LOCUS       NM_033364               4433 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens cilia and flagella associated protein 91 (CFAP91),
            transcript variant 1, mRNA.
ACCESSION   NM_033364 XM_291086
VERSION     NM_033364.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4433)
  AUTHORS   Martinez,G., Beurois,J., Dacheux,D., Cazin,C., Bidart,M.,
            Kherraf,Z.E., Robinson,D.R., Satre,V., Le Gac,G., Ka,C.,
            Gourlaouen,I., Fichou,Y., Petre,G., Dulioust,E., Zouari,R.,
            Thierry-Mieg,N., Toure,A., Arnoult,C., Bonhivers,M., Ray,P. and
            Coutton,C.
  TITLE     Biallelic variants in MAATS1 encoding CFAP91, a
            calmodulin-associated and spoke-associated complex protein, cause
            severe astheno-teratozoospermia and male infertility
  JOURNAL   J Med Genet 57 (10), 708-716 (2020)
   PUBMED   32161152
  REMARK    GeneRIF: Biallelic variants in MAATS1 encoding CFAP91, a
            calmodulin-associated and spoke-associated complex protein, cause
            severe astheno-teratozoospermia and male infertility.
REFERENCE   2  (bases 1 to 4433)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4433)
  AUTHORS   Dymek,E.E. and Smith,E.F.
  TITLE     A conserved CaM- and radial spoke associated complex mediates
            regulation of flagellar dynein activity
  JOURNAL   J Cell Biol 179 (3), 515-526 (2007)
   PUBMED   17967944
REFERENCE   4  (bases 1 to 4433)
  AUTHORS   Matsuda,E., Ishizaki,R., Taira,T., Iguchi-Ariga,S.M. and Ariga,H.
  TITLE     Structure and characterization of AAT-1 isoforms
  JOURNAL   Biol Pharm Bull 28 (5), 898-901 (2005)
   PUBMED   15863901
REFERENCE   5  (bases 1 to 4433)
  AUTHORS   Hayes,V.M. and Gardiner-Garden,M.
  TITLE     Are polymorphic markers within the alpha-1-antitrypsin gene
            associated with risk of human immunodeficiency virus disease?
  JOURNAL   J Infect Dis 188 (8), 1205-1208 (2003)
   PUBMED   14551891
  REMARK    GeneRIF: Allelic variants of the M2 and A332A haplotypes of the
            human alpha-1-antitrypsin (AAT) gene are associated with human
            immunodeficiency virus (HIV) infection in 2 African-based
            populations from HIV-pandemic sub-Saharan Africa.
REFERENCE   6  (bases 1 to 4433)
  AUTHORS   Talmud,P.J., Martin,S., Steiner,G., Flavell,D.M., Whitehouse,D.B.,
            Nagl,S., Jackson,R., Taskinen,M.R., Frick,M.H., Nieminen,M.S.,
            Kesaniemi,Y.A., Pasternack,A., Humphries,S.E. and Syvanne,M.
  CONSRTM   Diabetes Atherosclerosis Intervention Study Investigators
  TITLE     Progression of atherosclerosis is associated with variation in the
            alpha1-antitrypsin gene
  JOURNAL   Arterioscler Thromb Vasc Biol 23 (4), 644-649 (2003)
   PUBMED   12692006
  REMARK    GeneRIF: A hydrophobic groove near the exposed residue 213 allows
            AAT to entrap gemfibrozil (but not fenofibrate), preventing
            PPARalpha activation. 2 independent studies support a protective
            role for AAT in established coronary artery atherogenesis
            progression.
REFERENCE   7  (bases 1 to 4433)
  AUTHORS   Yukitake,H., Furusawa,M., Taira,T., Iguchi-Ariga,S.M. and Ariga,H.
  TITLE     AAT-1, a novel testis-specific AMY-1-binding protein, forms a
            quaternary complex with AMY-1, A-kinase anchor protein 84, and a
            regulatory subunit of cAMP-dependent protein kinase and is
            phosphorylated by its kinase
  JOURNAL   J Biol Chem 277 (47), 45480-45492 (2002)
   PUBMED   12223483
  REMARK    GeneRIF: identified a novel AMY-1-binding protein, AAT-1, and
            determined its expression profiles, genes, and cellular
            localization; results showed that AAT-1 was specifically expressed
            in the testis throughout spermatogenesis and was also present in
            mature sperm
REFERENCE   8  (bases 1 to 4433)
  AUTHORS   Mashiba,S., Wada,Y., Takeya,M., Sugiyama,A., Hamakubo,T.,
            Nakamura,A., Noguchi,N., Niki,E., Izumi,A., Kobayashi,M., Uchida,K.
            and Kodama,T.
  TITLE     In vivo complex formation of oxidized alpha(1)-antitrypsin and LDL
  JOURNAL   Arterioscler Thromb Vasc Biol 21 (11), 1801-1808 (2001)
   PUBMED   11701469
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC117466.4 and AC069444.17.
            
            On Nov 23, 2018 this sequence version replaced NM_033364.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.93884.1, BC126394.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000273390.9/ ENSP00000273390.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-201               AC117466.4         23722-23922         c
            202-278             AC117466.4         20059-20135         c
            279-436             AC117466.4         19383-19540         c
            437-520             AC117466.4         18270-18353         c
            521-577             AC117466.4         17049-17105         c
            578-759             AC117466.4         11201-11382         c
            760-937             AC117466.4         596-773             c
            938-1095            AC069444.17        159659-159816       c
            1096-1278           AC069444.17        157560-157742       c
            1279-1421           AC069444.17        156530-156672       c
            1422-1538           AC069444.17        152554-152670       c
            1539-1610           AC069444.17        150710-150781       c
            1611-1757           AC069444.17        149341-149487       c
            1758-1979           AC069444.17        145840-146061       c
            1980-2128           AC069444.17        142773-142921       c
            2129-2220           AC069444.17        142134-142225       c
            2221-2382           AC069444.17        138938-139099       c
            2383-4433           AC069444.17        122934-124984       c
FEATURES             Location/Qualifiers
     source          1..4433
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q13.33"
     gene            1..4433
                     /gene="CFAP91"
                     /gene_synonym="AAT1; AAT1alpha; C3orf15; CaM-IP2; MAATS1;
                     SPATA26; SPGF51"
                     /note="cilia and flagella associated protein 91"
                     /db_xref="GeneID:89876"
                     /db_xref="HGNC:HGNC:24010"
                     /db_xref="MIM:609910"
     exon            1..201
                     /gene="CFAP91"
                     /gene_synonym="AAT1; AAT1alpha; C3orf15; CaM-IP2; MAATS1;
                     SPATA26; SPGF51"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..2381
                     /gene="CFAP91"
                     /gene_synonym="AAT1; AAT1alpha; C3orf15; CaM-IP2; MAATS1;
                     SPATA26; SPGF51"
                     /note="isoform 1 is encoded by transcript variant 1;
                     MYCBP-binding protein; AAT1-alpha; AMY-1-associating
                     protein expressed in testis 1; AAT-1; spermatogenesis
                     associated 26; MYCBP/AMY-1-associated, testis expressed 1;
                     MYCBP-associated, testis expressed 1;
                     MYCBP/AMY-1-associated testis-expressed protein 1; protein
                     MAATS1; MYCBP associated and testis expressed 1"
                     /codon_start=1
                     /product="cilia- and flagella-associated protein 91
                     isoform 1"
                     /protein_id="NP_203528.3"
                     /db_xref="CCDS:CCDS2994.1"
                     /db_xref="GeneID:89876"
                     /db_xref="HGNC:HGNC:24010"
                     /db_xref="MIM:609910"
                     /translation="MSHAVTIEEPQAQPQVSQTRYRERSRAGSHISSNRAYDFLYDPL
                     FIVSSEKDHTQANIQATLIRSRLRKVPRFKTMFSNLIHYPRYSLYWSKSDPVPPFISR
                     EWKGHKEKHREALRQLTTTDASFQMPKEVYEDPEVTGKNRYKYFERPFLPFFQQMPFN
                     VVYAVSKAEPYTFPPTSTKHLSIPSKSTVGTQTDYRDADVQTDPYSAEYVVCQDSIPE
                     LLTLATLTWGRGLPAGQAEVEMIERAREKRAWEASLPALSDTSQFEKRRKMMNEMERK
                     EWAFREQEIEKLQEIRLEVLKELLRKREENQNEVNMKHLNARWSKLQEGKEAKMAKIQ
                     RTHVSTIRKLVGKRKNIEGKLERRNIIKDYSDYASQVYGPLSRLGCFPDNNSEDFVVK
                     NYYLNTYEGLVELESCLPDFVTQPQIRAPKPKVITTKAGFLKRAARLDYELAEVHKAL
                     LDKKNKVLEVKKPPRFLQRNPIPQPRLPTPTLEMTSNEEEEMEMAVIYLQKLLRGRVV
                     QNMMFEGKEKRLELIQELRTCHALQEDEKLVKKAEKQVTLALQRQRNLHEHKVSLVEN
                     HLAGLEGRALADMFDFLSKELVRLQEERRIHAFVMLAERQRRVREAEESGRRQVEKQR
                     LREEDEIFKEVVKVHHSTISSYLEDIILNTEANTAEEQARAEIEKMAEKINDIAYEME
                     SRRTYLQSEEIVAELVYSFLIPEVQKYFVKEKVRNAQRKHILAAHQIIHSYTESMVQK
                     KLTEGEQDEASNAAMLLEKETQNENNS"
     exon            202..278
                     /gene="CFAP91"
                     /gene_synonym="AAT1; AAT1alpha; C3orf15; CaM-IP2; MAATS1;
                     SPATA26; SPGF51"
                     /inference="alignment:Splign:2.1.0"
     exon            279..436
                     /gene="CFAP91"
                     /gene_synonym="AAT1; AAT1alpha; C3orf15; CaM-IP2; MAATS1;
                     SPATA26; SPGF51"
                     /inference="alignment:Splign:2.1.0"
     exon            437..520
                     /gene="CFAP91"
                     /gene_synonym="AAT1; AAT1alpha; C3orf15; CaM-IP2; MAATS1;
                     SPATA26; SPGF51"
                     /inference="alignment:Splign:2.1.0"
     exon            521..577
                     /gene="CFAP91"
                     /gene_synonym="AAT1; AAT1alpha; C3orf15; CaM-IP2; MAATS1;
                     SPATA26; SPGF51"
                     /inference="alignment:Splign:2.1.0"
     exon            578..759
                     /gene="CFAP91"
                     /gene_synonym="AAT1; AAT1alpha; C3orf15; CaM-IP2; MAATS1;
                     SPATA26; SPGF51"
                     /inference="alignment:Splign:2.1.0"
     exon            760..937
                     /gene="CFAP91"
                     /gene_synonym="AAT1; AAT1alpha; C3orf15; CaM-IP2; MAATS1;
                     SPATA26; SPGF51"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1095
                     /gene="CFAP91"
                     /gene_synonym="AAT1; AAT1alpha; C3orf15; CaM-IP2; MAATS1;
                     SPATA26; SPGF51"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1278
                     /gene="CFAP91"
                     /gene_synonym="AAT1; AAT1alpha; C3orf15; CaM-IP2; MAATS1;
                     SPATA26; SPGF51"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1421
                     /gene="CFAP91"
                     /gene_synonym="AAT1; AAT1alpha; C3orf15; CaM-IP2; MAATS1;
                     SPATA26; SPGF51"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..1538
                     /gene="CFAP91"
                     /gene_synonym="AAT1; AAT1alpha; C3orf15; CaM-IP2; MAATS1;
                     SPATA26; SPGF51"
                     /inference="alignment:Splign:2.1.0"
     exon            1539..1610
                     /gene="CFAP91"
                     /gene_synonym="AAT1; AAT1alpha; C3orf15; CaM-IP2; MAATS1;
                     SPATA26; SPGF51"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1757
                     /gene="CFAP91"
                     /gene_synonym="AAT1; AAT1alpha; C3orf15; CaM-IP2; MAATS1;
                     SPATA26; SPGF51"
                     /inference="alignment:Splign:2.1.0"
     exon            1758..1979
                     /gene="CFAP91"
                     /gene_synonym="AAT1; AAT1alpha; C3orf15; CaM-IP2; MAATS1;
                     SPATA26; SPGF51"
                     /inference="alignment:Splign:2.1.0"
     exon            1980..2128
                     /gene="CFAP91"
                     /gene_synonym="AAT1; AAT1alpha; C3orf15; CaM-IP2; MAATS1;
                     SPATA26; SPGF51"
                     /inference="alignment:Splign:2.1.0"
     exon            2129..2220
                     /gene="CFAP91"
                     /gene_synonym="AAT1; AAT1alpha; C3orf15; CaM-IP2; MAATS1;
                     SPATA26; SPGF51"
                     /inference="alignment:Splign:2.1.0"
     exon            2221..2382
                     /gene="CFAP91"
                     /gene_synonym="AAT1; AAT1alpha; C3orf15; CaM-IP2; MAATS1;
                     SPATA26; SPGF51"
                     /inference="alignment:Splign:2.1.0"
     exon            2383..4433
                     /gene="CFAP91"
                     /gene_synonym="AAT1; AAT1alpha; C3orf15; CaM-IP2; MAATS1;
                     SPATA26; SPGF51"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4146..4151
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CFAP91"
                     /gene_synonym="AAT1; AAT1alpha; C3orf15; CaM-IP2; MAATS1;
                     SPATA26; SPGF51"
                     /note="hexamer: AATAAA"
     polyA_site      4175
                     /gene="CFAP91"
                     /gene_synonym="AAT1; AAT1alpha; C3orf15; CaM-IP2; MAATS1;
                     SPATA26; SPGF51"
                     /note="major polyA site"
     regulatory      4409..4414
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CFAP91"
                     /gene_synonym="AAT1; AAT1alpha; C3orf15; CaM-IP2; MAATS1;
                     SPATA26; SPGF51"
                     /note="hexamer: AATAAA"
     polyA_site      4433
                     /gene="CFAP91"
                     /gene_synonym="AAT1; AAT1alpha; C3orf15; CaM-IP2; MAATS1;
                     SPATA26; SPGF51"
ORIGIN      
        1 gttaccatag cgacgtgcac gcagtagcca ggcctgaccc gctggtccct tgctggcggg
       61 aggaaagagg cggcaccatg agccacgcag taaccatcga ggagccccag gcccagccgc
      121 aggtgtctca aactcggtac cgggagaggt cgcgggctgg gagccacatc tcctccaatc
      181 gagcgtatga ttttctgtac gatccattgt ttattgtgtc aagtgagaaa gaccatacac
      241 aggcaaatat ccaagctacc ctgattcgca gcagactgag aaaagttccc aggtttaaaa
      301 ccatgttcag taacctgatc cattatccaa gatattctct atattggagc aagtcagatc
      361 ctgtcccacc atttatcagt cgggaatgga agggacataa ggagaaacac agagaagccc
      421 tccggcagct caccacaact gacgcttctt ttcagatgcc taaagaagtt tatgaagatc
      481 ctgaagttac tggaaagaat cgctataaat actttgaaag gccttttctc ccattttttc
      541 agcagatgcc attcaatgtt gtttatgccg tatccaaggc agaaccatac acttttcctc
      601 ctacttctac taagcaccta tccatccctt caaagtctac tgtgggcact cagactgatt
      661 atcgggatgc tgacgttcaa acagatccat actctgcaga atatgtagta tgtcaggact
      721 caatccctga gctcttgacc ctggctacgc ttacttgggg tcggggtctc ccagcaggac
      781 aagctgaggt ggagatgata gaaagagccc gcgagaagcg tgcttgggaa gcctctctcc
      841 ccgctctgag tgacacctcc cagtttgaga agaggaggaa aatgatgaat gaaatggaga
      901 ggaaggagtg ggccttcaga gagcaggaga ttgaaaaact gcaggagatt cgcctggaag
      961 ttctaaaaga gctgttgagg aagcgtgaag agaatcagaa tgaagtgaat atgaagcact
     1021 tgaatgcccg gtggtctaaa ctgcaggagg gaaaagaggc aaaaatggca aaaattcagc
     1081 gcacgcatgt atcaacaatc agaaaacttg taggaaagag aaagaatata gaagggaagt
     1141 tggagagaag aaatatcatc aaggattatt ctgattatgc atcacaggtc tatggacctc
     1201 tgtctcgtct tgggtgtttc ccagacaaca actcagagga ctttgtagta aaaaactact
     1261 atctcaacac ctatgaagga ttagtggaac ttgagtcatg tctcccagat tttgtgacac
     1321 aaccccaaat cagagctcca aaacctaaag tcattaccac caaagctggt tttctgaaga
     1381 gggcagcaag gttggactat gagttggcag aggttcataa ggcactgttg gataagaaga
     1441 ataaagttct tgaagtaaag aaaccccctc gcttccttca aagaaaccca atacctcaac
     1501 ctcggcttcc aactccaacc ttggaaatga cgtccaatga agaagaagaa atggaaatgg
     1561 ctgtgatcta ccttcaaaag ttactccggg gcagagtcgt tcagaacatg atgtttgaag
     1621 ggaaagaaaa gcgactggag ttgatccagg agttgcgcac ctgccacgca ctacaagaag
     1681 atgaaaagct ggtgaaaaaa gccgagaagc aagtgaccct ggccttacag cggcagagga
     1741 acttgcatga gcacaaggtg tcactggttg aaaaccattt ggccggactg gaaggaaggg
     1801 cactagcaga catgtttgac ttcctgtcca aagagctggt gagactgcag gaggagagga
     1861 ggatccatgc ctttgtcatg ctggctgagc gccagcggcg ggtacgagag gctgaagaga
     1921 gtggtcggcg ccaggtggaa aaacagcgcc tgcgggagga ggacgagata tttaaggagg
     1981 tggttaaagt tcaccatagt actataagct cctacctaga agacataata ctgaataccg
     2041 aagcgaatac tgcagaagaa caagccaggg cagaaataga gaagatggct gagaaaatca
     2101 atgacattgc ttatgaaatg gaaagccgcc gaacctatct tcagtcagag gagattgttg
     2161 ctgagttggt ttatagtttt ctgatcccag aggtgcaaaa atactttgtc aaagaaaaag
     2221 tgaggaacgc acagcggaaa catattcttg cagcccatca gatcatccac agttacacgg
     2281 aaagcatggt tcaaaagaaa ttaactgagg gagagcaaga tgaggcctca aatgctgcca
     2341 tgttacttga gaaagaaact caaaatgaga acaacagcta agattgtgat ttttttgtaa
     2401 aagaagctgt acgaatcatc ataaataatt ccaatagtct gcacttctcc caaggtgtgc
     2461 actgctcata aacttgccag tgtgtgattc atgagaaagg agatttattt tccttaaaca
     2521 tccaataatt taaaatgatt ttcaataata ataatcaaat gaaaaagctt cattctcttc
     2581 agtgtcttct agatgcccta cttaaagaga acattttctt atgtctcatt tcaatatttt
     2641 gttaactatg aggatgtgct ggtttgttga atcaaacaaa aggaaatgtt gtggaatatt
     2701 tttccaagta gttttggttc actattcaca ggacattggc attatctact aaggctgaaa
     2761 atgtgcatat tccatgactc aggattttat ctcctagata tatattcaac agaaatgcat
     2821 gagtatgtgc accaacaggc atgacaaaaa tatttatagt agtggtgttc acaatagtcc
     2881 caaactggaa acccaagtgt ccatctccat cggaacagaa aactatactt tggtctgctt
     2941 ctacagtggc acatcaaccc acctttgagc tttagatcta agaagtgtgt tcatgcaaca
     3001 gccatagaga tggtgctatt gaaaggcaat ctgcccatcc tgtgtattga caagcatcag
     3061 gattccagga ggattcttcc tgattcaaag actgtcaaat aggaaaaaag aaaacagtaa
     3121 atgaacaaaa acatcaacat ggagtccaag taatgaattt atagaggaaa atgtatgcta
     3181 ctctgaaaac aaagcttatg ttagagaata tcttactgta agaaacaagg aaaattgcag
     3241 aaacatttgc tgagtgtttt taataggagt caaaaagaaa gggtcttttc agaaactgaa
     3301 gtaggaaata ataacagaca aggtcaaaaa atagatgcag gctgaaaaga aaaggaagtg
     3361 ggctaagatg ggaaaaatat aaaaagattt aaaatccagc aacaaaattt acacattcat
     3421 ttggatgcag tgaaaagggc agaaatacca cagcagagaa taaaattgat aatgttggca
     3481 acacatttat taagtgatcc aacatgggat gggaaggaat gggcaaagag attaaaatga
     3541 cagaagttag ctgtagatga cctatcccac agcaatcgga gttcttgaag aagaaaccag
     3601 aacaaataaa atagaaacaa taatcagagt ttaataatta attttctgag ttttttttta
     3661 aaaaaactaa ttatacaaac ttgaaagggt tcaccttgcc ctagcaaaac taggattggg
     3721 acaccttttt ttccccctga ggatcactga caaaaaacac tgcaccagta aggaagcaac
     3781 taaattttgt tttgttcttt gaaaaaggct aacctgagct aggtaaaggt tatatcattc
     3841 acttttgaaa taaaccatcg agaacacaaa atgacaagtg agttaggttg ggctgatggg
     3901 atagaaggtg ggaggggaat gctatacagc tgggaacagc agactttctc tgaagggcca
     3961 gatggtaact acattagggt ttgcgggtct gatggtcgcc atcataactg catactcaac
     4021 tctgccgttg tagggtaaga gcagcactcg atgacacaga aatgaatgca catgactgtg
     4081 ttccagtaaa attttatttt aattaaaatc aattcatgtt tgaaaaagga tttaaagtag
     4141 cttctaataa aggacatgtg taatgaaact taaaatatga tattttcttt aaaaatcttt
     4201 atccttatgt agacttctaa aactatgttt tgcatttaga cagtcaagga aaatacaagt
     4261 tgttatacaa ttctcattga ctaattgaag tttactagga gaggaaaact ttttcttgat
     4321 accggcaatc ttttacttat aatggcttga gttaaaatgc tccaactttt ctaatttttg
     4381 cttttgaaaa taaaacacct atagtgacaa taaaaacaca catttaaagc caa
//
