LOCUS       NM_033377                693 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens chorionic gonadotropin subunit beta 1 (CGB1),
            transcript variant 1, mRNA.
ACCESSION   NM_033377
VERSION     NM_033377.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 693)
  AUTHORS   Wu,W., Gao,H., Li,X., Peng,S., Yu,J., Liu,N., Zhan,G., Zhu,Y.,
            Wang,K. and Guo,X.
  TITLE     beta-hCG promotes epithelial ovarian cancer metastasis through
            ERK/MMP2 signaling pathway
  JOURNAL   Cell Cycle 18 (1), 46-59 (2019)
   PUBMED   30582718
  REMARK    GeneRIF: these data provide new insight into the roles and
            mechanisms of b-hCG in regulating Epithelial ovarian cancer (EOC
            metastasis through ERK/MMP2 signaling pathway and may become a new
            target for therapeutic intervention.
REFERENCE   2  (bases 1 to 693)
  AUTHORS   Burczynska,B.B., Kobrouly,L., Butler,S.A., Naase,M. and Iles,R.K.
  TITLE     Novel insights into the expression of CGB1 & 2 genes by epithelial
            cancer cell lines secreting ectopic free hCGbeta
  JOURNAL   Anticancer Res 34 (5), 2239-2248 (2014)
   PUBMED   24778026
REFERENCE   3  (bases 1 to 693)
  AUTHORS   Kubiczak,M., Walkowiak,G.P., Nowak-Markwitz,E. and Jankowska,A.
  TITLE     Human chorionic gonadotropin beta subunit genes CGB1 and CGB2 are
            transcriptionally active in ovarian cancer
  JOURNAL   Int J Mol Sci 14 (6), 12650-12660 (2013)
   PUBMED   23774837
  REMARK    GeneRIF: The presence of CGB1 and CGB2 transcripts in 41% of
            analyzed ovarian cancer cases, is reported.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 693)
  AUTHORS   Goto-Kazeto,R., Kazeto,Y. and Trant,J.M.
  TITLE     Molecular cloning, characterization and expression of
            thyroid-stimulating hormone receptor in channel catfish
  JOURNAL   Gen Comp Endocrinol 161 (3), 313-319 (2009)
   PUBMED   19523396
REFERENCE   5  (bases 1 to 693)
  AUTHORS   Rull,K., Hallast,P., Uuskula,L., Jackson,J., Punab,M., Salumets,A.,
            Campbell,R.K. and Laan,M.
  TITLE     Fine-scale quantification of HCG beta gene transcription in human
            trophoblastic and non-malignant non-trophoblastic tissues
  JOURNAL   Mol Hum Reprod 14 (1), 23-31 (2008)
   PUBMED   18048458
REFERENCE   6  (bases 1 to 693)
  AUTHORS   Bo,M. and Boime,I.
  TITLE     Identification of the transcriptionally active genes of the
            chorionic gonadotropin beta gene cluster in vivo
  JOURNAL   J Biol Chem 267 (5), 3179-3184 (1992)
   PUBMED   1371113
REFERENCE   7  (bases 1 to 693)
  AUTHORS   Jameson,J.L. and Lindell,C.M.
  TITLE     Isolation and characterization of the human chorionic gonadotropin
            beta subunit (CG beta) gene cluster: regulation of
            transcriptionally active CG beta gene by cyclic AMP
  JOURNAL   Mol Cell Biol 8 (12), 5100-5107 (1988)
   PUBMED   2468994
REFERENCE   8  (bases 1 to 693)
  AUTHORS   Policastro,P.F., Daniels-McQueen,S., Carle,G. and Boime,I.
  TITLE     A map of the hCG beta-LH beta gene cluster
  JOURNAL   J Biol Chem 261 (13), 5907-5916 (1986)
   PUBMED   2422163
REFERENCE   9  (bases 1 to 693)
  AUTHORS   Julier,C., Weil,D., Couillin,P., Cote,J.C., Nguyen,V.C.,
            Foubert,C., Boue,A., Thirion,J.P., Kaplan,J.C. and Junien,C.
  TITLE     The beta chorionic gonadotropin-beta luteinizing gene cluster maps
            to human chromosome 19
  JOURNAL   Hum Genet 67 (2), 174-177 (1984)
   PUBMED   6204923
REFERENCE   10 (bases 1 to 693)
  AUTHORS   Policastro,P., Ovitt,C.E., Hoshina,M., Fukuoka,H., Boothby,M.R. and
            Boime,I.
  TITLE     The beta subunit of human chorionic gonadotropin is encoded by
            multiple genes
  JOURNAL   J Biol Chem 258 (19), 11492-11499 (1983)
   PUBMED   6194155
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC008687.5.
            
            On May 6, 2020 this sequence version replaced NM_033377.1.
            
            Summary: The beta subunit of chorionic gonadotropin (CGB) is
            encoded by six highly homologous and structurally similar genes
            that are arranged in tandem and inverted pairs on chromosome
            19q13.3, and contiguous with the luteinizing hormone beta (LHB)
            subunit gene. The CGB genes are primarily distinguished by
            differences in the 5' untranscribed region. This gene was
            originally thought to be one of the two pseudogenes (CGB1 and CGB2)
            of CGB subunit, however, detection of CGB1 and CGB2 transcripts in
            vivo, and their presence on the polysomes, suggested that these
            transcripts are translated. To date, a protein product
            corresponding to CGB1 has not been isolated. The deduced sequence
            of the hypothetical protein of 132 aa does not share any similarity
            with that of functional CGB subunits (PMID:8954017). However, a 155
            aa protein, translated from a different frame, is about the same
            size, and shares 98% identity with other CGB subunits. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC126460.1, GE745564.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968968,
                                           SAMEA2148874 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000301407.8/ ENSP00000301407.6
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-193               AC008687.5         48011-48203         c
            194-361             AC008687.5         47444-47611         c
            362-693             AC008687.5         46877-47208         c
FEATURES             Location/Qualifiers
     source          1..693
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..693
                     /gene="CGB1"
                     /note="chorionic gonadotropin subunit beta 1"
                     /db_xref="GeneID:114335"
                     /db_xref="HGNC:HGNC:16721"
                     /db_xref="MIM:608823"
     exon            1..193
                     /gene="CGB1"
                     /inference="alignment:Splign:2.1.0"
     CDS             185..652
                     /gene="CGB1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; chorionic gonadotropin, beta polypeptide 1;
                     chorionic gonadotropin beta subunit 1"
                     /codon_start=1
                     /product="choriogonadotropin subunit beta variant 1
                     isoform 1 precursor"
                     /protein_id="NP_203695.2"
                     /db_xref="CCDS:CCDS12751.2"
                     /db_xref="GeneID:114335"
                     /db_xref="HGNC:HGNC:16721"
                     /db_xref="MIM:608823"
                     /translation="MSKRLLLLLLLSMGGTWASKEPLRPRCRPINATLAVEKEGCPVC
                     ITVNTTICAGYCPTMTRVLQGVLPALPQVVCNYRDVRFESIRLPGCPRGVNPVVSYAV
                     ALSCQCALCRRSTTDCGGPKDHPLTCDDPRFQDSSSSKAPPPSLPSPSRLPGP"
     exon            194..361
                     /gene="CGB1"
                     /inference="alignment:Splign:2.1.0"
     exon            362..693
                     /gene="CGB1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      672..677
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CGB1"
                     /note="hexamer: AATAAA"
     polyA_site      693
                     /gene="CGB1"
                     /note="major polyA site"
ORIGIN      
        1 ctggagggag gaaggggaac tgcatctgag agagagcagc caattgggtc cgctgactct
       61 ggccaggttc ccgtgccgcg tccaacaccc ctcactccct gtctcactcc cccacggaga
      121 ctcaatttac tttccatgtc cacattccca gtgcttgcgg aagatatccc gctaagagag
      181 agacatgtca aagaggctgc tgctgttgct gctgctgagc atgggcggga catgggcatc
      241 caaggagccg cttcggccac ggtgccgccc catcaatgcc accctggctg tggagaagga
      301 gggctgcccc gtgtgcatca ccgtcaacac caccatctgt gccggctact gccccaccat
      361 gacccgcgtg ctgcaggggg tcctgccggc cctgcctcag gtggtgtgca actaccgcga
      421 tgtgcgcttc gagtccatcc ggctccctgg ctgcccgcgc ggcgtgaacc ccgtggtctc
      481 ctacgccgtg gctctcagct gtcaatgtgc actctgccgc cgcagcacca ctgactgcgg
      541 gggtcccaag gaccacccct tgacctgtga tgacccccgc ttccaggact cctcttcctc
      601 aaaggcccct ccccccagcc ttccaagtcc atcccgtctc ccggggccct aggacacccc
      661 gatcctccca caataaaggc ttctcaatcc gca
//
