LOCUS       NM_194302               5946 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens cilia and flagella associated protein 65 (CFAP65),
            transcript variant 1, mRNA.
ACCESSION   NM_194302 XM_173080
VERSION     NM_194302.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5946)
  AUTHORS   Zhao,H., Sun,J., Insinna,C., Lu,Q., Wang,Z., Nagashima,K.,
            Stauffer,J., Andresson,T., Specht,S., Perera,S., Daar,I.O. and
            Westlake,C.J.
  TITLE     Male infertility-associated Ccdc108 regulates multiciliogenesis via
            the intraflagellar transport machinery
  JOURNAL   EMBO Rep 23 (4), e52775 (2022)
   PUBMED   35201641
  REMARK    GeneRIF: Male infertility-associated Ccdc108 regulates
            multiciliogenesis via the intraflagellar transport machinery.
REFERENCE   2  (bases 1 to 5946)
  AUTHORS   Liu,C., Tu,C., Wang,L., Wu,H., Houston,B.J., Mastrorosa,F.K.,
            Zhang,W., Shen,Y., Wang,J., Tian,S., Meng,L., Cong,J., Yang,S.,
            Jiang,Y., Tang,S., Zeng,Y., Lv,M., Lin,G., Li,J., Saiyin,H., He,X.,
            Jin,L., Toure,A., Ray,P.F., Veltman,J.A., Shi,Q., O'Bryan,M.K.,
            Cao,Y., Tan,Y.Q. and Zhang,F.
  TITLE     Deleterious variants in X-linked CFAP47 induce
            asthenoteratozoospermia and primary male infertility
  JOURNAL   Am J Hum Genet 108 (2), 309-323 (2021)
   PUBMED   33472045
REFERENCE   3  (bases 1 to 5946)
  AUTHORS   Li,W., Wu,H., Li,F., Tian,S., Kherraf,Z.E., Zhang,J., Ni,X., Lv,M.,
            Liu,C., Tan,Q., Shen,Y., Amiri-Yekta,A., Cazin,C., Zhang,J.,
            Liu,W., Zheng,Y., Cheng,H., Wu,Y., Wang,J., Gao,Y., Chen,Y.,
            Zha,X., Jin,L., Liu,M., He,X., Ray,P.F., Cao,Y. and Zhang,F.
  TITLE     Biallelic mutations in CFAP65 cause male infertility with multiple
            morphological abnormalities of the sperm flagella in humans and
            mice
  JOURNAL   J Med Genet 57 (2), 89-95 (2020)
   PUBMED   31501240
  REMARK    GeneRIF: Biallelic mutations in CFAP65 cause male infertility with
            multiple morphological abnormalities of the sperm flagella in
            humans and mice.
REFERENCE   4  (bases 1 to 5946)
  AUTHORS   Wang,W., Tu,C., Nie,H., Meng,L., Li,Y., Yuan,S., Zhang,Q., Du,J.,
            Wang,J., Gong,F., Fan,L., Lu,G.X., Lin,G. and Tan,Y.Q.
  TITLE     Biallelic mutations in CFAP65 lead to severe asthenoteratospermia
            due to acrosome hypoplasia and flagellum malformations
  JOURNAL   J Med Genet 56 (11), 750-757 (2019)
   PUBMED   31413122
  REMARK    GeneRIF: CFAP65 mutations may cause spermatozoa to be completely
            immotile.
REFERENCE   5  (bases 1 to 5946)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 5946)
  AUTHORS   Imsland,F., Feng,C., Boije,H., Bed'hom,B., Fillon,V., Dorshorst,B.,
            Rubin,C.J., Liu,R., Gao,Y., Gu,X., Wang,Y., Gourichon,D.,
            Zody,M.C., Zecchin,W., Vieaud,A., Tixier-Boichard,M., Hu,X.,
            Hallbook,F., Li,N. and Andersson,L.
  TITLE     The Rose-comb mutation in chickens constitutes a structural
            rearrangement causing both altered comb morphology and defective
            sperm motility
  JOURNAL   PLoS Genet 8 (6), e1002775 (2012)
   PUBMED   22761584
REFERENCE   7  (bases 1 to 5946)
  AUTHORS   Xu,B., Roos,J.L., Dexheimer,P., Boone,B., Plummer,B., Levy,S.,
            Gogos,J.A. and Karayiorgou,M.
  TITLE     Exome sequencing supports a de novo mutational paradigm for
            schizophrenia
  JOURNAL   Nat Genet 43 (9), 864-868 (2011)
   PUBMED   21822266
  REMARK    Publication Status: Online-Only
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB070903.1, AK127189.1,
            AK302688.1, BC130281.1 and AA503417.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_194302.3.
            
            Summary: The protein encoded by this gene has putative coiled-coil
            domains and may be a transmembrane protein. The chicken ortholog of
            this gene is involved in the Rose-comb mutation, which is a large
            chromosome inversion, resulting in altered comb morphology and
            defects in sperm motility. [provided by RefSeq, Aug 2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed/partial sample support SAMEA1968540,
                              SAMEA1968968 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000341552.10/ ENSP00000340776.5
            RefSeq Select criteria    :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-534               DB070903.1         3-536
            535-1000            AK127189.1         535-1000
            1001-2070           AK302688.1         895-1964
            2071-3144           AK127189.1         2071-3144
            3145-5928           BC130281.1         959-3742
            5929-5946           AA503417.1         217-234
FEATURES             Location/Qualifiers
     source          1..5946
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q35"
     gene            1..5946
                     /gene="CFAP65"
                     /gene_synonym="CCDC108; SPGF40"
                     /note="cilia and flagella associated protein 65"
                     /db_xref="GeneID:255101"
                     /db_xref="HGNC:HGNC:25325"
                     /db_xref="MIM:614270"
     exon            1..29
                     /gene="CFAP65"
                     /gene_synonym="CCDC108; SPGF40"
                     /inference="alignment:Splign:2.1.0"
     exon            30..75
                     /gene="CFAP65"
                     /gene_synonym="CCDC108; SPGF40"
                     /inference="alignment:Splign:2.1.0"
     exon            76..230
                     /gene="CFAP65"
                     /gene_synonym="CCDC108; SPGF40"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..5855
                     /gene="CFAP65"
                     /gene_synonym="CCDC108; SPGF40"
                     /note="isoform 1 is encoded by transcript variant 1;
                     coiled-coil domain containing 108"
                     /codon_start=1
                     /product="cilia- and flagella-associated protein 65
                     isoform 1"
                     /protein_id="NP_919278.2"
                     /db_xref="CCDS:CCDS2430.2"
                     /db_xref="GeneID:255101"
                     /db_xref="HGNC:HGNC:25325"
                     /db_xref="MIM:614270"
                     /translation="MFTLTGCRLVEKTQKVENPSVSFASSFPLIPLLLRGKSVQKKQA
                     ESKSQIKLHTQSAPFGLCPKDMMLTQAPSSVVRSRNSRNHTVNSGGSCLSASTVAIPA
                     INDSSAAMSACSTISAQPASSMDTQMHSPKKQERVNKRVIWGIEVAEELHWKGWELGK
                     ETTRNLVLKNRSLKLQKMKYRPPKTKFFFTVIPQPIFLSPGITLTLPIVFRPLEAKEY
                     MDQLWFEKAEGMFCVGLRATLPCHRLICRPPSLQLPMCAVGDTTEAFFCLDNVGDLPT
                     FFTWEFSSPFQMLPATGLLEPGQASQIKVTFQPLTAVIYEVQATCWYGAGSRQRSSIQ
                     LQAVAKCAQLLVSIKHKCPEDQDAEGFQKLLYFGSVAVGCTSERQIRLHNPSAVNAPF
                     RIEISPDELAEDQAFSCPTAHGIVLPGEKKCVSVFFHPKTLDTRTVDYCSIMPSGCAS
                     KTLLKVVGFCRGPAVSLQHYCVNFSWVNLGERSEQPLWIENQSDCTAHFQFAIDCLES
                     VFTIRPAFGTLVGKARMTLHCAFQPTHPIICFRRVACLIHHQDPLFLDLMGTCHSDST
                     KPAILKPQHLTWYRTHLARGLTLYPPDILDAMLKEKKLAQDQNGALMIPIQDLEDMPA
                     PQYPYIPPMTEFFFDGTSDITIFPPPISVEPVEVDFGACPGPEAPNPVPLCLMNHTKG
                     KIMVVWTRRSDCPFWVTPESCDVPPLKSMAMRLHFQPPHPNCLYTVELEAFAIYKVLQ
                     SYSNIEEDCTMCPSWCLTVRARGHSYFAGFEHHIPQYSLDVPKLFPAVSSGEPTYRSL
                     LLVNKDCKLLTFSLAPQRGSDVILRPTSGLVAPGAHQIILICTYPEGSSWKQHTFYLQ
                     CNASPQYLKEVSMYSREEPLQLKLDTHKSLYFKPTWVGCSSTSPFTFRNPSRLPLQFE
                     WRVSEQHRKLLAVQPSRGLIQPNERLTLTWTFSPLEETKYLFQVGMWVWEAGLSPNAN
                     PAATTHYMLRLVGVGLTSSLSAKEKELAFGNVLVNSKQSRFLVLLNDGNCTLYYRLYL
                     EQGSPEAVDNHPLALQLDRTEGSMPPRSQDTICLTACPKQRSQYSWTITYSLLSHRDN
                     KAGEKQELCCVSLVAVYPLLSILDVSSMGSAEGITRKHLWRLFSLDLLNSYLERDPTP
                     CELTYKVPTRHSMSQIPPVLTPLRLDFNFGAAPFKAPPSVVFLALKNSGVVSLDWAFL
                     LPSDQRIDVELWAEQAELNSTELHQMRVQDNCLFSISPKAGSLSPGQEQMVELKYSHL
                     FIGTDHLPVLFKVSHGREILLNFIGVTVKPEQKYVHFTSTTHQFIPIPIGDTLPPRQI
                     YELYNGGSVPVTYEVQTDVLSQVQEKNFDHPIFCCLNPKGEIQPGSTARVLWIFSPIE
                     AKTYTVDVPIHILGWNSALIHFQGVGYNPHMMGDTAPFHNISSWDNSSIHSRLVVPGQ
                     NVFLSQSHISLGNIPVQSKCSRLLFLNNISKNEEIAFSWQPSPLDFGEVSVSPMIGVV
                     APEETVPFVVTLRASVHASFYSADLVCKLYSQQLMRQYHKELQEWKDEKVRQEVEFTI
                     TDMKVKKRTCCTACEPARKYKTLPPIKNQQSVSRPASWKLQTPKEEVSWPCPQPPSPG
                     MLCLGLTARAHATDYFLANFFSEFPCHFLHRELPKRKAPREESETSEEKSPNKWGPVS
                     KQKKQLLVDILTTIIRGLLEDKNFHEAVDQSLVEQVPYFRQFWNEQSTKFMDQKNSLY
                     LMPILPVPSSSWEDGKGKQPKEDRPEHYPGLGKKEEGEEEKGEEEEEELEEEEEEEEE
                     TEEEELGKEEIEEKEEERDEKEEKVSWAGIGPTPQPESQESMQWQWQQQLNVMVKEEQ
                     EQDEKEAIRRLPAFANLQEALLENMIQNILVEASRGEVVLTSRPRVIALPPFCVPRSL
                     TPDTLLPTQQAEVLHPVVPLPTDLP"
     exon            231..434
                     /gene="CFAP65"
                     /gene_synonym="CCDC108; SPGF40"
                     /inference="alignment:Splign:2.1.0"
     exon            435..619
                     /gene="CFAP65"
                     /gene_synonym="CCDC108; SPGF40"
                     /inference="alignment:Splign:2.1.0"
     exon            620..722
                     /gene="CFAP65"
                     /gene_synonym="CCDC108; SPGF40"
                     /inference="alignment:Splign:2.1.0"
     exon            723..892
                     /gene="CFAP65"
                     /gene_synonym="CCDC108; SPGF40"
                     /inference="alignment:Splign:2.1.0"
     exon            893..1092
                     /gene="CFAP65"
                     /gene_synonym="CCDC108; SPGF40"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1238
                     /gene="CFAP65"
                     /gene_synonym="CCDC108; SPGF40"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1461
                     /gene="CFAP65"
                     /gene_synonym="CCDC108; SPGF40"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1727
                     /gene="CFAP65"
                     /gene_synonym="CCDC108; SPGF40"
                     /inference="alignment:Splign:2.1.0"
     exon            1728..1928
                     /gene="CFAP65"
                     /gene_synonym="CCDC108; SPGF40"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..2288
                     /gene="CFAP65"
                     /gene_synonym="CCDC108; SPGF40"
                     /inference="alignment:Splign:2.1.0"
     exon            2289..2426
                     /gene="CFAP65"
                     /gene_synonym="CCDC108; SPGF40"
                     /inference="alignment:Splign:2.1.0"
     exon            2427..2672
                     /gene="CFAP65"
                     /gene_synonym="CCDC108; SPGF40"
                     /inference="alignment:Splign:2.1.0"
     exon            2673..2897
                     /gene="CFAP65"
                     /gene_synonym="CCDC108; SPGF40"
                     /inference="alignment:Splign:2.1.0"
     exon            2898..3056
                     /gene="CFAP65"
                     /gene_synonym="CCDC108; SPGF40"
                     /inference="alignment:Splign:2.1.0"
     exon            3057..3207
                     /gene="CFAP65"
                     /gene_synonym="CCDC108; SPGF40"
                     /inference="alignment:Splign:2.1.0"
     exon            3208..3336
                     /gene="CFAP65"
                     /gene_synonym="CCDC108; SPGF40"
                     /inference="alignment:Splign:2.1.0"
     exon            3337..3550
                     /gene="CFAP65"
                     /gene_synonym="CCDC108; SPGF40"
                     /inference="alignment:Splign:2.1.0"
     exon            3551..3679
                     /gene="CFAP65"
                     /gene_synonym="CCDC108; SPGF40"
                     /inference="alignment:Splign:2.1.0"
     exon            3680..3856
                     /gene="CFAP65"
                     /gene_synonym="CCDC108; SPGF40"
                     /inference="alignment:Splign:2.1.0"
     exon            3857..3923
                     /gene="CFAP65"
                     /gene_synonym="CCDC108; SPGF40"
                     /inference="alignment:Splign:2.1.0"
     exon            3924..4034
                     /gene="CFAP65"
                     /gene_synonym="CCDC108; SPGF40"
                     /inference="alignment:Splign:2.1.0"
     exon            4035..4226
                     /gene="CFAP65"
                     /gene_synonym="CCDC108; SPGF40"
                     /inference="alignment:Splign:2.1.0"
     exon            4227..4385
                     /gene="CFAP65"
                     /gene_synonym="CCDC108; SPGF40"
                     /inference="alignment:Splign:2.1.0"
     exon            4386..4529
                     /gene="CFAP65"
                     /gene_synonym="CCDC108; SPGF40"
                     /inference="alignment:Splign:2.1.0"
     exon            4530..4643
                     /gene="CFAP65"
                     /gene_synonym="CCDC108; SPGF40"
                     /inference="alignment:Splign:2.1.0"
     exon            4644..4751
                     /gene="CFAP65"
                     /gene_synonym="CCDC108; SPGF40"
                     /inference="alignment:Splign:2.1.0"
     exon            4752..4796
                     /gene="CFAP65"
                     /gene_synonym="CCDC108; SPGF40"
                     /inference="alignment:Splign:2.1.0"
     exon            4797..4999
                     /gene="CFAP65"
                     /gene_synonym="CCDC108; SPGF40"
                     /inference="alignment:Splign:2.1.0"
     exon            5000..5128
                     /gene="CFAP65"
                     /gene_synonym="CCDC108; SPGF40"
                     /inference="alignment:Splign:2.1.0"
     exon            5129..5632
                     /gene="CFAP65"
                     /gene_synonym="CCDC108; SPGF40"
                     /inference="alignment:Splign:2.1.0"
     exon            5633..5770
                     /gene="CFAP65"
                     /gene_synonym="CCDC108; SPGF40"
                     /inference="alignment:Splign:2.1.0"
     exon            5771..5946
                     /gene="CFAP65"
                     /gene_synonym="CCDC108; SPGF40"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5919..5924
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CFAP65"
                     /gene_synonym="CCDC108; SPGF40"
                     /note="hexamer: AGTAAA"
     polyA_site      5946
                     /gene="CFAP65"
                     /gene_synonym="CCDC108; SPGF40"
                     /note="major polyA site"
ORIGIN      
        1 atctatggag acggcaatat ggaggcgatc ttacatttct ttgatttcat ctgaacgtcc
       61 agttcacaat tggagtgatg tttaccttaa ccggttgtag actggtggag aaaacccaga
      121 aggtggagaa tccatcagtc tcatttgcct cttctttccc ccttattcct cttctcctaa
      181 gaggcaagag tgttcagaag aaacaagcag agagtaaaag ccagataaag ctccatactc
      241 agagtgctcc ctttggactg tgtcccaagg acatgatgct cacccaggct ccaagctccg
      301 tcgtgaggtc caggaacagc aggaaccaca ccgtgaactc tggtggatcc tgcctgagtg
      361 ccagcacagt ggccatccct gccatcaacg acagcagtgc agccatgagt gcctgcagca
      421 ccatcagcgc ccagcccgca agctccatgg acactcagat gcactcccca aagaagcagg
      481 agagagtgaa caagagggtc atctggggca ttgaggtggc tgaggagctg cattggaaag
      541 gctgggagct aggaaaggag accacaagga atctggttct gaaaaatcga tccttgaaac
      601 tccagaagat gaagtacagg ccccccaaga ccaagttctt cttcacggtc atccctcagc
      661 ccatcttcct gagcccaggc ataaccctca cgctccccat cgtcttccgg cctctggagg
      721 cgaaggagta catggaccag ctgtggtttg agaaagcgga ggggatgttc tgtgtcggcc
      781 tacgggccac cctgccctgc cacaggctga tctgccgccc accatccctg cagctgccca
      841 tgtgtgctgt gggagatacg actgaggcct ttttctgcct ggataatgtg ggggacctgc
      901 ccaccttctt cacctgggag ttctccagcc cattccagat gctgcccgcc acggggctcc
      961 tggagccagg ccaggcctct cagatcaagg tgacctttca gccccttaca gccgtcatct
     1021 acgaggtgca ggccacgtgc tggtacgggg cgggcagccg gcagaggagc agcatccagc
     1081 tgcaggctgt ggccaagtgc gcccagctgc tggtgagcat aaagcacaag tgcccggagg
     1141 accaggatgc cgagggcttc cagaagctgt tgtactttgg ctctgttgct gtgggctgca
     1201 cctcggagag gcagatcagg ctacacaacc cgtcggcggt aaatgccccc ttcaggattg
     1261 aaatttcccc ggatgaactg gccgaagacc aggccttctc atgccccacg gcccatggca
     1321 tcgtgcttcc gggagagaag aaatgtgtgt cggtgttctt ccaccccaag actctggaca
     1381 ccagaactgt ggactactgc tccatcatgc cttctggctg tgcctccaag accctgctta
     1441 aagtcgttgg tttctgtaga ggccctgctg tgtccctgca gcactactgt gtcaacttca
     1501 gctgggtcaa ccttggggag cgctccgagc agcccctgtg gattgagaac caatcggact
     1561 gcacggccca cttccagttt gccatcgact gcttggagag tgtctttacc atcaggcctg
     1621 cctttgggac gctggtgggc aaggcccgta tgaccctgca ctgtgccttc cagcccactc
     1681 accccatcat ctgctttcgg cgtgtggcct gtctcatcca ccaccaggac ccactgttcc
     1741 tggacctgat ggggacctgc cactcggaca gcaccaagcc agccatcctg aagcctcagc
     1801 acctcacctg gtaccgcaca cacctggccc ggggcctgac gctctacccc cctgacatcc
     1861 tggatgccat gctgaaggag aagaagctgg cacaggacca gaacggggct ctcatgattc
     1921 ccatccagga tctggaggac atgccggccc cgcagtaccc ttatatcccc cccatgaccg
     1981 agttcttctt cgacggcacc agcgacataa ccatcttccc cccgcccatc agtgtagagc
     2041 ctgtcgaggt agacttcggt gcctgcccag ggcctgaggc ccccaaccct gtacccctgt
     2101 gcctgatgaa ccacaccaag ggcaagatca tggtggtctg gacgcgaagg tctgactgcc
     2161 ccttctgggt gactccagag agctgcgacg tgcccccact caagtccatg gccatgcgcc
     2221 tgcacttcca gccgcctcac cccaactgcc tttacacggt ggagctcgaa gccttcgcca
     2281 tctataaggt cctgcagagc tacagtaata ttgaggagga ctgcaccatg tgcccatcct
     2341 ggtgcctgac ggtgcgggca cgaggccaca gctatttcgc tggctttgag caccacatcc
     2401 cccagtattc cctagatgtc cccaagctat ttccagcagt gtcctccggt gagcccacct
     2461 accgcagcct gctcctggtc aacaaagact gcaagctgct gaccttcagc ctggcccccc
     2521 agagaggctc agacgtcatc cttcggccca cttcgggcct tgtggcaccc ggggcccacc
     2581 agatcatcct catctgcacc taccctgagg gcagctcctg gaagcagcac actttctatc
     2641 tgcagtgcaa tgcttccccc cagtatctca aggaggtgag catgtacagc cgggaggagc
     2701 cactgcagct gaagctggac acccacaaaa gcctctactt caagcccacc tgggtgggct
     2761 gctcctccac cagccccttc accttccgca acccctcgcg tctgcccctg cagttcgagt
     2821 ggagggtctc tgagcagcat cgaaagctgc tggctgtcca gccctccagg gggctaatcc
     2881 agcccaacga gagacttacg ctgacgtgga ccttcagccc tttggaggag accaagtacc
     2941 tgttccaagt ggggatgtgg gtctgggaag ccggcctgtc cccaaatgcc aaccccgctg
     3001 ccaccaccca ctacatgctc cggctggtgg gcgttgggct caccagcagc ctctctgcaa
     3061 aggaaaagga gctggccttt gggaatgtgc tggtgaacag caagcagtcc aggttccttg
     3121 tcctcctgaa tgacggcaac tgcaccctct attaccgcct ctacctggag cagggcagcc
     3181 ctgaggccgt tgacaaccac cccctcgctc tgcagctgga ccgaacagag gggagcatgc
     3241 caccccggtc ccaggacacc atctgcctga ctgcctgtcc caagcagcgg tcccagtact
     3301 cctggaccat cacctactct ctcctttccc acagagataa caaggctggg gagaagcagg
     3361 agctgtgctg cgtctccctg gtggccgtgt accccttgct ttccatcctg gatgtcagct
     3421 ccatgggcag tgctgagggt atcacccgga agcacctgtg gcgcctcttc tctctggacc
     3481 tgcttaacag ttacttggag cgtgacccca ccccctgtga gctcacctac aaggtgccca
     3541 cccggcacag catgagccag atcccccccg tcctcacccc tttaaggctt gacttcaatt
     3601 tcggggccgc accattcaag gccccacctt ccgtggtatt cctggccctg aagaacagcg
     3661 gagtggtgtc cctggactgg gccttcctcc ttccaagtga ccagcggatt gacgtggagc
     3721 tctgggcaga gcaagcagag ttgaattcca ctgagctcca ccagatgcgc gtgcaggaca
     3781 attgcctctt ctccatcagc cccaaggctg ggagcctgag tcctgggcag gagcagatgg
     3841 tggagttaaa atacagccac ctgttcatcg gtactgatca cctcccagtg ctcttcaagg
     3901 tgtcccatgg ccgggagatc ctgctaaatt tcataggtgt gacagtgaag ccggagcaga
     3961 agtatgtgca cttcacctct actacccacc agttcatccc cattcccatt ggtgacacgc
     4021 tacccccacg gcagatttat gagctgtata atggtggctc agtgcccgtg acatatgagg
     4081 tccagaccga tgtcctgtca caggttcagg aaaaaaattt tgatcacccc atcttttgct
     4141 gcctcaaccc caaaggggag atccagccag gcagcactgc ccgggtcttg tggatcttct
     4201 cacctatcga ggccaagacc tacacggtgg acgtgcccat acacatcctg ggatggaact
     4261 cggccctcat ccacttccag ggagtgggct acaaccccca tatgatgggg gacacagccc
     4321 cattccacaa catctcctcg tgggacaaca gttccataca ctctaggctg gtggtgcctg
     4381 gacagaatgt cttcctgtcc cagtctcata tttccctggg aaacatacct gtgcagagca
     4441 agtgcagccg cctgctcttc ctcaacaaca tctccaagaa cgaggaaatt gccttctcct
     4501 ggcagccaag tcctctagat tttggggagg tgtctgtgag tcccatgata ggggtggtgg
     4561 ctcctgaaga gacggtccca tttgtggtga ccttgagggc ctctgtgcat gccagcttct
     4621 acagtgcaga cctggtatgc aagctgtact cgcagcagct catgaggcag tatcacaagg
     4681 agctgcagga gtggaaggac gagaaggtgc ggcaggaagt ggagttcacc atcaccgaca
     4741 tgaaagtgaa gaagagaaca tgctgcacag cctgtgaacc tgcgaggaag tacaagacac
     4801 tgcctcccat caagaaccag cagtctgtca gccggcctgc cagctggaaa ctgcagaccc
     4861 caaaggagga ggtgtcctgg ccctgccccc agccaccctc gccaggcatg ctctgcctgg
     4921 gccttactgc ccgagcccat gccaccgact actttctggc taacttcttc tcagagtttc
     4981 cctgccactt tttgcaccgg gagctgccaa agaggaaggc ccccagggaa gagtcagaga
     5041 cttctgagga aaaatcccct aacaagtggg gccctgtttc caagcagaag aagcagctcc
     5101 tggttgacat tctcaccaca ataatcaggg gcctgctgga agacaagaac ttccatgagg
     5161 ctgtggacca aagcctggtg gagcaggtgc cgtacttccg ccaattctgg aatgagcagt
     5221 caactaagtt catggaccag aaaaacagcc tgtacttaat gccaatcctg cctgtaccct
     5281 ccagcagctg ggaggatggg aagggcaagc agccgaagga agacagacca gagcactatc
     5341 cagggttggg aaagaaggaa gagggggagg aggagaaggg tgaagaggaa gaagaagagt
     5401 tggaggagga agaggaggaa gaagaggaga cagaagagga ggagttgggc aaggaggaga
     5461 tagaggagaa ggaggaggag agggatgaga aggaagagaa agtgagctgg gcgggcatcg
     5521 ggcccacacc acagcctgag tcccaggagt ccatgcaatg gcagtggcaa cagcagctga
     5581 atgtcatggt gaaggaggag caagaacagg acgagaagga ggccatcaga aggctcccgg
     5641 ccttcgccaa cctgcaggag gcgctgctgg agaacatgat ccagaacatc ctggtggagg
     5701 cgagccgcgg ggaggtggta ctcacctcgc ggccacgcgt catcgccctg ccgccgttct
     5761 gcgtgcccag gagtctgacc ccggacacgc tgctgccgac gcagcaagca gaggtactcc
     5821 acccggtggt gccacttcct accgaccttc cgtaaatgcc cgcgcccagc ctctccgaca
     5881 tgccgctagg ggtcacgcct ggccccctct ccaccgccag taaaagcatc tagtcttttt
     5941 tctgta
//
