LOCUS       NM_152770                879 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens cilia and flagella associated protein 299 (CFAP299),
            transcript variant 2, mRNA.
ACCESSION   NM_152770
VERSION     NM_152770.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 879)
  AUTHORS   Poh,J., Ponsford,A.H., Boyd,J., Woodsmith,J., Stelzl,U., Wanker,E.,
            Harper,N., MacEwan,D. and Sanderson,C.M.
  TITLE     A functionally defined high-density NRF2 interactome reveals new
            conditional regulators of ARE transactivation
  JOURNAL   Redox Biol 37, 101686 (2020)
   PUBMED   32911434
REFERENCE   2  (bases 1 to 879)
  AUTHORS   Li,H., Dai,Y., Luo,Z. and Nie,D.
  TITLE     Cloning of a new testis-enriched gene C4orf22 and its role in cell
            cycle and apoptosis in mouse spermatogenic cells
  JOURNAL   Mol Biol Rep 46 (2), 2029-2038 (2019)
   PUBMED   30820741
REFERENCE   3  (bases 1 to 879)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   4  (bases 1 to 879)
  AUTHORS   Uhl,G.R., Liu,Q.R., Drgon,T., Johnson,C., Walther,D., Rose,J.E.,
            David,S.P., Niaura,R. and Lerman,C.
  TITLE     Molecular genetics of successful smoking cessation: convergent
            genome-wide association study results
  JOURNAL   Arch Gen Psychiatry 65 (6), 683-693 (2008)
   PUBMED   18519826
  REMARK    GeneRIF: Clinical trial and genome-wide association study of
            gene-disease association, gene-environment interaction, and
            pharmacogenomic / toxicogenomic. (HuGE Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC034296.1, AI650567.1 and DB522959.1.
            
            On Jan 30, 2020 this sequence version replaced NM_152770.2.
            
            Transcript Variant: This variant (2) lacks an in-frame exon in the
            CDS, compared to variant 1. The resulting isoform (2) lacks an
            internal segment, compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC034296.1, BU568290.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358105.8/ ENSP00000350818.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-696               BC034296.1         11-706
            697-875             AI650567.1         1-179               c
            876-879             DB522959.1         445-448
FEATURES             Location/Qualifiers
     source          1..879
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q21.21"
     gene            1..879
                     /gene="CFAP299"
                     /gene_synonym="C4orf22"
                     /note="cilia and flagella associated protein 299"
                     /db_xref="GeneID:255119"
                     /db_xref="HGNC:HGNC:28554"
     exon            1..150
                     /gene="CFAP299"
                     /gene_synonym="C4orf22"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..741
                     /gene="CFAP299"
                     /gene_synonym="C4orf22"
                     /note="isoform 2 is encoded by transcript variant 2;
                     uncharacterized protein C4orf22"
                     /codon_start=1
                     /product="cilia- and flagella-associated protein 299
                     isoform 2"
                     /protein_id="NP_689983.2"
                     /db_xref="CCDS:CCDS3587.1"
                     /db_xref="GeneID:255119"
                     /db_xref="HGNC:HGNC:28554"
                     /translation="MDQEEGLKALDNIVTQFNAYEDFLDSQITTVDLYYLEDETLARQ
                     LVELGYRGTGERVKREDFEARKAAIEIARLAERAQQKTLTSAGKDLQDNFLTALAMRE
                     EDNRSGKLSSVIFIRDRNSHGQEISGYIDYAHRLKTEDFEVYFTGKKRLLPRPTDISF
                     YNWDADIAVSNSSPNYQVIADNPEGLLFRYKRDRKILNVDPKAQPGDNSTRITILTEL
                     YVQAVIFDHISRRKT"
     exon            151..281
                     /gene="CFAP299"
                     /gene_synonym="C4orf22"
                     /inference="alignment:Splign:2.1.0"
     exon            282..372
                     /gene="CFAP299"
                     /gene_synonym="C4orf22"
                     /inference="alignment:Splign:2.1.0"
     exon            373..515
                     /gene="CFAP299"
                     /gene_synonym="C4orf22"
                     /inference="alignment:Splign:2.1.0"
     exon            516..645
                     /gene="CFAP299"
                     /gene_synonym="C4orf22"
                     /inference="alignment:Splign:2.1.0"
     exon            646..879
                     /gene="CFAP299"
                     /gene_synonym="C4orf22"
                     /inference="alignment:Splign:2.1.0"
     regulatory      858..863
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CFAP299"
                     /gene_synonym="C4orf22"
                     /note="hexamer: AATAAA"
     polyA_site      879
                     /gene="CFAP299"
                     /gene_synonym="C4orf22"
                     /note="major polyA site"
ORIGIN      
        1 gcttccgttg ctagggacgc ttcggccgag gataccgcaa tggatcagga agaggggctg
       61 aaggccttgg acaatattgt cactcaattc aacgcctatg aagatttcct ggactcgcag
      121 atcactactg tggacttgta ctacctggag gatgaaaccc tggcccgcca gttggtggag
      181 ctaggctacc gagggactgg agagagagtg aaaagggaag attttgaagc aaggaaagcg
      241 gctatagaga ttgcaagact ggctgaaaga gctcagcaaa agacgctaac aagtgctggt
      301 aaagacctac aagataattt tctgacggcc ctggcaatga gagaagaaga caatcgcagt
      361 ggaaaactga gttccgtgat ctttattcgt gacagaaatt ctcatgggca agagatatca
      421 ggatacatcg actatgccca caggctaaag acggaagatt ttgaagtcta ctttactgga
      481 aaaaaaagac ttcttccaag gcctacagat ataagctttt acaactggga cgctgatatt
      541 gctgttagta attcaagtcc caactatcaa gtgattgccg ataatccaga aggcttactt
      601 ttcagataca aaagagacag aaaaattctt aatgtggacc caaaggcgca gccaggtgac
      661 aactctacta gaatcactat cctgacagaa ctctacgtac aagctgtcat ttttgaccac
      721 atttccagaa ggaagactta agtaccaaca tgttaatttc ctaataattt gctaaattta
      781 aataaattcc gtagacagag caaattagaa taataaatga gccctgtagc tggaaggcaa
      841 attagaacaa taaagttaat aaagaagtta gaaagaaaa
//
