LOCUS       NM_001144872            1648 bp    mRNA    linear   PRI 10-JUN-2024
DEFINITION  Homo sapiens cilia and flagella associated protein 73 (CFAP73),
            mRNA.
ACCESSION   NM_001144872 XM_001714517 XM_373547 XM_941496
VERSION     NM_001144872.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1648)
  AUTHORS   Yamamoto,R., Song,K., Yanagisawa,H.A., Fox,L., Yagi,T.,
            Wirschell,M., Hirono,M., Kamiya,R., Nicastro,D. and Sale,W.S.
  TITLE     The MIA complex is a conserved and novel dynein regulator essential
            for normal ciliary motility
  JOURNAL   J Cell Biol 201 (2), 263-278 (2013)
   PUBMED   23569216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC089999.20.
            
            On Sep 18, 2020 this sequence version replaced NM_001144872.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2145893,
                              SAMEA2154405 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000335621.11/ ENSP00000333915.6
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-190               AC089999.20        101102-101291       c
            191-296             AC089999.20        98992-99097         c
            297-401             AC089999.20        98128-98232         c
            402-602             AC089999.20        97607-97807         c
            603-824             AC089999.20        96380-96601         c
            825-983             AC089999.20        95597-95755         c
            984-1072            AC089999.20        93325-93413         c
            1073-1648           AC089999.20        91739-92314         c
FEATURES             Location/Qualifiers
     source          1..1648
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.13"
     gene            1..1648
                     /gene="CFAP73"
                     /gene_synonym="CCDC42B; MIA2"
                     /note="cilia and flagella associated protein 73"
                     /db_xref="GeneID:387885"
                     /db_xref="HGNC:HGNC:37100"
     exon            1..190
                     /gene="CFAP73"
                     /gene_synonym="CCDC42B; MIA2"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..1061
                     /gene="CFAP73"
                     /gene_synonym="CCDC42B; MIA2"
                     /note="coiled-coil domain-containing protein 42B;
                     coiled-coil domain containing 42B"
                     /codon_start=1
                     /product="cilia- and flagella-associated protein 73"
                     /protein_id="NP_001138344.1"
                     /db_xref="CCDS:CCDS44983.1"
                     /db_xref="GeneID:387885"
                     /db_xref="HGNC:HGNC:37100"
                     /translation="MAVPWEEYFRLALQEKLSTKLPEQAEDHVPPVLRLLEKRQELVD
                     ADQALQAQKEVFRTKTAALKQRWEQLEQKERELKGSFIRFDKFLQDSEARRNRALRRA
                     AEERHQAGRREVEALRLWTQLQELRREHARLQRRLKRLEPCARLLEQALELLPGFQEV
                     PELVARFDGLAETQAALRLREREQLAELEAARARLQQLRDAWPDEVLAQGQRRAQLQE
                     RLEAARERTLQWESKWIQIQNTAAEKTLLLGRSRMAVLNLFQLVCQHQGQPPTLDIED
                     TEGQLEHVKLFMQDLSAMLAGLGQAEPAAPAS"
     exon            191..296
                     /gene="CFAP73"
                     /gene_synonym="CCDC42B; MIA2"
                     /inference="alignment:Splign:2.1.0"
     exon            297..401
                     /gene="CFAP73"
                     /gene_synonym="CCDC42B; MIA2"
                     /inference="alignment:Splign:2.1.0"
     exon            402..602
                     /gene="CFAP73"
                     /gene_synonym="CCDC42B; MIA2"
                     /inference="alignment:Splign:2.1.0"
     exon            603..824
                     /gene="CFAP73"
                     /gene_synonym="CCDC42B; MIA2"
                     /inference="alignment:Splign:2.1.0"
     exon            825..983
                     /gene="CFAP73"
                     /gene_synonym="CCDC42B; MIA2"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1072
                     /gene="CFAP73"
                     /gene_synonym="CCDC42B; MIA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1648
                     /gene="CFAP73"
                     /gene_synonym="CCDC42B; MIA2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1627..1632
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CFAP73"
                     /gene_synonym="CCDC42B; MIA2"
                     /note="hexamer: AATAAA"
     polyA_site      1648
                     /gene="CFAP73"
                     /gene_synonym="CCDC42B; MIA2"
                     /note="major polyA site"
ORIGIN      
        1 agagcctgct ggtggctgcc ttctgggccg agctgagcag gcttccacac cacgctccac
       61 agaaccccca gggtctccta agcttgtgca aaactccagc tggtggaaag aaagctgggg
      121 caactgccag aaggatggcg gtgccctggg aggaatattt ccgactggct ttgcaagaga
      181 aactgtctac aaagctgcca gagcaggctg aggatcatgt cccaccagta ctgcgtctcc
      241 tggagaagag gcaagagctg gtagatgcag accaggccct gcaggcccag aaggaggtgt
      301 tccgcaccaa gacggcagcc ctgaaacagc gttgggaaca gctggaacaa aaggagcggg
      361 agctaaaggg atcgttcatc cgctttgaca agtttttgca ggactccgag gcccggcgca
      421 atcgcgcgct gcggagggcg gcggaggaga ggcaccaggc gggccgtcgg gaggtggagg
      481 cgctgcgtct gtggacccag ctccaggagc tacggcggga acacgcgcgg ctgcagcgcc
      541 ggcttaagcg cctggagccc tgcgcgcgcc tgctggagca agcgctggag ctgctgcccg
      601 ggttccaaga ggttccggag ctggtggcgc gcttcgacgg cctggccgag acgcaggcgg
      661 cgctgaggct cagggagcgc gagcagctcg cggagctgga ggcggcgcga gcgcggctgc
      721 agcagctgcg ggacgcctgg ccggacgagg tgctcgcaca gggccagcgg cgggcacagc
      781 tgcaggagcg cctggaggct gccagggagc gtacgctgca gtgggaatcc aagtggattc
      841 agattcagaa cacagcagcg gagaagactc tgctcctggg acgcagcagg atggctgtgc
      901 tcaacctgtt ccagctagtg tgccagcatc aggggcagcc tcccaccctg gacatcgagg
      961 acacggaggg acagctagag cacgtgaagc tgttcatgca ggacctctct gccatgctgg
     1021 ccggcctggg tcaggctgag cctgcagccc ctgcctccta gccctgacac aggctgacgc
     1081 agctgctgcc cttctgtggc catacagtgc tccttttcac agatgatggc tcctgcaggg
     1141 agtgccccca gtgcccagca cagggccagg cacacagtgg tgcacgggaa cgtctgctga
     1201 tgcccaccct aaggccaatc aaggagccac ggggctgggt cctggtcctc acatcctctt
     1261 ccgcatcttg cccttcttgg agcgggcacc ccggccgaag gcgccctgct gcagctcctg
     1321 gacgcggcgg cggttgcggg cagagagctg cttgaggcca ccacgctgca ggaagtgcag
     1381 cttctgggcc cggcgccgct gcttcaggat ctgctgcttg gtcttgagtt ccgggcggac
     1441 tcggcctgca ggggtgcctg gggcgtgggg ccgggatgca cctgctggga cagggattca
     1501 gggagctcag ctgttgggat cactcccaag atcccctcct cccagaagct tgcagactcc
     1561 tcccctgccc ctactcctgt tctgtgctta ttgctgtggc ccagtgtctg tacacagtag
     1621 gtggctaata aagttttagg cagcctca
//
