LOCUS       NM_001350338            4357 bp    mRNA    linear   PRI 17-APR-2022
DEFINITION  Homo sapiens CFAP298-TCP10L readthrough (CFAP298-TCP10L),
            transcript variant 1, mRNA.
ACCESSION   NM_001350338
VERSION     NM_001350338.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4357)
  AUTHORS   Denoeud F, Kapranov P, Ucla C, Frankish A, Castelo R, Drenkow J,
            Lagarde J, Alioto T, Manzano C, Chrast J, Dike S, Wyss C,
            Henrichsen CN, Holroyd N, Dickson MC, Taylor R, Hance Z, Foissac S,
            Myers RM, Rogers J, Hubbard T, Harrow J, Guigo R, Gingeras TR,
            Antonarakis SE and Reymond A.
  TITLE     Prominent use of distal 5' transcription start sites and discovery
            of a large number of additional exons in ENCODE regions
  JOURNAL   Genome Res. 17 (6), 746-759 (2007)
   PUBMED   17567994
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP000275.1 and AP000274.2.
            
            On Jun 3, 2019 this sequence version replaced NM_001350338.1.
            
            Summary: This locus represents naturally occurring readthrough
            transcription between the neighboring chromosome 21 open reading
            frame 59 (C21orf59) and TCP10L (t-complex 10 like) genes on
            chromosome 21. Readthrough transcripts may encode a fusion protein
            that shares sequence identity with each individual gene product.
            [provided by RefSeq, Apr 2017].
            
            Transcript Variant: This variant (1) encodes a protein with
            similarity to the proteins encoded by C21orf59 and TCP10L.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.116727.1,
                                           SRR1803611.117534.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 56683, 140290
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-273               AP000275.1         33912-34184         c
            274-441             AP000275.1         31645-31812         c
            442-509             AP000275.1         29456-29523         c
            510-668             AP000275.1         25932-26090         c
            669-800             AP000275.1         24968-25099         c
            801-1016            AP000275.1         4007-4222           c
            1017-1154           AP000275.1         501-638             c
            1155-4357           AP000274.2         26758-29960         c
FEATURES             Location/Qualifiers
     source          1..4357
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.11"
     gene            1..4357
                     /gene="CFAP298-TCP10L"
                     /gene_synonym="C21orf59-TCP10L; C21orf77; LINC00846"
                     /note="CFAP298-TCP10L readthrough"
                     /db_xref="GeneID:110091775"
                     /db_xref="HGNC:HGNC:54636"
     exon            1..273
                     /gene="CFAP298-TCP10L"
                     /gene_synonym="C21orf59-TCP10L; C21orf77; LINC00846"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..1304
                     /gene="CFAP298-TCP10L"
                     /gene_synonym="C21orf59-TCP10L; C21orf77; LINC00846"
                     /note="C21orf59-TCP10L readthrough; long intergenic
                     non-protein coding RNA 846"
                     /codon_start=1
                     /product="uncharacterized protein LOC110091775"
                     /protein_id="NP_001337267.1"
                     /db_xref="GeneID:110091775"
                     /db_xref="HGNC:HGNC:54636"
                     /translation="MVLLHVKRGDESQFLLQAPGSTELEELTVQVARVYNGRLKVQRL
                     CSEMEELAEHGIFLPPNMQGLTDDQIEELKLKDEWGEKCVPSGGAVFKKDDIGRRNGQ
                     APNEKMKQVLKKTIEEAKAIISKKQVEAGVCVTMEMVKDALDQLRGAVMIVYPMGLPP
                     YDPIRMEFENKEDLSGTQAGLNVIKEAEAQLWWAAKELRRTKKLSDYVGKNEKTKIIA
                     KIQQPLQQQIIRLHQELGRQKSLWADVHGKLRSHIDALREQNMELREKLRALQLQRWK
                     ARKKSAASPHAGQESHTLALEPAFGKISPLSADEETIPKYAGHKNQSATLLGQRSSSN
                     NSAPPKPMSLKIERISSWKTPPQENRDKNLSRRRQDRRATPTGRPTPCAERRGGV"
     exon            274..441
                     /gene="CFAP298-TCP10L"
                     /gene_synonym="C21orf59-TCP10L; C21orf77; LINC00846"
                     /inference="alignment:Splign:2.1.0"
     exon            442..509
                     /gene="CFAP298-TCP10L"
                     /gene_synonym="C21orf59-TCP10L; C21orf77; LINC00846"
                     /inference="alignment:Splign:2.1.0"
     exon            510..668
                     /gene="CFAP298-TCP10L"
                     /gene_synonym="C21orf59-TCP10L; C21orf77; LINC00846"
                     /inference="alignment:Splign:2.1.0"
     exon            669..800
                     /gene="CFAP298-TCP10L"
                     /gene_synonym="C21orf59-TCP10L; C21orf77; LINC00846"
                     /inference="alignment:Splign:2.1.0"
     exon            801..1016
                     /gene="CFAP298-TCP10L"
                     /gene_synonym="C21orf59-TCP10L; C21orf77; LINC00846"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1154
                     /gene="CFAP298-TCP10L"
                     /gene_synonym="C21orf59-TCP10L; C21orf77; LINC00846"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..4357
                     /gene="CFAP298-TCP10L"
                     /gene_synonym="C21orf59-TCP10L; C21orf77; LINC00846"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1391..1396
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CFAP298-TCP10L"
                     /gene_synonym="C21orf59-TCP10L; C21orf77; LINC00846"
                     /note="hexamer: AATAAA"
     polyA_site      1419
                     /gene="CFAP298-TCP10L"
                     /gene_synonym="C21orf59-TCP10L; C21orf77; LINC00846"
                     /note="major polyA site"
     regulatory      3211..3216
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CFAP298-TCP10L"
                     /gene_synonym="C21orf59-TCP10L; C21orf77; LINC00846"
                     /note="hexamer: ATTAAA"
     polyA_site      3237
                     /gene="CFAP298-TCP10L"
                     /gene_synonym="C21orf59-TCP10L; C21orf77; LINC00846"
     regulatory      3929..3934
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CFAP298-TCP10L"
                     /gene_synonym="C21orf59-TCP10L; C21orf77; LINC00846"
                     /note="hexamer: AATGAA"
     polyA_site      3957
                     /gene="CFAP298-TCP10L"
                     /gene_synonym="C21orf59-TCP10L; C21orf77; LINC00846"
     regulatory      4333..4338
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CFAP298-TCP10L"
                     /gene_synonym="C21orf59-TCP10L; C21orf77; LINC00846"
                     /note="hexamer: AATAAA"
     polyA_site      4357
                     /gene="CFAP298-TCP10L"
                     /gene_synonym="C21orf59-TCP10L; C21orf77; LINC00846"
ORIGIN      
        1 agcgtgggat tccggactgt gagcggctgt tagtgcgtcg cagctgctgg cgatccggcg
       61 accctcggcc ggcaggaccc gcgggccacg cagccggggc cttctcaacg cctcagtacc
      121 tcggcgggac cgccatggtt ctgctgcacg tgaagcgggg cgacgagagc cagttcctgc
      181 tgcaggcgcc tgggagtacc gagctggagg agctcacggt gcaggtggcc cgggtctata
      241 atgggcggct caaggtgcag cgcctctgct cagaaatgga agaattagcc gaacatggca
      301 tatttctccc tcctaatatg caaggactga ccgatgatca gattgaagaa ttgaaattga
      361 aggatgaatg gggtgaaaaa tgcgtaccca gcggaggtgc agtgtttaaa aaggatgata
      421 ttggacgaag gaatgggcaa gctccaaatg agaagatgaa gcaagtgtta aagaagacta
      481 tagaagaagc caaagcaata atatctaaga aacaagtgga agccggtgtc tgtgttacca
      541 tggagatggt gaaagatgcc ttggaccagc ttcgaggcgc ggtgatgatt gtttacccca
      601 tggggttgcc accgtatgat cccatccgca tggagtttga aaataaggaa gacttgtcgg
      661 gaacacaggc agggctcaac gtcattaaag aggcagaggc gcagctgtgg tgggcagcca
      721 aggagctgag aagaacgaag aagctttcag actacgtggg gaagaatgaa aaaaccaaaa
      781 ttatcgccaa gattcagcaa ccattacagc agcagatcat cagactccac caagagcttg
      841 ggagacagaa gtctctgtgg gctgatgttc atggaaaact ccggagtcat atagatgctt
      901 tgagggagca gaacatggag ctccgagaaa agctgagagc tctgcagctg cagcggtgga
      961 aagccaggaa gaaatctgca gcgtccccac acgcggggca agaatcgcac actctggcat
     1021 tggaacctgc ttttggaaaa atttcacctc tgtcagctga tgaagagaca atacccaaat
     1081 acgctggcca caagaatcag agtgccactc tcctgggaca aagatcgtca tctaacaatt
     1141 cagctcctcc aaagccaatg agtttaaaga tagaaagaat tagctcgtgg aaaacaccac
     1201 cacaggaaaa tagagataaa aatctttcca ggagacgtca agacagaaga gcaacaccta
     1261 ctggaaggcc aactccctgt gcagagagac gggggggtgt ctgaagatgg aaaggtggcc
     1321 tcggacacct gtgtcactct acactggccc cttggaaaat tcagattcag ataaagttcc
     1381 acttaggtct aataaaagta ctcaatttgt tattcaaaat agacctagta atttattaaa
     1441 ctaattatgt ttctatagat aaaaacttga agttcttcag acatgtctct aatgctataa
     1501 aagcaaacaa cttggattgg gttttataaa tcagttgctt tcctgagctc tgtagttggt
     1561 atatttctgc agagtcttta aaaaaattaa cccaccttgt agtatggagt gtcgggctgt
     1621 tgggtgagcc ctggggtctt gctggaaatc gaggatggct gaagatggct ttgtgctccc
     1681 agcctttggg ctcaaggcat tgcccgctcc agggaccttg tgacaaggcg ggcctgtgac
     1741 tgtcattgcc ccaggctatg catccatctt cccgaagtct gcaaaacttg agtggcagaa
     1801 aatcaccagt gcaggcttcc caggccgcca tgctgcagga gcagatggca gcagccggag
     1861 gagctggtga gcagagttgg ggactcctgt ttctatgctc cccgtgaaat gcggggcttt
     1921 ctcgtggata cgcgtgagca gaacatctta ctatggcaag gacatgtcct tcctggagct
     1981 gcctaatttg tggccacttt ttgtctgatt ccctcgttgg gtcctcacct gtgagacttg
     2041 ccaacacccc cagccctcca ccccacacac agcccacatg ccggtctcca ggggccgtga
     2101 ctggagattc cgaatcctag cggtcacttc cctctgagca cactcccagc agaaggcgtg
     2161 tggctggggc tagatgcact tgggtgcttt gttccccttt ctccatttgc cagcccatgg
     2221 cattgctgcc accctgatgg agcgccctct catctggcac cttcctggcc tctttcccag
     2281 gccccagttc tgtccatgca gctgtgggtg cttcctgcat tgcgggtctc acggggagga
     2341 gacgagagtg cccctggttg agtcaggaaa gaattctatc ttcacgtcgc tgccagcaaa
     2401 tgaccacagc agcttcacga cctctgcagg aacctatctt ggtaaagaaa cggggcctat
     2461 gtggtggccg agcctcaggt gtggccgagc ttcaggtgtg gcccttatgc acagcacagc
     2521 ccaagcctgt gggcaccact cgccctgggc tgcctggcac ctggactcct tcccatcctt
     2581 ggccgaggtc tgcgtggccc ttcagggccg aatctgacac tgtcttcctc ctgagtctgc
     2641 cccccgggct tcctgcccac ccccaggctg tttcatggcc tctgcaggga gcttcgtaga
     2701 ggtgaggctg gtgccatctg tctgcttcag accacctcag gctctgcgtg ccctcacagt
     2761 cccctctgca cttctctgtg gggcagggaa gcccttccca tcaggtctgc tccagcctgg
     2821 ctaccttgtt cctgctgtcc cctccccttc aggcccccgg acaagacttc agtgtacttg
     2881 ctggtgccgg gcagaatggg ggaccttgcc tctcacacac acctgctagt atctccgcaa
     2941 cctccaggca tcatctcagc tgacagtgac gccatcctgg ggaagctccc ctgactcctg
     3001 gctctcctgg aagcctgtgg tgctccttca caatggcccg tggcccttca taggtcccgt
     3061 aagccagtgt cacagggatt cggcttttct cttctgtgtt tgcctgctgc gggactgtga
     3121 gcagcttcag ggccaagaca gtgcctttcc atccgtgaat ctcctgatcc atcagaatac
     3181 tcgaaagaga aataccgact gagtgtattc attaaagaat taatgttcct tacaggatca
     3241 tttgttgttg aactgacctg acatgtgtat agtaatctca tgaacaagaa agaatgtgtt
     3301 cacacgtttg cttaaattga atttagcaat cgcattagga tactgatatt tccacaatgt
     3361 atatacacta tccttttaaa tttaacttat ttgcttttta gacggaagct cctcagtctt
     3421 agagagttct gaaggtggat ttctcagcca cgttcaacct gatgagttca ctgcttcttc
     3481 cccaaacatt gcagagctgc aggtaggtgg gctgagtggc ttctgcaagg gtggcccgcc
     3541 aggttcccct gagggagacc tgagaagctc accttttcat cctggggaag tgagattcgg
     3601 agtgggtgtc aagagatggt tgcatcttct tgacaagaac agaaaattaa gatgattcca
     3661 aatgtctctt tatttcctga ggttcagcct ttcaaacaga gactttcttt tatagattta
     3721 agttggttgc atttagcaca tagtcaaaca ggattaatat ttttcatggc ttaagagttt
     3781 cccaagtcaa agtttcattt tttatcattt tgatttacag ttctcaattg acattaatag
     3841 actcgaaggc acgaatagca aacatatttc taagccctag ctagtggtcc acttgtaaca
     3901 tgctatattt tacaaaaaat gtcaataaaa tgaaattatt ttctctacgg caggaaattt
     3961 gggctgtgaa cttacgtgtg atgtaagtag gcacctggcg gggaagtctg ggaacacagg
     4021 tcccgcttgt tttctgttct cccgagaaaa acccacattc tgttctgccc ttttcaacat
     4081 cttcagtggg gggacgagtg ggaacatttt tcttgggatt ttattttgtt tggggatcca
     4141 gctaatgggt ttgcctggaa gcctcagggc taatgatctg catttagaaa cagtgccaca
     4201 gtcatggcag gtgttatttg tatgttattt gtatgtctct gtgtgttatt tgtatcaggt
     4261 gttgaatgtg gcggttgtca ctgtggccac cctgacccca gagcaaacat ataagtggga
     4321 gataaccact ttaataaaac acaaaacatg gtccaaa
//
