LOCUS       NM_138638               4306 bp    mRNA    linear   PRI 11-OCT-2024
DEFINITION  Homo sapiens cofilin 2 (CFL2), transcript variant 2, mRNA.
ACCESSION   NM_138638
VERSION     NM_138638.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4306)
  AUTHORS   Robaszkiewicz,K., Wrobel,J. and Moraczewska,J.
  TITLE     Troponin and a Myopathy-Linked Mutation in TPM3 Inhibit
            Cofilin-2-Induced Thin Filament Depolymerization
  JOURNAL   Int J Mol Sci 24 (22), 16457 (2023)
   PUBMED   38003645
  REMARK    GeneRIF: Troponin and a Myopathy-Linked Mutation in TPM3 Inhibit
            Cofilin-2-Induced Thin Filament Depolymerization.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4306)
  AUTHORS   Kraus,J., Russell,R.W., Kudryashova,E., Xu,C., Katyal,N.,
            Perilla,J.R., Kudryashov,D.S. and Polenova,T.
  TITLE     Magic angle spinning NMR structure of human cofilin-2 assembled on
            actin filaments reveals isoform-specific conformation and binding
            mode
  JOURNAL   Nat Commun 13 (1), 2114 (2022)
   PUBMED   35440100
  REMARK    GeneRIF: Magic angle spinning NMR structure of human cofilin-2
            assembled on actin filaments reveals isoform-specific conformation
            and binding mode.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4306)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 4306)
  AUTHORS   Zhang,L., Zhang,W., Zuo,Z., Tang,J., Song,Y., Cao,F., Yu,X., Liu,S.
            and Cai,X.
  TITLE     Circ_0008673 regulates breast cancer malignancy by miR-153-3p/CFL2
            axis
  JOURNAL   Arch Gynecol Obstet 305 (1), 223-232 (2022)
   PUBMED   34324029
  REMARK    GeneRIF: Circ_0008673 regulates breast cancer malignancy by
            miR-153-3p/CFL2 axis.
REFERENCE   5  (bases 1 to 4306)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 4306)
  AUTHORS   Bamburg,J.R., McGough,A. and Ono,S.
  TITLE     Putting a new twist on actin: ADF/cofilins modulate actin dynamics
  JOURNAL   Trends Cell Biol 9 (9), 364-370 (1999)
   PUBMED   10461190
  REMARK    Review article
REFERENCE   7  (bases 1 to 4306)
  AUTHORS   Yang,N., Higuchi,O., Ohashi,K., Nagata,K., Wada,A., Kangawa,K.,
            Nishida,E. and Mizuno,K.
  TITLE     Cofilin phosphorylation by LIM-kinase 1 and its role in
            Rac-mediated actin reorganization
  JOURNAL   Nature 393 (6687), 809-812 (1998)
   PUBMED   9655398
REFERENCE   8  (bases 1 to 4306)
  AUTHORS   Nebl,G., Meuer,S.C. and Samstag,Y.
  TITLE     Dephosphorylation of serine 3 regulates nuclear translocation of
            cofilin
  JOURNAL   J Biol Chem 271 (42), 26276-26280 (1996)
   PUBMED   8824278
REFERENCE   9  (bases 1 to 4306)
  AUTHORS   Gillett,G.T., Fox,M.F., Rowe,P.S., Casimir,C.M. and Povey,S.
  TITLE     Mapping of human non-muscle type cofilin (CFL1) to chromosome 11q13
            and muscle-type cofilin (CFL2) to chromosome 14
  JOURNAL   Ann Hum Genet 60 (3), 201-211 (1996)
   PUBMED   8800436
REFERENCE   10 (bases 1 to 4306)
  AUTHORS   North,K.N. and Ryan,M.M.
  TITLE     Nemaline Myopathy - RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301465
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC022364.1, AL355885.4 and
            DB378917.1.
            
            On May 16, 2019 this sequence version replaced NM_138638.4.
            
            Summary: This gene encodes an intracellular protein that is
            involved in the regulation of actin-filament dynamics. This protein
            is a major component of intranuclear and cytoplasmic actin rods. It
            can bind G- and F-actin in a 1:1 ratio of cofilin to actin, and it
            reversibly controls actin polymerization and depolymerization in a
            pH-dependent manner. Mutations in this gene cause nemaline myopathy
            type 7, a form of congenital myopathy. Alternative splicing results
            in multiple transcript variants. [provided by RefSeq, Jul 2009].
            
            Transcript Variant: This variant (2) encodes the longer isoform
            (1). Both variants 1 and 2 encode the same isoform.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.372399.1,
                                           SRR14038191.3614043.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000298159.11/ ENSP00000298159.6
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1404              BC022364.1         98-1501
            1405-2621           AL355885.4         22323-23539         c
            2622-3037           DB378917.1         1-416               c
            3038-4306           AL355885.4         20638-21906         c
FEATURES             Location/Qualifiers
     source          1..4306
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q13.1"
     gene            1..4306
                     /gene="CFL2"
                     /gene_synonym="NEM7"
                     /note="cofilin 2"
                     /db_xref="GeneID:1073"
                     /db_xref="HGNC:HGNC:1875"
                     /db_xref="MIM:601443"
     exon            1..56
                     /gene="CFL2"
                     /gene_synonym="NEM7"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..554
                     /gene="CFL2"
                     /gene_synonym="NEM7"
                     /note="isoform 1 is encoded by transcript variant 2;
                     nemaline myopathy type 7; cofilin 2 (muscle)"
                     /codon_start=1
                     /product="cofilin-2 isoform 1"
                     /protein_id="NP_619579.1"
                     /db_xref="CCDS:CCDS9649.1"
                     /db_xref="GeneID:1073"
                     /db_xref="HGNC:HGNC:1875"
                     /db_xref="MIM:601443"
                     /translation="MASGVTVNDEVIKVFNDMKVRKSSTQEEIKKRKKAVLFCLSDDK
                     RQIIVEEAKQILVGDIGDTVEDPYTSFVKLLPLNDCRYALYDATYETKESKKEDLVFI
                     FWAPESAPLKSKMIYASSKDAIKKKFTGIKHEWQVNGLDDIKDRSTLGEKLGGNVVVS
                     LEGKPL"
     exon            57..364
                     /gene="CFL2"
                     /gene_synonym="NEM7"
                     /inference="alignment:Splign:2.1.0"
     exon            365..441
                     /gene="CFL2"
                     /gene_synonym="NEM7"
                     /inference="alignment:Splign:2.1.0"
     exon            442..4306
                     /gene="CFL2"
                     /gene_synonym="NEM7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1386..1391
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CFL2"
                     /gene_synonym="NEM7"
                     /note="hexamer: AATAAA"
     polyA_site      1408
                     /gene="CFL2"
                     /gene_synonym="NEM7"
                     /note="major polyA site"
     regulatory      2954..2959
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CFL2"
                     /gene_synonym="NEM7"
                     /note="hexamer: AATAAA"
     regulatory      2959..2964
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CFL2"
                     /gene_synonym="NEM7"
                     /note="hexamer: AATATA"
     polyA_site      2972
                     /gene="CFL2"
                     /gene_synonym="NEM7"
     polyA_site      2978
                     /gene="CFL2"
                     /gene_synonym="NEM7"
     regulatory      3012..3017
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CFL2"
                     /gene_synonym="NEM7"
                     /note="hexamer: ATTAAA"
     polyA_site      3045
                     /gene="CFL2"
                     /gene_synonym="NEM7"
     regulatory      4281..4286
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CFL2"
                     /gene_synonym="NEM7"
                     /note="hexamer: ATTAAA"
     polyA_site      4306
                     /gene="CFL2"
                     /gene_synonym="NEM7"
ORIGIN      
        1 agtgccacag agccgaagcc cgagctgccg ccgcagccac agccgagggc actatggctt
       61 ctggagttac agtgaatgat gaagtcatca aagtttttaa tgatatgaaa gtaaggaaat
      121 cttctacaca agaggagatc aaaaagagaa agaaagcagt tctcttctgt ttaagcgatg
      181 acaaaagaca aataattgta gaggaagcaa agcagatctt ggtgggtgac attggtgata
      241 ctgtagagga cccctacaca tcttttgtga agttgctacc tctgaatgat tgccgatatg
      301 ctttgtacga tgccacatac gaaacaaaag agtctaagaa agaagaccta gtatttatat
      361 tctgggctcc tgaaagtgca cctttaaaaa gcaagatgat ttatgctagc tctaaagatg
      421 ccattaaaaa gaaatttaca ggtattaaac atgagtggca agtaaatggc ttggatgata
      481 ttaaggaccg ttcgacactt ggagagaaat tgggaggcaa tgtagtagtt tcacttgaag
      541 gaaaaccatt ataaaatgac agtcaagtgc catctggatc ttaaggagct tccatttctc
      601 cagctcagtc cattggaata gtattaggtt ttggtttttt gttgtatttc cccctttcca
      661 ctgggccctt ccaacacaat gaatgaagga aatatcattt atttaagcag cctatcagtg
      721 attgccatta gactgttgaa tactgttact tttatataga acccaaggaa tgccttcctg
      781 tcatatttta gccaaaacaa ctggttatat gcctcccttg cagcaagcac tacaatgtat
      841 gtgatcgtca atgtgaatag cttagaatac tgcaaaggat aagctaattg aatgccttga
      901 aagtattatc cactggtcag atggtcaact tttttcagta ttatttatag ttggcacttg
      961 attgcagttc tgtgaggctt gagcattcat acacctcacc tgccttggca agcctatttt
     1021 agtgatatgg cagcacggat ataacactat gcattaaaag cactttttgt aataagttta
     1081 atatcctaaa aggaatgcca attaagtttt gttaactgtg tcatcaactt atcctagtac
     1141 ctcagtgttc attcctgtta cctgcatatc ttcttaaaag aaatagctgt tattaatgcc
     1201 tttttgtttt ccattgagtg tacactactg aataagtgta ggagttttat gtttaccatg
     1261 tgagtcctgc aacactaaag atattttgaa tatcagtcat gatggcaatt tctgtataaa
     1321 agagccttaa atggaacatt gttttgagat caaactcccc accctcacaa aaatggccac
     1381 gttgcaataa aaattgtggc atattacaga acgttgcctt gttttccttg gaaattttgc
     1441 aaaatgttat gtgaaacaac ttctagggta aaaacagcta ttactaatct ctgcactggt
     1501 catttgagaa ttttttttgt acagcattca tgtgtgatat tttccagatt tgttggatct
     1561 atttggttta aaaagtattc tatcttaagg ccaactaata taaaatacca ttgttaaaga
     1621 atggtacttt tataaacatt agtgtattta tttcctatgt gttaatatga agatcagaaa
     1681 ttattttttg cactttggca taaatacttt tcaatatctg atttgttctc tggataaatt
     1741 agcatagtta tttttttatt cacatttaca tttctaagta gttgtatagt agaagcagga
     1801 agctcttatt gcttatttgg tcgtaatgaa aataatttgt aaaatgtcct ttaaaagttt
     1861 aatgatactt ctgatgtttc ggaacagtca tttcacctac tatttctgaa tatattttgc
     1921 aaattgaatt ggaataggaa ttgataatag cagtcttaaa cattagtagt gggatttggc
     1981 tatggtccag actgtgctcc ttatagagaa tttgatctgc tcagtgtgag cggtttgctg
     2041 ttagccaggg ctatttatgg caaacacatg cttttgtatc ttgtcatagt tatccacaaa
     2101 tggcaaaact ggacttgatt ctactggtat gcaaaacagg catgctagta agcagtcagt
     2161 cgtggctcag aacttaaccc catagctcag aggaatgctt ttagcagaaa acaggaaaga
     2221 aaatatccct taaaaatttt ttttgaatgt gtggaagtaa ttttagtata attagatttt
     2281 ttccatattt ttgaaagatt tttcagatgt gaacattaaa aatagggatt aaatgtctag
     2341 gcttccattt aaaattatat gaatggtttg ggatcttttt gcactgagca attttatttc
     2401 aggcttccag ctgtccctgt gagttatcct ggacatttcg atggtttttg gtaaggccaa
     2461 actctgataa gcaaaacaga gaatactgac gtatacttaa ccatatgtgt aactgatact
     2521 tggcaccatg gaatttttca ttgagttatt tcctcattct tttaaaaaat aagggactat
     2581 aaatcagtta tgtagtatct tttgtttttg tagctgattc cttaactttc ttgtatgcct
     2641 ctagtaattt cagagattaa atattgcttt aaactgtgat actttgattt gctagattga
     2701 caaaactgat actaatataa ttaagttcat ctttgaaata catctttgtg cgtagagcca
     2761 aaaaaagaga taaaattaat aatagttcac ttgttatttg agattaattt ggcatttgaa
     2821 atgatcattt tattttacaa tcatttataa tgaatcaatg ttccagttag ctttaaaagg
     2881 tatacggtgc taattagtaa aatattgaag gcaatatttt actgctagct tgcaaagtta
     2941 tgagagttta aaaaataaaa tatatgaaaa tatgtaaagc tgttgagatg tgtttactta
     3001 tacttcagaa cattaaaagt ttaaaaactg gtatttcaga tcaaagaggc atcattatct
     3061 ttattctgtt tttcaggatt ttagttggta atactttctc atttatcaat aacaattttc
     3121 tttaaaaact gagtgttaca gcaattaatt ttagcatttt cagacaaatg ggaacagttg
     3181 gcatgtgtcc caaactggct atcagctgtt gttttccatc attatctaaa atagtgtggc
     3241 cagcattgtg tattgaaatg tgcctttttc gtacattgga agagaagcct cttactgggt
     3301 ttgagtttct ctgatacaga acatttgtag cagctaattt atggaatctg gcaaataagc
     3361 tttgggagga aattctttta aaagtgtttt cttgttaagg aataatctca acaatggtaa
     3421 atcatcaaga ggttgagaag actcttaggt ttgccactca gaaaaaacag tctcattttg
     3481 ctcttcatag gtcctgtttt tgcttgcaca tttaatagta ggtggagatg caaaacaacg
     3541 tgaatgttca tttttttatg aatagtatta aagctactag aggtgggcag gcaggtccca
     3601 gtaaatgttg cctttttttt tttttttttt tgagacaggg tctcactctg ttgcccaggc
     3661 tggagtgcag tgtcaaaatt tcagctcact tcaaactcaa ccttcccagc tcagatgatc
     3721 ctcccacctc agcctcccaa gtagctggga ctacaggcat gcaccaccat gcctaatttt
     3781 tttttttttt ttttttgtat ctcttttgta gagactgagt ttggccatgt tgcctaggct
     3841 gatctccaac tcctgggctc aagctgtcct ctgacctccg cctcccaaaa gtgctaggat
     3901 tgcatgcatg agccaccact tcaaaagctc aaatactgct tttgaagaca gcatgagttt
     3961 atggatgttc tgtctccttt cagcccataa agaagtctga ggcttttctt ttgctctgga
     4021 acatccaact aattgcttta tttccatgta gaagtagagg aatcatccct ccacttaaat
     4081 ttcctctcat aatgcaattt ggcaaattaa atctctaaat ctcagttttt taacccatag
     4141 tatgggaacg gtaatatctg tttaccatgt ttcctgagta ctaaatatgg aaatggtttt
     4201 tgaaaacagg aaaatgctat gtaaatgcaa taatctgttt aaactattca ttcttaatta
     4261 ctgtatgtaa gtagataaat attaaatgtt tttgttaaaa gatgta
//
