LOCUS       NM_173528               1612 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens cilia and flagella associated protein 161 (CFAP161),
            transcript variant 1, mRNA.
ACCESSION   NM_173528
VERSION     NM_173528.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1612)
  AUTHORS   Gui,M., Croft,J.T., Zabeo,D., Acharya,V., Kollman,J.M.,
            Burgoyne,T., Hoog,J.L. and Brown,A.
  TITLE     SPACA9 is a lumenal protein of human ciliary singlet and doublet
            microtubules
  JOURNAL   Proc Natl Acad Sci U S A 119 (41), e2207605119 (2022)
   PUBMED   36191189
REFERENCE   2  (bases 1 to 1612)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1612)
  AUTHORS   Austin-Tse,C., Halbritter,J., Zariwala,M.A., Gilberti,R.M.,
            Gee,H.Y., Hellman,N., Pathak,N., Liu,Y., Panizzi,J.R.,
            Patel-King,R.S., Tritschler,D., Bower,R., O'Toole,E., Porath,J.D.,
            Hurd,T.W., Chaki,M., Diaz,K.A., Kohl,S., Lovric,S., Hwang,D.Y.,
            Braun,D.A., Schueler,M., Airik,R., Otto,E.A., Leigh,M.W.,
            Noone,P.G., Carson,J.L., Davis,S.D., Pittman,J.E., Ferkol,T.W.,
            Atkinson,J.J., Olivier,K.N., Sagel,S.D., Dell,S.D., Rosenfeld,M.,
            Milla,C.E., Loges,N.T., Omran,H., Porter,M.E., King,S.M.,
            Knowles,M.R., Drummond,I.A. and Hildebrandt,F.
  TITLE     Zebrafish Ciliopathy Screen Plus Human Mutational Analysis
            Identifies C21orf59 and CCDC65 Defects as Causing Primary Ciliary
            Dyskinesia
  JOURNAL   Am J Hum Genet 93 (4), 672-686 (2013)
   PUBMED   24094744
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC398841.1, BC062471.1 and AC036196.10.
            
            On Nov 22, 2018 this sequence version replaced NM_173528.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062471.1, SRR5189667.218398.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2144333
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: lack of evidence for use of
                                                upstream AUG
            MANE Ensembl match               :: ENST00000286732.5/
                                                ENSP00000286732.4
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                DC398841.1         34-66
            34-1608             BC062471.1         1-1575
            1609-1612           AC036196.10        96576-96579
FEATURES             Location/Qualifiers
     source          1..1612
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q25.1"
     gene            1..1612
                     /gene="CFAP161"
                     /gene_synonym="C15orf26"
                     /note="cilia and flagella associated protein 161"
                     /db_xref="GeneID:161502"
                     /db_xref="HGNC:HGNC:26782"
     exon            1..129
                     /gene="CFAP161"
                     /gene_synonym="C15orf26"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..966
                     /gene="CFAP161"
                     /gene_synonym="C15orf26"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="cilia- and flagella-associated protein 161
                     isoform 1"
                     /protein_id="NP_775799.2"
                     /db_xref="CCDS:CCDS42068.1"
                     /db_xref="GeneID:161502"
                     /db_xref="HGNC:HGNC:26782"
                     /translation="MAQNVYGPGVRIGNWNEDVYLEEELMKDFLEKRDKGKLLIQRSR
                     RLKQNLLRPMQLSVTEDGYIHYGDKVMLVNPDDPDTEADVFLRGDLSLCMTPDEIQSH
                     LKDELEVPCGLSAVQAKTPIGRNTFIILSVHRDATGQVLRYGQDFCLGITGGFDNKML
                     YLSSDHRTLLKSSKRSWLQEVYLTDEVSHVNCWQAAFPDPQLRLEYEGFPVPANAKIL
                     INHCHTNRGLAAHRHLFLSTYFGKEAEVVAHTYLDSHRVEKPRNHWMLVTGNPRDASS
                     SMLDLPKPPTEDTRAMEQAMGLDTQ"
     exon            130..219
                     /gene="CFAP161"
                     /gene_synonym="C15orf26"
                     /inference="alignment:Splign:2.1.0"
     exon            220..452
                     /gene="CFAP161"
                     /gene_synonym="C15orf26"
                     /inference="alignment:Splign:2.1.0"
     exon            453..537
                     /gene="CFAP161"
                     /gene_synonym="C15orf26"
                     /inference="alignment:Splign:2.1.0"
     exon            538..696
                     /gene="CFAP161"
                     /gene_synonym="C15orf26"
                     /inference="alignment:Splign:2.1.0"
     exon            697..770
                     /gene="CFAP161"
                     /gene_synonym="C15orf26"
                     /inference="alignment:Splign:2.1.0"
     exon            771..1612
                     /gene="CFAP161"
                     /gene_synonym="C15orf26"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1589..1594
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CFAP161"
                     /gene_synonym="C15orf26"
                     /note="hexamer: AATAAA"
     polyA_site      1612
                     /gene="CFAP161"
                     /gene_synonym="C15orf26"
                     /note="major polyA site"
ORIGIN      
        1 gacgcgccac gctaacgcat ggtgtcggag ggaggcccac ttgctgaaca gcagggagcg
       61 atggcgcaga acgtgtatgg tccgggagtc cggataggca actggaatga ggatgtctac
      121 ctggaggagg agctcatgaa agacttctta gagaagagag acaaggggaa acttctcata
      181 cagagaagta gaagactaaa acagaatctc ttgagaccga tgcaactttc cgtaactgaa
      241 gatggctata ttcattacgg tgacaaagtg atgcttgtga atcctgatga tcctgacaca
      301 gaagctgatg tgtttctgcg tggggacctg agcctgtgta tgactccaga tgaaattcag
      361 tcccatctga aagacgaatt agaggtaccc tgtggcctga gcgcagttca agccaagacc
      421 ccaattggca gaaacacttt tatcattttg agtgtacaca gagatgccac tggtcaagtc
      481 cttagatatg ggcaggactt ttgcctgggg ataacaggag gatttgacaa caaaatgttg
      541 tatttgtcaa gtgaccacag gaccctcctg aaatcgtcta agaggtcttg gctccaggaa
      601 gtgtacctaa cagatgaggt ctcccatgtg aactgctggc aggctgcctt ccctgacccc
      661 cagttacgcc tggaatatga aggcttcccc gtcccggcaa atgctaaaat tctcatcaat
      721 cactgtcaca caaatcgggg actggcagcc caccggcatc ttttcttaag cacctatttt
      781 ggaaaggagg ctgaggttgt agctcacaca tacctggatt cacatagagt tgagaaacca
      841 aggaaccact ggatgttggt tactgggaat cccagggatg cctcgtcctc catgttggat
      901 ctgcccaaac cacccacaga ggacactcga gccatggagc aggccatggg ccttgacacg
      961 cagtaacacg ccaggcacgt gcatgttttc cctggtcccg ctctcatcaa atgtagcttt
     1021 aaaagaaatt aacaaccttg gtcatgcctc aagctatttt tgaatcagat gtgggactct
     1081 ctgggcacta tattaaaata aagattacat taagattatt gaatttgtgg tgggagtcta
     1141 gggctgaaga aaaacagctc tggagaataa ttagtatttg aaagtgacaa acaatagcct
     1201 tttgttgata aacaaattct gaagaactca gcttcctcta cttatatcct tcattgtcta
     1261 caaggacagt gcgttacttt ttaaagttat gtctatgtaa taaagctgtt ggacctatac
     1321 tgaatttttg gtaccacagt ttccctcttg aatgtactaa aacacaaaaa actgacagct
     1381 ctgagctgtg gccttacctt ggaattaaac atttccacct ttgtaaaaca tcctattttt
     1441 gtttctacct ttggctttcc aggtcaggac ctctacctga tcagtaacct attattttgt
     1501 aatgattttt aagctgcaga atctctacct tgtctttgaa actggcacat tagttgtggc
     1561 acccatgtga ttagatagtt cctgacaaaa taaatgtatg tccttccatg ta
//
