LOCUS       NM_001031743            2207 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens cilia and flagella associated protein 206 (CFAP206),
            mRNA.
ACCESSION   NM_001031743
VERSION     NM_001031743.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2207)
  AUTHORS   Shen,Q., Martinez,G., Liu,H., Beurois,J., Wu,H., Amiri-Yekta,A.,
            Liang,D., Kherraf,Z.E., Bidart,M., Cazin,C., Celse,T., Satre,V.,
            Thierry-Mieg,N., Whitfield,M., Toure,A., Song,B., Lv,M., Li,K.,
            Liu,C., Tao,F., He,X., Zhang,F., Arnoult,C., Ray,P.F., Cao,Y. and
            Coutton,C.
  TITLE     Bi-allelic truncating variants in CFAP206 cause male infertility in
            human and mouse
  JOURNAL   Hum Genet 140 (9), 1367-1377 (2021)
   PUBMED   34255152
  REMARK    GeneRIF: Bi-allelic truncating variants in CFAP206 cause male
            infertility in human and mouse.
REFERENCE   2  (bases 1 to 2207)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2207)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2207)
  AUTHORS   Sahni,N., Yi,S., Taipale,M., Fuxman Bass,J.I.,
            Coulombe-Huntington,J., Yang,F., Peng,J., Weile,J., Karras,G.I.,
            Wang,Y., Kovacs,I.A., Kamburov,A., Krykbaeva,I., Lam,M.H.,
            Tucker,G., Khurana,V., Sharma,A., Liu,Y.Y., Yachie,N., Zhong,Q.,
            Shen,Y., Palagi,A., San-Miguel,A., Fan,C., Balcha,D., Dricot,A.,
            Jordan,D.M., Walsh,J.M., Shah,A.A., Yang,X., Stoyanova,A.K.,
            Leighton,A., Calderwood,M.A., Jacob,Y., Cusick,M.E.,
            Salehi-Ashtiani,K., Whitesell,L.J., Sunyaev,S., Berger,B.,
            Barabasi,A.L., Charloteaux,B., Hill,D.E., Hao,T., Roth,F.P.,
            Xia,Y., Walhout,A.J.M., Lindquist,S. and Vidal,M.
  TITLE     Widespread macromolecular interaction perturbations in human
            genetic disorders
  JOURNAL   Cell 161 (3), 647-660 (2015)
   PUBMED   25910212
REFERENCE   5  (bases 1 to 2207)
  AUTHORS   Gupta,A., Diener,D.R., Sivadas,P., Rosenbaum,J.L. and Yang,P.
  TITLE     The versatile molecular complex component LC8 promotes several
            distinct steps of flagellar assembly
  JOURNAL   J Cell Biol 198 (1), 115-126 (2012)
   PUBMED   22753897
REFERENCE   6  (bases 1 to 2207)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   7  (bases 1 to 2207)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL049697.9.
            
            On Nov 23, 2018 this sequence version replaced NM_001031743.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.389050.1,
                                           SRR1803617.108958.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2144120
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369562.9/ ENSP00000358575.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-118               AL049697.9         6410-6527
            119-231             AL049697.9         8273-8385
            232-315             AL049697.9         9023-9106
            316-406             AL049697.9         12248-12338
            407-595             AL049697.9         14124-14312
            596-754             AL049697.9         15107-15265
            755-963             AL049697.9         16646-16854
            964-1083            AL049697.9         24964-25083
            1084-1282           AL049697.9         27064-27262
            1283-1423           AL049697.9         29471-29611
            1424-1617           AL049697.9         33298-33491
            1618-1761           AL049697.9         59460-59603
            1762-2207           AL049697.9         62458-62903
FEATURES             Location/Qualifiers
     source          1..2207
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q15"
     gene            1..2207
                     /gene="CFAP206"
                     /gene_synonym="C6orf165; dJ382I10.1"
                     /note="cilia and flagella associated protein 206"
                     /db_xref="GeneID:154313"
                     /db_xref="HGNC:HGNC:21405"
     exon            1..118
                     /gene="CFAP206"
                     /gene_synonym="C6orf165; dJ382I10.1"
                     /inference="alignment:Splign:2.1.0"
     exon            119..231
                     /gene="CFAP206"
                     /gene_synonym="C6orf165; dJ382I10.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..1992
                     /gene="CFAP206"
                     /gene_synonym="C6orf165; dJ382I10.1"
                     /note="UPF0704 protein C6orf165"
                     /codon_start=1
                     /product="cilia- and flagella-associated protein 206"
                     /protein_id="NP_001026913.1"
                     /db_xref="CCDS:CCDS34498.1"
                     /db_xref="GeneID:154313"
                     /db_xref="HGNC:HGNC:21405"
                     /translation="MPPTQAESVIRSIIREIGQECAAHGEIVSETLIAFMVKAVVLDP
                     SNGFNMDRTLMKSDVQNLVKLCMTRLLDTKNPSLDTIKMQVYFDMNYTNRVEFLEEHH
                     RVLESRLGSVTREITDNRACAKEELESLYRKIISYVLLRSGLGSPTDIKTVREVTAAL
                     QSVFPQAELGTFLTLSKKDKERQLKELTMIVTGIRLFNRDCGKGGEGIDDLPAVLHVA
                     IPATMQHIDYQLETARSQVYRYTAILEKAANDPLMRAELQPYMLKEALYNIRQYEVFL
                     QIILSDIITGAQEVEMMTKQLGAHLEQLKMTIKSKIAVPTSQVFPIFIALSTLWTSLQ
                     DETIVVGVLSNLFTHIQPFLGAHELYFPERVMQCHLNGATVKTDVCRMKEHMEDRVNV
                     ADFRKLEWLFPETTANFDKLLIQYRGFCAYTFAATDGLLLPGNPAIGILKYKEKYYTF
                     NSKDAAYSFAENPEHYIDIVREKAKKNTELIQLLELHQQFETFIPYSQMRDADKHYIK
                     PITKCESSTQTNTHILPPTIVRSYEWNEWELRRKAIKLANLRQKVTHSVQTDLSHLRR
                     ENCSQVYPPKDTSTQSMREDSTGVPRPQIYLAGLRGGKSEITDEVKVNLTRDVDET"
     exon            232..315
                     /gene="CFAP206"
                     /gene_synonym="C6orf165; dJ382I10.1"
                     /inference="alignment:Splign:2.1.0"
     exon            316..406
                     /gene="CFAP206"
                     /gene_synonym="C6orf165; dJ382I10.1"
                     /inference="alignment:Splign:2.1.0"
     exon            407..595
                     /gene="CFAP206"
                     /gene_synonym="C6orf165; dJ382I10.1"
                     /inference="alignment:Splign:2.1.0"
     exon            596..754
                     /gene="CFAP206"
                     /gene_synonym="C6orf165; dJ382I10.1"
                     /inference="alignment:Splign:2.1.0"
     exon            755..963
                     /gene="CFAP206"
                     /gene_synonym="C6orf165; dJ382I10.1"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1083
                     /gene="CFAP206"
                     /gene_synonym="C6orf165; dJ382I10.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1282
                     /gene="CFAP206"
                     /gene_synonym="C6orf165; dJ382I10.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1423
                     /gene="CFAP206"
                     /gene_synonym="C6orf165; dJ382I10.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1617
                     /gene="CFAP206"
                     /gene_synonym="C6orf165; dJ382I10.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..1761
                     /gene="CFAP206"
                     /gene_synonym="C6orf165; dJ382I10.1"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..2207
                     /gene="CFAP206"
                     /gene_synonym="C6orf165; dJ382I10.1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2183..2188
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CFAP206"
                     /gene_synonym="C6orf165; dJ382I10.1"
                     /note="hexamer: AATAAA"
     polyA_site      2207
                     /gene="CFAP206"
                     /gene_synonym="C6orf165; dJ382I10.1"
                     /note="major polyA site"
ORIGIN      
        1 cttccatctc catggttacg cggcggtggc tgcgagcgcc caactgctcc gaccgtcgcg
       61 gtgagggccc caggacagaa gcagacagac acggctcctg ctgtcgattc cgatccagcc
      121 agaatgcctc caactcaggc cgaaagtgtt ataaggagta ttatacgaga aataggacaa
      181 gaatgtgcag cccatggaga gattgtttct gaaactctga ttgcttttat ggtgaaagct
      241 gttgtcctgg atccaagtaa tggctttaac atggatagaa ccctcatgaa aagtgatgtg
      301 cagaatcttg ttaagctttg tatgactcgg ctattggata ctaaaaatcc atccctggac
      361 actattaaga tgcaagtcta cttcgatatg aattatacga atcgagtgga atttctcgaa
      421 gaacatcacc gggtcctaga gtctagatta ggctctgtta cccgagaaat tacagataac
      481 agagcatgtg ctaaagaaga attggaaagc ctctaccgga agattatcag ctatgtgtta
      541 ctccgctctg gccttggatc ccctacagac atcaagactg tcagagaggt aacagctgct
      601 ctacagagtg tttttcctca ggcagagctt gggacatttc taactctttc taagaaggac
      661 aaagaacgcc agctgaaaga actcaccatg attgttactg gaattcgttt atttaacaga
      721 gactgtggaa aaggaggaga aggcattgat gatttgccag ctgttctcca tgtagcaatc
      781 ccagccacca tgcagcatat tgattaccag cttgagactg cccggagcca ggtataccgc
      841 tacacagcca tccttgagaa ggcagccaac gacccactca tgagggctga acttcagcca
      901 tatatgttaa aagaagcgct atataatata cgacaatatg aggtcttcct tcagatcatt
      961 ttgtcagata taattactgg tgctcaagaa gtggaaatga tgacaaaaca gttaggagcc
     1021 catctggaac aactaaaaat gaccataaaa tcaaagatag cggtcccaac atcacaagtc
     1081 tttcctatct tcattgcact ttctactctg tggaccagct tgcaagacga aactattgtg
     1141 gttggtgtcc tcagtaattt attcactcac attcagccat tcttgggtgc tcacgaacta
     1201 tactttcctg agagagtgat gcaatgtcat cttaatggag cgactgtgaa aactgatgtg
     1261 tgtagaatga aagaacacat ggaagataga gtaaatgtgg cagatttcag aaaactagaa
     1321 tggcttttcc cagaaacaac agcaaatttt gataaactgt taattcaata tcggggattt
     1381 tgtgcttaca cgtttgctgc aacagatggt cttctccttc caggaaatcc agcaattgga
     1441 attttaaaat ataaagaaaa atattacaca ttcaatagta aagatgctgc atattcattt
     1501 gcagaaaatc ctgaacatta tattgacata gttagagaaa aggccaaaaa aaatacagag
     1561 ttaattcaac tattggaact tcatcaacag tttgaaacat ttattccata ttctcagatg
     1621 agagatgctg acaaacatta tataaaacca attacaaaat gtgaaagtag cacacagacg
     1681 aatacacaca tactgccacc aacgattgtg agatcatatg agtggaatga atgggaatta
     1741 agaagaaaag ctataaaatt ggctaatttg cgccagaaag ttactcactc agtacaaact
     1801 gatcttagtc acttgagaag agaaaattgt tcccaagtgt accctccaaa ggacactagc
     1861 acccagtcca tgagggaaga cagcactggg gtgcccaggc ctcagattta cttggctggt
     1921 cttcgtggag gaaagagcga aatcaccgat gaggtcaagg tgaacttaac tagagatgtg
     1981 gatgaaacct aattacagac aacgttttaa aatagatgct actcaattat gaacaatagc
     2041 aagtacttaa aggtatatta acatctatac aaattaattt tgtaggggtg gcacattcat
     2101 tggttgtgtg actgtttatt gggttcccat attttatcaa actgttttct gtaacacatt
     2161 tttcattctg ttgaaattga aaaataaaac tgtccattta tctttta
//
