LOCUS       NM_001114357            1333 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens cilia and flagella associated protein 96 (CFAP96),
            transcript variant 1, mRNA.
ACCESSION   NM_001114357 XM_001720135 XM_001723753 XM_001723780
VERSION     NM_001114357.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1333)
  AUTHORS   Na,L., Masuda,S., Nagao,S., Morisaki,S., Iwamoto,N., Sakanashi,K.
            and Onishi,H.
  TITLE     C4orf47 Contributes to the Induction of Stem-like Properties in
            Gallbladder Cancer Under Hypoxia
  JOURNAL   Anticancer Res 43 (5), 1925-1932 (2023)
   PUBMED   37097647
  REMARK    GeneRIF: C4orf47 Contributes to the Induction of Stem-like
            Properties in Gallbladder Cancer Under Hypoxia.
REFERENCE   2  (bases 1 to 1333)
  AUTHORS   Sigg,M.A., Menchen,T., Lee,C., Johnson,J., Jungnickel,M.K.,
            Choksi,S.P., Garcia,G. 3rd, Busengdal,H., Dougherty,G.W.,
            Pennekamp,P., Werner,C., Rentzsch,F., Florman,H.M., Krogan,N.,
            Wallingford,J.B., Omran,H. and Reiter,J.F.
  TITLE     Evolutionary Proteomics Uncovers Ancient Associations of Cilia with
            Signaling Pathways
  JOURNAL   Dev Cell 43 (6), 744-762 (2017)
   PUBMED   29257953
REFERENCE   3  (bases 1 to 1333)
  AUTHORS   Firat-Karalar,E.N., Sante,J., Elliott,S. and Stearns,T.
  TITLE     Proteomic analysis of mammalian sperm cells identifies new
            components of the centrosome
  JOURNAL   J Cell Sci 127 (Pt 19), 4128-4133 (2014)
   PUBMED   25074808
REFERENCE   4  (bases 1 to 1333)
  AUTHORS   Castelo,R., Reymond,A., Wyss,C., Camara,F., Parra,G.,
            Antonarakis,S.E., Guigo,R. and Eyras,E.
  TITLE     Comparative gene finding in chicken indicates that we are closing
            in on the set of multi-exonic widely expressed human genes
  JOURNAL   Nucleic Acids Res 33 (6), 1935-1939 (2005)
   PUBMED   15809229
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1333)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC106897.5.
            
            On Aug 13, 2020 this sequence version replaced NM_001114357.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.260581.1,
                                           SRR14038195.2047520.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145240
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000378850.5/ ENSP00000368127.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-143               AC106897.5         34284-34426
            144-321             AC106897.5         37364-37541
            322-541             AC106897.5         40012-40231
            542-679             AC106897.5         44076-44213
            680-755             AC106897.5         44314-44389
            756-935             AC106897.5         48570-48749
            936-1102            AC106897.5         52994-53160
            1103-1333           AC106897.5         57626-57856
FEATURES             Location/Qualifiers
     source          1..1333
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q35.1"
     gene            1..1333
                     /gene="CFAP96"
                     /gene_synonym="C4orf47"
                     /note="cilia and flagella associated protein 96"
                     /db_xref="GeneID:441054"
                     /db_xref="HGNC:HGNC:34346"
     exon            1..143
                     /gene="CFAP96"
                     /gene_synonym="C4orf47"
                     /inference="alignment:Splign:2.1.0"
     exon            144..321
                     /gene="CFAP96"
                     /gene_synonym="C4orf47"
                     /inference="alignment:Splign:2.1.0"
     CDS             222..1151
                     /gene="CFAP96"
                     /gene_synonym="C4orf47"
                     /note="isoform 1 is encoded by transcript variant 1;
                     UPF0602 protein C4orf47"
                     /codon_start=1
                     /product="cilia-and flagella-associated protein 96 isoform
                     1"
                     /protein_id="NP_001107829.1"
                     /db_xref="CCDS:CCDS47169.1"
                     /db_xref="GeneID:441054"
                     /db_xref="HGNC:HGNC:34346"
                     /translation="MPAEGGKTDMERIGLFSEMEYITVGDKYVSQFNRPFNEAASKNK
                     QMLPGGSKEMSDLQAGYFDPHFVRIFEGEGYINLNQVRRRDMVEAAKKNLGKAFLPSN
                     GEKKPCGLGSYYGTIGGPVPFFSAQSKPREKYKAPGKNLYTNPGKKGTGYGYANITIG
                     KQFSHSADFYDAAKLKYKKANEEHHRLLKGAPFKLNLHPRDYFDANPYFSEESLPPIK
                     KEEKKKTISNTFKPSSPGKKPGGMKAGTFDPYPSHSADPYVAKLANISGKDDKIFHPP
                     SGPKSRPVESIMTLNVRRALNSKNYKTSSVPSY"
     exon            322..541
                     /gene="CFAP96"
                     /gene_synonym="C4orf47"
                     /inference="alignment:Splign:2.1.0"
     exon            542..679
                     /gene="CFAP96"
                     /gene_synonym="C4orf47"
                     /inference="alignment:Splign:2.1.0"
     exon            680..755
                     /gene="CFAP96"
                     /gene_synonym="C4orf47"
                     /inference="alignment:Splign:2.1.0"
     exon            756..935
                     /gene="CFAP96"
                     /gene_synonym="C4orf47"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1102
                     /gene="CFAP96"
                     /gene_synonym="C4orf47"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1333
                     /gene="CFAP96"
                     /gene_synonym="C4orf47"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1312..1317
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CFAP96"
                     /gene_synonym="C4orf47"
                     /note="hexamer: AATAAA"
     polyA_site      1333
                     /gene="CFAP96"
                     /gene_synonym="C4orf47"
                     /note="major polyA site"
ORIGIN      
        1 agaggcgctg cgcagcccag gcgtgtcgcg cgcttgggaa ccctcgccgc tcccgcagcg
       61 cagttaacgt ggacaagctg gggcaacctg gacgagctgg ggcaacctga tctcggctgt
      121 cggagtgggt gtcctcaaga aaggactttg ctataaaaca cgtgacccta gggaaacttt
      181 tgaagttagc ggtatagaga gtaccaccac cagacgccac catgcctgcg gaaggaggaa
      241 aaacggacat ggaaaggatt ggcctcttta gtgagatgga atatattact gtgggtgata
      301 aatatgtgtc acaatttaat cgacccttta atgaggctgc aagcaaaaat aaacagatgc
      361 tacctggagg gtccaaagaa atgtcagatc ttcaggcagg ttattttgat ccccattttg
      421 taaggatttt tgaaggtgaa ggctacataa atctgaatca agtgaggaga cgggatatgg
      481 tggaagcagc caaaaaaaat ctaggcaaag cattcctccc tagtaatgga gagaaaaagc
      541 catgtggctt aggaagctac tatggaacaa taggtggtcc agtcccattt ttcagcgcac
      601 agtcaaaacc tcgagaaaaa tacaaggcac ctggaaagaa tttatacaca aacccgggaa
      661 agaaaggaac tggatatggc tatgcaaata ttaccatagg taaacagttt tcacactctg
      721 ccgacttcta tgatgcagca aaactaaagt ataagaaagc gaatgaagag caccatcgtt
      781 tacttaaagg agcaccattt aagttaaatc ttcacccaag ggactatttt gacgctaatc
      841 cttatttttc tgaggaatct ttaccaccaa ttaaaaaaga agagaagaag aaaacaattt
      901 caaatacttt taaaccgtct tctcctggta aaaagcctgg tggaatgaag gcaggaacat
      961 ttgatcctta cccatcacat tctgctgacc cttatgtggc taaattggca aatatttctg
     1021 gcaaagatga taagattttc cacccaccaa gtggaccaaa aagcagacca gttgaaagta
     1081 taatgacttt gaatgtcaga agggcactaa attcaaagaa ctacaagact tcttcagtac
     1141 catcctatta gcaactggaa gacaagtagc tttctagatc ttaactatga gtaattcact
     1201 atcaagagct aattatttga aaaaatataa gatgttatgg agcagatagc tcaagcagtt
     1261 aaaagaaatt ctgcaactct aattctcttc cttattttaa tactactagt taataaatag
     1321 tatttgctaa taa
//
