LOCUS       NM_001085447            2153 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens cilia and flagella associated protein 210 (CFAP210),
            mRNA.
ACCESSION   NM_001085447 XM_926895 XM_939043
VERSION     NM_001085447.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2153)
  AUTHORS   Gui,M., Croft,J.T., Zabeo,D., Acharya,V., Kollman,J.M.,
            Burgoyne,T., Hoog,J.L. and Brown,A.
  TITLE     SPACA9 is a lumenal protein of human ciliary singlet and doublet
            microtubules
  JOURNAL   Proc Natl Acad Sci U S A 119 (41), e2207605119 (2022)
   PUBMED   36191189
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ432665.1, BC117445.1, CB250451.1 and AC016772.9.
            
            On Nov 23, 2018 this sequence version replaced NM_001085447.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK301851.1, BC117445.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000447353.6/ ENSP00000391504.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-548               BQ432665.1         19-566
            549-1828            BC117445.1         508-1787
            1829-2024           CB250451.1         148-343             c
            2025-2025           AC016772.9         56467-56467
            2026-2153           CB250451.1         19-146              c
FEATURES             Location/Qualifiers
     source          1..2153
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q31.1"
     gene            1..2153
                     /gene="CFAP210"
                     /gene_synonym="C2orf77; CCDC173"
                     /note="cilia and flagella associated protein 210"
                     /db_xref="GeneID:129881"
                     /db_xref="HGNC:HGNC:25064"
     exon            1..145
                     /gene="CFAP210"
                     /gene_synonym="C2orf77; CCDC173"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..1737
                     /gene="CFAP210"
                     /gene_synonym="C2orf77; CCDC173"
                     /note="coiled-coil domain-containing protein 173;
                     coiled-coil domain containing 173; protein CFAP210"
                     /codon_start=1
                     /product="cilia- and flagella- associated protein 210"
                     /protein_id="NP_001078916.1"
                     /db_xref="CCDS:CCDS46445.1"
                     /db_xref="GeneID:129881"
                     /db_xref="HGNC:HGNC:25064"
                     /translation="MDTSSEMLVRFGRRCGRAKESTEIRNSEEDQVLYLPLLPSKVDL
                     QQVTIIPHDEWKRIQDSLDRLTREAACLRAERKAKKEMHLRSQEVVKHWTNTYAGMKE
                     QKLEAKKKRDEEIEAERQILDLEEEIYKQGKRKKAIENAKQYQFYQTERVKNFHSGLL
                     LSRVMKERDAQIEFRKSKIKSDKKWEEQLKLNIEKAFKEEQEKAEKRHRERVALAKDH
                     LKQIKEHEEEEERRKKYEEKDAEEIKRQNALYEIEMRKKLEKKREEMHESRRRFLEHM
                     QDKHIIKAVEQQQQEEEDEKMRKFIKAKKRLIQMGKEKEAETHRLMEKRRERIHNFLS
                     ELLKEKLDNEDMIIARDIAEAEAEWEKREREKDEKNKAELKTIAEYRAIVMKNKEEEE
                     RQRKIEAKEQLLAVMKADQIFWEHEKEKKCKADKEHQEVQDAHIQQMAKNKFNAKQAK
                     QAELDYCRLTEALVAEKEKEFQDYAREVIELESETTNKYIYPLVKAVQEGPGGGRGPV
                     FVDRGGLRPSYQANDVTGVQLPFYNSQGPKYNFQKSKRRLGFTW"
     exon            146..372
                     /gene="CFAP210"
                     /gene_synonym="C2orf77; CCDC173"
                     /inference="alignment:Splign:2.1.0"
     exon            373..546
                     /gene="CFAP210"
                     /gene_synonym="C2orf77; CCDC173"
                     /inference="alignment:Splign:2.1.0"
     exon            547..740
                     /gene="CFAP210"
                     /gene_synonym="C2orf77; CCDC173"
                     /inference="alignment:Splign:2.1.0"
     exon            741..897
                     /gene="CFAP210"
                     /gene_synonym="C2orf77; CCDC173"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1037
                     /gene="CFAP210"
                     /gene_synonym="C2orf77; CCDC173"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1230
                     /gene="CFAP210"
                     /gene_synonym="C2orf77; CCDC173"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1395
                     /gene="CFAP210"
                     /gene_synonym="C2orf77; CCDC173"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..2153
                     /gene="CFAP210"
                     /gene_synonym="C2orf77; CCDC173"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1812..1817
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CFAP210"
                     /gene_synonym="C2orf77; CCDC173"
                     /note="hexamer: AATAAA"
     polyA_site      1839
                     /gene="CFAP210"
                     /gene_synonym="C2orf77; CCDC173"
                     /note="major polyA site"
     regulatory      2133..2138
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CFAP210"
                     /gene_synonym="C2orf77; CCDC173"
                     /note="hexamer: AATAAA"
     polyA_site      2153
                     /gene="CFAP210"
                     /gene_synonym="C2orf77; CCDC173"
                     /note="major polyA site"
ORIGIN      
        1 gtggtacgag taacaactcc accggctggc gtccgcggcg cttggcgcca cagtcacttt
       61 tccagatcta ggagcatcat ggacacctcg tcagagatgc tggtacggtt tggacggcgc
      121 tgtggacggg cgaaggaaag tacagaaata agaaactctg aagaagatca agttctctat
      181 ctgcctcttc tacctagcaa agtagatctc cagcaggtca ccataattcc acacgatgag
      241 tggaaaagga ttcaagatag ccttgacagg ttgacaagag aagcagcatg cctccgtgca
      301 gaaagaaagg caaagaaaga aatgcatttg cgatctcaag aagtggtaaa acactggact
      361 aatacatatg cagggatgaa agaacagaaa cttgaagcca aaaagaagcg tgatgaagaa
      421 atagaggcag aaagacaaat tcttgatctg gaagaagaaa tatacaaaca aggaaaaaga
      481 aaaaaggcca ttgaaaatgc aaagcaatat caattttacc agacagaaag agtgaaaaac
      541 tttcattcgg gacttcttct tagtagagtt atgaaagaac gtgatgccca gattgaattc
      601 cgaaagagta agataaaatc agataaaaaa tgggaggaac agttgaaact caacattgaa
      661 aaagctttta aagaagaaca agaaaaagca gaaaaacgac acagagaaag ggtggctctt
      721 gccaaagatc atctaaaaca aataaaggaa catgaggaag aagaggaaag aaggaaaaaa
      781 tatgaagaaa aagatgctga ggaaataaag cgacagaatg cattatatga aattgaaatg
      841 agaaaaaaac tagaaaagaa aagagaagag atgcatgaaa gcaggagacg gtttcttgaa
      901 catatgcagg ataaacatat tatcaaagct gtagaacagc agcagcaaga ggaagaagat
      961 gaaaagatga gaaaattcat caaagcaaaa aagcgtctta tacaaatggg gaaagaaaaa
     1021 gaggctgaaa cacacaggct tatggagaaa cgaagagaaa gaatacataa cttcctgagt
     1081 gaactgttga aagagaaact tgacaatgaa gatatgatta ttgctagaga tattgcagaa
     1141 gctgaggctg aatgggaaaa aagagaaaga gaaaaagatg aaaaaaacaa agcagaatta
     1201 aaaacaattg cagaatatcg agccattgtg atgaaaaata aagaggaaga agaaagacaa
     1261 agaaaaatag aggctaaaga acaattgctg gctgtcatga aagcagatca gattttctgg
     1321 gaacatgaaa aggagaaaaa atgcaaagct gataaagaac atcaagaggt tcaagatgcc
     1381 catattcagc aaatggccaa aaataagttt aatgcaaagc aagcaaaaca agcagaatta
     1441 gattattgca gacttactga agctcttgtg gctgaaaagg agaaagaatt tcaggactat
     1501 gccagagagg taattgaact tgaatcggaa acaacaaata aatatattta ccctcttgta
     1561 aaagctgtac aggaaggacc tggaggtggc cgtggaccag tgtttgtgga cagaggtgga
     1621 ttaagaccca gctatcaggc aaatgatgtt actggagtcc agctcccttt ttataactct
     1681 cagggaccaa aatataattt tcaaaagtca aagagaaggc taggttttac atggtagaaa
     1741 aaaattattt ttaacattga gaagactaag ttgtagcata tatgagcttc aaatataaat
     1801 ggatttcagt taataaagct gttcttcatc taagtacaat tatgtctgat ttaattgatt
     1861 gttctcagta tttcttttgg gtatatataa aaccccaatt ttgagattcc tttttttaac
     1921 tgtggtaaaa tacacaagtt tactttttaa atgtacattc agtggtatta agtacattca
     1981 aaatattgtg tagccatgac cattgtgtag ttccagaatt tttcagtgct cttactagaa
     2041 accccatacc cattcattaa gcagtcactc cccattcccc ttccccacag ctcctggtaa
     2101 ctttatctgc tttgcctata ctgggtattt tgaataaaca gaatcatact gtg
//
