LOCUS       NM_001202515            9734 bp    mRNA    linear   PRI 07-OCT-2024
DEFINITION  Homo sapiens CASP8 and FADD like apoptosis regulator (CFLAR),
            transcript variant 4, mRNA.
ACCESSION   NM_001202515
VERSION     NM_001202515.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9734)
  AUTHORS   Yang,C.Y., Lien,C.I., Tseng,Y.C., Tu,Y.F., Kulczyk,A.W., Lu,Y.C.,
            Wang,Y.T., Su,T.W., Hsu,L.C., Lo,Y.C. and Lin,S.C.
  TITLE     Deciphering DED assembly mechanisms in FADD-procaspase-8-cFLIP
            complexes regulating apoptosis
  JOURNAL   Nat Commun 15 (1), 3791 (2024)
   PUBMED   38710704
  REMARK    GeneRIF: Deciphering DED assembly mechanisms in
            FADD-procaspase-8-cFLIP complexes regulating apoptosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9734)
  AUTHORS   Gao,Y., Yu,S., Chen,M., Wang,X., Pan,L., Wei,B. and Meng,G.
  TITLE     cFLIPS regulates alternative NLRP3 inflammasome activation in human
            monocytes
  JOURNAL   Cell Mol Immunol 20 (10), 1203-1215 (2023)
   PUBMED   37591930
  REMARK    GeneRIF: cFLIPS regulates alternative NLRP3 inflammasome activation
            in human monocytes.
REFERENCE   3  (bases 1 to 9734)
  AUTHORS   Yang,W.J., Han,F.H., Gu,Y.P., Qu,H., Liu,J., Shen,J.H. and Leng,Y.
  TITLE     TGR5 agonist inhibits intestinal epithelial cell apoptosis via
            cAMP/PKA/c-FLIP/JNK signaling pathway and ameliorates dextran
            sulfate sodium-induced ulcerative colitis
  JOURNAL   Acta Pharmacol Sin 44 (8), 1649-1664 (2023)
   PUBMED   36997665
  REMARK    GeneRIF: TGR5 agonist inhibits intestinal epithelial cell apoptosis
            via cAMP/PKA/c-FLIP/JNK signaling pathway and ameliorates dextran
            sulfate sodium-induced ulcerative colitis.
REFERENCE   4  (bases 1 to 9734)
  AUTHORS   Rasper,D.M., Vaillancourt,J.P., Hadano,S., Houtzager,V.M.,
            Seiden,I., Keen,S.L., Tawa,P., Xanthoudakis,S., Nasir,J.,
            Martindale,D., Koop,B.F., Peterson,E.P., Thornberry,N.A., Huang,J.,
            MacPherson,D.P., Black,S.C., Hornung,F., Lenardo,M.J., Hayden,M.R.,
            Roy,S. and Nicholson,D.W.
  TITLE     Cell death attenuation by 'Usurpin', a mammalian DED-caspase
            homologue that precludes caspase-8 recruitment and activation by
            the CD-95 (Fas, APO-1) receptor complex
  JOURNAL   Cell Death Differ 5 (4), 271-288 (1998)
   PUBMED   10200473
REFERENCE   5  (bases 1 to 9734)
  AUTHORS   Goltsev,Y.V., Kovalenko,A.V., Arnold,E., Varfolomeev,E.E.,
            Brodianskii,V.M. and Wallach,D.
  TITLE     CASH, a novel caspase homologue with death effector domains
  JOURNAL   J Biol Chem 272 (32), 19641-19644 (1997)
   PUBMED   9289491
REFERENCE   6  (bases 1 to 9734)
  AUTHORS   Srinivasula,S.M., Ahmad,M., Ottilie,S., Bullrich,F., Banks,S.,
            Wang,Y., Fernandes-Alnemri,T., Croce,C.M., Litwack,G.,
            Tomaselli,K.J., Armstrong,R.C. and Alnemri,E.S.
  TITLE     FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates
            Fas/TNFR1-induced apoptosis
  JOURNAL   J Biol Chem 272 (30), 18542-18545 (1997)
   PUBMED   9228018
REFERENCE   7  (bases 1 to 9734)
  AUTHORS   Kim,T.W., Pettingell,W.H., Jung,Y.K., Kovacs,D.M. and Tanzi,R.E.
  TITLE     Alternative cleavage of Alzheimer-associated presenilins during
            apoptosis by a caspase-3 family protease
  JOURNAL   Science 277 (5324), 373-376 (1997)
   PUBMED   9219695
REFERENCE   8  (bases 1 to 9734)
  AUTHORS   Hu,S., Vincenz,C., Ni,J., Gentz,R. and Dixit,V.M.
  TITLE     I-FLICE, a novel inhibitor of tumor necrosis factor receptor-1- and
            CD-95-induced apoptosis
  JOURNAL   J Biol Chem 272 (28), 17255-17257 (1997)
   PUBMED   9211860
REFERENCE   9  (bases 1 to 9734)
  AUTHORS   Irmler,M., Thome,M., Hahne,M., Schneider,P., Hofmann,K.,
            Steiner,V., Bodmer,J.L., Schroter,M., Burns,K., Mattmann,C.,
            Rimoldi,D., French,L.E. and Tschopp,J.
  TITLE     Inhibition of death receptor signals by cellular FLIP
  JOURNAL   Nature 388 (6638), 190-195 (1997)
   PUBMED   9217161
REFERENCE   10 (bases 1 to 9734)
  AUTHORS   Shu,H.B., Halpin,D.R. and Goeddel,D.V.
  TITLE     Casper is a FADD- and caspase-related inducer of apoptosis
  JOURNAL   Immunity 6 (6), 751-763 (1997)
   PUBMED   9208847
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF041459.1, AC007283.3 and
            BM969271.1.
            
            Summary: The protein encoded by this gene is a regulator of
            apoptosis and is structurally similar to caspase-8. However, the
            encoded protein lacks caspase activity and appears to be itself
            cleaved into two peptides by caspase-8. Several transcript variants
            encoding different isoforms have been found for this gene, and
            partial evidence for several more variants exists. [provided by
            RefSeq, Feb 2011].
            
            Transcript Variant: This variant (4) differs in the 5' UTR and
            coding sequence compared to variant 1. The resulting isoform (3) is
            shorter at the N-terminus compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF041459.1, SRR1163657.573057.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1002              AF041459.1         1-1002
            1003-9704           AC007283.3         63845-72546         c
            9705-9734           BM969271.1         1-30                c
FEATURES             Location/Qualifiers
     source          1..9734
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q33.1"
     gene            1..9734
                     /gene="CFLAR"
                     /gene_synonym="c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH;
                     CASP8AP1; Casper; cFLIP; CLARP; FLAME; FLAME-1; FLAME1;
                     FLIP; I-FLICE; MRIT"
                     /note="CASP8 and FADD like apoptosis regulator"
                     /db_xref="GeneID:8837"
                     /db_xref="HGNC:HGNC:1876"
                     /db_xref="MIM:603599"
     exon            1..165
                     /gene="CFLAR"
                     /gene_synonym="c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH;
                     CASP8AP1; Casper; cFLIP; CLARP; FLAME; FLAME-1; FLAME1;
                     FLIP; I-FLICE; MRIT"
                     /inference="alignment:Splign:2.1.0"
     exon            166..220
                     /gene="CFLAR"
                     /gene_synonym="c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH;
                     CASP8AP1; Casper; cFLIP; CLARP; FLAME; FLAME-1; FLAME1;
                     FLIP; I-FLICE; MRIT"
                     /inference="alignment:Splign:2.1.0"
     exon            221..270
                     /gene="CFLAR"
                     /gene_synonym="c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH;
                     CASP8AP1; Casper; cFLIP; CLARP; FLAME; FLAME-1; FLAME1;
                     FLIP; I-FLICE; MRIT"
                     /inference="alignment:Splign:2.1.0"
     exon            271..352
                     /gene="CFLAR"
                     /gene_synonym="c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH;
                     CASP8AP1; Casper; cFLIP; CLARP; FLAME; FLAME-1; FLAME1;
                     FLIP; I-FLICE; MRIT"
                     /inference="alignment:Splign:2.1.0"
     CDS             295..1002
                     /gene="CFLAR"
                     /gene_synonym="c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH;
                     CASP8AP1; Casper; cFLIP; CLARP; FLAME; FLAME-1; FLAME1;
                     FLIP; I-FLICE; MRIT"
                     /note="isoform 3 is encoded by transcript variant 4;
                     inhibitor of FLICE; caspase-related inducer of apoptosis;
                     usurpin beta; caspase homolog; caspase-eight-related
                     protein; MACH-related inducer of toxicity; FADD-like
                     antiapoptotic molecule 1; cellular FLICE-like inhibitory
                     protein; caspase-like apoptosis regulatory protein; testis
                     secretory sperm-binding protein Li 233m"
                     /codon_start=1
                     /product="CASP8 and FADD-like apoptosis regulator isoform
                     3"
                     /protein_id="NP_001189444.1"
                     /db_xref="GeneID:8837"
                     /db_xref="HGNC:HGNC:1876"
                     /db_xref="MIM:603599"
                     /translation="MKSKPLGICLIIDCIGNETELLRDTFTSLGYEVQKFLHLSMHGI
                     SQILGQFACMPEHRDYDSFVCVLVSRGGSQSVYGVDQTHSGLPLHHIRRMFMGDSCPY
                     LAGKPKMFFIQNYVVSEGQLEDSSLLEVDGPAMKNVEFKAQKRGLCTVHREADFFWSL
                     CTADMSLLEQSHSSPSLYLQCLSQKLRQERKRPLLDLHIELNGYMYDWNSRVSAKEKY
                     YVWLQHTLRKKLILSYT"
     exon            353..863
                     /gene="CFLAR"
                     /gene_synonym="c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH;
                     CASP8AP1; Casper; cFLIP; CLARP; FLAME; FLAME-1; FLAME1;
                     FLIP; I-FLICE; MRIT"
                     /inference="alignment:Splign:2.1.0"
     exon            864..9717
                     /gene="CFLAR"
                     /gene_synonym="c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH;
                     CASP8AP1; Casper; cFLIP; CLARP; FLAME; FLAME-1; FLAME1;
                     FLIP; I-FLICE; MRIT"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      6200
                     /gene="CFLAR"
                     /gene_synonym="c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH;
                     CASP8AP1; Casper; cFLIP; CLARP; FLAME; FLAME-1; FLAME1;
                     FLIP; I-FLICE; MRIT"
                     /note="major polyA site"
     regulatory      6776..6781
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CFLAR"
                     /gene_synonym="c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH;
                     CASP8AP1; Casper; cFLIP; CLARP; FLAME; FLAME-1; FLAME1;
                     FLIP; I-FLICE; MRIT"
                     /note="hexamer: AACAAA"
     polyA_site      6797
                     /gene="CFLAR"
                     /gene_synonym="c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH;
                     CASP8AP1; Casper; cFLIP; CLARP; FLAME; FLAME-1; FLAME1;
                     FLIP; I-FLICE; MRIT"
                     /note="major polyA site"
     regulatory      8743..8748
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CFLAR"
                     /gene_synonym="c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH;
                     CASP8AP1; Casper; cFLIP; CLARP; FLAME; FLAME-1; FLAME1;
                     FLIP; I-FLICE; MRIT"
                     /note="hexamer: AATAAA"
     polyA_site      8765
                     /gene="CFLAR"
                     /gene_synonym="c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH;
                     CASP8AP1; Casper; cFLIP; CLARP; FLAME; FLAME-1; FLAME1;
                     FLIP; I-FLICE; MRIT"
     regulatory      9678..9683
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CFLAR"
                     /gene_synonym="c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH;
                     CASP8AP1; Casper; cFLIP; CLARP; FLAME; FLAME-1; FLAME1;
                     FLIP; I-FLICE; MRIT"
                     /note="hexamer: AATAAA"
     polyA_site      9713
                     /gene="CFLAR"
                     /gene_synonym="c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS; CASH;
                     CASP8AP1; Casper; cFLIP; CLARP; FLAME; FLAME-1; FLAME1;
                     FLIP; I-FLICE; MRIT"
                     /note="major polyA site"
ORIGIN      
        1 accttggact gaaccactat tgaagattta tttgataata atttgtaagt tttaactcag
       61 tacctccctt ctgcttttat agttcaagga gcagggacaa gttacaggaa tgttctccaa
      121 gcagcaatcc aaaagagtct caaggatcct tcaaataact tcaggctcca taatgggaga
      181 agtaaagaac aaagacttaa ggaacagctt ggcgctcaac aagaaccagt gaagaaatcc
      241 attcaggaat cagaagcttt tttgcctcag agcatacctg aagagagata caagatgaag
      301 agcaagcccc taggaatctg cctgataatc gattgcattg gcaatgagac agagcttctt
      361 cgagacacct tcacttccct gggctatgaa gtccagaaat tcttgcatct cagtatgcat
      421 ggtatatccc agattcttgg ccaatttgcc tgtatgcccg agcaccgaga ctacgacagc
      481 tttgtgtgtg tcctggtgag ccgaggaggc tcccagagtg tgtatggtgt ggatcagact
      541 cactcagggc tccccctgca tcacatcagg aggatgttca tgggagattc atgcccttat
      601 ctagcaggga agccaaagat gttttttatt cagaactatg tggtgtcaga gggccagctg
      661 gaggacagca gcctcttgga ggtggatggg ccagcgatga agaatgtgga attcaaggct
      721 cagaagcgag ggctgtgcac agttcaccga gaagctgact tcttctggag cctgtgtact
      781 gcggacatgt ccctgctgga gcagtctcac agctcaccat ccctgtacct gcagtgcctc
      841 tcccagaaac tgagacaaga aagaaaacgc ccactcctgg atcttcacat tgaactcaat
      901 ggctacatgt atgattggaa cagcagagtt tctgccaagg agaaatatta tgtctggctg
      961 cagcacactc tgagaaagaa acttatcctc tcctacacat aagaaaccaa aaggctgggc
     1021 gtagtggctc acacctgtaa tcccagcact ttgggaggcc aaggagggca gatcacttca
     1081 ggtcaggagt tcgagaccag cctggccaac atggtaaacg ctgtccctag taaaaataca
     1141 aaaattagct gggtgtgggt gtgggtacct gtattcccag ttacttggga ggctgaggtg
     1201 ggaggatctt ttgaacccag gagttcaggg tcatagcatg ctgtgattgt gcctacgaat
     1261 agccactgca taccaacctg ggcaatatag caagatccca tctctttaaa aaaaaaaaaa
     1321 aaggacagga actatcttac tcaatgtatt agtcatgttt ctctagaggg acagaactaa
     1381 taggatacat gtatataaaa aggggagttt attaaggagt attgactcac atgatcacag
     1441 ggttaggtcc cacaataggt catctgcaag caaggaagcc aattcaagtc ccaaagctga
     1501 agaacttgga gtccaatgtt tgagggcagg aagcattcag catgagagaa agatggaggc
     1561 cagaagacta caccagtcta gtctttccat gttttgcctg cttttattct ggcagtgctg
     1621 gcagctgatt agatggtgcc cacccagatt gaggatggtc tgcctttccc agtccactga
     1681 ctcaaatgtt aaatctcctt tggcagcacc ctcacagatg tacccgggaa cactttgcat
     1741 ccttctattc aatcaagttg atactcagta ttaaccatca cagtccattt gggcaactat
     1801 accaaattac catagaccag gtgacttaaa cagcagttat ttctcacagt tccggaggct
     1861 gggaaatcca acatctaagt ggtagcatat ctggtgtctg gtaaggcatg cttccagatc
     1921 ttaccagatg tcagtctttt gatgttctca catggcagaa aaagaggatg caaactctca
     1981 agtatatctt taagggcaca aattccattc atgagggctc taccctcatc acctaattac
     2041 ctcccaaagg ccccaccttc tgatactgtc actttgggga tactgtctcc cctttgaatt
     2101 ctggggggaa tacaaacatt cagtttgtaa caatagcctt atgatttaga ggttacttgt
     2161 tcattcacct agacctcaaa ttgcatttta cagctagtca agtatatctt tctctgattt
     2221 gatagtgtga cctaaaaggg gaccattgtt tgaaatatca ttagagttgc ttattattat
     2281 tattattatt attattatta ttattattat tattattgag acagagtttc attctgctgc
     2341 ccaggctgga gtgcagtggc atcatcttgg ctcattgcaa cctctgcctt ctgggttcaa
     2401 gcgattctcc tgcctcagcc tcccgagtag ctgggattac aggctcctgc caccacaccc
     2461 ggctaatttt tgtattttta gtggagacag ggtttccacc atgttggcca gcgtggtctt
     2521 gaactcctga cctcaggtga ttcaccagcc tcggcctccc aaagtgctgg gattacaggt
     2581 gtgagccact gcacctggcc tattattatt tttaaatttt ttttttttaa ttgatcattc
     2641 ttgggtgttt ctcacagagg gtgatttggc agggtcacag gacaatagtg gagggaaggt
     2701 cagcagataa acaagtgaac aaaggtctct ggttttccta ggcagaggac cctgcggcct
     2761 tccgcagtgt ttgtgtccct gggtacttga gattagggag tggtgatgac tcttaaggag
     2821 catgctgcct tcaagcatct gtttaacaaa gcacatcttg cactgccctt aatccattta
     2881 accctgagtg gacacagcac atgtttcaga gagcacaggg ttgggggtaa ggtcatagat
     2941 caacagcatc ctaaggcaga agaatttttc ttagtacaga acaaaatgaa gtctcccatg
     3001 tctacttctt tctacacaga cacagcaaca atctgatttc tctatctttt ccccaccttt
     3061 cccccttttc tattccacaa aaccgccatc gtcatcatgg cctgttctca atgagctgtt
     3121 gggtacacct cccagacggg gtggcggctg ggcagagggg ctcctcactt cccagatggg
     3181 gcggccaggc ggacgcgccc cccacctccc tcccggacgg gatagctggc cgggcggggg
     3241 ctgacccccc acctccctcc ccgacggggc ggctggccgg gcgggggctg acccccacgc
     3301 ctccctcccg gacggggcgg ctgccaggcg gaggggctcc tcacttctca gacggggtgg
     3361 ctgctgggcg gagacgctcc tcacttccca gacagggtgg ctgtcgggcg gaggggctcc
     3421 tcacttctca gacggggcag ctgcgggcgg aggggctcct cacttctcag acggggtggc
     3481 cgggcagaga agctcctcac atcccagacg ggggggcggg gcagaggcgc tccccacatc
     3541 tcagacgatg ggcggccggg cagagacgct cctcacttca tcccagacgg ggtggcggcc
     3601 gggcagaagc tgtaatctcg gcaccctggg gggccaaggc aggcggctgg gaggcggagg
     3661 ccgtagccag ctgagatcac accactgcac tccagcctgg gcaacattga gcactgagtg
     3721 gacgagactc tgcccgcaat cccggcacct cgggaggccg aggctggcag atcactcgca
     3781 gtcaggagct ggagaccagc ccggccaaca cagtgaaacc ctgtctccac caaaaaaata
     3841 cgaaaaccag tcaggcgtgg cggcgcccgc aatggcaggc acgcggcagg ccgaggcggg
     3901 agaatcaggc agggaggctg cagtgagccg agatggcagc agtacagtcc agcttcggct
     3961 cggcatcaga gggagaccgt ggggagaggg agaagagagg gagggggaga gggctatttt
     4021 taaaattttt taaaattgct gaacaggggt acctctgggc agtgtgtcag aataccactt
     4081 tttaaatatt ttatgattta tttatttttc tatttcttga ggttttaact gatgtgtatc
     4141 tgtatgtcta tttgtgtata ttttgtcatg atcatgtaac agagtctgaa aagtgtcgaa
     4201 gagacagttt tcaggaacaa caagcaatta ttcctacttt ccaagttatt ttgatgccat
     4261 ggtggctcat acctataatc tgagtacttt gggaggctga ggtggactga tcacttgagc
     4321 ccaggagttt gagaccagcc tgggcaacat agcaagactc catctctaca aaaaaagaca
     4381 aaatttagct gagcgtggtg gcgtgttcct gtagtcccag ctacttggga ggctgaagtg
     4441 agtggatccc ctgagcccag agaggtcaag gttgtgatga gctgtgatca caccactgca
     4501 cttcagcatg ggagacagag tgagaccctg tttcagaaaa aataaataaa taaaaccacc
     4561 agcaccacaa acaacaacaa aaagttattt tgtacttgtt ttgagcacag gactcctgag
     4621 ggtatctttg catttaatat tacatagggg tgccagtggg aagtaatgtg tatgcttggc
     4681 ctcatgagct aaaaccctgt gttaattatg acagaaggaa agtgtgtgag agagatctta
     4741 actacctagc agctctagct gccatcttga accatgaaga tacgggccac acgtaggggt
     4801 agctgggtag tgagcagcaa gaagccttgt tggatgaggg cacgaaggag cagaatcact
     4861 ggaatcactg tgtcagccct aattacctac ctctggactt ttatgtgagg ggaaaaaaaa
     4921 ttgacagttt atatttatct caacctagtt aacccaagtg atgcattgtt atgagattaa
     4981 aatgtttgga ggccgggtgc ggtggctcac gcctataatc ccagcccttt gggaggccaa
     5041 ggcgggcgga tcacgaggtc aggagatcaa gaccatcctg gctaacatgt aaaaccccgt
     5101 ctctactaaa aatacaaaaa attagccagg cgttgtggcg gtcgcctgta gtccctgcta
     5161 tttgggaggc cgaggcaaga gaacggcatg aacctgggag gtggagcttg cagcgagctg
     5221 agatcttgcc actgcactcc agcctgggcg acagtgcgag actctgtctc aaaaataaat
     5281 aaataaataa ataataaata aaatgtttgg aatgttggct tcatccctgg gatgcaaggc
     5341 tggttcaaca tacgcaaatc aagaaacata attcatcaca taaacagaac taaagacaaa
     5401 aaccacatga ttatctcaat agatacagaa aaggccttca ataaaattca acgttgcttc
     5461 atgttaaaaa ctctcaataa actaggtatt gatggaaaat atctcaaaat aataaccatt
     5521 tatgacaaac ccacagccat tatcatactg aatgggcaaa agctggaagc attccccttg
     5581 aaaactggca caagacaggg atgccgtctc accactccta tttaacatag tattggaagt
     5641 tctggccaag aaaatcaggc aagagaaaca aataaggggt attcaaatag gaaaagagga
     5701 agtaaaactg tgtttgcaga tgacatgata ctatatctag aaaaccccat tatctccacc
     5761 caaaagttcc ttaagctgat aagcaacttc agcaaagtct caggatacaa aatcaatgtg
     5821 cagaaatcac aagcattcta tacaccaaca atacacaagc agagagccaa atcatgaatg
     5881 aactcccatt cacagttgct agaaagagaa taaaatacct aggaatacag ctaataagat
     5941 gtgaaggatc tcttcaagga gaactacaaa ccactgctca aggaaataag agaggacaca
     6001 aatgaaaaaa cattccattc tcgtggatag gaagaatcaa tatcatgaaa atggccatac
     6061 tacccaaagt aatttatagg ttcattgcta ttcccattaa actactattg acattcttca
     6121 cagaattaga aaaaaactac tttaaaattc aaatggaacc aaaaaagagc ccgtataacc
     6181 aagacaacaa taagcaaaaa gaacaaagct ggaagcatca cactacccaa cttcaaagta
     6241 tactgcaagg ctacagtagc caaaatggca tggtactggt acaaaaacag acacatagac
     6301 caatggaaca gaatagagac cagagaaaga agaccacaca tctacagcca tctgatcatc
     6361 gacaaacctg acaaaaacaa gcaatgggga aaagattccc tatttaataa atggtgctgg
     6421 gaaaactggc tagccatatg cagaaaattg aaactgaccc cttccttaca ccttatacaa
     6481 aaattaactc aagattaaag acttaatgta aaacctaaaa ctataaaaac cctagaagaa
     6541 aatctattta ataccattca agacataggc acaagcaaag gtttcatgac aaaaacatca
     6601 aaagcaattg caacaaaagc aaaaattaca aatgggatct aattaaacta aagagctcct
     6661 gcacagcaaa agaaactatc attagagtga acaggcaacc tacagaatgg gagaacattt
     6721 ttgcaatcta tccatctgac aaaggtctaa tatccagaac ctacaaggaa cttaaaacaa
     6781 atttacaagg aaaaaaacaa ccccatcaaa aagtggacaa aggacatgaa cagacacttc
     6841 tcaaaagaag acatttatgt ggccaacaaa catataaaaa aaagctcaac cttactgatc
     6901 attagagaaa tgcaaaggag aaccacaatg agataccatc tcatgccggt cagaatggtg
     6961 attattaaaa agtcaaaaaa caacagatgc tggcgaggct gtggagaagt aggaacactt
     7021 ttacattgtt ggtgggaatg taaattagtt caaccgttgt ggaagtgtgt gtggctattc
     7081 ctcaaagatc tagaactaga aatactattt gtcccagcaa tcccattact gggtatatac
     7141 ccaaaggaat ataaaccatt ttattataaa gatacatgca catttttgtt cattgcagca
     7201 ctcttcacaa tagcaaagac acaatagcaa atgcccatca aagatagact ggataaagaa
     7261 aatgtggtac atatacacca tggaatactg tgcagtgcag ccattacagc ttttggtgat
     7321 acagtgaatc agatttttca ttaattcttt taattggtta ttactgaacg tgaaaaagta
     7381 atgtttgtat tgaaatcttg agtctggcca tgtttctatt ttaaattcat aaagaattct
     7441 aacaagagga attccaagaa tgtcataaat ggatgtttct ccatggatga aggaactgtt
     7501 ttattcactt gctgataatt cagcctaatc cagtttgaca tcatatagat aagtagttga
     7561 attatggatt taaaatacat atcattttct aactccaaag gtaatactta tttaaatggt
     7621 tttgaaaata tagaaaggca caatttcttt ttaaatctgt tattctccac caccactcaa
     7681 tctgtctatc atctatctct ccattcattc ttccatttgt ttatatctgt taatctttgt
     7741 atgtgttcat gtatagcttt tacatgattg gaatcataat gcatattcca ttttgaagtc
     7801 tgcttttttt tacacaaaaa tatgttgtga atattttcct atattatgaa atatcattag
     7861 ctgagctttt agaattgact gcatgttttg gtaccattta gatatagttt aagatactta
     7921 gaagttatgt ggctttgcca ctatggatga atcttattta ctcaatatta attacttaca
     7981 aataacctca cctaaacact actcagccat aaaaaggaat gaattaatga cattcacagc
     8041 aacctggaga ctattactct aaaggaagta actgaggaat ggaaaaccaa acattgtatg
     8101 ttctcactca taagtgggag ataagctatg aggatgcaaa ggcataagaa ggatacaatg
     8161 gactttgggg acttagggga aagggtggga ggggggtgaa ggataaaaga atacaaattg
     8221 ggttcagtgt atactgctca ggtgatgggt gcaccagaat ctcacaagta accacttaat
     8281 tacttacgca tgtaaccaga taccacctgt tccccaaaca cctatggaaa taattttgtt
     8341 ttttttttta aaaaaggaat gagatcatgt cctttgcagg gacatggatg aagctggaag
     8401 ccattatcct cagcaaacta acagaggagc aggaaaccaa acaccacatg ttctcacttg
     8461 taagcggaag ctgaacaatg agaacacacg gacacaggga tgagatcaac acacactggg
     8521 gcctgatgca ggggccgtag cggggagagc atcaggataa ctagctaatg catgtggggc
     8581 ttaataccta ggtgataggt tgataggtgc agcaaaccac catgggacac gtttacctat
     8641 gtaacaaacc cgcacatcct gcacttgtat ccagaactta aaatatttta aaaatcttta
     8701 gagaatacaa aaaaaaaaaa aaagattctt caatgcatac acaataaaat tgcagttcag
     8761 tcaaacattg gaagtctttc tctgactgtc tagttggtat cttcattttc agcttcttca
     8821 agatcccact ccaaacactg ttagctcagc caaattgaac agctcatatc tcctacctct
     8881 ggatctttgg ttctggtgat tgtatatttc tggaccatct ggaaccccag catatcaccc
     8941 taccccacat ctccacatcc ccaaaatata accatacttc aagggcagtt caaataccat
     9001 ctccttctat cctccatgaa gtcagttatc tcttccattg gaattatcgc cccctctcct
     9061 gaacagtact atttcgtgtg aatctcctcc aagccttctt ttcattttat atctcatgct
     9121 gtaattcttg gaaagtatgc tgtagctcaa gtgcagaatt ctcatcagtt ttatctttat
     9181 atctctccta aacactttac ctgatgaaga gcctggcata cacataaata tatattgaat
     9241 gaatcagtga tggattgaaa agagaaatga tggatctcct aaattttaac ttttataaaa
     9301 tattttgata cattcatgac cttactttag caagcaatga acgtgatgta aactattgtt
     9361 gatatagttt ttatattgga agtgtaagta gtttgtggca tgggattgtg acatatccta
     9421 ggtttcctca tcttcttttt attgaaatgt aattcacaag ccataaaatt tgccccttta
     9481 aagtaaatga tgcagtggat tttagtatat ttacagagtt gtgcaatcat caccactatc
     9541 taattccaga acatttccat ctacctagaa actccatacc agtgagctgc cactctaatc
     9601 ctcctcttcc cccagcctct agaaacaata atccattttc tgtctctatg atttgcctgt
     9661 tctagatatt ttataaaaat aaacatgtgg cctttcgtgt ctgacttcct tcacttaaaa
     9721 aaaaaaaaaa aaaa
//
