LOCUS       NM_001394090            3870 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens cilia and flagella associated protein 92 (putative)
            (CFAP92), transcript variant 6, mRNA.
ACCESSION   NM_001394090
VERSION     NM_001394090.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3870)
  AUTHORS   Shaffer,J.R., Feingold,E., Wang,X., Lee,M., Tcuenco,K., Weeks,D.E.,
            Weyant,R.J., Crout,R., McNeil,D.W. and Marazita,M.L.
  TITLE     GWAS of dental caries patterns in the permanent dentition
  JOURNAL   J Dent Res 92 (1), 38-44 (2013)
   PUBMED   23064961
REFERENCE   2  (bases 1 to 3870)
  AUTHORS   Sakai,N., Terami,H., Suzuki,S., Haga,M., Nomoto,K., Tsuchida,N.,
            Morohashi,K., Saito,N., Asada,M., Hashimoto,M., Harada,D.,
            Asahara,H., Ishikawa,T., Shimada,F. and Sakurada,K.
  TITLE     Identification of NR5A1 (SF-1/AD4BP) gene expression modulators by
            large-scale gain and loss of function studies
  JOURNAL   J Endocrinol 198 (3), 489-497 (2008)
   PUBMED   18579725
  REMARK    GeneRIF: The gain of function studies indicated that KIAA1257
            activate NR5A1 gene expression.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC112484.8.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000645291.3/ ENSP00000496592.2
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-97                AC112484.8         139087-139183       c
            98-391              AC112484.8         138150-138443       c
            392-582             AC112484.8         133835-134025       c
            583-796             AC112484.8         132723-132936       c
            797-937             AC112484.8         123152-123292       c
            938-1025            AC112484.8         122086-122173       c
            1026-1150           AC112484.8         120886-121010       c
            1151-1297           AC112484.8         116394-116540       c
            1298-1482           AC112484.8         110618-110802       c
            1483-2387           AC112484.8         90178-91082         c
            2388-2582           AC112484.8         80232-80426         c
            2583-2880           AC112484.8         77807-78104         c
            2881-3045           AC112484.8         61214-61378         c
            3046-3252           AC112484.8         60464-60670         c
            3253-3409           AC112484.8         60226-60382         c
            3410-3870           AC112484.8         54980-55440         c
FEATURES             Location/Qualifiers
     source          1..3870
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q21.3"
     gene            1..3870
                     /gene="CFAP92"
                     /gene_synonym="FAP92; KIAA1257"
                     /note="cilia and flagella associated protein 92
                     (putative)"
                     /db_xref="GeneID:57501"
                     /db_xref="HGNC:HGNC:29231"
     exon            1..97
                     /gene="CFAP92"
                     /gene_synonym="FAP92; KIAA1257"
                     /inference="alignment:Splign:2.1.0"
     exon            98..391
                     /gene="CFAP92"
                     /gene_synonym="FAP92; KIAA1257"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..3444
                     /gene="CFAP92"
                     /gene_synonym="FAP92; KIAA1257"
                     /note="isoform e is encoded by transcript variant 6;
                     putative cilia and flagella associated protein 92"
                     /codon_start=1
                     /product="uncharacterized protein CFAP92 isoform e"
                     /protein_id="NP_001381019.1"
                     /db_xref="CCDS:CCDS93370.1"
                     /db_xref="GeneID:57501"
                     /db_xref="HGNC:HGNC:29231"
                     /translation="MSLHAWEWEEDPASIEPISSITSFYQSTSECDVEEHLKAKARAQ
                     ESDSDRPCSSIESSSEPASTFSSDVPHVVPCKFTISLAFPVNMGQKGKYASLIEKYKK
                     HPKTDSSVTKMRRFYHIEYFLLPDDEEPKKVDILLFPMVAKVFLESGVKTVKPWHEGD
                     KAWVSWEQTFNITVTKELLKKINFHKITLRLWNTKDKMSRKVRYYRLKTAGFTDDVGA
                     FHKSEVRHLVLNQRKLSEQGIENTNIVREESNQEHPPGKQEKTEKHPKSLQGSHQAEP
                     ETSSKNSEEYEKSLKMDDSSTIQWSVSRTPTISLAGASMMEIKELIESESLSSLTNIL
                     DRQRSQIKGKDSEGRRKIQRRHKKPLAEEEADPTLTGPRKQSAFSIQLAVMPLLAGWQ
                     TVVSRGSEKSANILDCLLTLKTEVPIMTEEQKQDLNPLTIKIKCASCLPSQPVPIQEL
                     ERLCMPVYCKYQFHKTPVHKTKGEPHGTHVYFQDINVIFLGALHPSDLREYLEGPPMV
                     VEVHDRDRKSEECSQKPVLFGEDPLDSYLNFQALISPRETENNPFESQNKMWYPYGIA
                     QVSFADLLLGHKYLNLAVPIHSCEVQPTHCGQDSRRRKVVGLGVPRDGHQHGPMPRGN
                     YLEADSQLKLRVDIAVPLRAGARAADPDLGGSQFGRIIFVFDFKKVSLLHSLLQDITM
                     INAKALGLDSYPVRTLQQILSAFKVRVRVQEQQHLDVLTGFHLLDGKTHLFILEGLAD
                     QGLRQLWENHQSWIPRSEHRKYKVLYNSQLLFRSRLYGDLEAILYHVHLFQPTELLLQ
                     QAVFFLRDTERRRVFQALARIHDICYNSTTLWDVTVRDLLPSSAMIKDLSQEFGMPLS
                     QEELTDEKLFALPPQPAPNLEDYHSRNSTLTLEIHAHQEKYLQWRSAMLMKNKDKKHS
                     FIQKNITEAYQVSKKPPKSVAKVIKISAPANKAVYNYSTQTMNSTELAKKELYQEIAK
                     EPRKRFTYSQDYLSAMVEPLDLKEEEKKAQKKSRQAWLTARGFQVTGLQSDTESSFQD
                     LKLPPIKELNEEWKENSLFANVLEPVLDRDRWSWDRHHVDFDLYKKPPPFLELLPSPA
                     PKPVTVRKKKGNSPIS"
     exon            392..582
                     /gene="CFAP92"
                     /gene_synonym="FAP92; KIAA1257"
                     /inference="alignment:Splign:2.1.0"
     exon            583..796
                     /gene="CFAP92"
                     /gene_synonym="FAP92; KIAA1257"
                     /inference="alignment:Splign:2.1.0"
     exon            797..937
                     /gene="CFAP92"
                     /gene_synonym="FAP92; KIAA1257"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1025
                     /gene="CFAP92"
                     /gene_synonym="FAP92; KIAA1257"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1150
                     /gene="CFAP92"
                     /gene_synonym="FAP92; KIAA1257"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1297
                     /gene="CFAP92"
                     /gene_synonym="FAP92; KIAA1257"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1482
                     /gene="CFAP92"
                     /gene_synonym="FAP92; KIAA1257"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..2387
                     /gene="CFAP92"
                     /gene_synonym="FAP92; KIAA1257"
                     /inference="alignment:Splign:2.1.0"
     exon            2388..2582
                     /gene="CFAP92"
                     /gene_synonym="FAP92; KIAA1257"
                     /inference="alignment:Splign:2.1.0"
     exon            2583..2880
                     /gene="CFAP92"
                     /gene_synonym="FAP92; KIAA1257"
                     /inference="alignment:Splign:2.1.0"
     exon            2881..3045
                     /gene="CFAP92"
                     /gene_synonym="FAP92; KIAA1257"
                     /inference="alignment:Splign:2.1.0"
     exon            3046..3252
                     /gene="CFAP92"
                     /gene_synonym="FAP92; KIAA1257"
                     /inference="alignment:Splign:2.1.0"
     exon            3253..3409
                     /gene="CFAP92"
                     /gene_synonym="FAP92; KIAA1257"
                     /inference="alignment:Splign:2.1.0"
     exon            3410..3870
                     /gene="CFAP92"
                     /gene_synonym="FAP92; KIAA1257"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3870
                     /gene="CFAP92"
                     /gene_synonym="FAP92; KIAA1257"
                     /note="major polyA site"
ORIGIN      
        1 agtcttggag tctcttcgcc caggtggctg tggatccggt acgggagttg ccgccgcggt
       61 ccaactcccc gctgccgccc agcgcatccg ctcgcaggag cgccggcggc cagcagtgcg
      121 ctctgcagca tgtcgctaca tgcctgggag tgggaagagg accccgcaag catagagccc
      181 atctcctcca tcactagctt ttaccagtcc acgagcgagt gtgacgtgga ggaacacctg
      241 aaggccaagg ccagggccca ggagtctgac tctgaccgcc cgtgcagcag catcgagtcc
      301 tcatctgagc ctgccagcac tttcagctcc gacgtgcccc acgtggtccc ctgcaaattc
      361 accatctcac tggccttccc tgtgaatatg ggtcagaagg gaaaatatgc aagtttgatt
      421 gaaaaatata agaaacaccc taaaacagac agttctgtta caaagatgcg tcgtttttac
      481 cacattgagt atttccttct gccggacgat gaagaaccta aaaaagttga catattgcta
      541 tttccaatgg tggccaaagt attcctggag tcaggagtaa agactgtgaa gccgtggcac
      601 gaaggtgaca aagcctgggt gtcgtgggag cagactttta atatcactgt gacaaaggaa
      661 ttattaaaga aaataaattt ccacaaaatc accttgaggc tctggaacac taaagacaag
      721 atgtcaagaa aagtcagata ttaccgatta aagactgccg gcttcacaga cgacgtggga
      781 gcttttcata agtcagaagt gagacatttg gttttaaatc agagaaaatt atctgaacag
      841 ggcattgaga ataccaacat tgtcagagaa gagtcgaacc aggaacatcc gccaggaaaa
      901 caagaaaaaa cagaaaaaca cccaaagtct ttgcaaggtt ctcaccaagc agagcccgaa
      961 acttcttcca agaacagtga ggaatatgag aagtccctca aaatggacga ttcttccacg
     1021 attcaatgga gtgtttcaag aacaccaacc atttctttgg caggagcaag catgatggag
     1081 atcaaggaat taattgagag tgaatcactt agcagcttaa caaacatatt agacagacaa
     1141 aggtctcaaa ttaaagggaa agattcagag ggaagaagga aaatccagag gagacataag
     1201 aagcccctgg cagaagaaga ggcagacccc acgctgacag gccccaggaa gcagagcgct
     1261 ttctccatcc agctggccgt catgccgctc cttgccggat ggcaaactgt cgtgagtcgt
     1321 ggcagtgaga agtctgccaa cattttagat tgccttttga ctttaaaaac agaagttccg
     1381 atcatgaccg aggagcaaaa gcaggattta aatcccctga ccataaagat caagtgtgct
     1441 tcctgccttc catcacagcc tgtacccatt caggaactag agaggctgtg catgcctgtg
     1501 tactgcaagt accagttcca taagactcca gttcacaaga ccaaggggga gccccatgga
     1561 acccacgttt atttccagga catcaacgtc atcttccttg gggcactgca ccccagtgac
     1621 ctaagggaat acctggaggg cccccccatg gtggtggaag ttcacgaccg ggaccgcaag
     1681 tcagaggagt gttctcagaa gcccgtgctg tttggggagg accctctgga ttcatacctc
     1741 aacttccagg ccctcatctc tcccagagag acagagaaca acccctttga gtcccagaac
     1801 aagatgtggt acccttatgg catcgcccag gtcagttttg ctgacctcct ccttggccac
     1861 aagtacttga atctggccgt ccccatccac agctgtgagg ttcagcccac acactgcggc
     1921 caggacagca ggagaaggaa ggttgtgggg cttggggtcc ccagagatgg ccaccagcac
     1981 ggcccaatgc ccaggggcaa ctacctagag gctgactccc agctcaagtt gcgagtggac
     2041 atcgcggtgc cactgagggc cggggccaga gctgctgatc ctgaccttgg gggctcccag
     2101 tttggccgca tcatcttcgt ctttgacttt aagaaggtct ccctgctcca cagcctgctg
     2161 caggacatca ccatgatcaa cgctaaggcc ctcggcctgg actcctaccc tgtcaggacc
     2221 ctgcagcaga tcctgtcagc cttcaaggtg cgtgtgcggg tccaggagca gcagcacctg
     2281 gatgtgctca ctggcttcca cctgctggac gggaagacac accttttcat cctggaaggc
     2341 ctggccgacc aaggcttgag gcagctgtgg gagaaccacc aaagctggat tcccaggtca
     2401 gaacacagga aatacaaggt gctgtacaac tcacagctgc tgttccgcag ccggctctat
     2461 ggggacctgg aggccatcct gtaccacgtg cacctcttcc agcccacgga gctgctgctg
     2521 cagcaggcgg tgttcttcct gcgagacact gagcggaggc gggtcttcca ggctctagcc
     2581 aggatccacg acatctgcta taacagcacc accctctggg acgtgacggt gagggacctg
     2641 ctgccctcct ctgctatgat aaaagacttg agccaagagt ttgggatgcc cctttcgcaa
     2701 gaagaactca cagatgagaa actgtttgcc ctaccacctc agcctgcccc caatcttgag
     2761 gactaccaca gtcggaactc caccctcacc ttagagatcc acgcccacca ggagaagtac
     2821 ctgcagtggc ggagtgccat gcttatgaag aacaaagaca aaaagcacag tttcatccag
     2881 aaaaatatca cagaagccta ccaggtcagc aagaagcctc cgaagtccgt ggcgaaggtg
     2941 attaaaattt cagcccctgc caacaaggcc gtctacaact atagtaccca gaccatgaat
     3001 tctacagagc ttgccaagaa ggagctgtat caagagatag ccaaggagcc aagaaagaga
     3061 ttcacgtact cacaggatta cctctcagcc atggtggagc ccctggactt gaaggaagag
     3121 gagaagaaag cccagaagaa atcccgccag gcctggctca cagccagggg attccaagtg
     3181 acaggtcttc agagcgacac cgaaagcagc tttcaggatc tcaagctgcc acccatcaaa
     3241 gagctgaatg aggagtggaa ggaaaactcc ctgtttgcta atgtactgga gcctgtgttg
     3301 gatcgagaca ggtggagctg ggacaggcac cacgtggact ttgatctgta caagaaacca
     3361 ccacctttcc tcgagctgct cccttcgccc gcaccaaagc ctgtaacagt caggaagaag
     3421 aaagggaaca gccccatctc ctgagcagca cagaccctcc cacggccacc gcatggtgaa
     3481 cctgcacagc ctcccccaca cccgaccaca ccctcctcaa caatcaactt cattaaagtg
     3541 cagcaggaca gatggcagca gccaggccct gtgtgaggct gggctgggct cacctcgtgg
     3601 tcgtggttgc ggagcccaat gcggatggag cggctggccc gcgacagcac ggccgtcatg
     3661 ccatacaggt tgatgaggat gttggccacc cgcttcagta ccagctgctc ctccatgatg
     3721 gtctgggatc acagaggctc caagtgggga ctcactacct agaccagtcc cccacatggt
     3781 ccctccctgg gctgcatctt tgcctgtctt agtctcctgt gttccttgag aaagtggagt
     3841 caataacacc tttctcttca ggttgtggga
//
