LOCUS       XM_047446191            9947 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens CASP8 and FADD like apoptosis regulator
            (CFLAR), transcript variant X8, mRNA.
ACCESSION   XM_047446191
VERSION     XM_047446191.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000002.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9947
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
     gene            1..9947
                     /gene="CFLAR"
                     /gene_synonym="c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH;
                     CASP8AP1; Casper; cFLIP; CLARP; FLAME; FLAME-1; FLAME1;
                     FLIP; I-FLICE; MRIT"
                     /note="CASP8 and FADD like apoptosis regulator; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 5 mRNAs, 16 ESTs, 264 long SRA reads, 2 Proteins, and
                     59% coverage of the annotated genomic feature by RNAseq
                     alignments, including 41 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:8837"
                     /db_xref="HGNC:HGNC:1876"
                     /db_xref="MIM:603599"
     CDS             78..1232
                     /gene="CFLAR"
                     /gene_synonym="c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH;
                     CASP8AP1; Casper; cFLIP; CLARP; FLAME; FLAME-1; FLAME1;
                     FLIP; I-FLICE; MRIT"
                     /codon_start=1
                     /product="CASP8 and FADD-like apoptosis regulator isoform
                     X2"
                     /protein_id="XP_047302147.1"
                     /db_xref="GeneID:8837"
                     /db_xref="HGNC:HGNC:1876"
                     /db_xref="MIM:603599"
                     /translation="MAEIGEDLDKSDVSSLIFLMKDYMGRGKISKEKSFLDLVVELEK
                     LNLVAPDQLDLLEKCLKNIHRIDLKTKIQKYKQSVQGAGTSYRNVLQAAIQKSLKDPS
                     NNFRLHNGRSKEQRLKEQLGAQQEPVKKSIQESEAFLPQSIPEERYKMKSKPLGICLI
                     IDCIGNETELLRDTFTSLGYEVQKFLHLSMHGISQILGQFACMPEHRDYDSFVCVLVS
                     RGGSQSVYGVDQTHSGLPLHHIRRMFMGDSCPYLAGKPKMFFIQNYVVSEGQLEDSSL
                     LEVDGPAMKNVEFKAQKRGLCTVHREADFFWSLCTADMSLLEQSHSSPSLYLQCLSQK
                     LRQERKRPLLDLHIELNGYMYDWNSRVSAKEKYYVWLQHTLRKKLILSYT"
ORIGIN      
        1 agaaactgtt agttggcaaa ggatgtacca tctcctatta aacgggcaag gacaagttcc
       61 cttttctgag agtgctgatg gcagagattg gtgaggattt ggataaatct gatgtgtcct
      121 cattaatttt cctcatgaag gattacatgg gccgaggcaa gataagcaag gagaagagtt
      181 tcttggacct tgtggttgag ttggagaaac taaatctggt tgccccagat caactggatt
      241 tattagaaaa atgcctaaag aacatccaca gaatagacct gaagacaaaa atccagaagt
      301 acaagcagtc tgttcaagga gcagggacaa gttacaggaa tgttctccaa gcagcaatcc
      361 aaaagagtct caaggatcct tcaaataact tcaggctcca taatgggaga agtaaagaac
      421 aaagacttaa ggaacagctt ggcgctcaac aagaaccagt gaagaaatcc attcaggaat
      481 cagaagcttt tttgcctcag agcatacctg aagagagata caagatgaag agcaagcccc
      541 taggaatctg cctgataatc gattgcattg gcaatgagac agagcttctt cgagacacct
      601 tcacttccct gggctatgaa gtccagaaat tcttgcatct cagtatgcat ggtatatccc
      661 agattcttgg ccaatttgcc tgtatgcccg agcaccgaga ctacgacagc tttgtgtgtg
      721 tcctggtgag ccgaggaggc tcccagagtg tgtatggtgt ggatcagact cactcagggc
      781 tccccctgca tcacatcagg aggatgttca tgggagattc atgcccttat ctagcaggga
      841 agccaaagat gttttttatt cagaactatg tggtgtcaga gggccagctg gaggacagca
      901 gcctcttgga ggtggatggg ccagcgatga agaatgtgga attcaaggct cagaagcgag
      961 ggctgtgcac agttcaccga gaagctgact tcttctggag cctgtgtact gcggacatgt
     1021 ccctgctgga gcagtctcac agctcaccat ccctgtacct gcagtgcctc tcccagaaac
     1081 tgagacaaga aagaaaacgc ccactcctgg atcttcacat tgaactcaat ggctacatgt
     1141 atgattggaa cagcagagtt tctgccaagg agaaatatta tgtctggctg cagcacactc
     1201 tgagaaagaa acttatcctc tcctacacat aagaaaccaa aaggctgggc gtagtggctc
     1261 acacctgtaa tcccagcact ttgggaggcc aaggagggca gatcacttca ggtcaggagt
     1321 tcgagaccag cctggccaac atggtaaacg ctgtccctag taaaaataca aaaattagct
     1381 gggtgtgggt gtgggtacct gtattcccag ttacttggga ggctgaggtg ggaggatctt
     1441 ttgaacccag gagttcaggg tcatagcatg ctgtgattgt gcctacgaat agccactgca
     1501 taccaacctg ggcaatatag caagatccca tctctttaaa aaaaaaaaaa aaggacagga
     1561 actatcttac tcaatgtatt agtcatgttt ctctagaggg acagaactaa taggatacat
     1621 gtatataaaa aggggagttt attaaggagt attgactcac atgatcacag ggttaggtcc
     1681 cacaataggt catctgcaag caaggaagcc aattcaagtc ccaaagctga agaacttgga
     1741 gtccaatgtt tgagggcagg aagcattcag catgagagaa agatggaggc cagaagacta
     1801 caccagtcta gtctttccat gttttgcctg cttttattct ggcagtgctg gcagctgatt
     1861 agatggtgcc cacccagatt gaggatggtc tgcctttccc agtccactga ctcaaatgtt
     1921 aaatctcctt tggcagcacc ctcacagatg tacccgggaa cactttgcat ccttctattc
     1981 aatcaagttg atactcagta ttaaccatca cagtccattt gggcaactat accaaattac
     2041 catagaccag gtgacttaaa cagcagttat ttctcacagt tccggaggct gggaaatcca
     2101 acatctaagt ggtagcatat ctggtgtctg gtaaggcatg cttccagatc ttaccagatg
     2161 tcagtctttt gatgttctca catggcagaa aaagaggatg caaactctca agtatatctt
     2221 taagggcaca aattccattc atgagggctc taccctcatc acctaattac ctcccaaagg
     2281 ccccaccttc tgatactgtc actttgggga tactgtctcc cctttgaatt ctggggggaa
     2341 tacaaacatt cagtttgtaa caatagcctt atgatttaga ggttacttgt tcattcacct
     2401 agacctcaaa ttgcatttta cagctagtca agtatatctt tctctgattt gatagtgtga
     2461 cctaaaaggg gaccattgtt tgaaatatca ttagagttgc ttattattat tattattatt
     2521 attattatta ttattattat tattattgag acagagtttc attctgctgc ccaggctgga
     2581 gtgcagtggc atcatcttgg ctcattgcaa cctctgcctt ctgggttcaa gcgattctcc
     2641 tgcctcagcc tcccgagtag ctgggattac aggctcctgc caccacaccc ggctaatttt
     2701 tgtattttta gtggagacag ggtttccacc atgttggcca gcgtggtctt gaactcctga
     2761 cctcaggtga ttcaccagcc tcggcctccc aaagtgctgg gattacaggt gtgagccact
     2821 gcacctggcc tattattatt tttaaatttt ttttttttaa ttgatcattc ttgggtgttt
     2881 ctcacagagg gtgatttggc agggtcacag gacaatagtg gagggaaggt cagcagataa
     2941 acaagtgaac aaaggtctct ggttttccta ggcagaggac cctgcggcct tccgcagtgt
     3001 ttgtgtccct gggtacttga gattagggag tggtgatgac tcttaaggag catgctgcct
     3061 tcaagcatct gtttaacaaa gcacatcttg cactgccctt aatccattta accctgagtg
     3121 gacacagcac atgtttcaga gagcacaggg ttgggggtaa ggtcatagat caacagcatc
     3181 ctaaggcaga agaatttttc ttagtacaga acaaaatgaa gtctcccatg tctacttctt
     3241 tctacacaga cacagcaaca atctgatttc tctatctttt ccccaccttt cccccttttc
     3301 tattccacaa aaccgccatc gtcatcatgg cctgttctca atgagctgtt gggtacacct
     3361 cccagacggg gtggcggctg ggcagagggg ctcctcactt cccagatggg gcggccaggc
     3421 ggacgcgccc cccacctccc tcccggacgg gatagctggc cgggcggggg ctgacccccc
     3481 acctccctcc ccgacggggc ggctggccgg gcgggggctg acccccacgc ctccctcccg
     3541 gacggggcgg ctgccaggcg gaggggctcc tcacttctca gacggggtgg ctgctgggcg
     3601 gagacgctcc tcacttccca gacagggtgg ctgtcgggcg gaggggctcc tcacttctca
     3661 gacggggcag ctgcgggcgg aggggctcct cacttctcag acggggtggc cgggcagaga
     3721 agctcctcac atcccagacg ggggggcggg gcagaggcgc tccccacatc tcagacgatg
     3781 ggcggccggg cagagacgct cctcacttca tcccagacgg ggtggcggcc gggcagaagc
     3841 tgtaatctcg gcaccctggg gggccaaggc aggcggctgg gaggcggagg ccgtagccag
     3901 ctgagatcac accactgcac tccagcctgg gcaacattga gcactgagtg gacgagactc
     3961 tgcccgcaat cccggcacct cgggaggccg aggctggcag atcactcgca gtcaggagct
     4021 ggagaccagc ccggccaaca cagtgaaacc ctgtctccac caaaaaaata cgaaaaccag
     4081 tcaggcgtgg cggcgcccgc aatggcaggc acgcggcagg ccgaggcggg agaatcaggc
     4141 agggaggctg cagtgagccg agatggcagc agtacagtcc agcttcggct cggcatcaga
     4201 gggagaccgt ggggagaggg agaagagagg gagggggaga gggctatttt taaaattttt
     4261 taaaattgct gaacaggggt acctctgggc agtgtgtcag aataccactt tttaaatatt
     4321 ttatgattta tttatttttc tatttcttga ggttttaact gatgtgtatc tgtatgtcta
     4381 tttgtgtata ttttgtcatg atcatgtaac agagtctgaa aagtgtcgaa gagacagttt
     4441 tcaggaacaa caagcaatta ttcctacttt ccaagttatt ttgatgccat ggtggctcat
     4501 acctataatc tgagtacttt gggaggctga ggtggactga tcacttgagc ccaggagttt
     4561 gagaccagcc tgggcaacat agcaagactc catctctaca aaaaaagaca aaatttagct
     4621 gagcgtggtg gcgtgttcct gtagtcccag ctacttggga ggctgaagtg agtggatccc
     4681 ctgagcccag agaggtcaag gttgtgatga gctgtgatca caccactgca cttcagcatg
     4741 ggagacagag tgagaccctg tttcagaaaa aataaataaa taaaaccacc agcaccacaa
     4801 acaacaacaa aaagttattt tgtacttgtt ttgagcacag gactcctgag ggtatctttg
     4861 catttaatat tacatagggg tgccagtggg aagtaatgtg tatgcttggc ctcatgagct
     4921 aaaaccctgt gttaattatg acagaaggaa agtgtgtgag agagatctta actacctagc
     4981 agctctagct gccatcttga accatgaaga tacgggccac acgtaggggt agctgggtag
     5041 tgagcagcaa gaagccttgt tggatgaggg cacgaaggag cagaatcact ggaatcactg
     5101 tgtcagccct aattacctac ctctggactt ttatgtgagg ggaaaaaaaa ttgacagttt
     5161 atatttatct caacctagtt aacccaagtg atgcattgtt atgagattaa aatgtttgga
     5221 ggccgggtgc ggtggctcac gcctataatc ccagcccttt gggaggccaa ggcgggcgga
     5281 tcacgaggtc aggagatcaa gaccatcctg gctaacatgt aaaaccccgt ctctactaaa
     5341 aatacaaaaa attagccagg cgttgtggcg gtcgcctgta gtccctgcta tttgggaggc
     5401 cgaggcaaga gaacggcatg aacctgggag gtggagcttg cagcgagctg agatcttgcc
     5461 actgcactcc agcctgggcg acagtgcgag actctgtctc aaaaataaat aaataaataa
     5521 ataataaata aaatgtttgg aatgttggct tcatccctgg gatgcaaggc tggttcaaca
     5581 tacgcaaatc aagaaacata attcatcaca taaacagaac taaagacaaa aaccacatga
     5641 ttatctcaat agatacagaa aaggccttca ataaaattca acgttgcttc atgttaaaaa
     5701 ctctcaataa actaggtatt gatggaaaat atctcaaaat aataaccatt tatgacaaac
     5761 ccacagccat tatcatactg aatgggcaaa agctggaagc attccccttg aaaactggca
     5821 caagacaggg atgccgtctc accactccta tttaacatag tattggaagt tctggccaag
     5881 aaaatcaggc aagagaaaca aataaggggt attcaaatag gaaaagagga agtaaaactg
     5941 tgtttgcaga tgacatgata ctatatctag aaaaccccat tatctccacc caaaagttcc
     6001 ttaagctgat aagcaacttc agcaaagtct caggatacaa aatcaatgtg cagaaatcac
     6061 aagcattcta tacaccaaca atacacaagc agagagccaa atcatgaatg aactcccatt
     6121 cacagttgct agaaagagaa taaaatacct aggaatacag ctaataagat gtgaaggatc
     6181 tcttcaagga gaactacaaa ccactgctca aggaaataag agaggacaca aatgaaaaaa
     6241 cattccattc tcgtggatag gaagaatcaa tatcatgaaa atggccatac tacccaaagt
     6301 aatttatagg ttcattgcta ttcccattaa actactattg acattcttca cagaattaga
     6361 aaaaaactac tttaaaattc aaatggaacc aaaaaagagc ccgtataacc aagacaacaa
     6421 taagcaaaaa gaacaaagct ggaagcatca cactacccaa cttcaaagta tactgcaagg
     6481 ctacagtagc caaaatggca tggtactggt acaaaaacag acacatagac caatggaaca
     6541 gaatagagac cagagaaaga agaccacaca tctacagcca tctgatcatc gacaaacctg
     6601 acaaaaacaa gcaatgggga aaagattccc tatttaataa atggtgctgg gaaaactggc
     6661 tagccatatg cagaaaattg aaactgaccc cttccttaca ccttatacaa aaattaactc
     6721 aagattaaag acttaatgta aaacctaaaa ctataaaaac cctagaagaa aatctattta
     6781 ataccattca agacataggc acaagcaaag gtttcatgac aaaaacatca aaagcaattg
     6841 caacaaaagc aaaaattaca aatgggatct aattaaacta aagagctcct gcacagcaaa
     6901 agaaactatc attagagtga acaggcaacc tacagaatgg gagaacattt ttgcaatcta
     6961 tccatctgac aaaggtctaa tatccagaac ctacaaggaa cttaaaacaa atttacaagg
     7021 aaaaaaacaa ccccatcaaa aagtggacaa aggacatgaa cagacacttc tcaaaagaag
     7081 acatttatgt ggccaacaaa catataaaaa aaagctcaac cttactgatc attagagaaa
     7141 tgcaaaggag aaccacaatg agataccatc tcatgccggt cagaatggtg attattaaaa
     7201 agtcaaaaaa caacagatgc tggcgaggct gtggagaagt aggaacactt ttacattgtt
     7261 ggtgggaatg taaattagtt caaccgttgt ggaagtgtgt gtggctattc ctcaaagatc
     7321 tagaactaga aatactattt gtcccagcaa tcccattact gggtatatac ccaaaggaat
     7381 ataaaccatt ttattataaa gatacatgca catttttgtt cattgcagca ctcttcacaa
     7441 tagcaaagac acaatagcaa atgcccatca aagatagact ggataaagaa aatgtggtac
     7501 atatacacca tggaatactg tgcagtgcag ccattacagc ttttggtgat acagtgaatc
     7561 agatttttca ttaattcttt taattggtta ttactgaacg tgaaaaagta atgtttgtat
     7621 tgaaatcttg agtctggcca tgtttctatt ttaaattcat aaagaattct aacaagagga
     7681 attccaagaa tgtcataaat ggatgtttct ccatggatga aggaactgtt ttattcactt
     7741 gctgataatt cagcctaatc cagtttgaca tcatatagat aagtagttga attatggatt
     7801 taaaatacat atcattttct aactccaaag gtaatactta tttaaatggt tttgaaaata
     7861 tagaaaggca caatttcttt ttaaatctgt tattctccac caccactcaa tctgtctatc
     7921 atctatctct ccattcattc ttccatttgt ttatatctgt taatctttgt atgtgttcat
     7981 gtatagcttt tacatgattg gaatcataat gcatattcca ttttgaagtc tgcttttttt
     8041 tacacaaaaa tatgttgtga atattttcct atattatgaa atatcattag ctgagctttt
     8101 agaattgact gcatgttttg gtaccattta gatatagttt aagatactta gaagttatgt
     8161 ggctttgcca ctatggatga atcttattta ctcaatatta attacttaca aataacctca
     8221 cctaaacact actcagccat aaaaaggaat gaattaatga cattcacagc aacctggaga
     8281 ctattactct aaaggaagta actgaggaat ggaaaaccaa acattgtatg ttctcactca
     8341 taagtgggag ataagctatg aggatgcaaa ggcataagaa ggatacaatg gactttgggg
     8401 acttagggga aagggtggga ggggggtgaa ggataaaaga atacaaattg ggttcagtgt
     8461 atactgctca ggtgatgggt gcaccagaat ctcacaagta accacttaat tacttacgca
     8521 tgtaaccaga taccacctgt tccccaaaca cctatggaaa taattttgtt ttttttttta
     8581 aaaaaggaat gagatcatgt cctttgcagg gacatggatg aagctggaag ccattatcct
     8641 cagcaaacta acagaggagc aggaaaccaa acaccacatg ttctcacttg taagcggaag
     8701 ctgaacaatg agaacacacg gacacaggga tgagatcaac acacactggg gcctgatgca
     8761 ggggccgtag cggggagagc atcaggataa ctagctaatg catgtggggc ttaataccta
     8821 ggtgataggt tgataggtgc agcaaaccac catgggacac gtttacctat gtaacaaacc
     8881 cgcacatcct gcacttgtat ccagaactta aaatatttta aaaatcttta gagaatacaa
     8941 aaaaaaaaaa aaagattctt caatgcatac acaataaaat tgcagttcag tcaaacattg
     9001 gaagtctttc tctgactgtc tagttggtat cttcattttc agcttcttca agatcccact
     9061 ccaaacactg ttagctcagc caaattgaac agctcatatc tcctacctct ggatctttgg
     9121 ttctggtgat tgtatatttc tggaccatct ggaaccccag catatcaccc taccccacat
     9181 ctccacatcc ccaaaatata accatacttc aagggcagtt caaataccat ctccttctat
     9241 cctccatgaa gtcagttatc tcttccattg gaattatcgc cccctctcct gaacagtact
     9301 atttcgtgtg aatctcctcc aagccttctt ttcattttat atctcatgct gtaattcttg
     9361 gaaagtatgc tgtagctcaa gtgcagaatt ctcatcagtt ttatctttat atctctccta
     9421 aacactttac ctgatgaaga gcctggcata cacataaata tatattgaat gaatcagtga
     9481 tggattgaaa agagaaatga tggatctcct aaattttaac ttttataaaa tattttgata
     9541 cattcatgac cttactttag caagcaatga acgtgatgta aactattgtt gatatagttt
     9601 ttatattgga agtgtaagta gtttgtggca tgggattgtg acatatccta ggtttcctca
     9661 tcttcttttt attgaaatgt aattcacaag ccataaaatt tgccccttta aagtaaatga
     9721 tgcagtggat tttagtatat ttacagagtt gtgcaatcat caccactatc taattccaga
     9781 acatttccat ctacctagaa actccatacc agtgagctgc cactctaatc ctcctcttcc
     9841 cccagcctct agaaacaata atccattttc tgtctctatg atttgcctgt tctagatatt
     9901 ttataaaaat aaacatgtgg cctttcgtgt ctgacttcct tcactta
//
