LOCUS       NM_022761               2568 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens cilia and flagella associated protein 68 (CFAP68),
            transcript variant 1, mRNA.
ACCESSION   NM_022761
VERSION     NM_022761.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2568)
  AUTHORS   Andersen,J.S., Vijayakumaran,A., Godbehere,C., Lorentzen,E.,
            Mennella,V. and Schou,K.B.
  TITLE     Uncovering structural themes across cilia microtubule inner
            proteins with implications for human cilia function
  JOURNAL   Nat Commun 15 (1), 2687 (2024)
   PUBMED   38538594
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2568)
  AUTHORS   Gui,M., Croft,J.T., Zabeo,D., Acharya,V., Kollman,J.M.,
            Burgoyne,T., Hoog,J.L. and Brown,A.
  TITLE     SPACA9 is a lumenal protein of human ciliary singlet and doublet
            microtubules
  JOURNAL   Proc Natl Acad Sci U S A 119 (41), e2207605119 (2022)
   PUBMED   36191189
REFERENCE   3  (bases 1 to 2568)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 2568)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2568)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   6  (bases 1 to 2568)
  AUTHORS   O'Brien,K.P., Tapia-Paez,I., Stahle-Backdahl,M., Kedra,D. and
            Dumanski,J.P.
  TITLE     Characterization of five novel human genes in the 11q13-q22 region
  JOURNAL   Biochem Biophys Res Commun 273 (1), 90-94 (2000)
   PUBMED   10873569
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP001781.5.
            
            On Nov 23, 2018 this sequence version replaced NM_022761.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.367184.1,
                                           SRR1803617.251005.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000260276.8/ ENSP00000260276.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                AP001781.5         160332-160396
            66-296              AP001781.5         163159-163389
            297-363             AP001781.5         163927-163993
            364-667             AP001781.5         164562-164865
            668-2568            AP001781.5         164866-166766
FEATURES             Location/Qualifiers
     source          1..2568
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.1"
     gene            1..2568
                     /gene="CFAP68"
                     /gene_synonym="C11orf1"
                     /note="cilia and flagella associated protein 68"
                     /db_xref="GeneID:64776"
                     /db_xref="HGNC:HGNC:1163"
     exon            1..65
                     /gene="CFAP68"
                     /gene_synonym="C11orf1"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..473
                     /gene="CFAP68"
                     /gene_synonym="C11orf1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     UPF0686 protein C11orf1"
                     /codon_start=1
                     /product="cilia- and flagella-associated protein 68
                     isoform 1"
                     /protein_id="NP_073598.1"
                     /db_xref="CCDS:CCDS8350.1"
                     /db_xref="GeneID:64776"
                     /db_xref="HGNC:HGNC:1163"
                     /translation="MAASQCLCCSKFLFQRQNLACFLTNPHCGSLVNADGHGEVWTDW
                     NNMSKFFQYGWRCTTNENTYSNRTLMGNWNQERYDLRNIVQPKPLPSQFGHYFETTYD
                     TSYNNKMPLSTHRFKREPHWFPGHQPELDPPRYKCTEKSTYMNSYSKP"
     exon            66..296
                     /gene="CFAP68"
                     /gene_synonym="C11orf1"
                     /inference="alignment:Splign:2.1.0"
     exon            297..363
                     /gene="CFAP68"
                     /gene_synonym="C11orf1"
                     /inference="alignment:Splign:2.1.0"
     exon            364..2568
                     /gene="CFAP68"
                     /gene_synonym="C11orf1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      641..646
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CFAP68"
                     /gene_synonym="C11orf1"
                     /note="hexamer: AATAAA"
     regulatory      645..650
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CFAP68"
                     /gene_synonym="C11orf1"
                     /note="hexamer: AATAAA"
     polyA_site      658
                     /gene="CFAP68"
                     /gene_synonym="C11orf1"
                     /note="major polyA site"
     polyA_site      667
                     /gene="CFAP68"
                     /gene_synonym="C11orf1"
                     /note="major polyA site"
     regulatory      2550..2555
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CFAP68"
                     /gene_synonym="C11orf1"
                     /note="hexamer: AATAAA"
     polyA_site      2568
                     /gene="CFAP68"
                     /gene_synonym="C11orf1"
ORIGIN      
        1 cttttttcac ctcgtctgaa atggctgcct cccagtgtct ctgctgctca aaatttctct
       61 tccagagaca gaacctcgcc tgtttcctca caaacccaca ctgtggcagc cttgttaatg
      121 cagatggcca tggtgaagtg tggacagatt ggaataatat gtccaagttt ttccagtatg
      181 gatggcgatg caccactaat gagaatacct attcaaaccg taccctgatg ggcaactgga
      241 accaggaaag atatgacctg aggaatatcg tgcagcccaa acccttgcct tcccagtttg
      301 gacactactt tgaaacaaca tatgatacaa gctacaacaa caaaatgcca ctttcaacac
      361 atagatttaa gcgagagcct cactggttcc caggacatca acctgaactg gatcctcccc
      421 gatacaaatg cacagaaaag tcaacttaca tgaatagcta ttcaaagcct taaattgggc
      481 atcactcagg atgtgtataa gatcttaata ttgactagtt tcacatccag gtttctaaga
      541 aatgataaga tacttcactt ttccagagtg aaatgtagga gggagcacat tctaagtaca
      601 gctaaaaatt tagctcactg taacacagtt tcactctctg aataaataaa gcaaaaaaca
      661 cagtaaatat tctttatccc tttttttgtt gttgttttaa ccaagattta aatgtcaaat
      721 ttaatacagc aactcagttc tacatttggg gtgttgtaga agggccttaa aaagaattat
      781 tttaggccag gcacggtggc tcatgcctgt aatcccagca ctttgggagg ccgaggcagg
      841 tggatcacgt gaggtcagga gttcgagacc agcctgacca acatggtgaa acactgtctc
      901 tactaaaaac acaaaaatta gctgagcatg gtggctcacg cctgtaatcc cagctactca
      961 ggaggctgag gcaggggaat cgcttgaacc tgagaagtgg aggttgtggt gagctgagat
     1021 catgccactg cactttagcc tgggtgacag agcgagactc tgtctcaaaa aaaaaaaaaa
     1081 aaaaagaatt atttctctga agtctacaac cactgtggtc ttcccttcct tctgtcgtag
     1141 caagacctca gaatctagca taacttaggc taggtttggc tagatgcttt ctgggtataa
     1201 gccagagtcg tatagtgcaa ctttgctgtg accttagtga acatcccctc ttgaggacta
     1261 caaaaacaaa cgtaactttt taaaattatt atggagaatt ttacgtaaaa caaaagtaga
     1321 caggctagtc taatgaactc ccatgtatca ttacccagca tcaactattt atgactaatc
     1381 ttacctactt ctactttgtc ttattgaatt aattttggag cagatcttag aaatagaatt
     1441 taatctataa aaatcttggt gggctgggtg cggtggctca tgcctgtaat cccagcactt
     1501 tgggaggctg aggtgggtgg atcacctgag gtcaggagtc caagaccagc ctggccaatg
     1561 tggtgaaact ccatctcttc taaaaataca aaaattagct ggtcttggtg gcgggcgcct
     1621 gtaatcccag ctacttggga ggctgaggca ggagaattgc ttgaacccag gaagcagagg
     1681 ttgcagtgag ctgagacggt gccattgctc tccagcctgg gcgacaagag cgaaactccg
     1741 tctcaaaaaa aaaaaagaaa agaaaaagaa aaaaaaaatc ttggtatact ggctgggcac
     1801 agtggctcac acctaatccc agcactttgg gaggctgagg caggaggata gcttgaggct
     1861 gggagttcaa aaccagcctg ggcaacatag caagacccca tctctaccaa aaaaaatttt
     1921 tttaaagatt tcagtatatt tctcaaaaag ataaggactg tcaattgtct actccccccc
     1981 aacaaaggtc actaaggaaa cctgttgact aaacaaagct cattaaacct attgtagtgt
     2041 agcaaaggag accatcaact tgacacagag tcttggtaat gattcaaagg gaggatgtta
     2101 gagtaaggta tttataagga tttgagataa gggtccaact ggtttaaaat gagtcaaaat
     2161 agggaactag tagagactga gaaagggttg tgaatagctt aggtttggta aacttaggaa
     2221 atcaacagtc ttaattttaa tatggttaaa ctgattagta tttcctattt ttttatctac
     2281 tgtgtaagaa gacactataa tatatgggca ttactgagag atactgccca tatgttgtcc
     2341 tcgtaagcaa ggagatattt tttatctccc atatattacc tctcaaacct ttgttacttt
     2401 agtttcgaga tatagatcca gaatttatgt tgttactcag tagtgaggaa gtttcttttt
     2461 tttttctaaa tggctatcaa gttgtcccac cattagttat tgaaaagacc ataatttttt
     2521 cactcctatt caatgccatt tttattgtaa ataaactatg tacatgta
//
