LOCUS       NM_013242               1281 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens cilia and flagella associated protein 20 (CFAP20),
            mRNA.
ACCESSION   NM_013242
VERSION     NM_013242.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1281)
  AUTHORS   Gui,M., Croft,J.T., Zabeo,D., Acharya,V., Kollman,J.M.,
            Burgoyne,T., Hoog,J.L. and Brown,A.
  TITLE     SPACA9 is a lumenal protein of human ciliary singlet and doublet
            microtubules
  JOURNAL   Proc Natl Acad Sci U S A 119 (41), e2207605119 (2022)
   PUBMED   36191189
REFERENCE   2  (bases 1 to 1281)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1281)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1281)
  AUTHORS   Lee,J.H., Han,J.H., Kim,H., Park,S.M., Joe,E.H. and Jou,I.
  TITLE     Parkinson's disease-associated LRRK2-G2019S mutant acts through
            regulation of SERCA activity to control ER stress in astrocytes
  JOURNAL   Acta Neuropathol Commun 7 (1), 68 (2019)
   PUBMED   31046837
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1281)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 1281)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   7  (bases 1 to 1281)
  AUTHORS   Laligne,C., Klotz,C., de Loubresse,N.G., Lemullois,M., Hori,M.,
            Laurent,F.X., Papon,J.F., Louis,B., Cohen,J. and Koll,F.
  TITLE     Bug22p, a conserved centrosomal/ciliary protein also present in
            higher plants, is required for an effective ciliary stroke in
            Paramecium
  JOURNAL   Eukaryot Cell 9 (4), 645-655 (2010)
   PUBMED   20118210
REFERENCE   8  (bases 1 to 1281)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   9  (bases 1 to 1281)
  AUTHORS   Jin,J., Smith,F.D., Stark,C., Wells,C.D., Fawcett,J.P.,
            Kulkarni,S., Metalnikov,P., O'Donnell,P., Taylor,P., Taylor,L.,
            Zougman,A., Woodgett,J.R., Langeberg,L.K., Scott,J.D. and Pawson,T.
  TITLE     Proteomic, functional, and domain-based analysis of in vivo 14-3-3
            binding proteins involved in cytoskeletal regulation and cellular
            organization
  JOURNAL   Curr Biol 14 (16), 1436-1450 (2004)
   PUBMED   15324660
REFERENCE   10 (bases 1 to 1281)
  AUTHORS   Rijkers,T. and Ruther,U.
  TITLE     Sequence and expression pattern of an evolutionarily conserved
            transcript identified by gene trapping
  JOURNAL   Biochim Biophys Acta 1307 (3), 294-300 (1996)
   PUBMED   8688464
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AV751497.1 and BC005152.2.
            
            On Nov 23, 2018 this sequence version replaced NM_013242.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.215958.1,
                                           SRR5189655.102631.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2467144
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262498.8/ ENSP00000262498.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                AV751497.1         12-40
            30-1281             BC005152.2         10-1261
FEATURES             Location/Qualifiers
     source          1..1281
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q21"
     gene            1..1281
                     /gene="CFAP20"
                     /gene_synonym="BUG22; C16orf80; EVORF; fSAP23; GTL3"
                     /note="cilia and flagella associated protein 20"
                     /db_xref="GeneID:29105"
                     /db_xref="HGNC:HGNC:29523"
                     /db_xref="MIM:617906"
     exon            1..350
                     /gene="CFAP20"
                     /gene_synonym="BUG22; C16orf80; EVORF; fSAP23; GTL3"
                     /inference="alignment:Splign:2.1.0"
     CDS             267..848
                     /gene="CFAP20"
                     /gene_synonym="BUG22; C16orf80; EVORF; fSAP23; GTL3"
                     /note="transcription factor IIB; functional
                     spliceosome-associated protein 23; gene trap locus 3;
                     UPF0468 protein C16orf80; flagellar associated protein 20
                     homolog; basal body up-regulated protein 22"
                     /codon_start=1
                     /product="cilia- and flagella-associated protein 20"
                     /protein_id="NP_037374.1"
                     /db_xref="CCDS:CCDS10793.1"
                     /db_xref="GeneID:29105"
                     /db_xref="HGNC:HGNC:29523"
                     /db_xref="MIM:617906"
                     /translation="MFKNTFQSGFLSILYSIGSKPLQIWDKKVRNGHIKRITDNDIQS
                     LVLEIEGTNVSTTYITCPADPKKTLGIKLPFLVMIIKNLKKYFTFEVQVLDDKNVRRR
                     FRASNYQSTTRVKPFICTMPMRLDDGWNQIQFNLLDFTRRAYGTNYIETLRVQIHANC
                     RIRRVYFSDRLYSEDELPAEFKLYLPVQNKAKQ"
     exon            351..430
                     /gene="CFAP20"
                     /gene_synonym="BUG22; C16orf80; EVORF; fSAP23; GTL3"
                     /inference="alignment:Splign:2.1.0"
     exon            431..542
                     /gene="CFAP20"
                     /gene_synonym="BUG22; C16orf80; EVORF; fSAP23; GTL3"
                     /inference="alignment:Splign:2.1.0"
     exon            543..731
                     /gene="CFAP20"
                     /gene_synonym="BUG22; C16orf80; EVORF; fSAP23; GTL3"
                     /inference="alignment:Splign:2.1.0"
     exon            732..842
                     /gene="CFAP20"
                     /gene_synonym="BUG22; C16orf80; EVORF; fSAP23; GTL3"
                     /inference="alignment:Splign:2.1.0"
     exon            843..1281
                     /gene="CFAP20"
                     /gene_synonym="BUG22; C16orf80; EVORF; fSAP23; GTL3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1253..1258
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CFAP20"
                     /gene_synonym="BUG22; C16orf80; EVORF; fSAP23; GTL3"
                     /note="hexamer: AATAAA"
     polyA_site      1281
                     /gene="CFAP20"
                     /gene_synonym="BUG22; C16orf80; EVORF; fSAP23; GTL3"
                     /note="major polyA site"
ORIGIN      
        1 attgaaggcg gggaaatacc gcggcgcgga cggtagttgc tgtggtttcc gttctgagct
       61 cgcagcttag gagctgaaga tcgcggactt agcgttgccg cgtccgagtc cggccatcag
      121 tggctgcaga tccggaggcc aggagctcaa ccacccttct tcggaacagg gccggcctgc
      181 tgctgtgccc tcgacgctcg gtgcctgtat ctactccggg gcctaggtcg gctccggggg
      241 cggcttagga gaaggccgcc ggcgagatgt tcaaaaacac gttccagagc ggcttcctct
      301 ccatcctcta cagcatcggc agcaagcctc tgcaaatctg ggacaaaaag gtacggaatg
      361 gccacatcaa aagaatcact gataatgaca tccagtccct ggtgctagag attgaaggga
      421 caaatgtaag caccacatat atcacatgcc ctgcagaccc caagaagacg ctgggaatta
      481 aacttccttt ccttgtcatg attatcaaaa acctgaagaa gtattttacc ttcgaagtgc
      541 aggtactaga tgacaagaat gtgcgtcgtc gctttcgggc aagtaactac cagagcacca
      601 cccgggtcaa acccttcatc tgcaccatgc ccatgcggct ggatgacggc tggaaccaga
      661 ttcagttcaa cttgctagac ttcacacggc gagcatacgg caccaattac atcgagaccc
      721 tcagagtgca gatccatgca aattgtcgca tccgacgggt ttacttctca gacagactct
      781 actcagaaga tgagctgccg gcagagttca aactgtatct cccagttcag aacaaggcaa
      841 agcaataact ggaattgtga ctcgagggat agacccctgg atgtgactct tctttttaaa
      901 aggaaactat gtggaggacg atgcaaaaac atatttatct tagtttgctc tgctgtagtt
      961 ctgttattta tacttggtgt tgcttgtcat ggacaccggt gaacatgccg taactctgtg
     1021 actgcattgt aagtgcagtg ggggtaagca gtcctgtgag tggcgcatga acgctggagc
     1081 ttattccgcc gcctgcccca gtgtgggggg agataccttt accatgaact tacagaatta
     1141 aagatggccc ataaggaatt ccagaccaat atttcttcct gcggtttatt ctatgtttta
     1201 tatattatct aaatatatgt atatgctgtg tcatactcat aatctggaaa tgaataaagt
     1261 gatatattcc tggtttgtaa a
//
