LOCUS       NM_015585               4098 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens cilia and flagella associated protein 61 (CFAP61),
            transcript variant 1, mRNA.
ACCESSION   NM_015585
VERSION     NM_015585.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4098)
  AUTHORS   Barbotin,A.L., Boursier,A., Jourdain,A.S., Moerman,A., Rabat,B.,
            Chehimi,M., Thuillier,C., Ghoumid,J. and Smol,T.
  TITLE     Identification of a novel CFAP61 homozygous splicing variant
            associated with multiple morphological abnormalities of the
            flagella
  JOURNAL   J Assist Reprod Genet 41 (6), 1499-1505 (2024)
   PUBMED   38775994
  REMARK    GeneRIF: Identification of a novel CFAP61 homozygous splicing
            variant associated with multiple morphological abnormalities of the
            flagella.
REFERENCE   2  (bases 1 to 4098)
  AUTHORS   Zhu,W., Mao,J., Qin,J. and Chen,X.
  TITLE     CFAP61 knockdown aggravates male infertility by inhibiting
            testosterone secretion by Leydig cells via the MAPK/COX-2 pathway
  JOURNAL   Funct Integr Genomics 23 (4), 340 (2023)
   PUBMED   37982895
  REMARK    GeneRIF: CFAP61 knockdown aggravates male infertility by inhibiting
            testosterone secretion by Leydig cells via the MAPK/COX-2 pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4098)
  AUTHORS   Hu,T., Meng,L., Tan,C., Luo,C., He,W.B., Tu,C., Zhang,H., Du,J.,
            Nie,H., Lu,G.X., Lin,G. and Tan,Y.Q.
  TITLE     Biallelic CFAP61 variants cause male infertility in humans and mice
            with severe oligoasthenoteratozoospermia
  JOURNAL   J Med Genet 60 (2), 144-153 (2023)
   PUBMED   35387802
  REMARK    GeneRIF: Biallelic CFAP61 variants cause male infertility in humans
            and mice with severe oligoasthenoteratozoospermia.
REFERENCE   4  (bases 1 to 4098)
  AUTHORS   Ma,A., Zeb,A., Ali,I., Zhao,D., Khan,A., Zhang,B., Zhou,J.,
            Khan,R., Zhang,H., Zhang,Y., Khan,I., Shah,W., Ali,H., Javed,A.R.,
            Ma,H. and Shi,Q.
  TITLE     Biallelic Variants in CFAP61 Cause Multiple Morphological
            Abnormalities of the Flagella and Male Infertility
  JOURNAL   Front Cell Dev Biol 9, 803818 (2022)
   PUBMED   35174165
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4098)
  AUTHORS   Liu,S., Zhang,J., Kherraf,Z.E., Sun,S., Zhang,X., Cazin,C.,
            Coutton,C., Zouari,R., Zhao,S., Hu,F., Fourati Ben Mustapha,S.,
            Arnoult,C., Ray,P.F. and Liu,M.
  TITLE     CFAP61 is required for sperm flagellum formation and male fertility
            in human and mouse
  JOURNAL   Development 148 (23) (2021)
   PUBMED   34792097
  REMARK    GeneRIF: CFAP61 is required for sperm flagellum formation and male
            fertility in human and mouse.
REFERENCE   6  (bases 1 to 4098)
  AUTHORS   Trynka,G., Zhernakova,A., Romanos,J., Franke,L., Hunt,K.A.,
            Turner,G., Bruinenberg,M., Heap,G.A., Platteel,M., Ryan,A.W., de
            Kovel,C., Holmes,G.K., Howdle,P.D., Walters,J.R., Sanders,D.S.,
            Mulder,C.J., Mearin,M.L., Verbeek,W.H., Trimble,V., Stevens,F.M.,
            Kelleher,D., Barisani,D., Bardella,M.T., McManus,R., van Heel,D.A.
            and Wijmenga,C.
  TITLE     Coeliac disease-associated risk variants in TNFAIP3 and REL
            implicate altered NF-kappaB signalling
  JOURNAL   Gut 58 (8), 1078-1083 (2009)
   PUBMED   19240061
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 4098)
  AUTHORS   Dymek,E.E. and Smith,E.F.
  TITLE     A conserved CaM- and radial spoke associated complex mediates
            regulation of flagellar dynein activity
  JOURNAL   J Cell Biol 179 (3), 515-526 (2007)
   PUBMED   17967944
REFERENCE   8  (bases 1 to 4098)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK307817.1, BC028708.2, AL035454.18, AL049648.9 and AL161658.21.
            
            On Nov 23, 2018 this sequence version replaced NM_015585.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC028708.2 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000245957.10/ ENSP00000245957.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                AK307817.1         19-42
            25-316              BC028708.2         5-296
            317-317             AL035454.18        52256-52256
            318-1200            BC028708.2         298-1180
            1201-1201           AL049648.9         33785-33785
            1202-3935           BC028708.2         1182-3915
            3936-4098           AL161658.21        27093-27255
FEATURES             Location/Qualifiers
     source          1..4098
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p11.23"
     gene            1..4098
                     /gene="CFAP61"
                     /gene_synonym="C20orf26; CaM-IP3; dJ1002M8.3; dJ1178H5.4;
                     SPGF84"
                     /note="cilia and flagella associated protein 61"
                     /db_xref="GeneID:26074"
                     /db_xref="HGNC:HGNC:15872"
                     /db_xref="MIM:620381"
     exon            1..60
                     /gene="CFAP61"
                     /gene_synonym="C20orf26; CaM-IP3; dJ1002M8.3; dJ1178H5.4;
                     SPGF84"
                     /inference="alignment:Splign:2.1.0"
     exon            61..239
                     /gene="CFAP61"
                     /gene_synonym="C20orf26; CaM-IP3; dJ1002M8.3; dJ1178H5.4;
                     SPGF84"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..3810
                     /gene="CFAP61"
                     /gene_synonym="C20orf26; CaM-IP3; dJ1002M8.3; dJ1178H5.4;
                     SPGF84"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="cilia- and flagella-associated protein 61
                     isoform 1"
                     /protein_id="NP_056400.3"
                     /db_xref="CCDS:CCDS33447.1"
                     /db_xref="GeneID:26074"
                     /db_xref="HGNC:HGNC:15872"
                     /db_xref="MIM:620381"
                     /translation="MSVLTSPRGKVEVVHCRRTESQDVYCIKSLIRKFTCKLFGKLNI
                     IYLLEKANLAVTLCNDKEEIMAQATFLDYPNWNVAKQDDWVSVFRELDSDIPCTPLNT
                     LFMHLFVAVDEYSVGCCKEILRTVYKAVPELHFIFLIVPSYMSLGSTLITVFDQVGNI
                     PCLTYEEDFAVHICHRHSHYPQLHVRKARVEDHDDLMPIFMRYDTILKETYGEYFLAE
                     LIEAQDEENHAVVCEVEGTAVGFMSVCSRVNMQLLHECFDLGPFHGLCFPHPDDVLES
                     PQDLSVRRSQDAELRSSSQGSQKIVEELQEPVSPDTMENIQGNIAREAASEEALTAVQ
                     SGNVSEPEDIEKLSDISTGYAQYHHVSSRSLASLVLPEEPVHFRPIYRGASAAFCIQL
                     FCIDEKYEARSLDFMNFVFSLFSDKNFCVISLPHLTPEFFLIQNFVKMVPFNTCTLEQ
                     DLYVFHRAGLLKSINIRFATLLDTPGVENLVSTLMLNKSILEDLDRYNKARKDPDGTL
                     LQAFVAEVAEQIVGIAVIRNEMDIEYIRSHYNIEDFIYFSHHQREEHGHMHHFALNPI
                     FRHYTKFFLKEILRLGFKSCLYYRVYPKSREGKFQNPYAHSLTSALHYLVPVRPRRQI
                     VYPLEKLGINAPSKAVSKDPMSYALNHTNRKLTLEPKITVNAKIIVVGASSVGISFLE
                     TLVFCSHMKFNNLTLISTHGLPGKKLLDTEQRKFLASDHCFNDKDYALMSLCSWVNVV
                     VGRMTGIDRAAKHVVLSTDEIVPYDHLILCTGQQYQVPCPTEADISQHLTNREVPNSS
                     QRRYTGKVPCNHFTLNEEEDCFKALIWIRNNSITTEGNIIVYGNTIDTYTTVETLLNL
                     GVSGSRIHLVQPPPASTITCINNYSVESAVADALGAAGVTMYRDAILAQWNDGLHPDP
                     IYSASFTTPTKPFRLQCSMFFSFCEKNVDYETFKALNDACLVYDSRLVIDTNFHTNDI
                     AIRAAGSLTKFSNRYYSNEWTHSNFSSKEIGFQLAAAMLHLFDPTLEPVTEPPANLDR
                     LIPMYKGAKIQGGILPGSYHYLHIAKPAIPTPLEVQMAQPNYGLELVTGSAKNGTYFR
                     IHINKYKMVETITCLSREPFPASNYIRLFGQHEQLLNNLCARYDENLITDLYSYFTEP
                     WCLALFHDRFIDLRKELRQILASKEEEDLPSIEQLAHQIEDEEINPTEKPRQYLKRVF
                     EESIYKTLVERSTLDYLHYNRYHLPMYAWPGIV"
     exon            240..390
                     /gene="CFAP61"
                     /gene_synonym="C20orf26; CaM-IP3; dJ1002M8.3; dJ1178H5.4;
                     SPGF84"
                     /inference="alignment:Splign:2.1.0"
     exon            391..467
                     /gene="CFAP61"
                     /gene_synonym="C20orf26; CaM-IP3; dJ1002M8.3; dJ1178H5.4;
                     SPGF84"
                     /inference="alignment:Splign:2.1.0"
     exon            468..535
                     /gene="CFAP61"
                     /gene_synonym="C20orf26; CaM-IP3; dJ1002M8.3; dJ1178H5.4;
                     SPGF84"
                     /inference="alignment:Splign:2.1.0"
     exon            536..662
                     /gene="CFAP61"
                     /gene_synonym="C20orf26; CaM-IP3; dJ1002M8.3; dJ1178H5.4;
                     SPGF84"
                     /inference="alignment:Splign:2.1.0"
     exon            663..795
                     /gene="CFAP61"
                     /gene_synonym="C20orf26; CaM-IP3; dJ1002M8.3; dJ1178H5.4;
                     SPGF84"
                     /inference="alignment:Splign:2.1.0"
     exon            796..955
                     /gene="CFAP61"
                     /gene_synonym="C20orf26; CaM-IP3; dJ1002M8.3; dJ1178H5.4;
                     SPGF84"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1047
                     /gene="CFAP61"
                     /gene_synonym="C20orf26; CaM-IP3; dJ1002M8.3; dJ1178H5.4;
                     SPGF84"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1122
                     /gene="CFAP61"
                     /gene_synonym="C20orf26; CaM-IP3; dJ1002M8.3; dJ1178H5.4;
                     SPGF84"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1301
                     /gene="CFAP61"
                     /gene_synonym="C20orf26; CaM-IP3; dJ1002M8.3; dJ1178H5.4;
                     SPGF84"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..1341
                     /gene="CFAP61"
                     /gene_synonym="C20orf26; CaM-IP3; dJ1002M8.3; dJ1178H5.4;
                     SPGF84"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1481
                     /gene="CFAP61"
                     /gene_synonym="C20orf26; CaM-IP3; dJ1002M8.3; dJ1178H5.4;
                     SPGF84"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1608
                     /gene="CFAP61"
                     /gene_synonym="C20orf26; CaM-IP3; dJ1002M8.3; dJ1178H5.4;
                     SPGF84"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..1686
                     /gene="CFAP61"
                     /gene_synonym="C20orf26; CaM-IP3; dJ1002M8.3; dJ1178H5.4;
                     SPGF84"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1893
                     /gene="CFAP61"
                     /gene_synonym="C20orf26; CaM-IP3; dJ1002M8.3; dJ1178H5.4;
                     SPGF84"
                     /inference="alignment:Splign:2.1.0"
     exon            1894..2028
                     /gene="CFAP61"
                     /gene_synonym="C20orf26; CaM-IP3; dJ1002M8.3; dJ1178H5.4;
                     SPGF84"
                     /inference="alignment:Splign:2.1.0"
     exon            2029..2156
                     /gene="CFAP61"
                     /gene_synonym="C20orf26; CaM-IP3; dJ1002M8.3; dJ1178H5.4;
                     SPGF84"
                     /inference="alignment:Splign:2.1.0"
     exon            2157..2255
                     /gene="CFAP61"
                     /gene_synonym="C20orf26; CaM-IP3; dJ1002M8.3; dJ1178H5.4;
                     SPGF84"
                     /inference="alignment:Splign:2.1.0"
     exon            2256..2424
                     /gene="CFAP61"
                     /gene_synonym="C20orf26; CaM-IP3; dJ1002M8.3; dJ1178H5.4;
                     SPGF84"
                     /inference="alignment:Splign:2.1.0"
     exon            2425..2599
                     /gene="CFAP61"
                     /gene_synonym="C20orf26; CaM-IP3; dJ1002M8.3; dJ1178H5.4;
                     SPGF84"
                     /inference="alignment:Splign:2.1.0"
     exon            2600..2892
                     /gene="CFAP61"
                     /gene_synonym="C20orf26; CaM-IP3; dJ1002M8.3; dJ1178H5.4;
                     SPGF84"
                     /inference="alignment:Splign:2.1.0"
     exon            2893..3220
                     /gene="CFAP61"
                     /gene_synonym="C20orf26; CaM-IP3; dJ1002M8.3; dJ1178H5.4;
                     SPGF84"
                     /inference="alignment:Splign:2.1.0"
     exon            3221..3312
                     /gene="CFAP61"
                     /gene_synonym="C20orf26; CaM-IP3; dJ1002M8.3; dJ1178H5.4;
                     SPGF84"
                     /inference="alignment:Splign:2.1.0"
     exon            3313..3518
                     /gene="CFAP61"
                     /gene_synonym="C20orf26; CaM-IP3; dJ1002M8.3; dJ1178H5.4;
                     SPGF84"
                     /inference="alignment:Splign:2.1.0"
     exon            3519..3609
                     /gene="CFAP61"
                     /gene_synonym="C20orf26; CaM-IP3; dJ1002M8.3; dJ1178H5.4;
                     SPGF84"
                     /inference="alignment:Splign:2.1.0"
     exon            3610..4098
                     /gene="CFAP61"
                     /gene_synonym="C20orf26; CaM-IP3; dJ1002M8.3; dJ1178H5.4;
                     SPGF84"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4072..4077
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CFAP61"
                     /gene_synonym="C20orf26; CaM-IP3; dJ1002M8.3; dJ1178H5.4;
                     SPGF84"
                     /note="hexamer: AATAAA"
     polyA_site      4098
                     /gene="CFAP61"
                     /gene_synonym="C20orf26; CaM-IP3; dJ1002M8.3; dJ1178H5.4;
                     SPGF84"
                     /note="major polyA site"
ORIGIN      
        1 aggctgcgcg tcctccttgc ggcagcgcgt ggagtgcggc gtcctggagc tgcggatgag
       61 tggacttttt tctctctttt ggggacagga taaaaaatgt cagtactcac ttctccaaga
      121 ggaaaggtag aagttgttca ttgccgaaga acagaatcac aggatgttta ttgtatcaaa
      181 agccttatta gaaaatttac ctgcaagctg tttgggaagc taaatatcat ctatcttcta
      241 gaaaaggcca accttgctgt taccctctgc aatgacaagg aggagatcat ggcccaggcc
      301 accttcctgg actaccccaa ctggaatgtt gccaagcagg atgactgggt gtcagtgttc
      361 cgggagctcg acagtgacat cccatgcaca cccctgaata cgttgttcat gcacctcttt
      421 gtggccgtgg atgagtattc tgttggctgt tgcaaagaga ttcttcgaac cgtgtataag
      481 gcagtgccag agctgcactt catatttctc atcgtgccat cctacatgag cctaggctca
      541 actctcataa ctgtttttga ccaagtgggg aacatcccgt gtctgacgta tgaggaagac
      601 tttgcagtgc atatatgtca caggcacagc cactatcctc agctgcacgt tcgcaaagcc
      661 agggtggaag accatgacga tctcatgcca atatttatgc gctatgacac aattctgaag
      721 gaaacttacg gtgaatactt cctggccgaa ctaatagagg cccaagatga agagaatcat
      781 gctgttgtgt gtgaggtgga aggcacagct gttgggttca tgagtgtgtg ctcaagagtg
      841 aacatgcaac tgctgcatga gtgctttgac ttgggccctt tccacggact ctgtttccca
      901 catcctgatg acgttctgga atcaccacaa gacctaagtg tccgaagaag tcaagatgct
      961 gagctcagga gtagcagcca aggttcccaa aaaatagtcg aggagttgca ggaacctgtc
     1021 tctccagata ccatggaaaa catccaggga aatattgcca gagaagctgc atccgaggaa
     1081 gctttaacag cagtccaaag tggaaatgtt agtgaaccgg aggacataga aaaactcagt
     1141 gacatctcca ctggatatgc acagtatcac catgtcagca gtaggagctt ggcatcgctc
     1201 gtactgcctg aagagcccgt ccacttccgc cccatctaca ggggagcctc agctgctttt
     1261 tgtattcagc tgttttgtat tgatgagaaa tatgaagcaa ggtcgctgga ttttatgaat
     1321 tttgttttca gtcttttttc tgataagaac ttctgtgtaa tttctctgcc ccatctcacc
     1381 cccgagttct tcctcatcca gaacttcgtg aaaatggtcc ctttcaacac ctgcaccctc
     1441 gagcaggacc tctacgtctt ccaccgggct ggattgctca agtccattaa tataagattt
     1501 gccactctct tggatactcc tggtgtggaa aatcttgtca gcaccctcat gttgaataaa
     1561 agcatattgg aggacttaga ccgttacaac aaggctcgca aagaccctga tggaacactg
     1621 ctgcaggcat ttgtagctga agttgcagaa caaatagttg gtattgcagt gatcagaaat
     1681 gaaatggaca ttgagtacat acggtcccat tacaacattg aagatttcat ctacttcagt
     1741 caccaccagc gcgaagaaca cgggcacatg catcactttg ccctcaaccc cattttccgg
     1801 cactacacca agttctttct gaaggagatc ctgcgtttag gctttaaatc ctgtctctac
     1861 taccgtgttt acccaaaatc cagagaaggc aagttccaga acccctacgc ccactccctg
     1921 acatctgccc ttcattactt ggttcccgtg cgaccacgac gacagattgt ctatcctctg
     1981 gaaaagcttg gcataaacgc tccatcaaag gcggtctcca aggatccgat gagttatgct
     2041 ttaaaccata caaacagaaa actaacattg gaacctaaaa ttactgtcaa tgccaagatc
     2101 attgtggttg gtgcatccag tgttggaatt tccttcctag agacattggt attttgctct
     2161 cacatgaagt ttaataatct taccctgatt tcaactcatg gactcccagg aaaaaaactt
     2221 ctggacactg aacaaaggaa atttttagcc agcgaccact gttttaatga taaagattat
     2281 gcactgatgt cactgtgctc ctgggttaat gtcgtggtgg gtagaatgac cggcatagac
     2341 cgagcagcca agcacgttgt gctttccacg gacgagatcg tgccctacga ccacctcatc
     2401 ctctgcaccg ggcagcagta ccaggtccca tgccctacag aggctgatat tagtcaacac
     2461 ctgacaaaca gggaggttcc caacagcagt cagcggcggt acacggggaa agttccttgc
     2521 aaccatttca ctctcaacga ggaagaggat tgctttaagg cactgatttg gataaggaat
     2581 aactccatca ccacagaagg gaatatcatt gtctatggga atacaattga tacttacacc
     2641 accgtggaga cgctcttaaa ccttggcgtg agcggcagcc gcatccacct cgtgcagccc
     2701 ccgcccgcct ccaccatcac ctgcatcaac aactactcgg tggagagcgc cgtggcggac
     2761 gcgctaggag ccgccggagt cactatgtac cgggatgcga tcctggccca gtggaatgac
     2821 ggcctgcacc cagaccccat ctacagcgcc tccttcacca cacccaccaa gcctttcaga
     2881 ctccagtgct ctatgttctt cagcttctgt gagaagaatg tggattatga aacgtttaaa
     2941 gccctcaatg atgcatgtct tgtgtatgac agtcgacttg tgattgatac caacttccac
     3001 accaacgaca tagccatcag agctgctggc tccctcacca aattctccaa tagatactac
     3061 tcaaatgagt ggactcacag caacttcagt tccaaagaaa ttggctttca gctggcagca
     3121 gctatgctac atctctttga tccaaccctt gagcctgtga ccgagccacc agctaatctt
     3181 gaccggctca tccccatgta caagggagcc aagattcaag ggggcattct tcctgggtct
     3241 taccattatc tgcatattgc caagcctgcc attccaactc ccttggaggt acaaatggca
     3301 cagcctaatt atggtttaga actagtaacc ggcagtgcga aaaatgggac ttacttccga
     3361 attcatatta acaagtataa aatggtggaa accatcacgt gcctttctag ggagcccttc
     3421 cccgcctcca actacatccg cttgtttggc cagcacgagc aactcctcaa caacctgtgt
     3481 gctcggtacg atgaaaacct gatcacagat ctctatagct acttcaccga gccgtggtgc
     3541 ctggccctgt tccacgatcg ttttattgat ctcaggaaag agttacgcca aatcttagcc
     3601 tccaaggagg aggaagatct tccttccata gagcagttag cccatcaaat agaagatgag
     3661 gaaatcaacc cgactgagaa gcccaggcaa tacctcaaaa gagtttttga ggaatccatc
     3721 tacaaaaccc tggtggagag aagcactctt gactacctgc actataaccg ctaccacctg
     3781 cccatgtacg cgtggccagg catcgtttag ttgtaggcag ggtctcccct ttatggtttt
     3841 catttattta gttcctggaa acgcgctctg tagaaataga aaagttctct gcagcctggt
     3901 ttgacagcga agccagcccc tggtggtttt gttcattcct ttccttccct gacttatgcc
     3961 tgtagttttc tatcatccca gtaggtggca cacggccgtg tgcctctctt ctggggcagg
     4021 ctcgctttac aaatcccagg catgttcctg tgcagaataa tccatttcag caataaaatg
     4081 agatcatagt gtgtaaaa
//
