LOCUS       NM_080667               1184 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens cilia and flagella associated protein 36 (CFAP36),
            transcript variant 2, mRNA.
ACCESSION   NM_080667
VERSION     NM_080667.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1184)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1184)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1184)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 1184)
  AUTHORS   Lokaj,M., Kosling,S.K., Koerner,C., Lange,S.M., van Beersum,S.E.,
            van Reeuwijk,J., Roepman,R., Horn,N., Ueffing,M., Boldt,K. and
            Wittinghofer,A.
  TITLE     The Interaction of CCDC104/BARTL1 with Arl3 and Implications for
            Ciliary Function
  JOURNAL   Structure 23 (11), 2122-2132 (2015)
   PUBMED   26455799
REFERENCE   5  (bases 1 to 1184)
  AUTHORS   Totland,C., Bredholt,G., Haugen,M., Haukanes,B.I. and Vedeler,C.A.
  TITLE     Antibody to CCDC104 is associated with a paraneoplastic antibody to
            CDR2 (anti-Yo)
  JOURNAL   Cancer Immunol Immunother 59 (2), 231-237 (2010)
   PUBMED   19680650
  REMARK    GeneRIF: The association between Yo and CCDC104 antibodies in
            paraneoplastic neurological syndromes may indicate functional
            similarities.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC010011.2 and BM980999.1.
            
            On Feb 27, 2020 this sequence version replaced NM_080667.6.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the 5' coding region, compared to variant 1, resulting in
            an isoform (b) that is shorter than isoform a.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC010011.2, SRR7346977.145637.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000349456.9/ ENSP00000295117.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-811               BC010011.2         31-841
            812-820             BM980999.1         376-384             c
            821-1184            BC010011.2         851-1214
FEATURES             Location/Qualifiers
     source          1..1184
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p16.1"
     gene            1..1184
                     /gene="CFAP36"
                     /gene_synonym="BARTL1; CCDC104"
                     /note="cilia and flagella associated protein 36"
                     /db_xref="GeneID:112942"
                     /db_xref="HGNC:HGNC:30540"
     exon            1..199
                     /gene="CFAP36"
                     /gene_synonym="BARTL1; CCDC104"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..1113
                     /gene="CFAP36"
                     /gene_synonym="BARTL1; CCDC104"
                     /note="isoform b is encoded by transcript variant 2;
                     coiled-coil domain-containing protein 104; coiled-coil
                     domain containing 104"
                     /codon_start=1
                     /product="cilia- and flagella-associated protein 36
                     isoform b"
                     /protein_id="NP_542398.3"
                     /db_xref="CCDS:CCDS1854.2"
                     /db_xref="GeneID:112942"
                     /db_xref="HGNC:HGNC:30540"
                     /translation="MAAEEEDEVEWVVESIAGFLRGPDWSIPILDFVEQKCEVFDDEE
                     ESKLTYTEIHQEYKELVEKLLEGYLKEIGINEDQFQEACTSPLAKTHTSQAILQPVLA
                     AEDFTIFKAMMVQKNIEMQLQAIRIIQERNGVLPDCLTDGSDVVSDLEHEEMKILREV
                     LRKSKEEYDQEEERKRKKQLSEAKTEEPTVHSSEAAIMNNSQGDGEHFAHPPSEVKMH
                     FANQSIEPLGRKVERSETSSLPQKDLKIPGLEHASIEGPIANLSVLGTEELRQREHYL
                     KQKRDKLMSMRKDMRTKQIQNMEQKGKPTGEVEEMTEKPEMTAEEKQTLLKRRLLAEK
                     LKEEVINK"
     exon            200..264
                     /gene="CFAP36"
                     /gene_synonym="BARTL1; CCDC104"
                     /inference="alignment:Splign:2.1.0"
     exon            265..366
                     /gene="CFAP36"
                     /gene_synonym="BARTL1; CCDC104"
                     /inference="alignment:Splign:2.1.0"
     exon            367..481
                     /gene="CFAP36"
                     /gene_synonym="BARTL1; CCDC104"
                     /inference="alignment:Splign:2.1.0"
     exon            482..569
                     /gene="CFAP36"
                     /gene_synonym="BARTL1; CCDC104"
                     /inference="alignment:Splign:2.1.0"
     exon            570..621
                     /gene="CFAP36"
                     /gene_synonym="BARTL1; CCDC104"
                     /inference="alignment:Splign:2.1.0"
     exon            622..724
                     /gene="CFAP36"
                     /gene_synonym="BARTL1; CCDC104"
                     /inference="alignment:Splign:2.1.0"
     exon            725..861
                     /gene="CFAP36"
                     /gene_synonym="BARTL1; CCDC104"
                     /inference="alignment:Splign:2.1.0"
     exon            862..1011
                     /gene="CFAP36"
                     /gene_synonym="BARTL1; CCDC104"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1184
                     /gene="CFAP36"
                     /gene_synonym="BARTL1; CCDC104"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1159..1164
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CFAP36"
                     /gene_synonym="BARTL1; CCDC104"
                     /note="hexamer: AATAAA"
     polyA_site      1184
                     /gene="CFAP36"
                     /gene_synonym="BARTL1; CCDC104"
                     /note="major polyA site"
ORIGIN      
        1 ctctcggctc cttgtggccc aaaggcctaa ccggggtccg gcggtctggc ctagggatct
       61 tccccgttgc ccctttgggg cgggatggct gcggaagaag aagacgaggt ggagtgggta
      121 gtggagagca tcgcggggtt cctgcgaggc ccagactggt ccatccccat cttggacttt
      181 gtggaacaga aatgtgaagt ttttgatgat gaagaagaaa gcaaattgac ctatacagag
      241 attcatcagg aatacaaaga actagttgaa aagctgttag aaggttacct caaagaaatt
      301 ggaattaatg aagatcaatt tcaagaagca tgcacttctc ctcttgcaaa gacccataca
      361 tcacaggcca ttttgcaacc tgtgttggca gcagaagatt ttactatctt taaagcaatg
      421 atggtccaga aaaacattga aatgcagctg caagccattc gaataattca agagagaaat
      481 ggtgtattac ctgactgctt aaccgatggc tctgatgtgg tcagtgacct tgaacacgaa
      541 gagatgaaaa tcctgaggga agttcttaga aaatcaaaag aggaatatga ccaggaagaa
      601 gaaaggaaga ggaaaaaaca gttatcagag gctaaaacag aagagcccac agtgcattcc
      661 agtgaagctg caataatgaa taattcccaa ggggatggtg aacattttgc acacccaccc
      721 tcagaagtta aaatgcattt tgctaatcag tcaatagaac ctttgggaag aaaagtggaa
      781 aggtctgaaa cttcctccct cccacaaaaa gacctgaaga ttcctggctt agagcatgcg
      841 agcattgaag gaccaatagc aaacttatca gtacttggaa cagaagaact tcggcaacga
      901 gaacactatc tcaagcagaa gagagataag ttgatgtcca tgagaaagga tatgaggact
      961 aaacagatac aaaatatgga gcagaaagga aaacccactg gggaggtaga ggaaatgaca
     1021 gagaaaccag aaatgacagc agaggagaag caaacattac taaagaggag attgcttgca
     1081 gagaaactca aagaagaagt tattaataag taataattaa gaacaattta acaaaatgga
     1141 agttcaaatt gtcttaaaaa taaattattt agtccttaca ctga
//
