LOCUS       NM_020827               4851 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens cilia and flagella associated protein 97 (CFAP97),
            transcript variant 1, mRNA.
ACCESSION   NM_020827 XM_927144 XM_940498
VERSION     NM_020827.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4851)
  AUTHORS   Gupta,G.D., Coyaud,E., Goncalves,J., Mojarad,B.A., Liu,Y., Wu,Q.,
            Gheiratmand,L., Comartin,D., Tkach,J.M., Cheung,S.W., Bashkurov,M.,
            Hasegan,M., Knight,J.D., Lin,Z.Y., Schueler,M., Hildebrandt,F.,
            Moffat,J., Gingras,A.C., Raught,B. and Pelletier,L.
  TITLE     A Dynamic Protein Interaction Landscape of the Human
            Centrosome-Cilium Interface
  JOURNAL   Cell 163 (6), 1484-1499 (2015)
   PUBMED   26638075
REFERENCE   2  (bases 1 to 4851)
  AUTHORS   Soulavie,F., Piepenbrock,D., Thomas,J., Vieillard,J.,
            Duteyrat,J.L., Cortier,E., Laurencon,A., Gopfert,M.C. and Durand,B.
  TITLE     hemingway is required for sperm flagella assembly and ciliary
            motility in Drosophila
  JOURNAL   Mol Biol Cell 25 (8), 1276-1286 (2014)
   PUBMED   24554765
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC030535.1, AK091993.1, AL133615.1 and AC093592.3.
            
            On Nov 22, 2018 this sequence version replaced NM_020827.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.25022.1,
                                           SRR1660803.255588.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000458385.7/ ENSP00000409964.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                BC030535.1         29-69
            42-1333             AK091993.1         1-1292
            1334-1334           BC030535.1         1474-1474
            1335-1811           AK091993.1         1294-1770
            1812-2049           AL133615.1         808-1045
            2050-3679           AL133615.1         1048-2677
            3680-4851           AC093592.3         10145-11316         c
FEATURES             Location/Qualifiers
     source          1..4851
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q35.1"
     gene            1..4851
                     /gene="CFAP97"
                     /gene_synonym="hmw; KIAA1430"
                     /note="cilia and flagella associated protein 97"
                     /db_xref="GeneID:57587"
                     /db_xref="HGNC:HGNC:29276"
                     /db_xref="MIM:616047"
     exon            1..103
                     /gene="CFAP97"
                     /gene_synonym="hmw; KIAA1430"
                     /inference="alignment:Splign:2.1.0"
     exon            104..1173
                     /gene="CFAP97"
                     /gene_synonym="hmw; KIAA1430"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..1718
                     /gene="CFAP97"
                     /gene_synonym="hmw; KIAA1430"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="cilia- and flagella-associated protein 97
                     isoform 1"
                     /protein_id="NP_065878.1"
                     /db_xref="CCDS:CCDS47168.1"
                     /db_xref="GeneID:57587"
                     /db_xref="HGNC:HGNC:29276"
                     /db_xref="MIM:616047"
                     /translation="MDQFGDILEGEVDHSFFDSDFEEGKKCETNSVFDKQNDDPKERI
                     DKDTKNVNSNTGMQTTENYLTEKGNERNVKFPPEHPVENDVTQTVSSFSLPASSRSKK
                     LCDVTTGLKIHVSIPNRIPKIVKEGEDDYYTDGEESSDDGKKYHVKSKSAKPSTNVKK
                     SIRKKYCKVSSSSSSSLSSSSSGSGTDCLDAGSDSHLSDSSPSSKSSKKHVSGITLLS
                     PKHKYKSGIKSTETQPSSTTPKCGHYPEESEDTVTDVSPLSTPDISPLQSFELGIAND
                     QKVKIKKQENVSQEIYEDVEDLKNNSKYLKAAKKGKEKHEPDVSSKSSSVLDSSLDHR
                     HKQKVLHDTMDLNHLLKAFLQLDKKGPQKHHFDQPSVAPGKNYSFTREEVRQIDRENQ
                     RLLKELSRQAEKPGSKSTIPRSADHPPKLYHSALNRQKEQQRIERENLALLKRLEAVK
                     PTVGMKRSEQLMDYHRNMGYLNSSPLSRRARSTLGQYSPLRASRTSSATSGLSCRSER
                     SAVDPSSGHPRRRPKPPNVRTAWL"
     exon            1174..1439
                     /gene="CFAP97"
                     /gene_synonym="hmw; KIAA1430"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1590
                     /gene="CFAP97"
                     /gene_synonym="hmw; KIAA1430"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..4851
                     /gene="CFAP97"
                     /gene_synonym="hmw; KIAA1430"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4393..4398
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CFAP97"
                     /gene_synonym="hmw; KIAA1430"
                     /note="hexamer: AATAAA"
     polyA_site      4419
                     /gene="CFAP97"
                     /gene_synonym="hmw; KIAA1430"
                     /note="major polyA site"
     regulatory      4832..4837
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CFAP97"
                     /gene_synonym="hmw; KIAA1430"
                     /note="hexamer: AATAAA"
     polyA_site      4851
                     /gene="CFAP97"
                     /gene_synonym="hmw; KIAA1430"
ORIGIN      
        1 ctctccgcct ccggaagcgc gggcgcgcgg cgccgggagc ccgttcaggg ccgcgggagt
       61 gcgccagcgc cgcgcgtggg gctgtggtgg ccgcggctct cagatatatt tttgccatca
      121 tggatcagtt tggagatata ttagaaggtg aagtggacca ttctttcttt gacagtgact
      181 ttgaagaagg aaagaaatgt gaaactaact cagtttttga caagcaaaat gatgacccaa
      241 aggaaagaat agataaagat acaaaaaatg taaattcgaa cactggaatg caaacaacag
      301 aaaattatct tactgagaag ggaaatgaaa gaaacgtgaa atttccccca gaacaccccg
      361 tagagaatga tgttacacaa actgtaagtt ctttctcatt gccagcctct tcaagatcaa
      421 aaaaattgtg tgatgttaca acaggactta aaatacacgt gtccattcca aatagaattc
      481 ccaaaattgt aaaagaaggt gaagatgatt actacacaga tggagaggaa agcagtgatg
      541 atgggaagaa ataccatgtg aagtccaagt ccgctaaacc atctactaac gttaaaaaaa
      601 gcataaggaa aaagtattgc aaagttagct cctcttcctc ctcctcttta tcttcctcat
      661 cttcaggttc aggtacagat tgtttagatg cagggtctga tagccatcta tctgattcgt
      721 ctccgtcatc taagtcatct aagaaacatg tatctggtat aaccctcctg tcaccaaaac
      781 acaagtataa atcaggaata aaatcgacag aaacacagcc ttcaagtact acaccaaaat
      841 gtggccacta ccctgaggag tctgaagata ctgtgactga cgtaagtccc ttatcaactc
      901 cagacattag ccctcttcag tcttttgaac tgggcatagc aaatgatcaa aaagtgaaaa
      961 ttaaaaagca agaaaatgtg agccaagaaa tatatgaaga tgttgaggat ttgaaaaata
     1021 attcaaaata tttgaaagca gccaaaaaag ggaaagaaaa acatgagcct gatgtctcct
     1081 caaagtcgtc ttcagtgtta gactccagtt tagaccacag acataaacag aaagtcttac
     1141 atgacacaat ggatctgaat catctcttga aagcttttct gcaattagat aaaaaaggac
     1201 cacaaaaaca tcactttgat cagccttcag tagcacccgg gaaaaactac tctttcacaa
     1261 gagaagaggt gagacagatc gatcgggaaa atcagaggct tttgaaagaa ctgtcaagac
     1321 aggcggaaaa gccgggaagc aaaagtacaa ttcctagatc ggctgatcat cccccaaagt
     1381 tatatcacag tgctctcaac agacagaagg aacaacaaag gattgagaga gaaaacttgg
     1441 ctttattgaa aaggcttgag gccgtgaaac caacagttgg tatgaaacgt tcagaacaac
     1501 tgatggacta tcatcgcaat atgggctatc tcaactcatc accattgtca agacgggcca
     1561 gatccactct tggccaatat agcccattaa gagcttccag gacatccagt gctacgagtg
     1621 gtctcagttg taggagtgag cgatcagcgg ttgacccctc cagtggccac cctcgaagaa
     1681 gacctaaacc ccctaatgtc cgtacagctt ggttataaaa cactttttta ctttaaacat
     1741 tgttcacaca acttttcttg aagtgctcgt gcatattcct ataattctct gtgtaaacat
     1801 ctagaatacc gttttagcaa ttgaaggtgt acaacagtga gttgtaatgt attgttattc
     1861 agtgcaaaat tattgtcaaa aaacgattta atgtaaaaag tgtttcctga ggatgtattt
     1921 atatgagatg tatgtgttct taatagagaa atagtggtat gcatgtgtat cttctaatta
     1981 ttcagttgtc atgctgtcaa aatagtagtg atagtatcat tgcatgtcgt acccaagatg
     2041 gtcactatag ttttcaattt gtgttatttt catttcttta taagtgttat accatgagct
     2101 cagctcctaa atttggctgg ctttgttttt catttgcttt agaacttatg tggcatgaca
     2161 tagctcgatt gtatgagatt taacacttat tatgaaacaa atcttgaaat ttgttttcac
     2221 tggtagagct gatctagatt tgatgagcag attgagagac gcttctattg gagcaattct
     2281 tgtaattcac cagaggtatc tagttgttgt ataagtgcac tgagttagat cttaaaagtt
     2341 tgatcaatca ttccaaacca tttcaaatat gaatattaga aagttcaact tagaagcttc
     2401 ccttttgtgt tttcatgcat tcaggtaaag tcctatttat gactcttaga aatgaggtag
     2461 gttttagagc tagtcttcta actcgtgaat agtttaagga ccacatcagt tgcaaaccaa
     2521 gtatttgttg aatcagtaaa atggcactat cagcatgaag agccgagaag cagatcctga
     2581 ggtgtgtcgg acagtgtttt aggtaattca gtatttatta tgttattaga gaagacttag
     2641 cgtaagaaag aaatgcttta gaaattccag caagtattta taaggcctga aaaaactaaa
     2701 atttgaacaa aaagggaaat aaatcacaca tttgttgagg ctgctgcttt aagtattagc
     2761 taattttctt gttttggttt actttgattt atttgattga accctggaag tattattttt
     2821 accagtccca catttaaaga cctagtaatc ttgatggaat tggtaatggc agatagggtt
     2881 taatgttgtt gacttttcaa attagaattt tttttctatg aaacttaggc ttttatataa
     2941 caaagtatgt tatctcattg ttaccgccgt ttttcactac tagccttttc agtatgccct
     3001 taaaatgtat tggaaaggtt ccatgttaaa tgacaaatat ctttttcagt atgaattttt
     3061 gatctgtagc cacaataaga ttttcatttt tcagtgctca ggctctgtag catgtatgct
     3121 gaatgctttt ttccttagca cctttaacag taaggtgtta ctgcatttta caaaacatca
     3181 attcaacatg tcttggattt agtttgtatt catagatttt gttaaggatc aggcctgtga
     3241 acatgggcac agtgaggtta aataattcac ctggccacaa cctggctttg aggttctgct
     3301 tttgggggcc ataattttca ttcaatgtta ttcgatgctc tgttctggtg aacaagttac
     3361 tatacctgct gtgtatataa gcttgagcta tactaaacca aggctttatt ttcttttgtt
     3421 ttttaactta ctgtactttt actgtttata taacctatat ttcaagagag agaagataat
     3481 gctgaatttt aaatttagca tttgaacatc tgtccaatag tgaattaatc agttttttta
     3541 aaattgattt ttaagttgtt ccagaaaaaa atatatatat atgttttata tatataatct
     3601 ttttatatat ataaaaaatc ttttttataa attttatttt aaaaatcttt taaaaaagat
     3661 ttttatatat atataaagat tatatattta tatatagtct tttctgttca taatggcatt
     3721 agtctctgag tacattttat attatctttg ttgccacatg tcaggataca acacaatagt
     3781 tttataaata acaactgtac tttgatttta ggtactaatt taatgcttta gtttttacta
     3841 ctttgaaagg ggaggttcat ctaagtatta ctgataacag ggatccaact taaagtaaaa
     3901 gttggaaagg gcaagagtct tttaagcgga acttcaattc tgttgtcatg gttacttata
     3961 tataatgaat ataaatagac aaataggact tggaaaatgt ggtatattct aagtcaagat
     4021 gctatgaagt tgttatagtt taagggacat tcttaagaag gaattactta agtacattac
     4081 tcttctcatt tcaaggacat gaaaaagtaa aggatggtct ggcactattt tattttattt
     4141 tttttttgac ttgtactgaa tatatgtact ttgaagattt acatctataa ctagaaagta
     4201 tgctaatccg aggtctggtt attaggccag attcttgttc agttattttt taaactaatg
     4261 ttgcctcctt tttagtaaga ttctacgaaa gttttttaac tattaaagtt atttcttaag
     4321 gggtagctct tatacttcct ctgctctctt tttcagtttc cataaaaagc tgttttctta
     4381 gctattactc caaataaagt tctttggttt gcttaaaaat gtagtgtaat gcagttgttt
     4441 tctctccgct aacctgagtg tccacagtag atatcgagac agctttagga aggtgacggt
     4501 catgggtaag tgacggctgt gcctgtcatc ttcagattct tcaaatactg caaactatga
     4561 aacatgttaa gaccaatata aacccaaaga tgtgagttga ttatacttta ataattacat
     4621 tcataaaaag tttactatct tcaatgccaa aaaagtctta acctataaat gattatatac
     4681 aatcttagaa aatgtgctta acagttatgg cttctttatt tctatgagga aagattagta
     4741 agaaacttaa aattaacatc cttttaagat tttctgttcc attttaatgt attttaggca
     4801 tttagaacta gcctggcata atgaagaaag aaataaaaga attaaagata a
//
