LOCUS       NM_014157               5272 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens cilia and flagella associated protein 263 (CFAP263),
            transcript variant 1, mRNA.
ACCESSION   NM_014157
VERSION     NM_014157.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5272)
  AUTHORS   Hou,C., Yang,Y., Wang,P., Xie,H., Jin,S., Zhao,L., Wu,G., Xing,H.,
            Chen,H., Liu,B., Du,C., Sun,X. and He,L.
  TITLE     CCDC113 promotes colorectal cancer tumorigenesis and metastasis via
            TGF-beta signaling pathway
  JOURNAL   Cell Death Dis 15 (9), 666 (2024)
   PUBMED   39261464
  REMARK    GeneRIF: CCDC113 promotes colorectal cancer tumorigenesis and
            metastasis via TGF-beta signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5272)
  AUTHORS   Bazan,R., Schrofel,A., Joachimiak,E., Poprzeczko,M., Pigino,G. and
            Wloga,D.
  TITLE     Ccdc113/Ccdc96 complex, a novel regulator of ciliary beating that
            connects radial spoke 3 to dynein g and the nexin link
  JOURNAL   PLoS Genet 17 (3), e1009388 (2021)
   PUBMED   33661892
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5272)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 5272)
  AUTHORS   Sigg,M.A., Menchen,T., Lee,C., Johnson,J., Jungnickel,M.K.,
            Choksi,S.P., Garcia,G. 3rd, Busengdal,H., Dougherty,G.W.,
            Pennekamp,P., Werner,C., Rentzsch,F., Florman,H.M., Krogan,N.,
            Wallingford,J.B., Omran,H. and Reiter,J.F.
  TITLE     Evolutionary Proteomics Uncovers Ancient Associations of Cilia with
            Signaling Pathways
  JOURNAL   Dev Cell 43 (6), 744-762 (2017)
   PUBMED   29257953
REFERENCE   5  (bases 1 to 5272)
  AUTHORS   Firat-Karalar,E.N., Sante,J., Elliott,S. and Stearns,T.
  TITLE     Proteomic analysis of mammalian sperm cells identifies new
            components of the centrosome
  JOURNAL   J Cell Sci 127 (Pt 19), 4128-4133 (2014)
   PUBMED   25074808
REFERENCE   6  (bases 1 to 5272)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC009107.11.
            
            On May 17, 2019 this sequence version replaced NM_014157.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL136785.1, SRR1803616.187772.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000219299.8/ ENSP00000219299.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-180               AC009107.11        121513-121692
            181-307             AC009107.11        124304-124430
            308-469             AC009107.11        125575-125736
            470-625             AC009107.11        129945-130100
            626-706             AC009107.11        131431-131511
            707-862             AC009107.11        133962-134117
            863-970             AC009107.11        139056-139163
            971-1126            AC009107.11        150059-150214
            1127-5272           AC009107.11        151268-155413
FEATURES             Location/Qualifiers
     source          1..5272
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q21"
     gene            1..5272
                     /gene="CFAP263"
                     /gene_synonym="CCDC113; HSPC065"
                     /note="cilia and flagella associated protein 263"
                     /db_xref="GeneID:29070"
                     /db_xref="HGNC:HGNC:25002"
                     /db_xref="MIM:616070"
     exon            1..180
                     /gene="CFAP263"
                     /gene_synonym="CCDC113; HSPC065"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..1213
                     /gene="CFAP263"
                     /gene_synonym="CCDC113; HSPC065"
                     /note="isoform 1 is encoded by transcript variant 1;
                     coiled-coil domain-containing protein 113; coiled-coil
                     domain containing 113"
                     /codon_start=1
                     /product="cilia- and flagella-associated protein 263
                     isoform 1"
                     /protein_id="NP_054876.2"
                     /db_xref="CCDS:CCDS10795.1"
                     /db_xref="GeneID:29070"
                     /db_xref="HGNC:HGNC:25002"
                     /db_xref="MIM:616070"
                     /translation="MTDDESESVLSDSHEGSELELPVIQLCGLVEELSYVNSALKTET
                     EMFEKYYAKLEPRDQRPPRLSEIKISAADYAQFRGRRRSKSRTGMDRGVGLTADQKLE
                     LVQKEVADMKDDLRHTRANAERDLQHHEAIIEEAEIRWSEVSREVHEFEKDILKAISK
                     KKGSILATQKVMKYIEDMNRRRDNMKEKLRLKNVSLKVQRKKMLLQLRQKEEVSEALH
                     DVDFQQLKIENAQFLETIEARNQELTQLKLSSGNTLQVLNAYKSKLHKAMEIYLNLDK
                     EILLRKELLEKIEKETLQVEEDRAKAEAVNKRLRKQLAEFRAPQVMTYVREKILNADL
                     EKSIRMWERKVEIAEMSLKGHRKAWNRMKITNEQLQADYLAGK"
     exon            181..307
                     /gene="CFAP263"
                     /gene_synonym="CCDC113; HSPC065"
                     /inference="alignment:Splign:2.1.0"
     exon            308..469
                     /gene="CFAP263"
                     /gene_synonym="CCDC113; HSPC065"
                     /inference="alignment:Splign:2.1.0"
     exon            470..625
                     /gene="CFAP263"
                     /gene_synonym="CCDC113; HSPC065"
                     /inference="alignment:Splign:2.1.0"
     exon            626..706
                     /gene="CFAP263"
                     /gene_synonym="CCDC113; HSPC065"
                     /inference="alignment:Splign:2.1.0"
     exon            707..862
                     /gene="CFAP263"
                     /gene_synonym="CCDC113; HSPC065"
                     /inference="alignment:Splign:2.1.0"
     exon            863..970
                     /gene="CFAP263"
                     /gene_synonym="CCDC113; HSPC065"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1126
                     /gene="CFAP263"
                     /gene_synonym="CCDC113; HSPC065"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..5272
                     /gene="CFAP263"
                     /gene_synonym="CCDC113; HSPC065"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1252..1257
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CFAP263"
                     /gene_synonym="CCDC113; HSPC065"
                     /note="hexamer: TATAAA"
     polyA_site      1276
                     /gene="CFAP263"
                     /gene_synonym="CCDC113; HSPC065"
                     /note="major polyA site"
     polyA_site      1945
                     /gene="CFAP263"
                     /gene_synonym="CCDC113; HSPC065"
                     /note="major polyA site"
     regulatory      2262..2267
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CFAP263"
                     /gene_synonym="CCDC113; HSPC065"
                     /note="hexamer: AATATA"
     polyA_site      2283
                     /gene="CFAP263"
                     /gene_synonym="CCDC113; HSPC065"
                     /note="major polyA site"
ORIGIN      
        1 gcagccggag tgacgcgtgg ccgccggcac ccggagctcc tgggcacacg gcattggcag
       61 gggccgcttc ggcagagtga tgactgatga tgagtccgag agcgtcctct ccgactccca
      121 tgaagggtcg gagctggagc tgcctgttat ccagctgtgc gggctggtgg aggagctcag
      181 ctatgtaaac tctgctctca aaactgagac tgagatgttt gagaaatatt acgctaaact
      241 ggagcccagg gatcagcgac ctccacgatt atcagaaatt aaaatatcag cagcagatta
      301 tgcacagttt cgaggcaggc gtagatccaa atcccggaca ggtatggacc gtggggtagg
      361 cctgactgcc gaccaaaaac ttgagctggt acaaaaagag gttgcggaca tgaaggatga
      421 cttacgacac acaagggcaa atgcggaacg cgacctgcag catcacgagg cgatcattga
      481 ggaggctgaa attcgatgga gtgaagtttc gagagaagtg catgagtttg aaaaagatat
      541 tctaaaagcc atatccaaga agaaagggag tattttggcc actcagaaag tgatgaaata
      601 cattgaggac atgaaccgcc ggagggataa tatgaaggag aaattacgtt tgaaaaatgt
      661 ttctctcaaa gttcagagga aaaaaatgct tttacaattg aggcagaagg aagaggtgag
      721 tgaggccctt cacgatgttg attttcagca gttgaagata gagaacgctc aatttcttga
      781 gacaattgaa gcaaggaatc aagaactgac ccagctaaag ctgtcatctg gaaacactct
      841 gcaggttctc aatgcctaca aaagcaagct tcacaaggca atggaaatat acctcaatct
      901 ggacaaggag atcttgctga gaaaagagct acttgaaaaa attgaaaaag aaacactaca
      961 agtagaggag gaccgggcca aagccgaggc agtgaataag aggctccgga agcagctggc
     1021 cgagttccgg gcaccacagg tgatgactta cgtccgggag aagatcttaa atgcggacct
     1081 ggagaagagc atcaggatgt gggaaaggaa agtggagata gcagagatgt ccttaaaagg
     1141 ccatcgtaag gcttggaatc gaatgaaaat aaccaatgag cagttgcagg cagattacct
     1201 tgctgggaag tagccagagg caggccacgg cttacagacc actacatgac ctataaaagt
     1261 aatcagctcc tttctagtca cgggctcctc tcactgttcc ctgtctgcct ggtgttccca
     1321 accccccacc caggctgcgt atcatctcct gggccacatc tgcccatggg gagtgttttc
     1381 acagcctggc ccctggaact gttaccactg aaagaaccac agggcactct aatggtttga
     1441 cacttgttag ccagcattta gttcacaagc atagtgaaag tgaccttccc acacctggga
     1501 gagggataga ggagggagag ccagcccagt gtatgccatg ggcttatccg tggcagcccc
     1561 agtgtgcaac tatcaaaaac agacatcaaa acagcatggt gaatgcctgg cactcagcat
     1621 tctcagttta ctcttcagtt tggtggggta gctcctggac tagatactgc tgcaaaagaa
     1681 aacaagcacg aaggaaacca agatgatttc ttcgggctga tacaacctgt tctgacctgc
     1741 aaaaatccta ccttccccca cctccccacc gtaatagtca tagtataagg gttgtacaga
     1801 cgcctcagga gacctgcctg attcctttac atccttctcc ctaacatcta gactatctct
     1861 agagctgttt cctagtcgtg aatgcgtgat ggtccttctt tgtccctgca agtatgatcc
     1921 aacatggccc agttcagaat cagaatatgt cttctgtgtc atggtggcat ttggtccatg
     1981 gtgggagaaa gaaatcaact tttcccagtg gtggagtgag gacaggggag ggccggccct
     2041 ctcagccttg gatgtgatcc atttgctgta gtcttccacc ttggtgtaca gaaacaggcc
     2101 agggcacgtc tcaccaccga agttcaggac tcctctcaga acccacagat cgaactgctg
     2161 tagctggcac atcattgggc ttcctgggtc cccctgtgat aaaagacaga aggcttcaag
     2221 tcttagaaaa actagttttt gttgtaaatc tatccttgtg caatatactg tttgttctag
     2281 aaatgtttta cgctggttct cactggaaat ggggcaaatt ataggataca atttcaaatc
     2341 taggcagcca ccaccacaaa ttccaacaag atgacttttc cttttattat gcaaattagc
     2401 tgtggacttc tgctgattgc ctatagcttc ctggttcata tttcattttc ttgccccttt
     2461 ccagtccttt ggccaaacct tccctctctt ctggcttctc attcctgaaa tgttggtgtt
     2521 tgtttctgtt ttgtcctgaa atgctcacat tttcccttct ctgccttgct tcaaccctta
     2581 gtgtaagcca cttcctgcca cctggcaact gcttaccagc ctggctggcc gtgctctggg
     2641 tcttccctac tcccaatgga gcagtcctct gggacttggg aattctgcca catacacttt
     2701 atctaactta aagtgacgga gtagaagctt ggcatcatta gctagatatg ggaccctggc
     2761 aagtgaccaa atcctctctg agccaaggtg ggaacacagt taatgcctgt aacacgtgct
     2821 gagcacagca cagtgcctgg cacacagcaa acactcaata gaatattagc taccatcatc
     2881 ctgatgtcgc tataaaggcc agcatttttc tgaaaagttg gggaaaatgg gaaaagcaac
     2941 aaggcaacta gtaggtatca cttaccttac ctgcccagac cccacacccc taggtctcct
     3001 ctcaaaggaa ttcctgcccc tcccatggcc catcttggtc cgagaagggg gtggtcatcc
     3061 ccaggctagc cagccacttc tgacctgtgt ggcctgcctg gctggaaggc ccaggcaatg
     3121 acatgttgct ctcgcagttt ggactgagac atggaatggg gccgcaatta acaacaggaa
     3181 acaatctgaa cagactgaac cacgagcagc agaaaggcag aagagcagcc gcttcagccc
     3241 cttaccatcc gagacctggg tgtgtggtct gtcttggtca ctctctctgt ctctctttct
     3301 ctctttcttt ctctgtcccc aaggctggag tgcagtggtg caatcttggc tcactgcaac
     3361 ctccacctct gggattcaag caattctccc acctcagcct ctcgagtagc tggggctaca
     3421 gctatgcgcc accatgccca gctaattttt tttttttttt ttgagatgga gtcttgctct
     3481 gtcccccatg ctggagtgca gtggcatgat ctcggctcgc tgcaacctcc tcctcctggg
     3541 ttcaagcgat tctcctacct cagcctcccc agtagctggg attacaggcg cccaccacca
     3601 cacctggcta atttttattt ttagtagaga tggggtttca ccatgttggc caggctggtc
     3661 tcgaactcct gacctcatga tccacccgcc tcggcctccc caagtgttgg gattacaggc
     3721 gtgagccact gcacccggcc taatttctgt atttttagta gagatggggt ttcacgatgt
     3781 tggccaggct ggtcttaatc taacttcaag tgatctgccc gcctcgccct ctcaaagtgc
     3841 tgggattagg catgaactac catgcccagt ggggtattct ctttcaataa agctcctctt
     3901 ttccaaggaa gccacaccag aacagagatg aagaccagtg ggaaaacatg ggagcaactc
     3961 cgtgggcagg ccagcgggga ggccatgctg caaagctgcc gtgattccct ggtgatctct
     4021 cagcaggcca aggccagaca tgtgaggaag gccttgagga cttcattctg tgcctctcct
     4081 tggatggaag ggggtgcttt agtgtggcac tcctgacttt tcaattgact ggtgaagagg
     4141 cccttgtgtg cacctcacta tgtctgccta ggtcatgggg gctccctggc caagaatgac
     4201 gtggttcccc ctttcatcag tccgattcgc agtttgtctt aactgtagtg gtatagccag
     4261 agcaagaaaa agaatgtgat ttaggacaaa tgattggatg agtgattggt agatgtcctc
     4321 agctatggcg tggttttgca ggtcactgtt ccacccacct gggcacagca tatacgcttt
     4381 ttctcttccc cataatcctg taggggctgc gacttctgaa gcacaagagg cagaggcgaa
     4441 cagctccagg tgcccctctg gagctaccct acctcatctc ccaagggagc ggccacagcc
     4501 cagagtgggg tctttcattt tgtgatcttt tcccttgaca ttcagcaaaa gccctgacag
     4561 tggtagaata aaggcaggat gggtgagtgc agagtgattc tgcttttgtt gggtttcagg
     4621 gaaacccata ggcagattct gaacctggtg gttgattcta catgtgggaa ttgtggcttt
     4681 gaagacctct ggacatgaga acatatttcc aagacagagg attctatggg gacgggtcac
     4741 cattaaatgg tgtgcaagca taattctgtt caaaaatgaa ggcatgttta gaggtgtgtc
     4801 acagttaaaa accaacctga actttgcagt tagattttaa aagatggtca gttagagtag
     4861 aaatagctta gaatattcca ttgagtctaa gatacagtta gaaatcaaca tctttgaaat
     4921 tagggtgtgt cttttaatca gttgatgtca gagtttaacg ggcagcattt ttttctttct
     4981 tgggattaca aaaaatgatg gtgcattcta taattggcag catcttagat ctgaggaagt
     5041 atgatacttg tttgacggaa tggttgacgg cagaattttg ttaaaaagct atatcttcac
     5101 tgtattttaa cacattatct aatttaagaa attgttaaga tcccccacct ggcagaggac
     5161 ccagtacaaa ataggcactc aatagatgtt acaccaactt tggaagggca aacatatttc
     5221 ttaatgagag gcagtccttc atgttttgca ataaaatgac ttttaaaaaa aa
//
