LOCUS       NM_001010979             674 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens cilia and flagella associated protein 141 (CFAP141),
            mRNA.
ACCESSION   NM_001010979 XM_371315
VERSION     NM_001010979.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 674)
  AUTHORS   Gui,M., Croft,J.T., Zabeo,D., Acharya,V., Kollman,J.M.,
            Burgoyne,T., Hoog,J.L. and Brown,A.
  TITLE     SPACA9 is a lumenal protein of human ciliary singlet and doublet
            microtubules
  JOURNAL   Proc Natl Acad Sci U S A 119 (41), e2207605119 (2022)
   PUBMED   36191189
REFERENCE   2  (bases 1 to 674)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 674)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY025946.1 and AI052706.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001010979.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: HY025946.1, BC127710.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2144333
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368525.4/ ENSP00000357511.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-438               HY025946.1         33-470
            439-674             AI052706.1         15-250              c
FEATURES             Location/Qualifiers
     source          1..674
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..674
                     /gene="CFAP141"
                     /gene_synonym="C1orf189"
                     /note="cilia and flagella associated protein 141"
                     /db_xref="GeneID:388701"
                     /db_xref="HGNC:HGNC:32305"
     exon            1..59
                     /gene="CFAP141"
                     /gene_synonym="C1orf189"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..332
                     /gene="CFAP141"
                     /gene_synonym="C1orf189"
                     /note="uncharacterized protein C1orf189; protein CFAP141"
                     /codon_start=1
                     /product="cilia- and flagella-associated protein 141"
                     /protein_id="NP_001010979.1"
                     /db_xref="CCDS:CCDS30876.1"
                     /db_xref="GeneID:388701"
                     /db_xref="HGNC:HGNC:32305"
                     /translation="MSVEKMTKVEESFQKAMGLKKTVDRWRNSHTHCLWQMALGQRRN
                     PYATLRMQDTMVQELALAKKQLLMVRQAALHQLFEKEHQQYQQELNQMGKAFYVERF"
     exon            60..100
                     /gene="CFAP141"
                     /gene_synonym="C1orf189"
                     /inference="alignment:Splign:2.1.0"
     exon            101..230
                     /gene="CFAP141"
                     /gene_synonym="C1orf189"
                     /inference="alignment:Splign:2.1.0"
     exon            231..674
                     /gene="CFAP141"
                     /gene_synonym="C1orf189"
                     /inference="alignment:Splign:2.1.0"
     regulatory      648..653
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CFAP141"
                     /gene_synonym="C1orf189"
                     /note="hexamer: AATAAA"
     polyA_site      674
                     /gene="CFAP141"
                     /gene_synonym="C1orf189"
                     /note="major polyA site"
ORIGIN      
        1 agactgtatc aagcaaatct atagacatgt ctgtggaaaa gatgacaaaa gtagaagaga
       61 gttttcaaaa ggccatggga cttaagaaga cggtcgacag gtggcgaaat tcacatactc
      121 actgtctgtg gcaaatggca ttgggccaga gaagaaaccc gtatgccacc ctaaggatgc
      181 aggacaccat ggtacaggaa ttggcactgg ccaaaaagca actactaatg gtccgtcaag
      241 ctgccctgca ccagctgttt gaaaaggagc atcagcagta ccagcaggaa ctaaatcaga
      301 tgggcaaagc tttttatgta gagagattct gatggcatcc aaaacactgc tcttccattc
      361 tcaacatgcc tgctaaccta gccttctaga acctctacca ccttgaacct ccttcccaaa
      421 acatacctgg atcttgctat ctgtcaggga cttaagacag cacttccact ctcacttctc
      481 cactctctcg ttaatccttt gccgctattt gggaaacaat ctatgaaaca acagtaacaa
      541 caagagtgac gccttgtggt catagtggga tttactatgt tgatgtaagg gggcaggggt
      601 ggggaggggt ggacaatgag agttgagaat cctgatttgg tataacaaat aaatttactt
      661 cctaaaggct caaa
//
