LOCUS       NM_001304360            5355 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens cilia and flagella associated protein 74 (CFAP74),
            mRNA.
ACCESSION   NM_001304360 XM_005244811
VERSION     NM_001304360.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5355)
  AUTHORS   Biebach,L., Cindric,S., Koenig,J., Aprea,I., Dougherty,G.W.,
            Raidt,J., Bracht,D., Ruppel,R., Schreiber,J., Hjeij,R., Olbrich,H.
            and Omran,H.
  TITLE     Recessive Mutations in CFAP74 Cause Primary Ciliary Dyskinesia with
            Normal Ciliary Ultrastructure
  JOURNAL   Am J Respir Cell Mol Biol 67 (3), 409-413 (2022)
   PUBMED   36047773
  REMARK    GeneRIF: Recessive Mutations in CFAP74 Cause Primary Ciliary
            Dyskinesia with Normal Ciliary Ultrastructure.
REFERENCE   2  (bases 1 to 5355)
  AUTHORS   Han,J.H., Ryan,G., Guy,A., Liu,L., Quinodoz,M., Helbling,I.,
            Lai-Cheong,J.E., Barwell,J., Folcher,M., McGrath,J.A., Moss,C. and
            Rivolta,C.
  CONSRTM   Genomics England Research Consortium
  TITLE     Mutations in the ribosome biogenesis factor gene LTV1 are linked to
            LIPHAK syndrome, a novel poikiloderma-like disorder
  JOURNAL   Hum Mol Genet 31 (12), 1970-1978 (2022)
   PUBMED   34999892
REFERENCE   3  (bases 1 to 5355)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 5355)
  AUTHORS   Sha,Y., Wei,X., Ding,L., Ji,Z., Mei,L., Huang,X., Su,Z., Wang,W.,
            Zhang,X. and Lin,S.
  TITLE     Biallelic mutations of CFAP74 may cause human primary ciliary
            dyskinesia and MMAF phenotype
  JOURNAL   J Hum Genet 65 (11), 961-969 (2020)
   PUBMED   32555313
  REMARK    GeneRIF: Biallelic mutations of CFAP74 may cause human primary
            ciliary dyskinesia and MMAF phenotype.
REFERENCE   5  (bases 1 to 5355)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 5355)
  AUTHORS   Warnatz,H.J., Schmidt,D., Manke,T., Piccini,I., Sultan,M.,
            Borodina,T., Balzereit,D., Wruck,W., Soldatov,A., Vingron,M.,
            Lehrach,H. and Yaspo,M.L.
  TITLE     The BTB and CNC homology 1 (BACH1) target genes are involved in the
            oxidative stress response and in control of the cell cycle
  JOURNAL   J Biol Chem 286 (26), 23521-23532 (2011)
   PUBMED   21555518
  REMARK    GeneRIF: KIAA1751 is a target gene of the BACH1 transcription
            factor according to ChIP-seq analysis in HEK 293 cells.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK127388.1, BC139754.1, AB051538.1, EG328263.1, AL109917.22,
            DN831193.1, BC114926.1 and AW665824.1.
            
            On Dec 22, 2018 this sequence version replaced NM_001304360.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1968189, SAMEA1968540
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000682832.2/ ENSP00000508276.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-72                AK127388.1         52-123
            73-723              BC139754.1         1-651
            724-2256            AB051538.1         447-1979
            2257-2501           EG328263.1         1-245
            2502-2502           AL109917.22        147596-147596       c
            2503-2615           EG328263.1         247-359
            2616-3207           DN831193.1         53-644
            3208-3393           AL109917.22        133236-133421       c
            3394-3492           AL109917.22        131960-132058       c
            3493-3632           AL109917.22        130783-130922       c
            3633-5135           BC114926.1         376-1878
            5136-5355           AW665824.1         9-228               c
FEATURES             Location/Qualifiers
     source          1..5355
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.33"
     gene            1..5355
                     /gene="CFAP74"
                     /gene_synonym="C1orf222; CILD49; KIAA1751"
                     /note="cilia and flagella associated protein 74"
                     /db_xref="GeneID:85452"
                     /db_xref="HGNC:HGNC:29368"
                     /db_xref="MIM:620187"
     exon            1..86
                     /gene="CFAP74"
                     /gene_synonym="C1orf222; CILD49; KIAA1751"
                     /inference="alignment:Splign:2.1.0"
     exon            87..172
                     /gene="CFAP74"
                     /gene_synonym="C1orf222; CILD49; KIAA1751"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..5025
                     /gene="CFAP74"
                     /gene_synonym="C1orf222; CILD49; KIAA1751"
                     /codon_start=1
                     /product="cilia- and flagella-associated protein 74"
                     /protein_id="NP_001291289.1"
                     /db_xref="CCDS:CCDS90840.1"
                     /db_xref="GeneID:85452"
                     /db_xref="HGNC:HGNC:29368"
                     /db_xref="MIM:620187"
                     /translation="MEDDGSLLPEDELLADALLLEDERDELEDPEFDIKCLLQEAEDD
                     VDPGHSSSVKELDTDADKLKKKTAEDRTQAFHLRQNLSALDKMHEEQELFTEKMRGEL
                     RACRQRRDLIDKQQEAVAAEIATEEEAGNMAAVGRLQAVSRRLFAELENERDLQSRTE
                     AVLKESENTMWHIEIQEGRLEAFRTADREEVEATGRRLQVRAAEQLCREQEALGKVER
                     NRLLRIRKSLNTQKELGLRHQKLLEDARKNHKVAVRFLKASLGRIREQEKKEEMECHE
                     YMRRRMDAVVALKGSISANRDTLRKFQAWDRAKAELAEQRVQAEKKAILAQGRDAFRH
                     LVHQRRRQELEAQKRAFEEEQKLRKQEIISRILKEEAEEEKRKKQHPPTSARHRLTLR
                     DKTWNYISDFCKKTTVPTNTYTLDYEAAAGPGPSRLLEVVSSELIQGDPGASSEEETL
                     AEPEISGLWNEDYKPYQVPKEDVDRKPVGGTKMDKDILERTVERLRSRVVHKQVVWGR
                     EFQGRPFNSKPELLHFQDFDIGKVYKKKITLVNTTYTINYCKLVGVEEHLRDFIHVDF
                     DPPGPLSAGMSCEVLVTFKPMINKDLEGNISFLAQTGEFSVPLKCSTKKCSLSLDKEL
                     IDFGSYVVGETTSRTITLTNVGGLGTTFKFLPASEPCEMDDSQSALKLSSLLTYEDKS
                     LYDKAATSFSEQQLEGTESSQADMQSRKELEKLDKEQEEEQPAEPERLTTVIPPSEEQ
                     TEITLGEVTEGEIGPFSSIKVPIVFTPVVPGDVQARFKVTFKNPQCPTLHFRVVGVAI
                     DVPVWVPKPSVDLKICMYDRLYQDSVLVHTRSKAALRLKFEVCKELRAHLELLPKTGY
                     IQAQSSYSVQLKFLPRHSLPEDAGRYFDKETRVLEAPMTIWVADQNKPVGFTVHAIVT
                     TSDLELSPSEVDFGYCTIYEAIRTEISLHNHSLLPQEFGFVRLPKFVDVQPNDGFGTI
                     LPLETLQFCVIFQPTKAEEHRFQLTCKSEINRCFKLSCRAVGVHPPLELSHYQIKFAA
                     TALYDTSVATVYVINSHLSMSSPTHSKPRIGSEDASPMGPTSFEFLLPPDSPITISPS
                     VGTVWPGKRCLVQVAFRPVLPEKLIRQEALPLLNKEMETKSFRKNMAPQRKDLHGLSF
                     SVLRAQNRDKLFKVSVPHVLEMRKRELRPSSDEYQAARATLLRAFQAKFDTFVVPCVV
                     ASGDIKDRKGSEPLSFSPHNTLYLELWCPTVAPSVVVTSHKGKTIFNFGDVAVGHRSI
                     KKISIQNVSPEDLALDFSLLNPNGPFVLLNHSSLLRAGGTQVLVLSFSPHESILAQET
                     LDIITKRGTLTLTLMGTGVASMITCSIEGSVLNMGYVIAGESVSSGFKLQNNSLLPIK
                     FSMHLDSLSSTRGRGQQQLPQFLSSPSQRTEVVGTQNLNGQSVFSVAPVKGVMDPGKT
                     QDFTVTFSPDHESLYFSDKLQVVLFEKKISHQILLKGAACQHMMFVEGGDPLDVPVES
                     LTAIPVFDPRHREASSRPGPLSPEAEELRPILVTLDYIQFDTDTPAPPATRELQVGCI
                     RTTQPSPKKTVEFSIDSVASLQHKGFSIEPSRGSVERGQTKTISISWVPPADFDPDHP
                     LMVSALLQLRGDVKETYKVIFVAQVLTGP"
     exon            173..257
                     /gene="CFAP74"
                     /gene_synonym="C1orf222; CILD49; KIAA1751"
                     /inference="alignment:Splign:2.1.0"
     exon            258..401
                     /gene="CFAP74"
                     /gene_synonym="C1orf222; CILD49; KIAA1751"
                     /inference="alignment:Splign:2.1.0"
     exon            402..500
                     /gene="CFAP74"
                     /gene_synonym="C1orf222; CILD49; KIAA1751"
                     /inference="alignment:Splign:2.1.0"
     exon            501..605
                     /gene="CFAP74"
                     /gene_synonym="C1orf222; CILD49; KIAA1751"
                     /inference="alignment:Splign:2.1.0"
     exon            606..779
                     /gene="CFAP74"
                     /gene_synonym="C1orf222; CILD49; KIAA1751"
                     /inference="alignment:Splign:2.1.0"
     exon            780..890
                     /gene="CFAP74"
                     /gene_synonym="C1orf222; CILD49; KIAA1751"
                     /inference="alignment:Splign:2.1.0"
     exon            891..993
                     /gene="CFAP74"
                     /gene_synonym="C1orf222; CILD49; KIAA1751"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1151
                     /gene="CFAP74"
                     /gene_synonym="C1orf222; CILD49; KIAA1751"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1350
                     /gene="CFAP74"
                     /gene_synonym="C1orf222; CILD49; KIAA1751"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1506
                     /gene="CFAP74"
                     /gene_synonym="C1orf222; CILD49; KIAA1751"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1680
                     /gene="CFAP74"
                     /gene_synonym="C1orf222; CILD49; KIAA1751"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1799
                     /gene="CFAP74"
                     /gene_synonym="C1orf222; CILD49; KIAA1751"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..1866
                     /gene="CFAP74"
                     /gene_synonym="C1orf222; CILD49; KIAA1751"
                     /inference="alignment:Splign:2.1.0"
     exon            1867..1956
                     /gene="CFAP74"
                     /gene_synonym="C1orf222; CILD49; KIAA1751"
                     /inference="alignment:Splign:2.1.0"
     exon            1957..2121
                     /gene="CFAP74"
                     /gene_synonym="C1orf222; CILD49; KIAA1751"
                     /inference="alignment:Splign:2.1.0"
     exon            2122..2281
                     /gene="CFAP74"
                     /gene_synonym="C1orf222; CILD49; KIAA1751"
                     /inference="alignment:Splign:2.1.0"
     exon            2282..2346
                     /gene="CFAP74"
                     /gene_synonym="C1orf222; CILD49; KIAA1751"
                     /inference="alignment:Splign:2.1.0"
     exon            2347..2469
                     /gene="CFAP74"
                     /gene_synonym="C1orf222; CILD49; KIAA1751"
                     /inference="alignment:Splign:2.1.0"
     exon            2470..2591
                     /gene="CFAP74"
                     /gene_synonym="C1orf222; CILD49; KIAA1751"
                     /inference="alignment:Splign:2.1.0"
     exon            2592..2720
                     /gene="CFAP74"
                     /gene_synonym="C1orf222; CILD49; KIAA1751"
                     /inference="alignment:Splign:2.1.0"
     exon            2721..2808
                     /gene="CFAP74"
                     /gene_synonym="C1orf222; CILD49; KIAA1751"
                     /inference="alignment:Splign:2.1.0"
     exon            2809..2982
                     /gene="CFAP74"
                     /gene_synonym="C1orf222; CILD49; KIAA1751"
                     /inference="alignment:Splign:2.1.0"
     exon            2983..3116
                     /gene="CFAP74"
                     /gene_synonym="C1orf222; CILD49; KIAA1751"
                     /inference="alignment:Splign:2.1.0"
     exon            3117..3393
                     /gene="CFAP74"
                     /gene_synonym="C1orf222; CILD49; KIAA1751"
                     /inference="alignment:Splign:2.1.0"
     exon            3394..3492
                     /gene="CFAP74"
                     /gene_synonym="C1orf222; CILD49; KIAA1751"
                     /inference="alignment:Splign:2.1.0"
     exon            3493..3632
                     /gene="CFAP74"
                     /gene_synonym="C1orf222; CILD49; KIAA1751"
                     /inference="alignment:Splign:2.1.0"
     exon            3633..3767
                     /gene="CFAP74"
                     /gene_synonym="C1orf222; CILD49; KIAA1751"
                     /inference="alignment:Splign:2.1.0"
     exon            3768..3877
                     /gene="CFAP74"
                     /gene_synonym="C1orf222; CILD49; KIAA1751"
                     /inference="alignment:Splign:2.1.0"
     exon            3878..3933
                     /gene="CFAP74"
                     /gene_synonym="C1orf222; CILD49; KIAA1751"
                     /inference="alignment:Splign:2.1.0"
     exon            3934..4053
                     /gene="CFAP74"
                     /gene_synonym="C1orf222; CILD49; KIAA1751"
                     /inference="alignment:Splign:2.1.0"
     exon            4054..4209
                     /gene="CFAP74"
                     /gene_synonym="C1orf222; CILD49; KIAA1751"
                     /inference="alignment:Splign:2.1.0"
     exon            4210..4339
                     /gene="CFAP74"
                     /gene_synonym="C1orf222; CILD49; KIAA1751"
                     /inference="alignment:Splign:2.1.0"
     exon            4340..4494
                     /gene="CFAP74"
                     /gene_synonym="C1orf222; CILD49; KIAA1751"
                     /inference="alignment:Splign:2.1.0"
     exon            4495..4627
                     /gene="CFAP74"
                     /gene_synonym="C1orf222; CILD49; KIAA1751"
                     /inference="alignment:Splign:2.1.0"
     exon            4628..4788
                     /gene="CFAP74"
                     /gene_synonym="C1orf222; CILD49; KIAA1751"
                     /inference="alignment:Splign:2.1.0"
     exon            4789..4923
                     /gene="CFAP74"
                     /gene_synonym="C1orf222; CILD49; KIAA1751"
                     /inference="alignment:Splign:2.1.0"
     exon            4924..5355
                     /gene="CFAP74"
                     /gene_synonym="C1orf222; CILD49; KIAA1751"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5333..5338
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CFAP74"
                     /gene_synonym="C1orf222; CILD49; KIAA1751"
                     /note="hexamer: AATAAA"
     polyA_site      5355
                     /gene="CFAP74"
                     /gene_synonym="C1orf222; CILD49; KIAA1751"
                     /note="major polyA site"
ORIGIN      
        1 aatcgccaag gaccgccgcc tgcctgagca gcccggggtg tctgtgcctc cggagcccga
       61 gaacctggga cccaggccag ccagagctaa tttctatctc ccagcatgga ggatgacggc
      121 agcctgctcc ctgaggacga gcttttggcc gatgcccttc ttttggaaga tgaaagagat
      181 gaattagagg atccggagtt tgacatcaaa tgtcttctac aggaagctga ggatgacgtg
      241 gacccgggac acagcagctc agtgaaagaa ctagatactg atgctgataa attgaagaag
      301 aaaacagctg aggacagaac gcaggcattt cacctgcggc agaacctgag cgccctggat
      361 aagatgcatg aggagcaaga gcttttcact gagaagatga gaggggagct gcgcgcctgt
      421 cggcagaggc gggacctgat cgacaagcag caggaggctg tggcagccga gatcgccaca
      481 gaggaagagg cgggcaacat ggccgctgtg ggccgcctcc aggccgtgtc cagacgcctg
      541 tttgcagagc tggagaacga gagagacctg cagtcgagga ctgaggccgt gctgaaggag
      601 agcgagaaca ccatgtggca catcgagatc caggaggggc gactcgaggc cttccggaca
      661 gctgaccgtg aggaggtgga ggccacgggg cggcggctcc aggtgcgcgc agccgagcag
      721 ctctgcagag agcaggaggc cctggggaag gtggagcgga accgactgct gaggatcagg
      781 aagtccctga acacccagaa ggagctcggg ctcaggcacc agaagctgct ggaggacgcc
      841 cggaagaacc acaaggttgc cgtgcggttc ctgaaggcct ccctgggaag aatccgagag
      901 caagagaaga aggaggagat ggagtgccac gagtacatga ggcgacgcat ggatgcggtg
      961 gtggcgctga agggcagcat ctccgcgaac cgggacacac tgcggaagtt ccaagcatgg
     1021 gaccgtgcca aggcagagct ggcggagcag agggtccagg ctgagaagaa ggcgattctg
     1081 gcccagggca gggatgcatt caggcacctt gtccaccagc gccggcgcca ggagctggag
     1141 gcccagaaga gggcctttga ggaggagcag aagctcagaa agcaggagat catcagtcgg
     1201 attctgaaag aggaggctga ggaggaaaag aggaagaaac agcatccccc caccagtgcc
     1261 aggcaccggc tgaccctgag ggacaagacc tggaactaca tttctgactt ttgcaagaag
     1321 accacagtcc caaccaacac gtacacactg gactacgagg ctgctgcagg ccccgggccc
     1381 tctcggttgc tggaagtcgt ttccagtgag cttatccagg gggaccccgg ggccagctca
     1441 gaggaggaaa cgttagctga gcccgagatc tctgggcttt ggaatgaaga ctacaagcca
     1501 taccaggtgc ccaaggagga cgtggaccga aagcccgtgg gcgggacaaa gatggacaag
     1561 gacatcctgg agcgcacggt ggagcggctg cggagcaggg tggtccacaa gcaggtggtg
     1621 tgggggcgtg agttccaagg acgccccttc aacagcaaac cggagctcct ccacttccag
     1681 gactttgata ttggcaaagt gtacaagaaa aagatcacgt tggtaaacac cacctacacg
     1741 atcaactact gcaagctggt gggcgtggag gagcacctcc gggacttcat ccacgttgac
     1801 tttgaccccc ctggccccct gtcagccgga atgtcctgtg aagtgcttgt caccttcaag
     1861 ccgatgataa acaaggatct agaaggaaat atctcatttt tggctcagac gggcgagttt
     1921 tcagttccac tgaaatgttc aacaaagaaa tgttcgctgt ccctcgacaa ggagctcatt
     1981 gacttcggca gctacgtggt aggagagacc acgtctcgga ccatcacgct gaccaacgtt
     2041 gggggcttgg gcacgacttt caagttcctg ccagcttcag agccctgtga gatggacgac
     2101 tcccagtctg ccctgaaatt aagcagtctc ctgacctacg aagataaaag cttgtatgac
     2161 aaagccgcca ccagcttctc tgagcagcag ctagagggca cggagtcctc ccaggcggac
     2221 atgcagagcc ggaaggagct ggagaagctg gacaaggagc aggaggagga gcagcccgca
     2281 gaaccagaga gattaaccac agtgatacct cccagcgaag agcagacgga gatcacgctg
     2341 ggggaggtaa cagaagggga aattggcccc ttcagctcca tcaaggtgcc catcgtcttc
     2401 actccggtcg tcccaggcga cgtccaagcc aggttcaaag tcacgtttaa gaacccccag
     2461 tgccccacgc tgcatttcag ggtcgtgggc gtggccatcg atgtgccggt ctgggtgccg
     2521 aagcccagcg tggacctgaa gatctgcatg tatgaccggc tctaccagga ctctgtgctc
     2581 gtgcacacgc ggtcgaaagc tgccctgcgc ctgaagttcg aggtgtgcaa ggagctgagg
     2641 gcccacctgg agctcctgcc caagacaggc tatatccagg cacagtcgtc ctactccgtg
     2701 cagctcaagt tcctgccgcg acactccctc ccggaggacg cagggaggta ttttgacaag
     2761 gagacccgag tcctggaggc cccgatgacc atatgggttg ccgaccagaa caagccagtg
     2821 ggattcaccg tgcatgccat tgtcaccacc tcggacctgg agctcagtcc ctcggaggtg
     2881 gattttggct actgcaccat ctatgaggcc atcaggacgg aaatcagcct ccacaaccac
     2941 tcgctcctgc cccaggagtt cgggttcgtc aggcttccca agtttgtgga cgtccaaccc
     3001 aacgatgggt ttgggacgat cctgcccctg gaaacgctgc agttctgtgt gatcttccag
     3061 cccaccaagg ccgaggaaca cagattccaa ctgacctgca agtctgagat caaccggtgc
     3121 ttcaagctgt cttgccgggc tgtaggcgtc cacccacccc tggagctgtc ccactaccag
     3181 atcaagtttg ccgccacggc cctatacgac acctccgtgg ctacagtgta cgtcatcaac
     3241 tctcacctga gcatgagctc accgacccac tccaagcccc gcattggctc agaggacgcc
     3301 tctcccatgg ggcccacgtc tttcgagttc ctgctgcccc cagactcgcc tatcaccatc
     3361 tcgccctcag tggggaccgt gtggccagga aagaggtgcc tggtccaggt ggccttccgg
     3421 ccagtgctgc ccgagaagct gatccgccag gaagccctcc cactcctgaa caaagaaatg
     3481 gagaccaaat ctttccgaaa gaatatggcc ccccagagga aggacctgca tggactgtca
     3541 ttctccgttc ttcgagcaca gaaccgcgac aagctgttca aagtctctgt cccccacgtc
     3601 ctggagatgc ggaagcggga gctgaggccc agttccgacg agtaccaggc cgcccgagcc
     3661 accctgctca gagcgttcca ggcgaagttt gacacatttg tagttccctg tgttgttgcc
     3721 agtggcgaca tcaaagacag gaaggggtca gaacccctga gcttcagccc ccacaacacc
     3781 ctgtacctgg agctgtggtg cccgacggtg gcaccatctg ttgtggtgac gtcccataaa
     3841 ggcaagacca tctttaactt cggcgacgtc gctgtggggc accgcagtat caagaagatc
     3901 tccatccaga acgtctctcc cgaggatctg gccctggact tctccctgct gaaccccaac
     3961 ggcccctttg tcctgctgaa ccactccagc ctgctgcgtg caggtgggac ccaggtcctg
     4021 gtgctttcct tctctcccca cgagagcatc ctggctcaag aaacactgga catcatcacc
     4081 aagagaggca cgctcaccct caccctcatg ggcactggcg tggcgtccat gatcacgtgc
     4141 tccattgaag gcagcgtcct caacatgggc tatgtgattg ccggagagtc tgtgtcctca
     4201 ggcttcaagc tgcagaacaa ctctctgctc cccatcaagt tctccatgca cctggacagc
     4261 ctctccagca cccggggccg gggccagcag cagctgccgc agttcctcag ctcgccctcc
     4321 cagaggacgg aggtggtcgg gacgcagaat ctcaacggtc agagcgtgtt cagcgtggcc
     4381 cccgtcaagg gcgtcatgga ccccgggaag acacaagact tcactgtcac cttcagcccc
     4441 gaccacgaaa gcctctactt ctccgacaag ctccaggtgg tgctctttga aaagaaaatc
     4501 tcccaccaga tcctgctgaa gggtgccgcc tgtcagcaca tgatgttcgt ggagggcggc
     4561 gaccccctgg acgtgcccgt ggagtctctg acagcgatcc ctgtatttga ccccaggcac
     4621 agagaggcca gctcccggcc aggccctctc tctccagaag ctgaggagct gaggcccatc
     4681 ctggtgaccc tggactacat ccagtttgac acagacacgc cagccccacc tgccacccga
     4741 gagctgcagg tgggctgtat ccggaccacc cagccatctc caaagaagac cgttgagttc
     4801 agcatagaca gcgtcgcatc cctgcagcac aagggtttct ctattgagcc ctccaggggc
     4861 tccgtggagc gcggccagac gaagaccatc agcatctcct gggtgccacc tgcggacttt
     4921 gatccagacc acccactcat ggtgtcggcc ctgctgcagc taagggggga tgtgaaggag
     4981 acctacaagg tcatctttgt agcccaggtg ttgactggcc cctaagcctc tgcacagagc
     5041 accctcgggc cctcctgtcc accctcaaag ccctccccag gctgagggcc aggtcatact
     5101 accctagagc ctgggacctg gccatcctct gccagattcc aataggccgc cctccacatg
     5161 gcgccacggc cacttcctgc tgccctggac cccgcaagcc cagggacatc caagagcacc
     5221 cctcctgaga ccccagactc agaagcagcg agaaggccag gccagccctc agccatccta
     5281 gccagacccc ctcagagccc ccagccccca ggagagccct ccacagcctg tcaataaatt
     5341 ttttgtaggc caaca
//
