LOCUS       NM_001089584            2028 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens cilia and flagella associated protein 90 (CFAP90),
            mRNA.
ACCESSION   NM_001089584 XM_376372 XM_940803
VERSION     NM_001089584.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2028)
  AUTHORS   Gui,M., Croft,J.T., Zabeo,D., Acharya,V., Kollman,J.M.,
            Burgoyne,T., Hoog,J.L. and Brown,A.
  TITLE     SPACA9 is a lumenal protein of human ciliary singlet and doublet
            microtubules
  JOURNAL   Proc Natl Acad Sci U S A 119 (41), e2207605119 (2022)
   PUBMED   36191189
REFERENCE   2  (bases 1 to 2028)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2028)
  AUTHORS   Sigg,M.A., Menchen,T., Lee,C., Johnson,J., Jungnickel,M.K.,
            Choksi,S.P., Garcia,G. 3rd, Busengdal,H., Dougherty,G.W.,
            Pennekamp,P., Werner,C., Rentzsch,F., Florman,H.M., Krogan,N.,
            Wallingford,J.B., Omran,H. and Reiter,J.F.
  TITLE     Evolutionary Proteomics Uncovers Ancient Associations of Cilia with
            Signaling Pathways
  JOURNAL   Dev Cell 43 (6), 744-762 (2017)
   PUBMED   29257953
REFERENCE   4  (bases 1 to 2028)
  AUTHORS   Shaheen,R., Faqeih,E., Alshammari,M.J., Swaid,A., Al-Gazali,L.,
            Mardawi,E., Ansari,S., Sogaty,S., Seidahmed,M.Z., AlMotairi,M.I.,
            Farra,C., Kurdi,W., Al-Rasheed,S. and Alkuraya,F.S.
  TITLE     Genomic analysis of Meckel-Gruber syndrome in Arabs reveals marked
            genetic heterogeneity and novel candidate genes
  JOURNAL   Eur J Hum Genet 21 (7), 762-768 (2013)
   PUBMED   23169490
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC062569.1 and AC010346.6.
            
            On Nov 23, 2018 this sequence version replaced NM_001089584.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062569.1, SRR1803613.219564.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2151119 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000399810.7/ ENSP00000382708.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1371              BC062569.1         358-1728
            1372-1372           AC010346.6         41662-41662         c
            1373-2028           BC062569.1         1730-2385
FEATURES             Location/Qualifiers
     source          1..2028
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p15.31"
     gene            1..2028
                     /gene="CFAP90"
                     /gene_synonym="C5orf49"
                     /note="cilia and flagella associated protein 90"
                     /db_xref="GeneID:134121"
                     /db_xref="HGNC:HGNC:27028"
     exon            1..259
                     /gene="CFAP90"
                     /gene_synonym="C5orf49"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..556
                     /gene="CFAP90"
                     /gene_synonym="C5orf49"
                     /note="uncharacterized protein C5orf49"
                     /codon_start=1
                     /product="cilia- and flagella-associated protein 90"
                     /protein_id="NP_001083053.1"
                     /db_xref="CCDS:CCDS43300.1"
                     /db_xref="GeneID:134121"
                     /db_xref="HGNC:HGNC:27028"
                     /translation="MEDDEEETTASTLRGKPRPPPVSAQSAFSYIPPRRLDPKEHSYY
                     YRPARTGIISLYDCIFKRRLDYDQKLHRDDREHAKSLGLHVNEEEQERPVGVLTSSVY
                     GKRINQPIEPLNRDFGRANHVQADFYRKNDIPSLKEPGFGHIAPS"
     exon            260..376
                     /gene="CFAP90"
                     /gene_synonym="C5orf49"
                     /inference="alignment:Splign:2.1.0"
     exon            377..2028
                     /gene="CFAP90"
                     /gene_synonym="C5orf49"
                     /inference="alignment:Splign:2.1.0"
     regulatory      862..867
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CFAP90"
                     /gene_synonym="C5orf49"
                     /note="hexamer: AATGAA"
     polyA_site      888
                     /gene="CFAP90"
                     /gene_synonym="C5orf49"
                     /note="major polyA site"
     regulatory      1740..1745
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CFAP90"
                     /gene_synonym="C5orf49"
                     /note="hexamer: AATAAA"
     polyA_site      1764
                     /gene="CFAP90"
                     /gene_synonym="C5orf49"
     regulatory      2007..2012
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CFAP90"
                     /gene_synonym="C5orf49"
                     /note="hexamer: AATAAA"
     polyA_site      2028
                     /gene="CFAP90"
                     /gene_synonym="C5orf49"
ORIGIN      
        1 agacgcgggc tagacgctgg cgctgagcaa cctgaggcct gcagactccg actgggcccc
       61 tgggcgggcg ggacggaccg cggccaaggc gggggcgctg gacggtggcg gcatggagga
      121 cgacgaggag gagaccaccg cgtccacgct gcggggcaag cccaggccgc cgcccgtctc
      181 ggcgcagtcc gccttcagct acatcccgcc gcggcgcctg gaccccaaag agcacagcta
      241 ctactaccgc ccggcgcgga caggaattat ttccctctat gattgtattt ttaagaggcg
      301 cctagattat gatcagaagt tgcaccgaga tgacagagaa catgcaaaaa gcctgggact
      361 tcatgttaac gaagaggaac aggagaggcc ggttggagtg ctgacgtctt ctgtctatgg
      421 gaagcgcatc aatcagccca ttgagcccct aaaccgggac tttggccgtg ccaaccatgt
      481 gcaggctgac ttctacagga agaacgacat ccccagcctc aaggaacccg gctttgggca
      541 cattgctcca tcctgaagca tccccgtggc ccacagggca tgtccgatac cctgtggcct
      601 ggcaagtttg cacagcgaga aggtggcatc tggagcctcc tttccccttc tcatgacgcc
      661 taggagcttg gctatgcctg tgttgcatct ctacagtggg acacatgaac acgttagcag
      721 cccccctcag gttgctgggt taggagcctg accaacaaca cctttagtac atgtgaagag
      781 tctctgatgt gatgattttc agctggaatt atttttgatc aaatgaatct ggagaccgat
      841 tcattgtgag cacctgaata aaatgaaaac tttgtttccc cttggtaact gttgggttgg
      901 tttctgttca ctggctctct acatttgcca ggattctttg gggaggcagt cacaggagtg
      961 aggtgcagtt gcttttccca cgagttaggg gaactcctgc tgcctgaaca caaacaaccc
     1021 tgacatgttc ccttctccaa gaggagatgt gatgacaatt gtcttttggc acaattgaac
     1081 tctagaaact ccatttttgt ttttccagag gtctgaatcc caaataacag aattttgtgc
     1141 agtagggacc aggagcccta gtaaggatgg gtggccctgg tggccagcaa tgctcactat
     1201 tactgctcag agagaggggg ccagtcatgg gaagaggcta gatttcggtg ttcaacaaac
     1261 ttgggtaaaa ttctggttgc tgcattttct agatttgtgt tctagggcaa gtcatatcat
     1321 ctacatgagc agacatttcc tcatatttaa agtggaattt ccaaacctag aggagttcat
     1381 gcgggaggca atgagctgct ggagcacagg cataacacag gtacccagtg tgtgccccac
     1441 ccagtgcccc gtcatcacag caatgacttg actttaaaca gtcttctttt tggaagcagt
     1501 cgcttgtaac ctaagttgga aatacttact ttggagataa tttgaaactt acccaagtat
     1561 taaagtatca tcagctacat ttttaatgaa tggatccctt ggaagaaatc atctctcatc
     1621 taccatgatt aaatttccca cagtttagca gtgaatgggc aggtggccta attaatttca
     1681 atactgatcg ctccatcact ggttttattg ttttgaatat ggaaaaagga ttctctaaaa
     1741 ataaatgaca ctgaattccg gcaatttcaa ggctgagtga ctcctaagta tttctttatt
     1801 tttttgaaaa cagtttttca gtgtaggtgt cttttattta tttcaaacaa atggcagtag
     1861 tttatttcga atgcctttgg gtgcattata ccatatttat agtaacataa tagaaaatat
     1921 ataaagtttg ggttatagaa atatttataa attattcatt attcagactt gatttcaaca
     1981 aagacaaggc atctgtaagt gactgtaata aatcaaagtc aaactaaa
//
