LOCUS       NM_005507               1245 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens cofilin 1 (CFL1), mRNA.
ACCESSION   NM_005507
VERSION     NM_005507.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1245)
  AUTHORS   Wang,Z., Li,Y., Yang,J., Sun,Y., He,Y., Wang,Y., Liang,Y., Chen,X.,
            Chen,T., Han,D., Zhang,N., Chen,B., Zhao,W., Wang,L., Luo,D. and
            Yang,Q.
  TITLE     CircCFL1 Promotes TNBC Stemness and Immunoescape via
            Deacetylation-Mediated c-Myc Deubiquitylation to Facilitate Mutant
            TP53 Transcription
  JOURNAL   Adv Sci (Weinh) 11 (34), e2404628 (2024)
   PUBMED   38981022
  REMARK    GeneRIF: CircCFL1 Promotes TNBC Stemness and Immunoescape via
            Deacetylation-Mediated c-Myc Deubiquitylation to Facilitate Mutant
            TP53 Transcription.
REFERENCE   2  (bases 1 to 1245)
  AUTHORS   Falace,A., Corbieres,L., Palminha,C., Guarnieri,F.C., Schaller,F.,
            Buhler,E., Tuccari di San Carlo,C., Montheil,A., Watrin,F.,
            Manent,J.B., Represa,A., de Chevigny,A., Pallesi-Pocachard,E. and
            Cardoso,C.
  TITLE     FLNA regulates neuronal maturation by modulating RAC1-Cofilin
            activity in the developing cortex
  JOURNAL   Neurobiol Dis 198, 106558 (2024)
   PUBMED   38852754
  REMARK    GeneRIF: FLNA regulates neuronal maturation by modulating
            RAC1-Cofilin activity in the developing cortex.
REFERENCE   3  (bases 1 to 1245)
  AUTHORS   Griesler,B., Holzel,M., Oswald,J., Fander,J., Fischer,T.,
            Buttner,M., Quandt,D., Bahr,I., Jasinski-Bergner,S.,
            Bazwinsky-Wutschke,I. and Kielstein,H.
  TITLE     Impact of siRNA-Mediated Cofilin-1 Knockdown and Obesity Associated
            Microenvironment on the Motility of Natural Killer Cells
  JOURNAL   Immunol Invest 53 (5), 713-729 (2024)
   PUBMED   38721960
  REMARK    GeneRIF: Impact of siRNA-Mediated Cofilin-1 Knockdown and Obesity
            Associated Microenvironment on the Motility of Natural Killer
            Cells.
REFERENCE   4  (bases 1 to 1245)
  AUTHORS   Ullo,M.F., D'Amico,A.E., Lavenus,S.B. and Logue,J.S.
  TITLE     The amoeboid migration of monocytes in confining channels requires
            the local remodeling of the cortical actin cytoskeleton by
            cofilin-1
  JOURNAL   Sci Rep 14 (1), 10241 (2024)
   PUBMED   38702365
  REMARK    GeneRIF: The amoeboid migration of monocytes in confining channels
            requires the local remodeling of the cortical actin cytoskeleton by
            cofilin-1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1245)
  AUTHORS   Sexton,J.A., Potchernikov,T., Bibeau,J.P., Casanova-Sepulveda,G.,
            Cao,W., Lou,H.J., Boggon,T.J., De La Cruz,E.M. and Turk,B.E.
  TITLE     Distinct functional constraints driving conservation of the cofilin
            N-terminal regulatory tail
  JOURNAL   Nat Commun 15 (1), 1426 (2024)
   PUBMED   38365893
  REMARK    GeneRIF: Distinct functional constraints driving conservation of
            the cofilin N-terminal regulatory tail.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1245)
  AUTHORS   van der Steege,G., Draaijers,T.G., Grootscholten,P.M., Osinga,J.,
            Anzevino,R., Velona,I., Den Dunnen,J.T., Scheffer,H., Brahe,C., van
            Ommen,G.J. et al.
  TITLE     A provisional transcript map of the spinal muscular atrophy (SMA)
            critical region
  JOURNAL   Eur J Hum Genet 3 (2), 87-95 (1995)
   PUBMED   7552146
REFERENCE   7  (bases 1 to 1245)
  AUTHORS   Kato,S., Sekine,S., Oh,S.W., Kim,N.S., Umezawa,Y., Abe,N.,
            Yokoyama-Kobayashi,M. and Aoki,T.
  TITLE     Construction of a human full-length cDNA bank
  JOURNAL   Gene 150 (2), 243-250 (1994)
   PUBMED   7821789
REFERENCE   8  (bases 1 to 1245)
  AUTHORS   Davidson,M.M. and Haslam,R.J.
  TITLE     Dephosphorylation of cofilin in stimulated platelets: roles for a
            GTP-binding protein and Ca2+
  JOURNAL   Biochem J 301 (Pt 1) (Pt 1), 41-47 (1994)
   PUBMED   8037689
REFERENCE   9  (bases 1 to 1245)
  AUTHORS   Ono,S., Minami,N., Abe,H. and Obinata,T.
  TITLE     Characterization of a novel cofilin isoform that is predominantly
            expressed in mammalian skeletal muscle
  JOURNAL   J Biol Chem 269 (21), 15280-15286 (1994)
   PUBMED   8195165
REFERENCE   10 (bases 1 to 1245)
  AUTHORS   Ogawa,K., Tashima,M., Yumoto,Y., Okuda,T., Sawada,H., Okuma,M. and
            Maruyama,Y.
  TITLE     Coding sequence of human placenta cofilin cDNA
  JOURNAL   Nucleic Acids Res 18 (23), 7169 (1990)
   PUBMED   2263493
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK097690.1, BC018256.2,
            CB850882.1 and AP001266.4.
            
            On Nov 23, 2018 this sequence version replaced NM_005507.2.
            
            Summary: The protein encoded by this gene can polymerize and
            depolymerize F-actin and G-actin in a pH-dependent manner.
            Increased phosphorylation of this protein by LIM kinase aids in
            Rho-induced reorganization of the actin cytoskeleton. Cofilin is a
            widely distributed intracellular actin-modulating protein that
            binds and depolymerizes filamentous F-actin and inhibits the
            polymerization of monomeric G-actin in a pH-dependent manner. It is
            involved in the translocation of actin-cofilin complex from
            cytoplasm to nucleus.[supplied by OMIM, Apr 2004].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.75700.1,
                                           SRR1163657.204330.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000308162.10/ ENSP00000309629.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-278               AK097690.1         636-913
            279-855             BC018256.2         260-836
            856-1107            CB850882.1         33-284              c
            1108-1245           AP001266.4         154365-154502       c
FEATURES             Location/Qualifiers
     source          1..1245
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..1245
                     /gene="CFL1"
                     /gene_synonym="CFL; cofilin; HEL-S-15"
                     /note="cofilin 1"
                     /db_xref="GeneID:1072"
                     /db_xref="HGNC:HGNC:1874"
                     /db_xref="MIM:601442"
     exon            1..84
                     /gene="CFL1"
                     /gene_synonym="CFL; cofilin; HEL-S-15"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..582
                     /gene="CFL1"
                     /gene_synonym="CFL; cofilin; HEL-S-15"
                     /note="p18; 18 kDa phosphoprotein; epididymis secretory
                     protein Li 15; cofilin 1 (non-muscle)"
                     /codon_start=1
                     /product="cofilin-1"
                     /protein_id="NP_005498.1"
                     /db_xref="CCDS:CCDS8114.1"
                     /db_xref="GeneID:1072"
                     /db_xref="HGNC:HGNC:1874"
                     /db_xref="MIM:601442"
                     /translation="MASGVAVSDGVIKVFNDMKVRKSSTPEEVKKRKKAVLFCLSEDK
                     KNIILEEGKEILVGDVGQTVDDPYATFVKMLPDKDCRYALYDATYETKESKKEDLVFI
                     FWAPESAPLKSKMIYASSKDAIKKKLTGIKHELQANCYEEVKDRCTLAEKLGGSAVIS
                     LEGKPL"
     exon            85..392
                     /gene="CFL1"
                     /gene_synonym="CFL; cofilin; HEL-S-15"
                     /inference="alignment:Splign:2.1.0"
     exon            393..469
                     /gene="CFL1"
                     /gene_synonym="CFL; cofilin; HEL-S-15"
                     /inference="alignment:Splign:2.1.0"
     exon            470..1245
                     /gene="CFL1"
                     /gene_synonym="CFL; cofilin; HEL-S-15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      972..977
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CFL1"
                     /gene_synonym="CFL; cofilin; HEL-S-15"
                     /note="hexamer: TATAAA"
     polyA_site      996
                     /gene="CFL1"
                     /gene_synonym="CFL; cofilin; HEL-S-15"
                     /note="major polyA site"
     regulatory      1100..1105
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CFL1"
                     /gene_synonym="CFL; cofilin; HEL-S-15"
                     /note="hexamer: AATAAA"
     polyA_site      1122
                     /gene="CFL1"
                     /gene_synonym="CFL; cofilin; HEL-S-15"
     polyA_site      1245
                     /gene="CFL1"
                     /gene_synonym="CFL; cofilin; HEL-S-15"
ORIGIN      
        1 gttcagtcgg gtcccggcag cggctgcagc gctctcgtct tctgcggctc tcggtgccct
       61 ctccttttcg tttccggaaa catggcctcc ggtgtggctg tctctgatgg tgtcatcaag
      121 gtgttcaacg acatgaaggt gcgtaagtct tcaacgccag aggaggtgaa gaagcgcaag
      181 aaggcggtgc tcttctgcct gagtgaggac aagaagaaca tcatcctgga ggagggcaag
      241 gagatcctgg tgggcgatgt gggccagact gtcgacgacc cctacgccac ctttgtcaag
      301 atgctgccag ataaggactg ccgctatgcc ctctatgatg caacctatga gaccaaggag
      361 agcaagaagg aggatctggt gtttatcttc tgggcccccg agtctgcgcc ccttaagagc
      421 aaaatgattt atgccagctc caaggacgcc atcaagaaga agctgacagg gatcaagcat
      481 gaattgcaag caaactgcta cgaggaggtc aaggaccgct gcaccctggc agagaagctg
      541 gggggcagtg ccgtcatctc cctggagggc aagcctttgt gagccccttc tggccccctg
      601 cctggagcat ctggcagccc cacacctgcc cttgggggtt gcaggctgcc cccttcctgc
      661 cagaccggag gggctggggg gatcccagca gggggagggc aatcccttca ccccagttgc
      721 caaacagacc ccccaccccc tggattttcc ttctccctcc atcccttgac ggttctggcc
      781 ttcccaaact gcttttgatc ttttgattcc tcttgggctg aagcagacca agttcccccc
      841 aggcacccca gttgtggggg agcctgtatt ttttttaaca acatccccat tccccacctg
      901 gtcctccccc ttcccatgct gccaacttct aaccgcaata gtgactctgt gcttgtctgt
      961 ttagttctgt gtataaatgg aatgttgtgg agatgacccc tccctgtgcc ggctggttcc
     1021 tctccctttt cccctggtca cggctactca tggaagcagg accagtaagg gaccttcgat
     1081 taaaaaaaaa aaagacaata ataaaaaggc tcattaatgg gatgtgtttt tcaaggttgg
     1141 gacacaggag acttcaggat tgggggtgca ctgggataat ggtgctatct ctctcctctg
     1201 tactccacac ccaaccagcc cctgcacacc cttatctggc tccaa
//
