LOCUS       NM_145054               2166 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens cilia and flagella associated protein 52 (CFAP52),
            transcript variant 2, mRNA.
ACCESSION   NM_145054 NM_001037306
VERSION     NM_145054.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2166)
  AUTHORS   Wu,B., Li,R., Ma,S., Ma,Y., Fan,L., Gong,C., Liu,C., Sun,L. and
            Yuan,L.
  TITLE     The cilia and flagella associated protein CFAP52 orchestrated with
            CFAP45 is required for sperm motility in mice
  JOURNAL   J Biol Chem 299 (7), 104858 (2023)
   PUBMED   37236356
  REMARK    GeneRIF: The cilia and flagella associated protein CFAP52
            orchestrated with CFAP45 is required for sperm motility in mice.
REFERENCE   2  (bases 1 to 2166)
  AUTHORS   Gui,M., Croft,J.T., Zabeo,D., Acharya,V., Kollman,J.M.,
            Burgoyne,T., Hoog,J.L. and Brown,A.
  TITLE     SPACA9 is a lumenal protein of human ciliary singlet and doublet
            microtubules
  JOURNAL   Proc Natl Acad Sci U S A 119 (41), e2207605119 (2022)
   PUBMED   36191189
REFERENCE   3  (bases 1 to 2166)
  AUTHORS   Dougherty,G.W., Mizuno,K., Nothe-Menchen,T., Ikawa,Y., Boldt,K.,
            Ta-Shma,A., Aprea,I., Minegishi,K., Pang,Y.P., Pennekamp,P.,
            Loges,N.T., Raidt,J., Hjeij,R., Wallmeier,J., Mussaffi,H.,
            Perles,Z., Elpeleg,O., Rabert,F., Shiratori,H., Letteboer,S.J.,
            Horn,N., Young,S., Strunker,T., Stumme,F., Werner,C., Olbrich,H.,
            Takaoka,K., Ide,T., Twan,W.K., Biebach,L., Grosse-Onnebrink,J.,
            Klinkenbusch,J.A., Praveen,K., Bracht,D.C., Hoben,I.M., Junger,K.,
            Gutzlaff,J., Cindric,S., Aviram,M., Kaiser,T., Memari,Y.,
            Dzeja,P.P., Dworniczak,B., Ueffing,M., Roepman,R., Bartscherer,K.,
            Katsanis,N., Davis,E.E., Amirav,I., Hamada,H. and Omran,H.
  TITLE     CFAP45 deficiency causes situs abnormalities and asthenospermia by
            disrupting an axonemal adenine nucleotide homeostasis module
  JOURNAL   Nat Commun 11 (1), 5520 (2020)
   PUBMED   33139725
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2166)
  AUTHORS   Silva,F.P., Hamamoto,R., Nakamura,Y. and Furukawa,Y.
  TITLE     WDRPUH, a novel WD-repeat-containing protein, is highly expressed
            in human hepatocellular carcinoma and involved in cell
            proliferation
  JOURNAL   Neoplasia 7 (4), 348-355 (2005)
   PUBMED   15967112
  REMARK    GeneRIF: WDRPUH is a novel WD-repeat-containing protein highly
            expressed in human hepatocellular carcinoma and involved in cell
            proliferation
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB040461.1 and AB065281.1.
            
            On Nov 22, 2018 this sequence version replaced NM_145054.4.
            
            Summary: WD repeat-containing proteins, such as WDR16, play crucial
            roles in a wide range of physiologic functions, including signal
            transduction, RNA processing, remodeling the cytoskeleton,
            regulation of vesicular traffic, and cell division (Silva et al.,
            2005 [PubMed 15967112]).[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (2) represents the longer
            transcript and encodes the longer isoform (B).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB065281.1, BC025392.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2144333
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000352665.10/ ENSP00000339449.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                DB040461.1         16-39
            25-2166             AB065281.1         5-2146
FEATURES             Location/Qualifiers
     source          1..2166
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..2166
                     /gene="CFAP52"
                     /gene_synonym="HTX10; WDR16; WDRPUH"
                     /note="cilia and flagella associated protein 52"
                     /db_xref="GeneID:146845"
                     /db_xref="HGNC:HGNC:16053"
                     /db_xref="MIM:609804"
     exon            1..124
                     /gene="CFAP52"
                     /gene_synonym="HTX10; WDR16; WDRPUH"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..1917
                     /gene="CFAP52"
                     /gene_synonym="HTX10; WDR16; WDRPUH"
                     /note="isoform b is encoded by transcript variant 2; WD
                     repeat-containing protein 16; WD40-repeat protein
                     upregulated in HCC; WD40-repeat protein up-regulated in
                     HCC; WD repeat domain 16"
                     /codon_start=1
                     /product="cilia- and flagella-associated protein 52
                     isoform b"
                     /protein_id="NP_659491.4"
                     /db_xref="CCDS:CCDS11149.2"
                     /db_xref="GeneID:146845"
                     /db_xref="HGNC:HGNC:16053"
                     /db_xref="MIM:609804"
                     /translation="MDNKISPEAQVAELELDAVIGFNGHVPTGLKCHPDQEHMIYPLG
                     CTVLIQAINTKEQNFLQGHGNNVSCLAISRSGEYIASGQVTFMGFKADIILWDYKNRE
                     LLARLSLHKGKIEALAFSPNDLYLVSLGGPDDGSVVVWSIAKRDAICGSPAAGLNVGN
                     ATNVIFSRCRDEMFMTAGNGTIRVWELDLPNRKIWPTECQTGQLKRIVMSIGVDDDDS
                     FFYLGTTTGDILKMNPRTKLLTDVGPAKDKFSLGVSAIRCLKMGGLLVGSGAGLLVFC
                     KSPGYKPIKKIQLQGGITSITLRGEGHQFLVGTEESHIYRVSFTDFKETLIATCHFDA
                     VEDIVFPFGTAELFATCAKKDIRVWHTSSNRELLRITVPNMTCHGIDFMRDGKSIISA
                     WNDGKIRAFAPETGRLMYVINNAHRIGVTAIATTSDCKRVISGGGEGEVRVWQIGCQT
                     QKLEEALKEHKSSVSCIRVKRNNEECVTASTDGTCIIWDLVRLRRNQMILANTLFQCV
                     CYHPEEFQIITSGTDRKIAYWEVFDGTVIRELEGSLSGSINGMDITQEGVHFVTGGND
                     HLVKVWDYNEGEVTHVGVGHSGNITRIRISPGNQYIVSVSADGAILRWKYPYTS"
     exon            125..324
                     /gene="CFAP52"
                     /gene_synonym="HTX10; WDR16; WDRPUH"
                     /inference="alignment:Splign:2.1.0"
     exon            325..461
                     /gene="CFAP52"
                     /gene_synonym="HTX10; WDR16; WDRPUH"
                     /inference="alignment:Splign:2.1.0"
     exon            462..590
                     /gene="CFAP52"
                     /gene_synonym="HTX10; WDR16; WDRPUH"
                     /inference="alignment:Splign:2.1.0"
     exon            591..690
                     /gene="CFAP52"
                     /gene_synonym="HTX10; WDR16; WDRPUH"
                     /inference="alignment:Splign:2.1.0"
     exon            691..807
                     /gene="CFAP52"
                     /gene_synonym="HTX10; WDR16; WDRPUH"
                     /inference="alignment:Splign:2.1.0"
     exon            808..908
                     /gene="CFAP52"
                     /gene_synonym="HTX10; WDR16; WDRPUH"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1079
                     /gene="CFAP52"
                     /gene_synonym="HTX10; WDR16; WDRPUH"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1228
                     /gene="CFAP52"
                     /gene_synonym="HTX10; WDR16; WDRPUH"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1374
                     /gene="CFAP52"
                     /gene_synonym="HTX10; WDR16; WDRPUH"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1526
                     /gene="CFAP52"
                     /gene_synonym="HTX10; WDR16; WDRPUH"
                     /inference="alignment:Splign:2.1.0"
     exon            1527..1629
                     /gene="CFAP52"
                     /gene_synonym="HTX10; WDR16; WDRPUH"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..1741
                     /gene="CFAP52"
                     /gene_synonym="HTX10; WDR16; WDRPUH"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..2166
                     /gene="CFAP52"
                     /gene_synonym="HTX10; WDR16; WDRPUH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2082..2087
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CFAP52"
                     /gene_synonym="HTX10; WDR16; WDRPUH"
                     /note="hexamer: ATTAAA"
     polyA_site      2106
                     /gene="CFAP52"
                     /gene_synonym="HTX10; WDR16; WDRPUH"
                     /note="major polyA site"
     regulatory      2146..2151
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CFAP52"
                     /gene_synonym="HTX10; WDR16; WDRPUH"
                     /note="hexamer: AATAAA"
     polyA_site      2166
                     /gene="CFAP52"
                     /gene_synonym="HTX10; WDR16; WDRPUH"
ORIGIN      
        1 agaagacgct gcagccacta gggaggagag caaagtaatc agaacctccc aaggatggat
       61 aacaaaattt cgccggaggc ccaagtggcg gagctggaac ttgacgccgt gatcggcttc
      121 aatggacatg tgcccactgg tctcaaatgc catcctgacc aggagcatat gatttatcct
      181 cttggttgca cagtcctcat tcaggcaata aatactaaag agcagaactt cctacagggt
      241 catggcaaca acgtctcctg cttggccatc tccaggtctg gagagtacat cgcctccgga
      301 caagtcacat tcatggggtt caaggcagac atcattttgt gggattataa gaacagagag
      361 ctgcttgctc ggctgtccct tcacaaaggc aaaattgaag ctctggcctt ttctccaaat
      421 gatttgtact tggtatcact aggaggccca gatgacggaa gtgtggtggt gtggagcata
      481 gccaagagag atgccatctg tggcagccct gcagccggcc tcaatgttgg caatgccacc
      541 aatgtgatct tctccaggtg ccgggatgag atgtttatga ctgctggaaa tgggacaatt
      601 cgagtatggg aattggatct tccaaataga aaaatctggc caactgagtg ccaaacagga
      661 cagttgaaaa gaatagtcat gagtattgga gtggatgatg atgatagctt tttctacctt
      721 ggcaccacga ctggagatat tctaaaaatg aaccccagga ctaaactgct gacagatgtt
      781 gggcctgcga aggacaaatt cagtttggga gtgtcagcta tcaggtgcct gaagatgggg
      841 ggtttgttgg tgggctctgg agccggactg ctggtcttct gtaaaagccc tggctacaaa
      901 cccatcaaga agattcagtt acaaggcggc atcacttcta tcacacttcg aggagaagga
      961 caccagtttc tcgtaggaac agaagaatcg cacatttatc gtgtcagctt cacggatttc
     1021 aaagagacgc tcatagcgac ttgtcacttt gatgctgtcg aggatattgt ctttccattt
     1081 ggcactgctg agctatttgc aacctgtgcc aagaaggata tcagggtgtg gcacacatca
     1141 tccaacaggg agctgctgcg gatcaccgtg cccaacatga cctgccacgg catcgacttc
     1201 atgagggacg gcaaaagcat catttcagca tggaacgacg gtaaaatccg agccttcgcc
     1261 ccagagacag gccgactgat gtatgtcatt aacaatgctc acaggatcgg cgtcaccgcc
     1321 atcgccacca ccagtgactg taaaagggtc atcagtggcg gtggggaagg ggaggtgagg
     1381 gtatggcaga taggctgtca gacccagaag ctggaggagg ccctgaagga acacaagtca
     1441 tcagtgtcct gcattagggt gaagaggaac aacgaggagt gtgtcaccgc cagcaccgat
     1501 gggacttgta tcatttggga ccttgtgcgt ctcaggagga atcagatgat actagccaac
     1561 accttattcc agtgtgtgtg ctatcaccct gaggagttcc agatcatcac cagcggaaca
     1621 gacagaaaga ttgcttactg ggaagtattt gatgggacag taatcagaga attggaaggt
     1681 tccctgtctg ggtcgataaa tggcatggat atcacacagg aaggggtgca ctttgtcaca
     1741 ggtggaaatg accatctggt caaagtttgg gattataatg agggtgaagt gactcacgtt
     1801 ggggtgggac acagtggcaa catcacacgc atccgcataa gtccaggaaa tcaatatatt
     1861 gttagtgtaa gtgccgatgg agccattttg cgatggaagt acccatatac ctcctgaagc
     1921 tgatgagatg tctctgagcc ttggcgttgc acgcagtcct gttgaagact gagtttagat
     1981 aactccaaca ctagtcttca tttctcacag ctctgttttt gttcttgagt caatttttct
     2041 ctttttcttt atagaatgca ttttatattc ttaaattgca tattaaaatt gaagtatgtt
     2101 caagaataat ttgtgcagac tctaattaga acttttaaca ttttgaataa attcttagtt
     2161 gttggt
//
