LOCUS       NM_000186               3962 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens complement factor H (CFH), transcript variant 1, mRNA.
ACCESSION   NM_000186
VERSION     NM_000186.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3962)
  AUTHORS   Gebetsberger,L., Malekshahi,Z., Teutsch,A., Tajti,G., Fontaine,F.,
            Marella,N., Mueller,A., Prantl,L., Stockinger,H., Stoiber,H. and
            Ohradanova-Repic,A.
  TITLE     SARS-CoV-2 hijacks host CD55, CD59 and factor H to impair
            antibody-dependent complement-mediated lysis
  JOURNAL   Emerg Microbes Infect 13 (1), 2417868 (2024)
   PUBMED   39435487
  REMARK    GeneRIF: SARS-CoV-2 hijacks host CD55, CD59 and factor H to impair
            antibody-dependent complement-mediated lysis.
REFERENCE   2  (bases 1 to 3962)
  AUTHORS   Kang,Y.H., Varghese,P.M., Aiyan,A.A., Pondman,K., Kishore,U. and
            Sim,R.B.
  TITLE     Complement-Coagulation Cross-talk: Factor H-mediated regulation of
            the Complement Classical Pathway activation by fibrin clots
  JOURNAL   Front Immunol 15, 1368852 (2024)
   PUBMED   38933264
  REMARK    GeneRIF: Complement-Coagulation Cross-talk: Factor H-mediated
            regulation of the Complement Classical Pathway activation by fibrin
            clots.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3962)
  AUTHORS   Yasmin,H., Agostinis,C., Toffoli,M., Roy,T., Pegoraro,S.,
            Balduit,A., Zito,G., Di Simone,N., Ricci,G., Madan,T., Kishore,U.
            and Bulla,R.
  TITLE     Protective role of complement factor H against the development of
            preeclampsia
  JOURNAL   Front Immunol 15, 1351898 (2024)
   PUBMED   38464530
  REMARK    GeneRIF: Protective role of complement factor H against the
            development of preeclampsia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3962)
  AUTHORS   Martin,B. and Smith,R.J.H.
  TITLE     C3 Glomerulopathy
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301598
REFERENCE   5  (bases 1 to 3962)
  AUTHORS   Noris,M., Bresin,E., Mele,C. and Remuzzi,G.
  TITLE     Genetic Atypical Hemolytic-Uremic Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301541
REFERENCE   6  (bases 1 to 3962)
  AUTHORS   DiScipio,R.G.
  TITLE     Ultrastructures and interactions of complement factors H and I
  JOURNAL   J Immunol 149 (8), 2592-2599 (1992)
   PUBMED   1401896
REFERENCE   7  (bases 1 to 3962)
  AUTHORS   Barlow,P.N., Norman,D.G., Steinkasserer,A., Horne,T.J., Pearce,J.,
            Driscoll,P.C., Sim,R.B. and Campbell,I.D.
  TITLE     Solution structure of the fifth repeat of factor H: a second
            example of the complement control protein module
  JOURNAL   Biochemistry 31 (14), 3626-3634 (1992)
   PUBMED   1533152
REFERENCE   8  (bases 1 to 3962)
  AUTHORS   Schwaeble,W., Schwaiger,H., Brooimans,R.A., Barbieri,A., Most,J.,
            Hirsch-Kauffmann,M., Tiefenthaler,M., Lappin,D.F., Daha,M.R.,
            Whaley,K. et al.
  TITLE     Human complement factor H. Tissue specificity in the expression of
            three different mRNA species
  JOURNAL   Eur J Biochem 198 (2), 399-404 (1991)
   PUBMED   1828229
REFERENCE   9  (bases 1 to 3962)
  AUTHORS   Estaller,C., Koistinen,V., Schwaeble,W., Dierich,M.P. and
            Weiss,E.H.
  TITLE     Cloning of the 1.4-kb mRNA species of human complement factor H
            reveals a novel member of the short consensus repeat family related
            to the carboxy terminal of the classical 150-kDa molecule
  JOURNAL   J Immunol 146 (9), 3190-3196 (1991)
   PUBMED   1826708
REFERENCE   10 (bases 1 to 3962)
  AUTHORS   Estaller,C., Schwaeble,W., Dierich,M. and Weiss,E.H.
  TITLE     Human complement factor H: two factor H proteins are derived from
            alternatively spliced transcripts
  JOURNAL   Eur J Immunol 21 (3), 799-802 (1991)
   PUBMED   1826264
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM842566.1, Y00716.1,
            AL049744.8, BP324193.1 and BC142699.1.
            
            On Aug 31, 2019 this sequence version replaced NM_000186.3.
            
            Summary: This gene is a member of the Regulator of Complement
            Activation (RCA) gene cluster and encodes a protein with twenty
            short consensus repeat (SCR) domains. This protein is secreted into
            the bloodstream and has an essential role in the regulation of
            complement activation, restricting this innate defense mechanism to
            microbial infections. Mutations in this gene have been associated
            with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic
            nephropathy. Alternate transcriptional splice variants, encoding
            different isoforms, have been characterized. [provided by RefSeq,
            Oct 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC142699.1, Y00716.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            MANE Ensembl match                 :: ENST00000367429.9/
                                                  ENSP00000356399.4
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 BM842566.1         166-167
            3-995               Y00716.1           1-993
            996-996             AL049744.8         87139-87139         c
            997-1551            Y00716.1           995-1549
            1552-1554           BP324193.1         287-289
            1555-3928           Y00716.1           1553-3926
            3929-3962           BC142699.1         3906-3939
FEATURES             Location/Qualifiers
     source          1..3962
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q31.3"
     gene            1..3962
                     /gene="CFH"
                     /gene_synonym="AHUS1; AMBP1; ARMD4; ARMS1; CFHL3; FH;
                     FHL1; HF; HF1; HF2; HUS"
                     /note="complement factor H"
                     /db_xref="GeneID:3075"
                     /db_xref="HGNC:HGNC:4883"
                     /db_xref="MIM:134370"
     exon            1..133
                     /gene="CFH"
                     /gene_synonym="AHUS1; AMBP1; ARMD4; ARMS1; CFHL3; FH;
                     FHL1; HF; HF1; HF2; HUS"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..3771
                     /gene="CFH"
                     /gene_synonym="AHUS1; AMBP1; ARMD4; ARMS1; CFHL3; FH;
                     FHL1; HF; HF1; HF2; HUS"
                     /EC_number="4.2.1.2"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; H factor 1 (complement); H factor 2
                     (complement); beta-1H; age-related maculopathy
                     susceptibility 1; beta-1-H-globulin; factor H-like 1;
                     adrenomedullin binding protein"
                     /codon_start=1
                     /product="complement factor H isoform a precursor"
                     /protein_id="NP_000177.2"
                     /db_xref="CCDS:CCDS1385.1"
                     /db_xref="GeneID:3075"
                     /db_xref="HGNC:HGNC:4883"
                     /db_xref="MIM:134370"
                     /translation="MRLLAKIICLMLWAICVAEDCNELPPRRNTEILTGSWSDQTYPE
                     GTQAIYKCRPGYRSLGNVIMVCRKGEWVALNPLRKCQKRPCGHPGDTPFGTFTLTGGN
                     VFEYGVKAVYTCNEGYQLLGEINYRECDTDGWTNDIPICEVVKCLPVTAPENGKIVSS
                     AMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDVING
                     SPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESGWRPLPSCEEKSCDNPYIPNGD
                     YSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTGWIPAPRCTLKPCDYPDIKHGG
                     LYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGWSPAVPCLRKCYFP
                     YLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENGWSPTPRCIRVKTCSK
                     SSIDIENGFISESQYTYALKEKAKYQCKLGYVTADGETSGSITCGKDGWSAQPTCIKS
                     CDIPVFMNARTKNDFTWFKLNDTLDYECHDGYESNTGSTTGSIVCGYNGWSDLPICYE
                     RECELPKIDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQCYHFGLSPDLPICK
                     EQVQSCGPPPELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCVDGEWTTLP
                     VCIVEESTCGDIPELEHGWAQLSSPPYYYGDSVEFNCSESFTMIGHRSITCIHGVWTQ
                     LPQCVAIDKLKKCKSSNLIILEEHLKNKKEFDHNSNIRYRCRGKEGWIHTVCINGRWD
                     PEVNCSMAQIQLCPPPPQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQEGEEITCKDG
                     RWQSIPLCVEKIPCSQPPQIEHGTINSSRSSQESYAHGTKLSYTCEGGFRISEENETT
                     CYMGKWSSPPQCEGLPCKSPPEISHGVVAHMSDSYQYGEEVTYKCFEGFGIDGPAIAK
                     CLGEKWSHPPSCIKTDCLSLPSFENAIPMGEKKDVYKAGEQVTYTCATYYKMDGASNV
                     TCINSRWTGRPTCRDTSCVNPPTVQNAYIVSRQMSKYPSGERVRYQCRSPYEMFGDEE
                     VMCLNGNWTEPPQCKDSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEG
                     NKRITCRNGQWSEPPKCLHPCVISREIMENYNIALRWTAKQKLYSRTGESVEFVCKRG
                     YRLSSRSHTLRTTCWDGKLEYPTCAKR"
     exon            134..319
                     /gene="CFH"
                     /gene_synonym="AHUS1; AMBP1; ARMD4; ARMS1; CFHL3; FH;
                     FHL1; HF; HF1; HF2; HUS"
                     /inference="alignment:Splign:2.1.0"
     exon            320..425
                     /gene="CFH"
                     /gene_synonym="AHUS1; AMBP1; ARMD4; ARMS1; CFHL3; FH;
                     FHL1; HF; HF1; HF2; HUS"
                     /inference="alignment:Splign:2.1.0"
     exon            426..502
                     /gene="CFH"
                     /gene_synonym="AHUS1; AMBP1; ARMD4; ARMS1; CFHL3; FH;
                     FHL1; HF; HF1; HF2; HUS"
                     /inference="alignment:Splign:2.1.0"
     exon            503..694
                     /gene="CFH"
                     /gene_synonym="AHUS1; AMBP1; ARMD4; ARMS1; CFHL3; FH;
                     FHL1; HF; HF1; HF2; HUS"
                     /inference="alignment:Splign:2.1.0"
     exon            695..865
                     /gene="CFH"
                     /gene_synonym="AHUS1; AMBP1; ARMD4; ARMS1; CFHL3; FH;
                     FHL1; HF; HF1; HF2; HUS"
                     /inference="alignment:Splign:2.1.0"
     exon            866..1039
                     /gene="CFH"
                     /gene_synonym="AHUS1; AMBP1; ARMD4; ARMS1; CFHL3; FH;
                     FHL1; HF; HF1; HF2; HUS"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1234
                     /gene="CFH"
                     /gene_synonym="AHUS1; AMBP1; ARMD4; ARMS1; CFHL3; FH;
                     FHL1; HF; HF1; HF2; HUS"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1411
                     /gene="CFH"
                     /gene_synonym="AHUS1; AMBP1; ARMD4; ARMS1; CFHL3; FH;
                     FHL1; HF; HF1; HF2; HUS"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1594
                     /gene="CFH"
                     /gene_synonym="AHUS1; AMBP1; ARMD4; ARMS1; CFHL3; FH;
                     FHL1; HF; HF1; HF2; HUS"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..1771
                     /gene="CFH"
                     /gene_synonym="AHUS1; AMBP1; ARMD4; ARMS1; CFHL3; FH;
                     FHL1; HF; HF1; HF2; HUS"
                     /inference="alignment:Splign:2.1.0"
     exon            1772..1948
                     /gene="CFH"
                     /gene_synonym="AHUS1; AMBP1; ARMD4; ARMS1; CFHL3; FH;
                     FHL1; HF; HF1; HF2; HUS"
                     /inference="alignment:Splign:2.1.0"
     exon            1949..2131
                     /gene="CFH"
                     /gene_synonym="AHUS1; AMBP1; ARMD4; ARMS1; CFHL3; FH;
                     FHL1; HF; HF1; HF2; HUS"
                     /inference="alignment:Splign:2.1.0"
     exon            2132..2311
                     /gene="CFH"
                     /gene_synonym="AHUS1; AMBP1; ARMD4; ARMS1; CFHL3; FH;
                     FHL1; HF; HF1; HF2; HUS"
                     /inference="alignment:Splign:2.1.0"
     exon            2312..2488
                     /gene="CFH"
                     /gene_synonym="AHUS1; AMBP1; ARMD4; ARMS1; CFHL3; FH;
                     FHL1; HF; HF1; HF2; HUS"
                     /inference="alignment:Splign:2.1.0"
     exon            2489..2671
                     /gene="CFH"
                     /gene_synonym="AHUS1; AMBP1; ARMD4; ARMS1; CFHL3; FH;
                     FHL1; HF; HF1; HF2; HUS"
                     /inference="alignment:Splign:2.1.0"
     exon            2672..2857
                     /gene="CFH"
                     /gene_synonym="AHUS1; AMBP1; ARMD4; ARMS1; CFHL3; FH;
                     FHL1; HF; HF1; HF2; HUS"
                     /inference="alignment:Splign:2.1.0"
     exon            2858..3031
                     /gene="CFH"
                     /gene_synonym="AHUS1; AMBP1; ARMD4; ARMS1; CFHL3; FH;
                     FHL1; HF; HF1; HF2; HUS"
                     /inference="alignment:Splign:2.1.0"
     exon            3032..3208
                     /gene="CFH"
                     /gene_synonym="AHUS1; AMBP1; ARMD4; ARMS1; CFHL3; FH;
                     FHL1; HF; HF1; HF2; HUS"
                     /inference="alignment:Splign:2.1.0"
     exon            3209..3385
                     /gene="CFH"
                     /gene_synonym="AHUS1; AMBP1; ARMD4; ARMS1; CFHL3; FH;
                     FHL1; HF; HF1; HF2; HUS"
                     /inference="alignment:Splign:2.1.0"
     exon            3386..3568
                     /gene="CFH"
                     /gene_synonym="AHUS1; AMBP1; ARMD4; ARMS1; CFHL3; FH;
                     FHL1; HF; HF1; HF2; HUS"
                     /inference="alignment:Splign:2.1.0"
     exon            3569..3962
                     /gene="CFH"
                     /gene_synonym="AHUS1; AMBP1; ARMD4; ARMS1; CFHL3; FH;
                     FHL1; HF; HF1; HF2; HUS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3943..3948
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CFH"
                     /gene_synonym="AHUS1; AMBP1; ARMD4; ARMS1; CFHL3; FH;
                     FHL1; HF; HF1; HF2; HUS"
                     /note="hexamer: ATTAAA"
     polyA_site      3962
                     /gene="CFH"
                     /gene_synonym="AHUS1; AMBP1; ARMD4; ARMS1; CFHL3; FH;
                     FHL1; HF; HF1; HF2; HUS"
                     /note="major polyA site"
ORIGIN      
        1 acaattcttg gaagaggaga actggacgtt gtgaacagag ttagctggta aatgtcctct
       61 taaaagatcc aaaaaatgag acttctagca aagattattt gccttatgtt atgggctatt
      121 tgtgtagcag aagattgcaa tgaacttcct ccaagaagaa atacagaaat tctgacaggt
      181 tcctggtctg accaaacata tccagaaggc acccaggcta tctataaatg ccgccctgga
      241 tatagatctc ttggaaatgt aataatggta tgcaggaagg gagaatgggt tgctcttaat
      301 ccattaagga aatgtcagaa aaggccctgt ggacatcctg gagatactcc ttttggtact
      361 tttaccctta caggaggaaa tgtgtttgaa tatggtgtaa aagctgtgta tacatgtaat
      421 gaggggtatc aattgctagg tgagattaat taccgtgaat gtgacacaga tggatggacc
      481 aatgatattc ctatatgtga agttgtgaag tgtttaccag tgacagcacc agagaatgga
      541 aaaattgtca gtagtgcaat ggaaccagat cgggaatacc attttggaca agcagtacgg
      601 tttgtatgta actcaggcta caagattgaa ggagatgaag aaatgcattg ttcagacgat
      661 ggtttttgga gtaaagagaa accaaagtgt gtggaaattt catgcaaatc cccagatgtt
      721 ataaatggat ctcctatatc tcagaagatt atttataagg agaatgaacg atttcaatat
      781 aaatgtaaca tgggttatga atacagtgaa agaggagatg ctgtatgcac tgaatctgga
      841 tggcgtccgt tgccttcatg tgaagaaaaa tcatgtgata atccttatat tccaaatggt
      901 gactactcac ctttaaggat taaacacaga actggagatg aaatcacgta ccagtgtaga
      961 aatggttttt atcctgcaac ccggggaaat acagcaaaat gcacaagtac tggctggata
     1021 cctgctccga gatgtacctt gaaaccttgt gattatccag acattaaaca tggaggtcta
     1081 tatcatgaga atatgcgtag accatacttt ccagtagctg taggaaaata ttactcctat
     1141 tactgtgatg aacattttga gactccgtca ggaagttact gggatcacat tcattgcaca
     1201 caagatggat ggtcgccagc agtaccatgc ctcagaaaat gttattttcc ttatttggaa
     1261 aatggatata atcaaaatca tggaagaaag tttgtacagg gtaaatctat agacgttgcc
     1321 tgccatcctg gctacgctct tccaaaagcg cagaccacag ttacatgtat ggagaatggc
     1381 tggtctccta ctcccagatg catccgtgtc aaaacatgtt ccaaatcaag tatagatatt
     1441 gagaatgggt ttatttctga atctcagtat acatatgcct taaaagaaaa agcgaaatat
     1501 caatgcaaac taggatatgt aacagcagat ggtgaaacat caggatcaat tacatgtggg
     1561 aaagatggat ggtcagctca acccacgtgc attaaatctt gtgatatccc agtatttatg
     1621 aatgccagaa ctaaaaatga cttcacatgg tttaagctga atgacacatt ggactatgaa
     1681 tgccatgatg gttatgaaag caatactgga agcaccactg gttccatagt gtgtggttac
     1741 aatggttggt ctgatttacc catatgttat gaaagagaat gcgaacttcc taaaatagat
     1801 gtacacttag ttcctgatcg caagaaagac cagtataaag ttggagaggt gttgaaattc
     1861 tcctgcaaac caggatttac aatagttgga cctaattccg ttcagtgcta ccactttgga
     1921 ttgtctcctg acctcccaat atgtaaagag caagtacaat catgtggtcc acctcctgaa
     1981 ctcctcaatg ggaatgttaa ggaaaaaacg aaagaagaat atggacacag tgaagtggtg
     2041 gaatattatt gcaatcctag atttctaatg aagggaccta ataaaattca atgtgttgat
     2101 ggagagtgga caactttacc agtgtgtatt gtggaggaga gtacctgtgg agatatacct
     2161 gaacttgaac atggctgggc ccagctttct tcccctcctt attactatgg agattcagtg
     2221 gaattcaatt gctcagaatc atttacaatg attggacaca gatcaattac gtgtattcat
     2281 ggagtatgga cccaacttcc ccagtgtgtg gcaatagata aacttaagaa gtgcaaatca
     2341 tcaaatttaa ttatacttga ggaacattta aaaaacaaga aggaattcga tcataattct
     2401 aacataaggt acagatgtag aggaaaagaa ggatggatac acacagtctg cataaatgga
     2461 agatgggatc cagaagtgaa ctgctcaatg gcacaaatac aattatgccc acctccacct
     2521 cagattccca attctcacaa tatgacaacc acactgaatt atcgggatgg agaaaaagta
     2581 tctgttcttt gccaagaaaa ttatctaatt caggaaggag aagaaattac atgcaaagat
     2641 ggaagatggc agtcaatacc actctgtgtt gaaaaaattc catgttcaca accacctcag
     2701 atagaacacg gaaccattaa ttcatccagg tcttcacaag aaagttatgc acatgggact
     2761 aaattgagtt atacttgtga gggtggtttc aggatatctg aagaaaatga aacaacatgc
     2821 tacatgggaa aatggagttc tccacctcag tgtgaaggcc ttccttgtaa atctccacct
     2881 gagatttctc atggtgttgt agctcacatg tcagacagtt atcagtatgg agaagaagtt
     2941 acgtacaaat gttttgaagg ttttggaatt gatgggcctg caattgcaaa atgcttagga
     3001 gaaaaatggt ctcaccctcc atcatgcata aaaacagatt gtctcagttt acctagcttt
     3061 gaaaatgcca tacccatggg agagaagaag gatgtgtata aggcgggtga gcaagtgact
     3121 tacacttgtg caacatatta caaaatggat ggagccagta atgtaacatg cattaatagc
     3181 agatggacag gaaggccaac atgcagagac acctcctgtg tgaatccgcc cacagtacaa
     3241 aatgcttata tagtgtcgag acagatgagt aaatatccat ctggtgagag agtacgttat
     3301 caatgtagga gcccttatga aatgtttggg gatgaagaag tgatgtgttt aaatggaaac
     3361 tggacggaac cacctcaatg caaagattct acaggaaaat gtgggccccc tccacctatt
     3421 gacaatgggg acattacttc attcccgttg tcagtatatg ctccagcttc atcagttgag
     3481 taccaatgcc agaacttgta tcaacttgag ggtaacaagc gaataacatg tagaaatgga
     3541 caatggtcag aaccaccaaa atgcttacat ccgtgtgtaa tatcccgaga aattatggaa
     3601 aattataaca tagcattaag gtggacagcc aaacagaagc tttattcgag aacaggtgaa
     3661 tcagttgaat ttgtgtgtaa acggggatat cgtctttcat cacgttctca cacattgcga
     3721 acaacatgtt gggatgggaa actggagtat ccaacttgtg caaaaagata gaatcaatca
     3781 taaagtgcac acctttattc agaactttag tattaaatca gttctcaatt tcatttttta
     3841 tgtattgttt tactcctttt tattcatacg taaaattttg gattaatttg tgaaaatgta
     3901 attataagct gagaccggtg gctctcttct taaaagcacc atattaaatc ctggaaaact
     3961 aa
//
