUBMED   18048458
REFERENCE   5  (bases 1 to 715)
  AUTHORS   Hallast,P., Rull,K. and Laan,M.
  TITLE     The evolution and genomic landscape of CGB1 and CGB2 genes
  JOURNAL   Mol Cell Endocrinol 260-262 (9), 2-11 (2007)
   PUBMED   17055150
  REMARK    GeneRIF: In silico prediction of putative transcription factor
            binding sites supports the hypothesis that CGB1 and CGB2 gene
            products are expressed in, and may contribute to, implantation and
            placental development.
REFERENCE   6  (bases 1 to 715)
  AUTHORS   Bo,M. and Boime,I.
  TITLE     Identification of the transcriptionally active genes of the
            chorionic gonadotropin beta gene cluster in vivo
  JOURNAL   J Biol Chem 267 (5), 3179-3184 (1992)
   PUBMED   1371113
REFERENCE   7  (bases 1 to 715)
  AUTHORS   Policastro,P.F., Daniels-McQueen,S., Carle,G. and Boime,I.
  TITLE     A map of the hCG beta-LH beta gene cluster
  JOURNAL   J Biol Chem 261 (13), 5907-5916 (1986)
   PUBMED   2422163
REFERENCE   8  (bases 1 to 715)
  AUTHORS   Julier,C., Weil,D., Couillin,P., Cote,J.C., Nguyen,V.C.,
            Foubert,C., Boue,A., Thirion,J.P., Kaplan,J.C. and Junien,C.
  TITLE     The beta chorionic gonadotropin-beta luteinizing gene cluster maps
            to human chromosome 19
  JOURNAL   Hum Genet 67 (2), 174-177 (1984)
   PUBMED   6204923
REFERENCE   9  (bases 1 to 715)
  AUTHORS   Policastro,P., Ovitt,C.E., Hoshina,M., Fukuoka,H., Boothby,M.R. and
            Boime,I.
  TITLE     The beta subunit of human chorionic gonadotropin is encoded by
            multiple genes
  JOURNAL   J Biol Chem 258 (19), 11492-11499 (1983)
   PUBMED   6194155
REFERENCE   10 (bases 1 to 715)
  AUTHORS   Talmadge,K., Boorstein,W.R. and Fiddes,J.C.
  TITLE     The human genome contains seven genes for the beta-subunit of
            chorionic gonadotropin but only one gene for the beta-subunit of
            luteinizing hormone
  JOURNAL   DNA 2 (4), 281-289 (1983)
   PUBMED   6319099
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC008687.5.
            
            On May 6, 2020 this sequence version replaced NM_033378.1.
            
            Summary: The beta subunit of chorionic gonadotropin (CGB) is
            encoded by six highly homologous and structurally similar genes
            that are arranged in tandem and inverted pairs on chromosome
            19q13.3, and contiguous with the luteinizing hormone beta (LHB)
            subunit gene. The CGB genes are primarily distinguished by
            differences in the 5' untranscribed region. This gene was
            originally thought to be one of the two pseudogenes (CGB1 and CGB2)
            of CGB subunit, however, detection of CGB1 and CGB2 transcripts in
            vivo, and their presence on the polysomes, suggested that these
            transcripts are translated. To date, a protein product
            corresponding to CGB2 has not been isolated. The deduced sequence
            of the hypothetical protein of 132 aa does not share any similarity
            with that of functional CGB subunits (PMID:8954017). However, a 163
            aa protein, translated from a different frame, is about the same
            size, and shares 98% identity with other CGB subunits. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC069367.1, AA393716.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000359342.7/ ENSP00000352295.6
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-215               AC008687.5         43198-43412
            216-383             AC008687.5         43812-43979
            384-715             AC008687.5         44215-44546
FEATURES             Location/Qualifiers
     source          1..715
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..715
                     /gene="CGB2"
                     /note="chorionic gonadotropin subunit beta 2"
                     /db_xref="GeneID:114336"
                     /db_xref="HGNC:HGNC:16722"
                     /db_xref="MIM:608824"
     exon            1..215
                     /gene="CGB2"
                     /inference="alignment:Splign:2.1.0"
     CDS             207..698
                     /gene="CGB2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; product of CGB2; chorionic gonadotropin beta
                     subunit 2; chorionic gonadotropin, beta polypeptide 2"
                     /codon_start=1
                     /product="choriogonadotropin subunit beta variant 2
                     isoform 1 precursor"
                     /protein_id="NP_203696.2"
                     /db_xref="CCDS:CCDS12750.2"
                     /db_xref="GeneID:114336"
                     /db_xref="HGNC:HGNC:16722"
                     /db_xref="MIM:608824"
                     /translation="MSKGLLLLLLLSMGGTWASKEPLRPRCRPINATLAVEKEGCPVC
                     ITVNTTICAGYCPTMTRVLQGVLPALPQVVCNYRDVRFESIRLPGCPRGVNPVVSYAV
                     ALSCQCALCRRSTTDCGGPKDHPLTCDDPRFQASSSSKAPPPSLPSPSRLPGPSDTPI
                     LPQ"
     exon            216..383
                     /gene="CGB2"
                     /inference="alignment:Splign:2.1.0"
     exon            384..715
                     /gene="CGB2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      694..699
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CGB2"
                     /note="hexamer: AATAAA"
     polyA_site      715
                     /gene="CGB2"
                     /note="major polyA site"
ORIGIN      
        1 gccctgcgtt ccgtggcgcc ccctggaggg aggaagggga actgtatctg agagagagca
       61 gccaattggg tccgctgact ccggccgggt tcccgtgccg cgtccaacac ccctcactcc
      121 ctgtctcact cccccacgga gactcaattt actttccatg tccacatccc cagtgcttgc
      181 ggaagatatc ccgctaagag agagacatgt caaaggggct gctgctgttg ctgctgctga
      241 gcatgggcgg gacatgggca tccaaggagc cgcttcggcc acggtgccgc cccatcaatg
      301 ccaccctggc tgtggagaag gagggctgcc ccgtgtgcat caccgtcaac accaccatct
      361 gtgccggcta ctgccccacc atgacccgcg tgctgcaggg ggtcctgccg gccctgcctc
      421 aggtggtgtg caactaccgc gatgtgcgct tcgagtccat ccggctccct ggctgcccgc
      481 gcggcgtgaa ccccgtggtc tcctacgccg tggctctcag ctgtcaatgt gcactctgcc
      541 gccgcagcac cactgactgc gggggtccca aggaccaccc cttgacctgt gatgaccccc
      601 gcttccaggc ctcctcttcc tcaaaggccc ctccccccag ccttccaagc ccatcccgac
      661 tcccggggcc ctcagacacc ccgatcctcc cacaataaag gcttctcaat ccgca
//
